Epocrates Drug Updates - Editor's Pick

September 11, 2014
First-Time Generic for Precedex Available

The FDA recently approved dexmedetomidine injection, the first-time generic for Precedex. Precedex is a selective alpha-2 adrenergic agonist approved for ICU sedation and sedation of non-intubated patients prior to and/or during surgical and other procedures.

First-Time Generic for Precedex Available

Recent Updates

September 5, 2014
Avastin Approved for Advanced Cervical Cancer
The FDA recently approved a new indication for Avastin (bevacizumab) as treatment for persistent, recurrent, or metastatic cervical cancer when used in combination with paclitaxel and cisplatin or with paclitaxel and topotecan. Avastin is an angiogenesis inhibitor that is also indicated for use in metastatic colorectal cancer, advanced NSCLC, progressive glioblastoma, and metastatic renal cell carcinoma. It carries a Boxed Warning for GI perforation, surgery and wound healing complications, and hemorrhage.
Avastin Approved for Advanced Cervical Cancer

August 28, 2014
Tramadol Declared Schedule IV Drug
The DEA designated the synthetic opioid analgesic tramadol a Schedule IV substance, effective August 18, 2014. Its opioid activity and abuse potential are attributable to both the parent compound and a highly potent active metabolite, M1. Tramadol was previously an uncontrolled substance at the federal level, but its status varied by state, with multiple states already scheduling it as a C-IV drug.
Tramadol Declared Schedule IV Drug

August 28, 2014
Errata
The Delsym Cough + Cold Day Time monograph has been updated to correct the dosing for patients >12 years old to 20 mL PO q4h prn, with a maximum dose of 120 mL/24h. The Delsym Night Time Multi-Symptom monograph has been updated to correct the maximum dose for patients >12 years old to 120 mL/24h.

The Tanzeum half-life was updated for consistency with the product’s labeling. Tanzeum has an elimination half-life of 5 days.

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Errata

August 14, 2014
Zydelig Approved for Three Types of Blood Cancers
The FDA recently approved Zydelig (idelalisib) for the treatment of three types of relapsed blood cancers: chronic lymphocytic leukemia (CLL), follicular B-cell non-Hodgkin lymphoma (FL), and small lymphocytic lymphoma (SLL). Zydelig is an oral phosphatidylinositol 3-kinase (PI3K) inhibitor and has a Boxed Warning for hepatotoxicity, severe diarrhea or colitis, pneumonitis, and intestinal perforation.
Zydelig Approved for Three Types of Blood Cancers

August 8, 2014
Beleodaq Approved for Relapsed or Refractory Peripheral T-cell Lymphoma
The FDA recently approved Beleodaq (belinostat), a new histone deacetylase (HDAC) inhibitor for the treatment of relapsed or refractory peripheral T-cell lymphoma. Beleodaq is given as an IV infusion once daily for 5 days each cycle.
Beleodaq Approved for Relapsed or Refractory Peripheral T-cell Lymphoma

New Drug Monographs

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