Javadin

Overview

clonidine

alpha-2 agonist, central

• affects growth hormone diagnostic test results
• antihypertensive agent
• bradycardia
• CNS depression
• delays atrioventricular conduction
• hyperglycemic effects
• hypoglycemic effects
• hypotensive effects
• potential for modified drug release

• avoid combo with beverages or products containing ethanol and clonidine extended-release (ER) suspension or tablets; combo may incr. clonidine release rate, levels, risk of adverse effects, decr. duration of efficacy

Avoid/Use Alternative

• 5-HTP
Javadin (clonidine)

+

5-HTP

1 interaction

Avoid/Use Alternative

clonidine + 5-HTP

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• acebutolol
Javadin (clonidine)

+

acebutolol

1 interaction

Avoid/Use Alternative

clonidine + acebutolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C acebutolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• adenosine
Javadin (clonidine)

+

adenosine

1 interaction

Avoid/Use Alternative

clonidine + adenosine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• aldesleukin
Javadin (clonidine)

+

aldesleukin

1 interaction

Avoid/Use Alternative

clonidine + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, severe or life-threatening hypotension, including orthostasis (additive effects)

• alfentanil
Javadin (clonidine)

+

alfentanil

1 interaction

Avoid/Use Alternative

clonidine + alfentanil

if ADHD use, avoid combo; otherwise, monitor BP, HR, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, bradycardia, severe hypotension, including orthostasis, syncope (additive effects)

• allopurinol
Javadin (clonidine)

+

allopurinol

1 interaction

Avoid/Use Alternative

clonidine + allopurinol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• almotriptan
Javadin (clonidine)

+

almotriptan

1 interaction

Avoid/Use Alternative

clonidine + almotriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• alprazolam
Javadin (clonidine)

+

alprazolam

1 interaction

Avoid/Use Alternative

clonidine + alprazolam

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• amantadine
Javadin (clonidine)

+

amantadine

1 interaction

Avoid/Use Alternative

clonidine + amantadine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• amiodarone
Javadin (clonidine)

+

amiodarone

1 interaction

Avoid/Use Alternative

clonidine + amiodarone

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• amitriptyline
Javadin (clonidine)

+

amitriptyline

1 interaction

Avoid/Use Alternative

clonidine + amitriptyline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• amoxapine
Javadin (clonidine)

+

amoxapine

1 interaction

Avoid/Use Alternative

clonidine + amoxapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• apomorphine
Javadin (clonidine)

+

apomorphine

1 interaction

Avoid/Use Alternative

clonidine + apomorphine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• apraclonidine ophthalmic
Javadin (clonidine)

+

apraclonidine ophthalmic

1 interaction

Avoid/Use Alternative

clonidine + apraclonidine ophthalmic

if ADHD use, avoid combo; otherwise, monitor BP, HR if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia, hypotension, including orthostasis (additive effects)

• aripiprazole bimonthly injection
Javadin (clonidine)

+

aripiprazole bimonthly injection

1 interaction

Avoid/Use Alternative

clonidine + aripiprazole bimonthly injection

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• aripiprazole lauroxil
Javadin (clonidine)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

clonidine + aripiprazole lauroxil

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• aripiprazole monthly injection
Javadin (clonidine)

+

aripiprazole monthly injection

1 interaction

Avoid/Use Alternative

clonidine + aripiprazole monthly injection

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• aripiprazole oral
Javadin (clonidine)

+

aripiprazole oral

1 interaction

Avoid/Use Alternative

clonidine + aripiprazole oral

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• arsenic trioxide
Javadin (clonidine)

+

arsenic trioxide

1 interaction

Avoid/Use Alternative

clonidine + arsenic trioxide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• asenapine
Javadin (clonidine)

+

asenapine

1 interaction

Avoid/Use Alternative

clonidine + asenapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• atazanavir
Javadin (clonidine)

+

atazanavir

1 interaction

Avoid/Use Alternative

clonidine + atazanavir

if ADHD use, avoid combo; otherwise, monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• atenolol
Javadin (clonidine)

+

atenolol

1 interaction

Avoid/Use Alternative

clonidine + atenolol

if ADHD use, avoid combo; otherwise, monitor BP, HR; D/C atenolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• baclofen
Javadin (clonidine)

+

baclofen

1 interaction

Avoid/Use Alternative

clonidine + baclofen

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen intrathecal
Javadin (clonidine)

+

baclofen intrathecal

1 interaction

Avoid/Use Alternative

clonidine + baclofen intrathecal

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• betaxolol
Javadin (clonidine)

+

betaxolol

1 interaction

Avoid/Use Alternative

clonidine + betaxolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C betaxolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• bisoprolol
Javadin (clonidine)

+

bisoprolol

1 interaction

Avoid/Use Alternative

clonidine + bisoprolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C bisoprolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• brexpiprazole
Javadin (clonidine)

+

brexpiprazole

1 interaction

Avoid/Use Alternative

clonidine + brexpiprazole

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• brigatinib
Javadin (clonidine)

+

brigatinib

1 interaction

Avoid/Use Alternative

clonidine + brigatinib

use alternative or monitor BP, HR: combo may incr. risk of bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• brimonidine ophthalmic
Javadin (clonidine)

+

brimonidine ophthalmic

1 interaction

Avoid/Use Alternative

clonidine + brimonidine ophthalmic

if ADHD use, avoid combo; otherwise, monitor BP if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• brimonidine topical
Javadin (clonidine)

+

brimonidine topical

1 interaction

Avoid/Use Alternative

clonidine + brimonidine topical

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• brivaracetam
Javadin (clonidine)

+

brivaracetam

1 interaction

Avoid/Use Alternative

clonidine + brivaracetam

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• bromocriptine
Javadin (clonidine)

+

bromocriptine

1 interaction

Avoid/Use Alternative

clonidine + bromocriptine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• brompheniramine
Javadin (clonidine)

+

brompheniramine

1 interaction

Avoid/Use Alternative

clonidine + brompheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• buprenorphine
Javadin (clonidine)

+

buprenorphine

1 interaction

Avoid/Use Alternative

clonidine + buprenorphine

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• buspirone
Javadin (clonidine)

+

buspirone

1 interaction

Avoid/Use Alternative

clonidine + buspirone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• butalbital
Javadin (clonidine)

+

butalbital

1 interaction

Avoid/Use Alternative

clonidine + butalbital

avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• butorphanol
Javadin (clonidine)

+

butorphanol

1 interaction

Avoid/Use Alternative

clonidine + butorphanol

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• cannabidiol
Javadin (clonidine)

+

cannabidiol

1 interaction

Avoid/Use Alternative

clonidine + cannabidiol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cannabis
Javadin (clonidine)

+

cannabis

1 interaction

Avoid/Use Alternative

clonidine + cannabis

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may alter blood pressure control (additive effects, antagonistic effects)

• carbamazepine
Javadin (clonidine)

+

carbamazepine

1 interaction

Avoid/Use Alternative

clonidine + carbamazepine

if ADHD use, avoid combo; otherwise, monitor BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of PR interval prolongation, AV block, bradycardia, CNS depression, psychomotor impairment, hypotension, including syncope (additive effects)

• carbinoxamine
Javadin (clonidine)

+

carbinoxamine

1 interaction

Avoid/Use Alternative

clonidine + carbinoxamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cariprazine
Javadin (clonidine)

+

cariprazine

1 interaction

Avoid/Use Alternative

clonidine + cariprazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• carisoprodol
Javadin (clonidine)

+

carisoprodol

1 interaction

Avoid/Use Alternative

clonidine + carisoprodol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carteolol ophthalmic
Javadin (clonidine)

+

carteolol ophthalmic

1 interaction

Avoid/Use Alternative

clonidine + carteolol ophthalmic

if ADHD use, avoid combo; otherwise, monitor BP, HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension, including orthostasis (additive effects)

• carvedilol
Javadin (clonidine)

+

carvedilol

1 interaction

Avoid/Use Alternative

clonidine + carvedilol

if ADHD use, avoid combo; otherwise, monitor BP, HR; D/C carvedilol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• cenobamate
Javadin (clonidine)

+

cenobamate

1 interaction

Avoid/Use Alternative

clonidine + cenobamate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cetirizine
Javadin (clonidine)

+

cetirizine

1 interaction

Avoid/Use Alternative

clonidine + cetirizine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chamomile, German
Javadin (clonidine)

+

chamomile, German

1 interaction

Avoid/Use Alternative

clonidine + chamomile, German

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Javadin (clonidine)

+

chlophedianol

1 interaction

Avoid/Use Alternative

clonidine + chlophedianol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorcyclizine
Javadin (clonidine)

+

chlorcyclizine

1 interaction

Avoid/Use Alternative

clonidine + chlorcyclizine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlordiazepoxide
Javadin (clonidine)

+

chlordiazepoxide

1 interaction

Avoid/Use Alternative

clonidine + chlordiazepoxide

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• chlorpheniramine
Javadin (clonidine)

+

chlorpheniramine

1 interaction

Avoid/Use Alternative

clonidine + chlorpheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorpromazine
Javadin (clonidine)

+

chlorpromazine

1 interaction

Avoid/Use Alternative

clonidine + chlorpromazine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• chlorzoxazone
Javadin (clonidine)

+

chlorzoxazone

1 interaction

Avoid/Use Alternative

clonidine + chlorzoxazone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• citalopram
Javadin (clonidine)

+

citalopram

1 interaction

Avoid/Use Alternative

clonidine + citalopram

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clemastine
Javadin (clonidine)

+

clemastine

1 interaction

Avoid/Use Alternative

clonidine + clemastine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clobazam
Javadin (clonidine)

+

clobazam

1 interaction

Avoid/Use Alternative

clonidine + clobazam

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clomipramine
Javadin (clonidine)

+

clomipramine

1 interaction

Avoid/Use Alternative

clonidine + clomipramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• clonazepam
Javadin (clonidine)

+

clonazepam

1 interaction

Avoid/Use Alternative

clonidine + clonazepam

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clonidine
Javadin (clonidine)

+

clonidine

1 interaction

Avoid/Use Alternative

clonidine + clonidine

avoid combo: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, CNS depression, psychomotor impairment (duplicate therapy; additive effects)

• clorazepate
Javadin (clonidine)

+

clorazepate

1 interaction

Avoid/Use Alternative

clonidine + clorazepate

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clozapine
Javadin (clonidine)

+

clozapine

1 interaction

Avoid/Use Alternative

clonidine + clozapine

if ADHD use, avoid combo; otherwise, monitor BP, HR: combo may incr. risk of severe bradycardia, hypotension (including orthostasis, syncope), CNS depression, psychomotor impairment (additive effects)

• codeine
Javadin (clonidine)

+

codeine

1 interaction

Avoid/Use Alternative

clonidine + codeine

avoid combo if ADHD or antitussive use; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• cyclobenzaprine
Javadin (clonidine)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

clonidine + cyclobenzaprine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cyproheptadine
Javadin (clonidine)

+

cyproheptadine

1 interaction

Avoid/Use Alternative

clonidine + cyproheptadine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dantrolene
Javadin (clonidine)

+

dantrolene

1 interaction

Avoid/Use Alternative

clonidine + dantrolene

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• daridorexant
Javadin (clonidine)

+

daridorexant

1 interaction

Avoid/Use Alternative

clonidine + daridorexant

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Javadin (clonidine)

+

darifenacin

1 interaction

Avoid/Use Alternative

clonidine + darifenacin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• desipramine
Javadin (clonidine)

+

desipramine

1 interaction

Avoid/Use Alternative

clonidine + desipramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• desvenlafaxine
Javadin (clonidine)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

clonidine + desvenlafaxine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• deutetrabenazine
Javadin (clonidine)

