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Redemplo
plozasiran
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 25 mg per 0.5 mL
familial chylomicronemia syndrome
- [25 mg SC q3mo]
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: no adjustment; moderate-severe impairment: not defined
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: diabetes mellitus
Drug Interactions .
Overview
plozasiran
apolipoprotein-directed C-III siRNA
- hyperglycemic effects
Monitor/Modify Tx
- acarbose
- alogliptin
- bexagliflozin
- bromocriptine
- canagliflozin
- colesevelam
- dapagliflozin
- dulaglutide
- empagliflozin
- ertugliflozin
- exenatide
- glimepiride
- glipizide
- glyburide
- insulin
- linagliptin
- liraglutide
- lixisenatide
- metformin
- miglitol
- nateglinide
- pioglitazone
- pramlintide
- repaglinide
- rosiglitazone
- saxagliptin
- semaglutide
- sitagliptin
- tirzepatide
Adverse Reactions .
Serious Reactions
- hyperglycemia
Common Reactions
- hyperglycemia
- headache
- nausea
- injection site reaction
Safety/Monitoring .
Monitoring Parameters
blood glucose
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of embryo-fetal toxicity or malformations based on animal data at 23x and 140x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available, though risk of infant harm low based on drug properties; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for plozasiran: nucleases; CYP450: none
Excretion: for plozasiran: urine 16-19%; Half-life: 3-4h
Subclass: Dyslipidemia: Apolipoprotein C-III (APOC3) Inhibitors ; Inherited Metabolic Disorders
Mechanism of Action
for plozasiran: degrades apolipoprotein C-III (APOC3) mRNA by RNA interference, reducing APOC3 production and increasing triglyceride clearance (siRNA)
Formulary .
No Formulary Selected
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