+

deutetrabenazine

1 interaction

Avoid/Use Alternative

clonidine + deutetrabenazine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Javadin (clonidine)

+

dexbrompheniramine

1 interaction

Avoid/Use Alternative

clonidine + dexbrompheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Javadin (clonidine)

+

dexchlorpheniramine

1 interaction

Avoid/Use Alternative

clonidine + dexchlorpheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine
Javadin (clonidine)

+

dexmedetomidine

1 interaction

Avoid/Use Alternative

clonidine + dexmedetomidine

if ADHD use, avoid combo; otherwise, monitor BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia, hypotension, including orthostasis, syncope (additive effects)

• dexmedetomidine injection
Javadin (clonidine)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

clonidine + dexmedetomidine injection

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, bradycardia, severe or life-threatening hypotension, including orthostasis (additive effects)

• diazepam
Javadin (clonidine)

+

diazepam

1 interaction

Avoid/Use Alternative

clonidine + diazepam

if ADHD use, avoid combo; otherwise, monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dichlorphenamide
Javadin (clonidine)

+

dichlorphenamide

1 interaction

Avoid/Use Alternative

clonidine + dichlorphenamide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difelikefalin
Javadin (clonidine)

+

difelikefalin

1 interaction

Avoid/Use Alternative

clonidine + difelikefalin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Javadin (clonidine)

+

difenoxin

1 interaction

Avoid/Use Alternative

clonidine + difenoxin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dihydrocodeine
Javadin (clonidine)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

clonidine + dihydrocodeine

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• diltiazem
Javadin (clonidine)

+

diltiazem

1 interaction

Avoid/Use Alternative

clonidine + diltiazem

if ADHD use, avoid combo; otherwise, monitor HR, BP, consider monitoring ECG: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia (additive effects)

• dimenhydrinate
Javadin (clonidine)

+

dimenhydrinate

1 interaction

Avoid/Use Alternative

clonidine + dimenhydrinate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diphenhydramine
Javadin (clonidine)

+

diphenhydramine

1 interaction

Avoid/Use Alternative

clonidine + diphenhydramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diphenoxylate
Javadin (clonidine)

+

diphenoxylate

1 interaction

Avoid/Use Alternative

clonidine + diphenoxylate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• disopyramide
Javadin (clonidine)

+

disopyramide

1 interaction

Avoid/Use Alternative

clonidine + disopyramide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• domperidone
Javadin (clonidine)

+

domperidone

1 interaction

Avoid/Use Alternative

clonidine + domperidone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• donepezil
Javadin (clonidine)

+

donepezil

1 interaction

Avoid/Use Alternative

clonidine + donepezil

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• doxepin
Javadin (clonidine)

+

doxepin

1 interaction

Avoid/Use Alternative

clonidine + doxepin

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• doxepin topical
Javadin (clonidine)

+

doxepin topical

1 interaction

Avoid/Use Alternative

clonidine + doxepin topical

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• doxylamine
Javadin (clonidine)

+

doxylamine

1 interaction

Avoid/Use Alternative

clonidine + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting or clonidine use for ADHD; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dronabinol
Javadin (clonidine)

+

dronabinol

1 interaction

Avoid/Use Alternative

clonidine + dronabinol

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects, antagonistic effects)

• dronedarone
Javadin (clonidine)

+

dronedarone

1 interaction

Avoid/Use Alternative

clonidine + dronedarone

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• droperidol
Javadin (clonidine)

+

droperidol

1 interaction

Avoid/Use Alternative

clonidine + droperidol

if ADHD use, avoid combo; otherwise, decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dulaglutide
Javadin (clonidine)

+

dulaglutide

1 interaction

Avoid/Use Alternative

clonidine + dulaglutide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• duloxetine
Javadin (clonidine)

+

duloxetine

1 interaction

Avoid/Use Alternative

clonidine + duloxetine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• efavirenz
Javadin (clonidine)

+

efavirenz

1 interaction

Avoid/Use Alternative

clonidine + efavirenz

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eletriptan
Javadin (clonidine)

+

eletriptan

1 interaction

Avoid/Use Alternative

clonidine + eletriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• eliglustat
Javadin (clonidine)

+

eliglustat

1 interaction

Avoid/Use Alternative

clonidine + eliglustat

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• elinzanetant
Javadin (clonidine)

+

elinzanetant

1 interaction

Avoid/Use Alternative

clonidine + elinzanetant

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entacapone
Javadin (clonidine)

+

entacapone

1 interaction

Avoid/Use Alternative

clonidine + entacapone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• entrectinib
Javadin (clonidine)

+

entrectinib

1 interaction

Avoid/Use Alternative

clonidine + entrectinib

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• escitalopram
Javadin (clonidine)

+

escitalopram

1 interaction

Avoid/Use Alternative

clonidine + escitalopram

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• esketamine
Javadin (clonidine)

+

esketamine

1 interaction

Avoid/Use Alternative

clonidine + esketamine

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP: combo may incr. risk of CNS and respiratory depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• eslicarbazepine acetate
Javadin (clonidine)

+

eslicarbazepine acetate

1 interaction

Avoid/Use Alternative

clonidine + eslicarbazepine acetate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• esmolol
Javadin (clonidine)

+

esmolol

1 interaction

Avoid/Use Alternative

clonidine + esmolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C esmolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• estazolam
Javadin (clonidine)

+

estazolam

1 interaction

Avoid/Use Alternative

clonidine + estazolam

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• eszopiclone
Javadin (clonidine)

+

eszopiclone

1 interaction

Avoid/Use Alternative

clonidine + eszopiclone

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethanol (alcoholic beverage)
Javadin (clonidine)

+

ethanol (alcoholic beverage)

1 interaction

Avoid/Use Alternative

clonidine + ethanol (alcoholic beverage)

avoid combo: combo with all clonidine formulations may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter BP control, initially incr. risk of severe hypotension, followed by HTN; coingestion of oral ethanol with clonidine ER suspension or ER tablets may incr. clonidine levels, further incr. risk of adverse effects, decr. duration of clonidine efficacy; dose dumping not observed with other clonidine formulations (additive effects, antagonistic effects, acute alcohol intake may have biphasic effects on blood pressure; chronic alcohol use may further increase HTN risk; rapid release from clonidine ER suspension or ER tablets)

• ethanol (in some formulations)
Javadin (clonidine)

+

ethanol (in some formulations)

1 interaction

Avoid/Use Alternative

clonidine + ethanol (in some formulations)

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ethanol injection
Javadin (clonidine)

+

ethanol injection

1 interaction

Avoid/Use Alternative

clonidine + ethanol injection

if ADHD use, avoid combo; otherwise, use alternative or monitor respiratory rate, BP: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis (additive effects)

• ethosuximide
Javadin (clonidine)

+

ethosuximide

1 interaction

Avoid/Use Alternative

clonidine + ethosuximide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• etrasimod
Javadin (clonidine)

+

etrasimod

1 interaction

Avoid/Use Alternative

clonidine + etrasimod

if ADHD use, avoid combo; otherwise, monitor BP, HR, especially when starting or restarting etrasimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• etripamil nasal
Javadin (clonidine)

+

etripamil nasal

1 interaction

Avoid/Use Alternative

clonidine + etripamil nasal

if ADHD use, avoid combo; otherwise, monitor BP, HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension, including orthostasis, syncope (additive effects)

• felbamate
Javadin (clonidine)

+

felbamate

1 interaction

Avoid/Use Alternative

clonidine + felbamate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fenfluramine
Javadin (clonidine)

+

fenfluramine

1 interaction

Avoid/Use Alternative

clonidine + fenfluramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may decr. antihypertensive agent efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• fentanyl
Javadin (clonidine)

+

fentanyl

1 interaction

Avoid/Use Alternative

clonidine + fentanyl

if ADHD use, avoid combo; otherwise, monitor HR, BP, respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), bradycardia (additive effects)

• fesoterodine
Javadin (clonidine)

+

fesoterodine

1 interaction

Avoid/Use Alternative

clonidine + fesoterodine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fexinidazole
Javadin (clonidine)

+

fexinidazole

1 interaction

Avoid/Use Alternative

clonidine + fexinidazole

if possible, do not initiate fexinidazole until 5 half-lives after clonidine D/C; use alternative or monitor ECG during and x7 days after fexinidazole tx: combo may incr. risk of QT prolongation, cardiac arrhythmias (bradycardia may incr. risk of QT prolongation)

• fingolimod
Javadin (clonidine)

+

fingolimod

1 interaction

Avoid/Use Alternative

clonidine + fingolimod

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR, ECG overnight, esp. during fingolimod initiation/titration: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• flecainide
Javadin (clonidine)

+

flecainide

1 interaction

Avoid/Use Alternative

clonidine + flecainide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• flibanserin
Javadin (clonidine)

+

flibanserin

1 interaction

Avoid/Use Alternative

clonidine + flibanserin

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• fluoxetine
Javadin (clonidine)

+

fluoxetine

1 interaction

Avoid/Use Alternative

clonidine + fluoxetine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluphenazine
Javadin (clonidine)

+

fluphenazine

1 interaction

Avoid/Use Alternative

clonidine + fluphenazine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• flurazepam
Javadin (clonidine)

+

flurazepam

1 interaction

Avoid/Use Alternative

clonidine + flurazepam

if ADHD use, avoid combo; otherwise, monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• fluvoxamine
Javadin (clonidine)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

clonidine + fluvoxamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• foslevodopa
Javadin (clonidine)

+

foslevodopa

1 interaction

Avoid/Use Alternative

clonidine + foslevodopa

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• fosphenytoin
Javadin (clonidine)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

clonidine + fosphenytoin

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of CNS depression, psychomotor impairment, PR interval prolongation, AV block, bradycardia (additive effects)

• frovatriptan
Javadin (clonidine)

+

frovatriptan

1 interaction

Avoid/Use Alternative

clonidine + frovatriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• gabapentin
Javadin (clonidine)

+

gabapentin

1 interaction

Avoid/Use Alternative

clonidine + gabapentin

if ADHD use, avoid combo; otherwise, monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Javadin (clonidine)

+

gabapentin enacarbil

1 interaction

Avoid/Use Alternative

clonidine + gabapentin enacarbil

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• gadobenate dimeglumine
Javadin (clonidine)

+

gadobenate dimeglumine

1 interaction

Avoid/Use Alternative

clonidine + gadobenate dimeglumine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• galantamine
Javadin (clonidine)

+

galantamine

1 interaction

Avoid/Use Alternative

clonidine + galantamine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• ganaxolone
Javadin (clonidine)

+

ganaxolone

1 interaction

Avoid/Use Alternative

clonidine + ganaxolone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glofitamab
Javadin (clonidine)

+

glofitamab

1 interaction

Avoid/Use Alternative

clonidine + glofitamab

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate
Javadin (clonidine)

+

glycopyrrolate

1 interaction

Avoid/Use Alternative

clonidine + glycopyrrolate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• guanfacine
Javadin (clonidine)

+

guanfacine

1 interaction

Avoid/Use Alternative

clonidine + guanfacine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia (additive effects, duplicate therapy)

• haloperidol
Javadin (clonidine)

+

haloperidol

1 interaction

Avoid/Use Alternative

clonidine + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• hydrocodone
Javadin (clonidine)

+

hydrocodone

1 interaction

Avoid/Use Alternative

clonidine + hydrocodone

avoid combo if ADHD or antitussive use; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• hydromorphone
Javadin (clonidine)

+

hydromorphone

1 interaction

Avoid/Use Alternative

clonidine + hydromorphone

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• hydroxyzine
Javadin (clonidine)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

clonidine + hydroxyzine

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hyoscyamine
Javadin (clonidine)

+

hyoscyamine

1 interaction

Avoid/Use Alternative

clonidine + hyoscyamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ifosfamide
Javadin (clonidine)

+

ifosfamide

1 interaction

Avoid/Use Alternative

clonidine + ifosfamide

if ADHD use, avoid combo; otherwise, D/C one or both drugs if encephalopathy occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• iloperidone
Javadin (clonidine)

+

iloperidone

1 interaction

Avoid/Use Alternative

clonidine + iloperidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• imipramine
Javadin (clonidine)

+

imipramine

1 interaction

Avoid/Use Alternative

clonidine + imipramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• isocarboxazid
Javadin (clonidine)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

clonidine + isocarboxazid

if ADHD use, avoid combo; otherwise, use alternative or monitor BP during and x10 days after isocarboxazid use: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• ivabradine
Javadin (clonidine)

+

ivabradine

1 interaction

Avoid/Use Alternative

clonidine + ivabradine

if ADHD use, avoid combo; otherwise, monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• kava
Javadin (clonidine)

+

kava

1 interaction

Avoid/Use Alternative

clonidine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Javadin (clonidine)

+

kratom

1 interaction

Avoid/Use Alternative

clonidine + kratom

if ADHD use, avoid combo; otherwise, use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• labetalol
Javadin (clonidine)

+

labetalol

1 interaction

Avoid/Use Alternative

clonidine + labetalol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C labetalol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• lacosamide
Javadin (clonidine)

+

lacosamide

1 interaction

Avoid/Use Alternative

clonidine + lacosamide

if ADHD use, avoid combo; otherwise, monitor HR, ECG, especially during lacosamide initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, PR interval prolongation, AV block, bradycardia (additive effects)

• lamotrigine
Javadin (clonidine)

+

lamotrigine

1 interaction

Avoid/Use Alternative

clonidine + lamotrigine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia (additive effects)

• landiolol
Javadin (clonidine)

+

landiolol

1 interaction

Avoid/Use Alternative

clonidine + landiolol

avoid combo: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension, including orthostasis (additive effects)

• lemborexant
Javadin (clonidine)

+

lemborexant

1 interaction

Avoid/Use Alternative

clonidine + lemborexant

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levetiracetam
Javadin (clonidine)

+

levetiracetam

1 interaction

Avoid/Use Alternative

clonidine + levetiracetam

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levocetirizine
Javadin (clonidine)

+

levocetirizine

1 interaction

Avoid/Use Alternative

clonidine + levocetirizine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Javadin (clonidine)

+

levodopa

1 interaction

Avoid/Use Alternative

clonidine + levodopa

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• levomilnacipran
Javadin (clonidine)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

clonidine + levomilnacipran

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• levorphanol
Javadin (clonidine)

+

levorphanol

1 interaction

Avoid/Use Alternative

clonidine + levorphanol

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• linezolid
Javadin (clonidine)

+

linezolid

1 interaction

Avoid/Use Alternative

clonidine + linezolid

use alternative or monitor BP: combo may result in severe HTN followed by severe hypotension; may result in HTN crisis upon alpha-2 agonist D/C (complex effects on neuronal catecholamines, linezolid reversibly inhibits monoamine oxidase)

• linvoseltamab
Javadin (clonidine)

+

linvoseltamab

1 interaction

Avoid/Use Alternative

clonidine + linvoseltamab

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lofexidine
Javadin (clonidine)

+

lofexidine

1 interaction

Avoid/Use Alternative

clonidine + lofexidine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• lopinavir/ritonavir
Javadin (clonidine)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

clonidine + lopinavir/ ritonavir

if ADHD use, avoid combo; otherwise, monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• lorazepam
Javadin (clonidine)

+

lorazepam

1 interaction

Avoid/Use Alternative

clonidine + lorazepam

if ADHD use, avoid combo; otherwise, monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lorlatinib
Javadin (clonidine)

+

lorlatinib

1 interaction

Avoid/Use Alternative

clonidine + lorlatinib

if ADHD use, avoid combo; otherwise, monitor BP, HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• loxapine
Javadin (clonidine)

+

loxapine

1 interaction

Avoid/Use Alternative

clonidine + loxapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• lumateperone
Javadin (clonidine)

+

lumateperone

1 interaction

Avoid/Use Alternative

clonidine + lumateperone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• lurasidone
Javadin (clonidine)

+

lurasidone

1 interaction

Avoid/Use Alternative

clonidine + lurasidone

if ADHD use, avoid combo; otherwise, monitor BP; consider lowest lurasidone start dose, titrate slowly: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• macimorelin
Javadin (clonidine)

+

macimorelin

1 interaction

Avoid/Use Alternative

clonidine + macimorelin

avoid combo or D/C clonidine, allowing sufficient washout time before diagnostic test: combo may interfere with test results (clonidine may transiently incr. growth hormone levels)

• meclizine
Javadin (clonidine)

+

meclizine

1 interaction

Avoid/Use Alternative

clonidine + meclizine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mefloquine
Javadin (clonidine)

+

mefloquine

1 interaction

Avoid/Use Alternative

clonidine + mefloquine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• melatonin
Javadin (clonidine)

+

melatonin

1 interaction

Avoid/Use Alternative

clonidine + melatonin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meperidine
Javadin (clonidine)

+

meperidine

1 interaction

Avoid/Use Alternative

clonidine + meperidine

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• meprobamate
Javadin (clonidine)

+

meprobamate

1 interaction

Avoid/Use Alternative

clonidine + meprobamate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metaxalone
Javadin (clonidine)

+

metaxalone

1 interaction

Avoid/Use Alternative

clonidine + metaxalone

if ADHD use, avoid combo; otherwise, use alternative or monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methadone
Javadin (clonidine)

+

methadone

1 interaction

Avoid/Use Alternative

clonidine + methadone

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• methocarbamol
Javadin (clonidine)

+

methocarbamol

1 interaction

Avoid/Use Alternative

clonidine + methocarbamol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methohexital
Javadin (clonidine)

+

methohexital

1 interaction

Avoid/Use Alternative

clonidine + methohexital

if ADHD use, avoid combo; otherwise, monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• methsuximide
Javadin (clonidine)

+

methsuximide

1 interaction

Avoid/Use Alternative

clonidine + methsuximide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methyldopa
Javadin (clonidine)

+

methyldopa

1 interaction

Avoid/Use Alternative

clonidine + methyldopa

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects, duplicate therapy)

• metoclopramide
Javadin (clonidine)

+

metoclopramide

1 interaction

Avoid/Use Alternative

clonidine + metoclopramide

if ADHD use, avoid combo; otherwise, use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• metoprolol
Javadin (clonidine)

+

metoprolol

1 interaction

Avoid/Use Alternative

clonidine + metoprolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C metoprolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• metyrapone
Javadin (clonidine)

+

metyrapone

1 interaction

Avoid/Use Alternative

clonidine + metyrapone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Javadin (clonidine)

+

metyrosine

1 interaction

Avoid/Use Alternative

clonidine + metyrosine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• midazolam
Javadin (clonidine)

+

midazolam

1 interaction

Avoid/Use Alternative

clonidine + midazolam

if ADHD use, avoid combo; otherwise, use alternative or monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• milnacipran
Javadin (clonidine)

+

milnacipran

1 interaction

Avoid/Use Alternative

clonidine + milnacipran

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• milsaperidone
Javadin (clonidine)

+

milsaperidone

1 interaction

Avoid/Use Alternative

clonidine + milsaperidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• mirtazapine
Javadin (clonidine)

+

mirtazapine

1 interaction

Avoid/Use Alternative

clonidine + mirtazapine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• mitotane
Javadin (clonidine)

+

mitotane

1 interaction

Avoid/Use Alternative

clonidine + mitotane

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• molindone
Javadin (clonidine)

+

molindone

1 interaction

Avoid/Use Alternative

clonidine + molindone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• morphine
Javadin (clonidine)

+

morphine

1 interaction

Avoid/Use Alternative

clonidine + morphine

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• mosunetuzumab
Javadin (clonidine)

+

mosunetuzumab

1 interaction

Avoid/Use Alternative

clonidine + mosunetuzumab

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Javadin (clonidine)

+

mycophenolate mofetil

1 interaction

Avoid/Use Alternative

clonidine + mycophenolate mofetil

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nadolol
Javadin (clonidine)

+

nadolol

1 interaction

Avoid/Use Alternative

clonidine + nadolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C nadolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• nalbuphine
Javadin (clonidine)

+

nalbuphine

1 interaction

Avoid/Use Alternative

clonidine + nalbuphine

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• naltrexone
Javadin (clonidine)

+

naltrexone

1 interaction

Avoid/Use Alternative

clonidine + naltrexone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naratriptan
Javadin (clonidine)

+

naratriptan

1 interaction

Avoid/Use Alternative

clonidine + naratriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may decr. antihypertensive agent efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• nebivolol
Javadin (clonidine)

+

nebivolol

1 interaction

Avoid/Use Alternative

clonidine + nebivolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C nebivolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• nefazodone
Javadin (clonidine)

+

nefazodone

1 interaction

Avoid/Use Alternative

clonidine + nefazodone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nelarabine
Javadin (clonidine)

+

nelarabine

1 interaction

Avoid/Use Alternative

clonidine + nelarabine

if ADHD use, avoid combo; otherwise, withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nortriptyline
Javadin (clonidine)

+

nortriptyline

1 interaction

Avoid/Use Alternative

clonidine + nortriptyline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• olanzapine
Javadin (clonidine)

+

olanzapine

1 interaction

Avoid/Use Alternative

clonidine + olanzapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• oliceridine
Javadin (clonidine)

+

oliceridine

1 interaction

Avoid/Use Alternative

clonidine + oliceridine

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• opicapone
Javadin (clonidine)

+

opicapone

1 interaction

Avoid/Use Alternative

clonidine + opicapone

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• opium
Javadin (clonidine)

+

opium

1 interaction

Avoid/Use Alternative

clonidine + opium

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• orphenadrine
Javadin (clonidine)

+

orphenadrine

1 interaction

Avoid/Use Alternative

clonidine + orphenadrine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• oxazepam
Javadin (clonidine)

+

oxazepam

1 interaction

Avoid/Use Alternative

clonidine + oxazepam

if ADHD use, avoid combo; otherwise, monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• oxcarbazepine
Javadin (clonidine)

+

oxcarbazepine

1 interaction

Avoid/Use Alternative

clonidine + oxcarbazepine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• oxybate
Javadin (clonidine)

+

oxybate

1 interaction

Avoid/Use Alternative

clonidine + oxybate

if ADHD use, avoid combo; otherwise, use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxybutynin
Javadin (clonidine)

+

oxybutynin

1 interaction

Avoid/Use Alternative

clonidine + oxybutynin

if ADHD use, avoid combo; otherwise, decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment; somnolence less likely with oxybutynin transdermal patch (additive effects)

• oxycodone
Javadin (clonidine)

+

oxycodone

1 interaction

Avoid/Use Alternative

clonidine + oxycodone

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. oxycodone start dose by at least 50%, consider decr. clonidine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• oxymorphone
Javadin (clonidine)

+

oxymorphone

1 interaction

Avoid/Use Alternative

clonidine + oxymorphone

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. oxymorphone start dose by at least 50%, consider decr. clonidine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• ozanimod
Javadin (clonidine)

+

ozanimod

1 interaction

Avoid/Use Alternative

clonidine + ozanimod

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR, ECG, especially when starting or restarting ozanimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• paliperidone
Javadin (clonidine)

+

paliperidone

1 interaction

Avoid/Use Alternative

clonidine + paliperidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• paltusotine
Javadin (clonidine)

+

paltusotine

1 interaction

Avoid/Use Alternative

clonidine + paltusotine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• paroxetine
Javadin (clonidine)

+

paroxetine

1 interaction

Avoid/Use Alternative

clonidine + paroxetine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• passion flower
Javadin (clonidine)

+

passion flower

1 interaction

Avoid/Use Alternative

clonidine + passion flower

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pentazocine
Javadin (clonidine)

+

pentazocine

1 interaction

Avoid/Use Alternative

clonidine + pentazocine

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• pentobarbital
Javadin (clonidine)

+

pentobarbital

1 interaction

Avoid/Use Alternative

clonidine + pentobarbital

if ADHD use, avoid combo; otherwise, monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• perampanel
Javadin (clonidine)

+

perampanel

1 interaction

Avoid/Use Alternative

clonidine + perampanel

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• perphenazine
Javadin (clonidine)

+

perphenazine

1 interaction

Avoid/Use Alternative

clonidine + perphenazine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• phenelzine
Javadin (clonidine)

+

phenelzine

1 interaction

Avoid/Use Alternative

clonidine + phenelzine

if ADHD use, avoid combo; otherwise, use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• pheniramine
Javadin (clonidine)

+

pheniramine

1 interaction

Avoid/Use Alternative

clonidine + pheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• phenobarbital
Javadin (clonidine)

+

phenobarbital

1 interaction

Avoid/Use Alternative

clonidine + phenobarbital

if ADHD use, avoid combo; otherwise, monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• phenytoin
Javadin (clonidine)

+

phenytoin

1 interaction

Avoid/Use Alternative

clonidine + phenytoin

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of bradycardia, CNS depression, psychomotor impairment (additive effects)

• pimozide
Javadin (clonidine)

+

pimozide

1 interaction

Avoid/Use Alternative

clonidine + pimozide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pindolol
Javadin (clonidine)

+

pindolol

1 interaction

Avoid/Use Alternative

clonidine + pindolol

if ADHD use, avoid combo; otherwise monitor HR, BP; D/C pindolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• ponesimod
Javadin (clonidine)

+

ponesimod

1 interaction

Avoid/Use Alternative

clonidine + ponesimod

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR, ECG, especially when starting or restarting ponesimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• pramipexole
Javadin (clonidine)

+

pramipexole

1 interaction

Avoid/Use Alternative

clonidine + pramipexole

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• praziquantel
Javadin (clonidine)

+

praziquantel

1 interaction

Avoid/Use Alternative

clonidine + praziquantel

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• pregabalin
Javadin (clonidine)

+

pregabalin

1 interaction

Avoid/Use Alternative

clonidine + pregabalin

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• primidone
Javadin (clonidine)

+

primidone

1 interaction

Avoid/Use Alternative

clonidine + primidone

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• procainamide
Javadin (clonidine)

+

procainamide

1 interaction

Avoid/Use Alternative

clonidine + procainamide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• procarbazine
Javadin (clonidine)

+

procarbazine

1 interaction

Avoid/Use Alternative

clonidine + procarbazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• prochlorperazine
Javadin (clonidine)

+

prochlorperazine

1 interaction

Avoid/Use Alternative

clonidine + prochlorperazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• promethazine
Javadin (clonidine)

+

promethazine

1 interaction

Avoid/Use Alternative

clonidine + promethazine

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• propafenone
Javadin (clonidine)

+

propafenone

1 interaction

Avoid/Use Alternative

clonidine + propafenone

if ADHD use, avoid combo; otherwise, monitor HR, BP: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension, including orthostasis (additive effects)

• propranolol
Javadin (clonidine)

+

propranolol

1 interaction

Avoid/Use Alternative

clonidine + propranolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C propranolol prior to clonidine taper: combo may incr. risk of PR interval prolongation, AV block, bradycardia, altered BP, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• protriptyline
Javadin (clonidine)

+

protriptyline

1 interaction

Avoid/Use Alternative

clonidine + protriptyline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• pyrilamine
Javadin (clonidine)

+

pyrilamine

1 interaction

Avoid/Use Alternative

clonidine + pyrilamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• quazepam
Javadin (clonidine)

+

quazepam

1 interaction

Avoid/Use Alternative

clonidine + quazepam

if ADHD use, avoid combo; otherwise, monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• quetiapine
Javadin (clonidine)

+

quetiapine

1 interaction

Avoid/Use Alternative

clonidine + quetiapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. antihypertensive agent efficacy (peds patients) (additive effects, antagonistic effects)

• quinine
Javadin (clonidine)

+

quinine

1 interaction

Avoid/Use Alternative

clonidine + quinine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• ramelteon
Javadin (clonidine)

+

ramelteon

1 interaction

Avoid/Use Alternative

clonidine + ramelteon

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rasagiline
Javadin (clonidine)

+

rasagiline

1 interaction

Avoid/Use Alternative

clonidine + rasagiline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• regadenoson
Javadin (clonidine)

+

regadenoson

1 interaction

Avoid/Use Alternative

clonidine + regadenoson

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• remifentanil
Javadin (clonidine)

+

remifentanil

1 interaction

Avoid/Use Alternative

clonidine + remifentanil

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP, HR; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, bradycardia, severe hypotension, including orthostasis, syncope (additive effects)

• remimazolam
Javadin (clonidine)

+

remimazolam

1 interaction

Avoid/Use Alternative

clonidine + remimazolam

if ADHD use, avoid combo; otherwise, monitor BP, HR, respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of hypotension (including orthostasis), bradycardia, profound CNS and respiratory depression, psychomotor impairment (additive effects)

• repotrectinib
Javadin (clonidine)

+

repotrectinib

1 interaction

Avoid/Use Alternative

clonidine + repotrectinib

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• risperidone
Javadin (clonidine)

+

risperidone

1 interaction

Avoid/Use Alternative

clonidine + risperidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• ritonavir
Javadin (clonidine)

+

ritonavir

1 interaction

Avoid/Use Alternative

clonidine + ritonavir

if ADHD use, avoid combo; otherwise, monitor HR, consider monitoring ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• rizatriptan
Javadin (clonidine)

+

rizatriptan

1 interaction

Avoid/Use Alternative

clonidine + rizatriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• ropeginterferon alfa-2b
Javadin (clonidine)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

clonidine + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ropinirole
Javadin (clonidine)

+

ropinirole

1 interaction

Avoid/Use Alternative

clonidine + ropinirole

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects, antagonistic effects)

• rotigotine transdermal
Javadin (clonidine)

+

rotigotine transdermal

1 interaction

Avoid/Use Alternative

clonidine + rotigotine transdermal

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects)

• rufinamide
Javadin (clonidine)

+

rufinamide

1 interaction

Avoid/Use Alternative

clonidine + rufinamide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• safinamide
Javadin (clonidine)

+

safinamide

1 interaction

Avoid/Use Alternative

clonidine + safinamide

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• scopolamine
Javadin (clonidine)

+

scopolamine

1 interaction

Avoid/Use Alternative

clonidine + scopolamine

if ADHD use, avoid combo; otherwise, use alternative: combo may increase risk of CNS depression, psychomotor impairment (additive effects)

• selegiline
Javadin (clonidine)

+

selegiline

1 interaction

Avoid/Use Alternative

clonidine + selegiline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• selegiline transdermal
Javadin (clonidine)

+

selegiline transdermal

1 interaction

Avoid/Use Alternative

clonidine + selegiline transdermal

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• selinexor
Javadin (clonidine)

+

selinexor

1 interaction

Avoid/Use Alternative

clonidine + selinexor

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sertraline
Javadin (clonidine)

+

sertraline

1 interaction

Avoid/Use Alternative

clonidine + sertraline

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• siponimod
Javadin (clonidine)

+

siponimod

1 interaction

Avoid/Use Alternative

clonidine + siponimod

if ADHD use, avoid combo; otherwise, consider alternative or monitor BP, HR, ECG, especially when starting or restarting siponimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• solifenacin
Javadin (clonidine)

+

solifenacin

1 interaction

Avoid/Use Alternative

clonidine + solifenacin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sotalol
Javadin (clonidine)

+

sotalol

1 interaction

Avoid/Use Alternative

clonidine + sotalol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C sotalol prior to clonidine taper: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension (including orthostasis), severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• stiripentol
Javadin (clonidine)

+

stiripentol

1 interaction

Avoid/Use Alternative

clonidine + stiripentol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sufentanil
Javadin (clonidine)

+

sufentanil

1 interaction

Avoid/Use Alternative

clonidine + sufentanil

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP, HR; decr. sufentanil start dose, consider decr. clonidine dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, bradycardia, severe hypotension, including orthostasis, syncope (additive effects)

• sumatriptan
Javadin (clonidine)

+

sumatriptan

1 interaction

Avoid/Use Alternative

clonidine + sumatriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• suvorexant
Javadin (clonidine)

+

suvorexant

1 interaction

Avoid/Use Alternative

clonidine + suvorexant

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tapentadol
Javadin (clonidine)

+

tapentadol

1 interaction

Avoid/Use Alternative

clonidine + tapentadol

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• tasimelteon
Javadin (clonidine)

+

tasimelteon

1 interaction

Avoid/Use Alternative

clonidine + tasimelteon

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• temazepam
Javadin (clonidine)

+

temazepam

1 interaction

Avoid/Use Alternative

clonidine + temazepam

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• tetrabenazine
Javadin (clonidine)

+

tetrabenazine

1 interaction

Avoid/Use Alternative

clonidine + tetrabenazine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thalidomide
Javadin (clonidine)

+

thalidomide

1 interaction

Avoid/Use Alternative

clonidine + thalidomide

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia, hypotension, including orthostasis (additive effects)

• thioridazine
Javadin (clonidine)

+

thioridazine

1 interaction

Avoid/Use Alternative

clonidine + thioridazine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• thiotepa
Javadin (clonidine)

+

thiotepa

1 interaction

Avoid/Use Alternative

clonidine + thiotepa

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiothixene
Javadin (clonidine)

+

thiothixene

1 interaction

Avoid/Use Alternative

clonidine + thiothixene

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• tiagabine
Javadin (clonidine)

+

tiagabine

1 interaction

Avoid/Use Alternative

clonidine + tiagabine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ticagrelor
Javadin (clonidine)

+

ticagrelor

1 interaction

Avoid/Use Alternative

clonidine + ticagrelor

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• timolol
Javadin (clonidine)

+

timolol

1 interaction

Avoid/Use Alternative

clonidine + timolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C timolol prior to clonidine taper: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• tizanidine
Javadin (clonidine)

+

tizanidine

1 interaction

Avoid/Use Alternative

clonidine + tizanidine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• tolcapone
Javadin (clonidine)

+

tolcapone

1 interaction

Avoid/Use Alternative

clonidine + tolcapone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• tolterodine
Javadin (clonidine)

+

tolterodine

1 interaction

Avoid/Use Alternative

clonidine + tolterodine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• topiramate
Javadin (clonidine)

+

topiramate

1 interaction

Avoid/Use Alternative

clonidine + topiramate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tradipitant
Javadin (clonidine)

+

tradipitant

1 interaction

Avoid/Use Alternative

clonidine + tradipitant

if ADHD use, avoid combo; otherwise, use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tramadol
Javadin (clonidine)

+

tramadol

1 interaction

Avoid/Use Alternative

clonidine + tramadol

if ADHD use, avoid combo; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• tranylcypromine
Javadin (clonidine)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

clonidine + tranylcypromine

if ADHD use, avoid combo; otherwise, use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• trazodone
Javadin (clonidine)

+

trazodone

1 interaction

Avoid/Use Alternative

clonidine + trazodone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• triazolam
Javadin (clonidine)

+

triazolam

1 interaction

Avoid/Use Alternative

clonidine + triazolam

if ADHD use, avoid combo; otherwise, monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• trifluoperazine
Javadin (clonidine)

+

trifluoperazine

1 interaction

Avoid/Use Alternative

clonidine + trifluoperazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis (additive effects)

• trihexyphenidyl
Javadin (clonidine)

+

trihexyphenidyl

1 interaction

Avoid/Use Alternative

clonidine + trihexyphenidyl

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimethobenzamide
Javadin (clonidine)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

clonidine + trimethobenzamide

if ADHD use, avoid combo; otherwise, use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Javadin (clonidine)

+

trimipramine

1 interaction

Avoid/Use Alternative

clonidine + trimipramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• triprolidine
Javadin (clonidine)

+

triprolidine

1 interaction

Avoid/Use Alternative

clonidine + triprolidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trospium
Javadin (clonidine)

+

trospium

1 interaction

Avoid/Use Alternative

clonidine + trospium

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valbenazine
Javadin (clonidine)

+

valbenazine

1 interaction

Avoid/Use Alternative

clonidine + valbenazine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Javadin (clonidine)

+

valerian

1 interaction

Avoid/Use Alternative

clonidine + valerian

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
Javadin (clonidine)

+

valproic acid

1 interaction

Avoid/Use Alternative

clonidine + valproic acid

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• venlafaxine
Javadin (clonidine)

+

venlafaxine

1 interaction

Avoid/Use Alternative

clonidine + venlafaxine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• verapamil
Javadin (clonidine)

+

verapamil

1 interaction

Avoid/Use Alternative

clonidine + verapamil

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia (additive effects)

• vigabatrin
Javadin (clonidine)

+

vigabatrin

1 interaction

Avoid/Use Alternative

clonidine + vigabatrin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vilazodone
Javadin (clonidine)

+

vilazodone

1 interaction

Avoid/Use Alternative

clonidine + vilazodone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• viloxazine
Javadin (clonidine)

+

viloxazine

1 interaction

Avoid/Use Alternative

clonidine + viloxazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• yohimbe
Javadin (clonidine)

+

yohimbe

1 interaction

Avoid/Use Alternative

clonidine + yohimbe

avoid combo: combo may decr. efficacy of both drugs (antagonistic effects)

• zaleplon
Javadin (clonidine)

+

zaleplon

1 interaction

Avoid/Use Alternative

clonidine + zaleplon

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziconotide
Javadin (clonidine)

+

ziconotide

1 interaction

Avoid/Use Alternative

clonidine + ziconotide

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziprasidone
Javadin (clonidine)

+

ziprasidone

1 interaction

Avoid/Use Alternative

clonidine + ziprasidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• zolmitriptan
Javadin (clonidine)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

clonidine + zolmitriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may decr. antihypertensive agent efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• zolpidem
Javadin (clonidine)

+

zolpidem

1 interaction

Avoid/Use Alternative

clonidine + zolpidem

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
Javadin (clonidine)

+

zonisamide

1 interaction

Avoid/Use Alternative

clonidine + zonisamide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zuranolone
Javadin (clonidine)

+

zuranolone

1 interaction

Avoid/Use Alternative

clonidine + zuranolone

if ADHD use, avoid combo; otherwise, use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• abiraterone acetate
Javadin (clonidine)

+

abiraterone acetate

1 interaction

Monitor/Modify Tx

clonidine + abiraterone acetate

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• albuterol
Javadin (clonidine)

+

albuterol

1 interaction

Monitor/Modify Tx

clonidine + albuterol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• albuterol inhaled
Javadin (clonidine)

+

albuterol inhaled

1 interaction

Monitor/Modify Tx

clonidine + albuterol inhaled

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• alectinib
Javadin (clonidine)

+

alectinib

1 interaction

Monitor/Modify Tx

clonidine + alectinib

monitor HR: combo may incr. risk of bradycardia (additive effects)

• alfuzosin
Javadin (clonidine)

+

alfuzosin

1 interaction

Monitor/Modify Tx

clonidine + alfuzosin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• aliskiren
Javadin (clonidine)

+

aliskiren

1 interaction

Monitor/Modify Tx

clonidine + aliskiren

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• alprostadil intracavernous
Javadin (clonidine)

+

alprostadil intracavernous

1 interaction

Monitor/Modify Tx

clonidine + alprostadil intracavernous

monitor BP: combo may increase risk of hypotension, including orthostasis (additive effects)

• amifostine
Javadin (clonidine)

+

amifostine

1 interaction

Monitor/Modify Tx

clonidine + amifostine

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• amiloride
Javadin (clonidine)

+

amiloride

1 interaction

Monitor/Modify Tx

clonidine + amiloride

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• amlodipine
Javadin (clonidine)

+

amlodipine

1 interaction

Monitor/Modify Tx

clonidine + amlodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• amphetamine
Javadin (clonidine)

+

amphetamine

1 interaction

Monitor/Modify Tx

clonidine + amphetamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• aprocitentan
Javadin (clonidine)

+

aprocitentan

1 interaction

Monitor/Modify Tx

clonidine + aprocitentan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• arformoterol inhaled
Javadin (clonidine)

+

arformoterol inhaled

1 interaction

Monitor/Modify Tx

clonidine + arformoterol inhaled

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• armodafinil
Javadin (clonidine)

+

armodafinil

1 interaction

Monitor/Modify Tx

clonidine + armodafinil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• articaine
Javadin (clonidine)

+

articaine

1 interaction

Monitor/Modify Tx

clonidine + articaine

monitor BP, HR: combo may incr. risk of bradycardia, hypotension, including orthostasis (additive effects)

• asciminib
Javadin (clonidine)

+

asciminib

1 interaction

Monitor/Modify Tx

clonidine + asciminib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• aspirin
Javadin (clonidine)

+

aspirin

1 interaction

Monitor/Modify Tx

clonidine + aspirin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atogepant
Javadin (clonidine)

+

atogepant

1 interaction

Monitor/Modify Tx

clonidine + atogepant

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atomoxetine
Javadin (clonidine)

+

atomoxetine

1 interaction

Monitor/Modify Tx

clonidine + atomoxetine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atropine ophthalmic
Javadin (clonidine)

+

atropine ophthalmic

1 interaction

Monitor/Modify Tx

clonidine + atropine ophthalmic

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• avanafil
Javadin (clonidine)

+

avanafil

1 interaction

Monitor/Modify Tx

clonidine + avanafil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• axitinib
Javadin (clonidine)

+

axitinib

1 interaction

Monitor/Modify Tx

clonidine + axitinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• azilsartan medoxomil
Javadin (clonidine)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

clonidine + azilsartan medoxomil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• benazepril
Javadin (clonidine)

+

benazepril

1 interaction

Monitor/Modify Tx

clonidine + benazepril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• benzphetamine
Javadin (clonidine)

+

benzphetamine

1 interaction

Monitor/Modify Tx

clonidine + benzphetamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• berberine
Javadin (clonidine)

+

berberine

1 interaction

Monitor/Modify Tx

clonidine + berberine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• betamethasone
Javadin (clonidine)

+

betamethasone

1 interaction

Monitor/Modify Tx

clonidine + betamethasone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• betaxolol ophthalmic
Javadin (clonidine)

+

betaxolol ophthalmic

1 interaction

Monitor/Modify Tx

clonidine + betaxolol ophthalmic

monitor BP, HR: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia (additive effects)

• bethanechol
Javadin (clonidine)

+

bethanechol

1 interaction

Monitor/Modify Tx

clonidine + bethanechol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• bevacizumab
Javadin (clonidine)

+

bevacizumab

1 interaction

Monitor/Modify Tx

clonidine + bevacizumab

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bexagliflozin
Javadin (clonidine)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

clonidine + bexagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• bismuth subsalicylate
Javadin (clonidine)

+

bismuth subsalicylate

1 interaction

Monitor/Modify Tx

clonidine + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bortezomib
Javadin (clonidine)

+

bortezomib

1 interaction

Monitor/Modify Tx

clonidine + bortezomib

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• budesonide
Javadin (clonidine)

+

budesonide

1 interaction

Monitor/Modify Tx

clonidine + budesonide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bumetanide
Javadin (clonidine)

+

bumetanide

1 interaction

Monitor/Modify Tx

clonidine + bumetanide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• bupivacaine
Javadin (clonidine)

+

bupivacaine

1 interaction

Monitor/Modify Tx

clonidine + bupivacaine

monitor BP, HR: combo may incr. risk of bradycardia, hypotension, including orthostasis (additive effects)

• bupivacaine liposomal
Javadin (clonidine)

+

bupivacaine liposomal

1 interaction

Monitor/Modify Tx

clonidine + bupivacaine liposomal

monitor BP, HR: combo may incr. risk of bradycardia, hypotension, including orthostasis (additive effects)

• bupropion
Javadin (clonidine)

+

bupropion

1 interaction

Monitor/Modify Tx

clonidine + bupropion

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• cabergoline
Javadin (clonidine)

+

cabergoline

1 interaction

Monitor/Modify Tx

clonidine + cabergoline

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• cabozantinib
Javadin (clonidine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

clonidine + cabozantinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• caffeine
Javadin (clonidine)

+

caffeine

1 interaction

Monitor/Modify Tx

clonidine + caffeine

monitor BP; avoid excessive caffeine intake: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• caffeine citrate
Javadin (clonidine)

+

caffeine citrate

1 interaction

Monitor/Modify Tx

clonidine + caffeine citrate

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• canagliflozin
Javadin (clonidine)

+

canagliflozin

1 interaction

Monitor/Modify Tx

clonidine + canagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• candesartan cilexetil
Javadin (clonidine)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

clonidine + candesartan cilexetil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• captopril
Javadin (clonidine)

+

captopril

1 interaction

Monitor/Modify Tx

clonidine + captopril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• carfilzomib
Javadin (clonidine)

+

carfilzomib

1 interaction

Monitor/Modify Tx

clonidine + carfilzomib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• celecoxib
Javadin (clonidine)

+

celecoxib

1 interaction

Monitor/Modify Tx

clonidine + celecoxib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ceritinib
Javadin (clonidine)

+

ceritinib

1 interaction

Monitor/Modify Tx

clonidine + ceritinib

use alternative or monitor HR, BP: combo may incr. risk of bradycardia (additive effects)

• chloroprocaine
Javadin (clonidine)

+

chloroprocaine

1 interaction

Monitor/Modify Tx

clonidine + chloroprocaine

monitor BP, HR: combo may incr. risk of bradycardia, hypotension, including orthostasis (additive effects)

• chlorothiazide
Javadin (clonidine)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

clonidine + chlorothiazide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• chlorthalidone
Javadin (clonidine)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

clonidine + chlorthalidone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• cilostazol
Javadin (clonidine)

+

cilostazol

1 interaction

Monitor/Modify Tx

clonidine + cilostazol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• clevidipine
Javadin (clonidine)

+

clevidipine

1 interaction

Monitor/Modify Tx

clonidine + clevidipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• clofarabine
Javadin (clonidine)

+

clofarabine

1 interaction

Monitor/Modify Tx

clonidine + clofarabine

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• cocaine
Javadin (clonidine)

+

cocaine

1 interaction

Monitor/Modify Tx

clonidine + cocaine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• coenzyme Q-10
Javadin (clonidine)

+

coenzyme Q-10

1 interaction

Monitor/Modify Tx

clonidine + coenzyme Q-10

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• copanlisib
Javadin (clonidine)

+

copanlisib

1 interaction

Monitor/Modify Tx

clonidine + copanlisib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects, copanlisib may cause infusion-related HTN)

• corticotropin
Javadin (clonidine)

+

corticotropin

1 interaction

Monitor/Modify Tx

clonidine + corticotropin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• cortisone
Javadin (clonidine)

+

cortisone

1 interaction

Monitor/Modify Tx

clonidine + cortisone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• crizotinib
Javadin (clonidine)

+

crizotinib

1 interaction

Monitor/Modify Tx

clonidine + crizotinib

use alternative or monitor HR, BP: combo may incr. risk of bradycardia (additive effects)

• cyclosporine
Javadin (clonidine)

+

cyclosporine

1 interaction

Monitor/Modify Tx

clonidine + cyclosporine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• danazol
Javadin (clonidine)

+

danazol

1 interaction

Monitor/Modify Tx

clonidine + danazol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dapagliflozin
Javadin (clonidine)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

clonidine + dapagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• darbepoetin alfa
Javadin (clonidine)

+

darbepoetin alfa

1 interaction

Monitor/Modify Tx

clonidine + darbepoetin alfa

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• deflazacort
Javadin (clonidine)

+

deflazacort

1 interaction

Monitor/Modify Tx

clonidine + deflazacort

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• denileukin diftitox
Javadin (clonidine)

+

denileukin diftitox

1 interaction

Monitor/Modify Tx

clonidine + denileukin diftitox

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• desflurane
Javadin (clonidine)

+

desflurane

1 interaction

Monitor/Modify Tx

clonidine + desflurane

monitor BP, respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• desmopressin
Javadin (clonidine)

+

desmopressin

1 interaction

Monitor/Modify Tx

clonidine + desmopressin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dexamethasone
Javadin (clonidine)

+

dexamethasone

1 interaction

Monitor/Modify Tx

clonidine + dexamethasone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dexmethylphenidate
Javadin (clonidine)

+

dexmethylphenidate

1 interaction

Monitor/Modify Tx

clonidine + dexmethylphenidate

monitor BP in hypertensive pts: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dextroamphetamine
Javadin (clonidine)

+

dextroamphetamine

1 interaction

Monitor/Modify Tx

clonidine + dextroamphetamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• diclofenac
Javadin (clonidine)

+

diclofenac

1 interaction

Monitor/Modify Tx

clonidine + diclofenac

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• diclofenac topical
Javadin (clonidine)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

clonidine + diclofenac topical

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• diethylpropion
Javadin (clonidine)

+

diethylpropion

1 interaction

Monitor/Modify Tx

clonidine + diethylpropion

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• diflunisal
Javadin (clonidine)

+

diflunisal

1 interaction

Monitor/Modify Tx

clonidine + diflunisal

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• digoxin
Javadin (clonidine)

+

digoxin

1 interaction

Monitor/Modify Tx

clonidine + digoxin

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• dihydroergotamine
Javadin (clonidine)

+

dihydroergotamine

1 interaction

Monitor/Modify Tx

clonidine + dihydroergotamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dinutuximab
Javadin (clonidine)

+

dinutuximab

1 interaction

Monitor/Modify Tx

clonidine + dinutuximab

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• dipyridamole
Javadin (clonidine)

+

dipyridamole

1 interaction

Monitor/Modify Tx

clonidine + dipyridamole

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• doxapram
Javadin (clonidine)

+

doxapram

1 interaction

Monitor/Modify Tx

clonidine + doxapram

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• doxazosin
Javadin (clonidine)

+

doxazosin

1 interaction

Monitor/Modify Tx

clonidine + doxazosin

monitor BP, especially during doxazosin initiation/titration: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• droxidopa
Javadin (clonidine)

+

droxidopa

1 interaction

Monitor/Modify Tx

clonidine + droxidopa

monitor BP: combo may decr. efficacy of both drugs (antagonistic effects)

• empagliflozin
Javadin (clonidine)

+

empagliflozin

1 interaction

Monitor/Modify Tx

clonidine + empagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• enalapril
Javadin (clonidine)

+

enalapril

1 interaction

Monitor/Modify Tx

clonidine + enalapril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• enalaprilat
Javadin (clonidine)

+

enalaprilat

1 interaction

Monitor/Modify Tx

clonidine + enalaprilat

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ensartinib
Javadin (clonidine)

+

ensartinib

1 interaction

Monitor/Modify Tx

clonidine + ensartinib

monitor HR; consider decr. dose or hold one or both drugs: combo may incr. risk of bradycardia (additive effects)

• ephedra
Javadin (clonidine)

+

ephedra

1 interaction

Monitor/Modify Tx

clonidine + ephedra

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ephedrine injection
Javadin (clonidine)

+

ephedrine injection

1 interaction

Monitor/Modify Tx

clonidine + ephedrine injection

monitor BP: combo may incr. pressor response; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• ephedrine oral
Javadin (clonidine)

+

ephedrine oral

1 interaction

Monitor/Modify Tx

clonidine + ephedrine oral

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epinephrine
Javadin (clonidine)

+

epinephrine

1 interaction

Monitor/Modify Tx

clonidine + epinephrine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epinephrine inhaled
Javadin (clonidine)

+

epinephrine inhaled

1 interaction

Monitor/Modify Tx

clonidine + epinephrine inhaled

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• eplerenone
Javadin (clonidine)

+

eplerenone

1 interaction

Monitor/Modify Tx

clonidine + eplerenone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• epoetin alfa
Javadin (clonidine)

+

epoetin alfa

1 interaction

Monitor/Modify Tx

clonidine + epoetin alfa

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epoprostenol
Javadin (clonidine)

+

epoprostenol

1 interaction

Monitor/Modify Tx

clonidine + epoprostenol

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• eptinezumab
Javadin (clonidine)

+

eptinezumab

1 interaction

Monitor/Modify Tx

clonidine + eptinezumab

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• erenumab
Javadin (clonidine)

+

erenumab

1 interaction

Monitor/Modify Tx

clonidine + erenumab

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ergotamine
Javadin (clonidine)

+

ergotamine

1 interaction

Monitor/Modify Tx

clonidine + ergotamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ertugliflozin
Javadin (clonidine)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

clonidine + ertugliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• estetrol (contraceptive)
Javadin (clonidine)

+

estetrol (contraceptive)

1 interaction

Monitor/Modify Tx

clonidine + estetrol (contraceptive)

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• estradiol (contraceptive)
Javadin (clonidine)

+

estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

clonidine + estradiol (contraceptive)

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ethacrynic acid
Javadin (clonidine)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

clonidine + ethacrynic acid

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ethinyl estradiol (contraceptive)
Javadin (clonidine)

+

ethinyl estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

clonidine + ethinyl estradiol (contraceptive)

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• etodolac
Javadin (clonidine)

+

etodolac

1 interaction

Monitor/Modify Tx

clonidine + etodolac

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• etomidate
Javadin (clonidine)

+

etomidate

1 interaction

Monitor/Modify Tx

clonidine + etomidate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• felodipine
Javadin (clonidine)

+

felodipine

1 interaction

Monitor/Modify Tx

clonidine + felodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• fenoldopam
Javadin (clonidine)

+

fenoldopam

1 interaction

Monitor/Modify Tx

clonidine + fenoldopam

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• fenoprofen
Javadin (clonidine)

+

fenoprofen

1 interaction

Monitor/Modify Tx

clonidine + fenoprofen

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ferumoxytol
Javadin (clonidine)

+

ferumoxytol

1 interaction

Monitor/Modify Tx

clonidine + ferumoxytol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• flaxseed
Javadin (clonidine)

+

flaxseed

1 interaction

Monitor/Modify Tx

clonidine + flaxseed

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• fludrocortisone
Javadin (clonidine)

+

fludrocortisone

1 interaction

Monitor/Modify Tx

clonidine + fludrocortisone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• flurbiprofen
Javadin (clonidine)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

clonidine + flurbiprofen

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• formoterol inhaled
Javadin (clonidine)

+

formoterol inhaled

1 interaction

Monitor/Modify Tx

clonidine + formoterol inhaled

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fosinopril
Javadin (clonidine)

+

fosinopril

1 interaction

Monitor/Modify Tx

clonidine + fosinopril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• fostamatinib
Javadin (clonidine)

+

fostamatinib

1 interaction

Monitor/Modify Tx

clonidine + fostamatinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fremanezumab
Javadin (clonidine)

+

fremanezumab

1 interaction

Monitor/Modify Tx

clonidine + fremanezumab

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fruquintinib
Javadin (clonidine)

+

fruquintinib

1 interaction

Monitor/Modify Tx

clonidine + fruquintinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• furosemide
Javadin (clonidine)

+

furosemide

1 interaction

Monitor/Modify Tx

clonidine + furosemide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• galcanezumab
Javadin (clonidine)

+

galcanezumab

1 interaction

Monitor/Modify Tx

clonidine + galcanezumab

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• garlic
Javadin (clonidine)

+

garlic

1 interaction

Monitor/Modify Tx

clonidine + garlic

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, including orthostasis (additive effects)

• gilteritinib
Javadin (clonidine)

+

gilteritinib

1 interaction

Monitor/Modify Tx

clonidine + gilteritinib

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• glimepiride
Javadin (clonidine)

+

glimepiride

1 interaction

Monitor/Modify Tx

clonidine + glimepiride

monitor glucose: combo may alter glycemic control, incr. risk of hyperglycemia or hypoglycemia (antagonistic effects, additive effects)

• glipizide
Javadin (clonidine)

+

glipizide

1 interaction

Monitor/Modify Tx

clonidine + glipizide

monitor glucose: combo may alter glycemic control, incr. risk of hyperglycemia or hypoglycemia (antagonistic effects, additive effects)

• glyburide
Javadin (clonidine)

+

glyburide

1 interaction

Monitor/Modify Tx

clonidine + glyburide

monitor glucose: combo may alter glycemic control, incr. risk of hyperglycemia or hypoglycemia (additive effects, antagonistic effects)

• hoodia
Javadin (clonidine)

+

hoodia

1 interaction

Monitor/Modify Tx

clonidine + hoodia

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydralazine
Javadin (clonidine)

+

hydralazine

1 interaction

Monitor/Modify Tx

clonidine + hydralazine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• hydrochlorothiazide
Javadin (clonidine)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

clonidine + hydrochlorothiazide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• hydrocortisone
Javadin (clonidine)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

clonidine + hydrocortisone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydroxocobalamin IV
Javadin (clonidine)

+

hydroxocobalamin IV

1 interaction

Monitor/Modify Tx

clonidine + hydroxocobalamin IV

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ibrutinib
Javadin (clonidine)

+

ibrutinib

1 interaction

Monitor/Modify Tx

clonidine + ibrutinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ibuprofen
Javadin (clonidine)

+

ibuprofen

1 interaction

Monitor/Modify Tx

clonidine + ibuprofen

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• iloprost
Javadin (clonidine)

+

iloprost

1 interaction

Monitor/Modify Tx

clonidine + iloprost

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• indapamide
Javadin (clonidine)

+

indapamide

1 interaction

Monitor/Modify Tx

clonidine + indapamide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• indomethacin
Javadin (clonidine)

+

indomethacin

1 interaction

Monitor/Modify Tx

clonidine + indomethacin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• insulin
Javadin (clonidine)

+

insulin

1 interaction

Monitor/Modify Tx

clonidine + insulin

monitor glucose: combo may alter glycemic control, incr. risk of hyperglycemia or hypoglycemia (additive effects, antagonistic effects)

• irbesartan
Javadin (clonidine)

+

irbesartan

1 interaction

Monitor/Modify Tx

clonidine + irbesartan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• iron sucrose
Javadin (clonidine)

+

iron sucrose

1 interaction

Monitor/Modify Tx

clonidine + iron sucrose

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• isoflurane
Javadin (clonidine)

+

isoflurane

1 interaction

Monitor/Modify Tx

clonidine + isoflurane

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• isosorbide dinitrate
Javadin (clonidine)

+

isosorbide dinitrate

1 interaction

Monitor/Modify Tx

clonidine + isosorbide dinitrate

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• isosorbide mononitrate
Javadin (clonidine)

+

isosorbide mononitrate

1 interaction

Monitor/Modify Tx

clonidine + isosorbide mononitrate

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• isradipine
Javadin (clonidine)

+

isradipine

1 interaction

Monitor/Modify Tx

clonidine + isradipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ketamine
Javadin (clonidine)

+

ketamine

1 interaction

Monitor/Modify Tx

clonidine + ketamine

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• ketoprofen
Javadin (clonidine)

+

ketoprofen

1 interaction

Monitor/Modify Tx

clonidine + ketoprofen

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ketorolac
Javadin (clonidine)

+

ketorolac

1 interaction

Monitor/Modify Tx

clonidine + ketorolac

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lanreotide
Javadin (clonidine)

+

lanreotide

1 interaction

Monitor/Modify Tx

clonidine + lanreotide

monitor BP, HR: combo may incr. risk of bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• leflunomide
Javadin (clonidine)

+

leflunomide

1 interaction

Monitor/Modify Tx

clonidine + leflunomide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lenvatinib
Javadin (clonidine)

+

lenvatinib

1 interaction

Monitor/Modify Tx

clonidine + lenvatinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• levalbuterol inhaled
Javadin (clonidine)

+

levalbuterol inhaled

1 interaction

Monitor/Modify Tx

clonidine + levalbuterol inhaled

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• levobunolol ophthalmic
Javadin (clonidine)

+

levobunolol ophthalmic

1 interaction

Monitor/Modify Tx

clonidine + levobunolol ophthalmic

monitor BP, HR: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia (additive effects)

• levothyroxine
Javadin (clonidine)

+

levothyroxine

1 interaction

Monitor/Modify Tx

clonidine + levothyroxine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• licorice
Javadin (clonidine)

+

licorice

1 interaction

Monitor/Modify Tx

clonidine + licorice

monitor BP w/ large amounts of licorice: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lidocaine
Javadin (clonidine)

+

lidocaine

1 interaction

Monitor/Modify Tx

clonidine + lidocaine

monitor BP, HR: combo may incr. risk of bradycardia, hypotension, including orthostasis (additive effects)

• liothyronine
Javadin (clonidine)

+

liothyronine

1 interaction

Monitor/Modify Tx

clonidine + liothyronine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lisdexamfetamine
Javadin (clonidine)

+

lisdexamfetamine

1 interaction

Monitor/Modify Tx

clonidine + lisdexamfetamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lisinopril
Javadin (clonidine)

+

lisinopril

1 interaction

Monitor/Modify Tx

clonidine + lisinopril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• losartan
Javadin (clonidine)

+

losartan

1 interaction

Monitor/Modify Tx

clonidine + losartan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• lubiprostone
Javadin (clonidine)

+

lubiprostone

1 interaction

Monitor/Modify Tx

clonidine + lubiprostone

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• lumacaftor/ivacaftor
Javadin (clonidine)

+

lumacaftor/ ivacaftor

1 interaction

Monitor/Modify Tx

clonidine + lumacaftor/ ivacaftor

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• luspatercept
Javadin (clonidine)

+

luspatercept

1 interaction

Monitor/Modify Tx

clonidine + luspatercept

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• magnesium salicylate
Javadin (clonidine)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

clonidine + magnesium salicylate

monitor BP w/ high-dose magnesium salicylate: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• magnesium sulfate
Javadin (clonidine)

+

magnesium sulfate

1 interaction

Monitor/Modify Tx

clonidine + magnesium sulfate

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• maraviroc
Javadin (clonidine)

+

maraviroc

1 interaction

Monitor/Modify Tx

clonidine + maraviroc

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• meclofenamate
Javadin (clonidine)

+

meclofenamate

1 interaction

Monitor/Modify Tx

clonidine + meclofenamate

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• mefenamic acid
Javadin (clonidine)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

clonidine + mefenamic acid

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• meloxicam
Javadin (clonidine)

+

meloxicam

1 interaction

Monitor/Modify Tx

clonidine + meloxicam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• mepivacaine
Javadin (clonidine)

+

mepivacaine

1 interaction

Monitor/Modify Tx

clonidine + mepivacaine

monitor BP, HR: combo may incr. risk of bradycardia, hypotension, including orthostasis (additive effects)

• methamphetamine
Javadin (clonidine)

+

methamphetamine

1 interaction

Monitor/Modify Tx

clonidine + methamphetamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• methoxy polyethylene glycol-epoetin beta
Javadin (clonidine)

+

methoxy polyethylene glycol-epoetin beta

1 interaction

Monitor/Modify Tx

clonidine + methoxy polyethylene glycol-epoetin beta

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• methylene blue injection
Javadin (clonidine)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

clonidine + methylene blue injection

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• methylergonovine
Javadin (clonidine)

+

methylergonovine

1 interaction

Monitor/Modify Tx

clonidine + methylergonovine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• methylphenidate
Javadin (clonidine)

+

methylphenidate

1 interaction

Monitor/Modify Tx

clonidine + methylphenidate

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• methylprednisolone
Javadin (clonidine)

+

methylprednisolone

1 interaction

Monitor/Modify Tx

clonidine + methylprednisolone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• methyltestosterone
Javadin (clonidine)

+

methyltestosterone

1 interaction

Monitor/Modify Tx

clonidine + methyltestosterone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• metolazone
Javadin (clonidine)

+

metolazone

1 interaction

Monitor/Modify Tx

clonidine + metolazone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• midodrine
Javadin (clonidine)

+

midodrine

1 interaction

Monitor/Modify Tx

clonidine + midodrine

monitor HR, BP: combo may decr. efficacy of both drugs; may incr. risk of bradycardia (antagonistic effects; additive effects)

• milrinone
Javadin (clonidine)

+

milrinone

1 interaction

Monitor/Modify Tx

clonidine + milrinone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• minoxidil
Javadin (clonidine)

+

minoxidil

1 interaction

Monitor/Modify Tx

clonidine + minoxidil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• mirabegron
Javadin (clonidine)

+

mirabegron

1 interaction

Monitor/Modify Tx

clonidine + mirabegron

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• modafinil
Javadin (clonidine)

+

modafinil

1 interaction

Monitor/Modify Tx

clonidine + modafinil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• moexipril
Javadin (clonidine)

+

moexipril

1 interaction

Monitor/Modify Tx

clonidine + moexipril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nabumetone
Javadin (clonidine)

+

nabumetone

1 interaction

Monitor/Modify Tx

clonidine + nabumetone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• naphazoline ophthalmic
Javadin (clonidine)

+

naphazoline ophthalmic

1 interaction

Monitor/Modify Tx

clonidine + naphazoline ophthalmic

consider monitoring BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• naproxen
Javadin (clonidine)

+

naproxen

1 interaction

Monitor/Modify Tx

clonidine + naproxen

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nattokinase
Javadin (clonidine)

+

nattokinase

1 interaction

Monitor/Modify Tx

clonidine + nattokinase

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• naxitamab
Javadin (clonidine)

+

naxitamab

1 interaction

Monitor/Modify Tx

clonidine + naxitamab

monitor BP: combo may alter blood pressure control (additive effects, antagonistic effects)

• neostigmine
Javadin (clonidine)

+

neostigmine

1 interaction

Monitor/Modify Tx

clonidine + neostigmine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• niacin (vitamin B3)
Javadin (clonidine)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

clonidine + niacin (vitamin B3)

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nicardipine
Javadin (clonidine)

+

nicardipine

1 interaction

Monitor/Modify Tx

clonidine + nicardipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nifedipine
Javadin (clonidine)

+

nifedipine

1 interaction

Monitor/Modify Tx

clonidine + nifedipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nimodipine
Javadin (clonidine)

+

nimodipine

1 interaction

Monitor/Modify Tx

clonidine + nimodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• niraparib
Javadin (clonidine)

+

niraparib

1 interaction

Monitor/Modify Tx

clonidine + niraparib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nisoldipine
Javadin (clonidine)

+

nisoldipine

1 interaction

Monitor/Modify Tx

clonidine + nisoldipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nitric oxide
Javadin (clonidine)

+

nitric oxide

1 interaction

Monitor/Modify Tx

clonidine + nitric oxide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nitrite
Javadin (clonidine)

+

nitrite

1 interaction

Monitor/Modify Tx

clonidine + nitrite

monitor BP: combo may incr. risk of severe or life-threatening hypotension, including orthostasis, syncope (additive effects)

• nitroglycerin
Javadin (clonidine)

+

nitroglycerin

1 interaction

Monitor/Modify Tx

clonidine + nitroglycerin

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• nitroprusside
Javadin (clonidine)

+

nitroprusside

1 interaction

Monitor/Modify Tx

clonidine + nitroprusside

monitor BP: combo may incr. risk of severe or life-threatening hypotension, including orthostasis (additive effects)

• obinutuzumab
Javadin (clonidine)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

clonidine + obinutuzumab

monitor BP: combo may incr. risk of hypotension, including orthostasis; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• octreotide
Javadin (clonidine)

+

octreotide

1 interaction

Monitor/Modify Tx

clonidine + octreotide

monitor HR: combo may incr. risk of bradycardia (additive effects)

• olmesartan medoxomil
Javadin (clonidine)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

clonidine + olmesartan medoxomil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• olodaterol inhaled
Javadin (clonidine)

+

olodaterol inhaled

1 interaction

Monitor/Modify Tx

clonidine + olodaterol inhaled

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• osilodrostat
Javadin (clonidine)

+

osilodrostat

1 interaction

Monitor/Modify Tx

clonidine + osilodrostat

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• oxaprozin
Javadin (clonidine)

+

oxaprozin

1 interaction

Monitor/Modify Tx

clonidine + oxaprozin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• oxymetazoline nasal
Javadin (clonidine)

+

oxymetazoline nasal

1 interaction

Monitor/Modify Tx

clonidine + oxymetazoline nasal

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• oxymetazoline ophthalmic
Javadin (clonidine)

+

oxymetazoline ophthalmic

1 interaction

Monitor/Modify Tx

clonidine + oxymetazoline ophthalmic

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• oxymetazoline topical
Javadin (clonidine)

+

oxymetazoline topical

1 interaction

Monitor/Modify Tx

clonidine + oxymetazoline topical

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• oxytocin
Javadin (clonidine)

+

oxytocin

1 interaction

Monitor/Modify Tx

clonidine + oxytocin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• palopegteriparatide
Javadin (clonidine)

+

palopegteriparatide

1 interaction

Monitor/Modify Tx

clonidine + palopegteriparatide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• pasireotide
Javadin (clonidine)

+

pasireotide

1 interaction

Monitor/Modify Tx

clonidine + pasireotide

monitor HR: combo may incr. risk of bradycardia (additive effects)

• pazopanib
Javadin (clonidine)

+

pazopanib

1 interaction

Monitor/Modify Tx

clonidine + pazopanib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• pentamidine
Javadin (clonidine)

+

pentamidine

1 interaction

Monitor/Modify Tx

clonidine + pentamidine

monitor BP: combo may incr. risk of severe or life-threatening hypotension, including orthostasis (additive effects)

• perindopril
Javadin (clonidine)

+

perindopril

1 interaction

Monitor/Modify Tx

clonidine + perindopril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• pexidartinib
Javadin (clonidine)

+

pexidartinib

1 interaction

Monitor/Modify Tx

clonidine + pexidartinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phendimetrazine
Javadin (clonidine)

+

phendimetrazine

1 interaction

Monitor/Modify Tx

clonidine + phendimetrazine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phenoxybenzamine
Javadin (clonidine)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

clonidine + phenoxybenzamine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• phentermine
Javadin (clonidine)

+

phentermine

1 interaction

Monitor/Modify Tx

clonidine + phentermine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phentolamine
Javadin (clonidine)

+

phentolamine

1 interaction

Monitor/Modify Tx

clonidine + phentolamine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• phenylephrine
Javadin (clonidine)

+

phenylephrine

1 interaction

Monitor/Modify Tx

clonidine + phenylephrine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phenylephrine injection
Javadin (clonidine)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

clonidine + phenylephrine injection

monitor BP: combo may decr. efficacy of both drugs (antagonistic effects)

• phenylephrine nasal
Javadin (clonidine)

+

phenylephrine nasal

1 interaction

Monitor/Modify Tx

clonidine + phenylephrine nasal

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phenylephrine ophthalmic
Javadin (clonidine)

+

phenylephrine ophthalmic

1 interaction

Monitor/Modify Tx

clonidine + phenylephrine ophthalmic

monitor BP; HTN risk may be lower w/ phenylephrine ophthalmic 2.5%: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phenylephrine rectal
Javadin (clonidine)

+

phenylephrine rectal

1 interaction

Monitor/Modify Tx

clonidine + phenylephrine rectal

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• piroxicam
Javadin (clonidine)

+

piroxicam

1 interaction

Monitor/Modify Tx

clonidine + piroxicam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ponatinib
Javadin (clonidine)

+

ponatinib

1 interaction

Monitor/Modify Tx

clonidine + ponatinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• pralsetinib
Javadin (clonidine)

+

pralsetinib

1 interaction

Monitor/Modify Tx

clonidine + pralsetinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• prazosin
Javadin (clonidine)

+

prazosin

1 interaction

Monitor/Modify Tx

clonidine + prazosin

monitor BP, especially during prazosin initiation/titration: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• prednisolone
Javadin (clonidine)

+

prednisolone

1 interaction

Monitor/Modify Tx

clonidine + prednisolone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• prednisone
Javadin (clonidine)

+

prednisone

1 interaction

Monitor/Modify Tx

clonidine + prednisone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• propofol
Javadin (clonidine)

+

propofol

1 interaction

Monitor/Modify Tx

clonidine + propofol

monitor respiratory rate, BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis), bradycardia (additive effects)

• pseudoephedrine
Javadin (clonidine)

+

pseudoephedrine

1 interaction

Monitor/Modify Tx

clonidine + pseudoephedrine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• pyridostigmine
Javadin (clonidine)

+

pyridostigmine

1 interaction

Monitor/Modify Tx

clonidine + pyridostigmine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• quinapril
Javadin (clonidine)

+

quinapril

1 interaction

Monitor/Modify Tx

clonidine + quinapril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• quinidine (antiarrhythmic)
Javadin (clonidine)

+

quinidine (antiarrhythmic)

1 interaction

Monitor/Modify Tx

clonidine + quinidine (antiarrhythmic)

monitor HR: combo may incr. risk of bradycardia (additive effects)

• ramipril
Javadin (clonidine)

+

ramipril

1 interaction

Monitor/Modify Tx

clonidine + ramipril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ramucirumab
Javadin (clonidine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

clonidine + ramucirumab

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• regorafenib
Javadin (clonidine)

+

regorafenib

1 interaction

Monitor/Modify Tx

clonidine + regorafenib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• rimegepant
Javadin (clonidine)

+

rimegepant

1 interaction

Monitor/Modify Tx

clonidine + rimegepant

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• riociguat
Javadin (clonidine)

+

riociguat

1 interaction

Monitor/Modify Tx

clonidine + riociguat

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• ripretinib
Javadin (clonidine)

+

ripretinib

1 interaction

Monitor/Modify Tx

clonidine + ripretinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• rivastigmine
Javadin (clonidine)

+

rivastigmine

1 interaction

Monitor/Modify Tx

clonidine + rivastigmine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• ropivacaine
Javadin (clonidine)

+

ropivacaine

1 interaction

Monitor/Modify Tx

clonidine + ropivacaine

monitor BP, HR: combo may incr. risk of bradycardia, hypotension, including orthostasis (additive effects)

• sacubitril
Javadin (clonidine)

+

sacubitril

1 interaction

Monitor/Modify Tx

clonidine + sacubitril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• salmeterol inhaled
Javadin (clonidine)

+

salmeterol inhaled

1 interaction

Monitor/Modify Tx

clonidine + salmeterol inhaled

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• salsalate
Javadin (clonidine)

+

salsalate

1 interaction

Monitor/Modify Tx

clonidine + salsalate

monitor BP w/ high-dose salsalate: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• selpercatinib
Javadin (clonidine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

clonidine + selpercatinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• sevoflurane
Javadin (clonidine)

+

sevoflurane

1 interaction

Monitor/Modify Tx

clonidine + sevoflurane

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• sildenafil
Javadin (clonidine)

+

sildenafil

1 interaction

Monitor/Modify Tx

clonidine + sildenafil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• silodosin
Javadin (clonidine)

+

silodosin

1 interaction

Monitor/Modify Tx

clonidine + silodosin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• sodium ferric gluconate complex
Javadin (clonidine)

+

sodium ferric gluconate complex

1 interaction

Monitor/Modify Tx

clonidine + sodium ferric gluconate complex

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• sorafenib
Javadin (clonidine)

+

sorafenib

1 interaction

Monitor/Modify Tx

clonidine + sorafenib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• sotagliflozin
Javadin (clonidine)

+

sotagliflozin

1 interaction

Monitor/Modify Tx

clonidine + sotagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• sparsentan
Javadin (clonidine)

+

sparsentan

1 interaction

Monitor/Modify Tx

clonidine + sparsentan

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• spironolactone
Javadin (clonidine)

+

spironolactone

1 interaction

Monitor/Modify Tx

clonidine + spironolactone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• succinylcholine
Javadin (clonidine)

+

succinylcholine

1 interaction

Monitor/Modify Tx

clonidine + succinylcholine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• sugammadex
Javadin (clonidine)

+

sugammadex

1 interaction

Monitor/Modify Tx

clonidine + sugammadex

monitor HR: combo may incr. risk of bradycardia (additive effects)

• sulindac
Javadin (clonidine)

+

sulindac

1 interaction

Monitor/Modify Tx

clonidine + sulindac

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• sunitinib
Javadin (clonidine)

+

sunitinib

1 interaction

Monitor/Modify Tx

clonidine + sunitinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tacrolimus
Javadin (clonidine)

+

tacrolimus

1 interaction

Monitor/Modify Tx

clonidine + tacrolimus

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tadalafil
Javadin (clonidine)

+

tadalafil

1 interaction

Monitor/Modify Tx

clonidine + tadalafil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• tagraxofusp
Javadin (clonidine)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

clonidine + tagraxofusp

monitor BP: combo may alter blood pressure control (additive effects)

• tamsulosin
Javadin (clonidine)

+

tamsulosin

1 interaction

Monitor/Modify Tx

clonidine + tamsulosin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• taurine
Javadin (clonidine)

+

taurine

1 interaction

Monitor/Modify Tx

clonidine + taurine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• telmisartan
Javadin (clonidine)

+

telmisartan

1 interaction

Monitor/Modify Tx

clonidine + telmisartan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• terazosin
Javadin (clonidine)

+

terazosin

1 interaction

Monitor/Modify Tx

clonidine + terazosin

monitor BP, especially during terazosin initiation/titration: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• terbutaline
Javadin (clonidine)

+

terbutaline

1 interaction

Monitor/Modify Tx

clonidine + terbutaline

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• teriflunomide
Javadin (clonidine)

+

teriflunomide

1 interaction

Monitor/Modify Tx

clonidine + teriflunomide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• testosterone
Javadin (clonidine)

+

testosterone

1 interaction

Monitor/Modify Tx

clonidine + testosterone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tetrahydrozoline ophthalmic
Javadin (clonidine)

+

tetrahydrozoline ophthalmic

1 interaction

Monitor/Modify Tx

clonidine + tetrahydrozoline ophthalmic

consider monitoring BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• thyroid
Javadin (clonidine)

+

thyroid

1 interaction

Monitor/Modify Tx

clonidine + thyroid

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• timolol ophthalmic
Javadin (clonidine)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

clonidine + timolol ophthalmic

monitor BP, HR: combo may incr. risk of hypotension (including orthostasis), PR interval prolongation, AV block, bradycardia (additive effects)

• tivozanib
Javadin (clonidine)

+

tivozanib

1 interaction

Monitor/Modify Tx

clonidine + tivozanib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tolmetin
Javadin (clonidine)

+

tolmetin

1 interaction

Monitor/Modify Tx

clonidine + tolmetin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• torsemide
Javadin (clonidine)

+

torsemide

1 interaction

Monitor/Modify Tx

clonidine + torsemide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• trametinib
Javadin (clonidine)

+

trametinib

1 interaction

Monitor/Modify Tx

clonidine + trametinib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• trandolapril
Javadin (clonidine)

+

trandolapril

1 interaction

Monitor/Modify Tx

clonidine + trandolapril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• treprostinil
Javadin (clonidine)

+

treprostinil

1 interaction

Monitor/Modify Tx

clonidine + treprostinil

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• triamcinolone
Javadin (clonidine)

+

triamcinolone

1 interaction

Monitor/Modify Tx

clonidine + triamcinolone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triamterene
Javadin (clonidine)

+

triamterene

1 interaction

Monitor/Modify Tx

clonidine + triamterene

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ubrogepant
Javadin (clonidine)

+

ubrogepant

1 interaction

Monitor/Modify Tx

clonidine + ubrogepant

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vadadustat
Javadin (clonidine)

+

vadadustat

1 interaction

Monitor/Modify Tx

clonidine + vadadustat

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• valsartan
Javadin (clonidine)

+

valsartan

1 interaction

Monitor/Modify Tx

clonidine + valsartan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• vamorolone
Javadin (clonidine)

+

vamorolone

1 interaction

Monitor/Modify Tx

clonidine + vamorolone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vandetanib
Javadin (clonidine)

+

vandetanib

1 interaction

Monitor/Modify Tx

clonidine + vandetanib

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vardenafil
Javadin (clonidine)

+

vardenafil

1 interaction

Monitor/Modify Tx

clonidine + vardenafil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• vasopressin
Javadin (clonidine)

+

vasopressin

1 interaction

Monitor/Modify Tx

clonidine + vasopressin

monitor BP: combo may decr. efficacy of both drugs (antagonistic effects)

• vilanterol inhaled
Javadin (clonidine)

+

vilanterol inhaled

1 interaction

Monitor/Modify Tx

clonidine + vilanterol inhaled

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vinpocetine
Javadin (clonidine)

+

vinpocetine

1 interaction

Monitor/Modify Tx

clonidine + vinpocetine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• voclosporin
Javadin (clonidine)

+

voclosporin

1 interaction

Monitor/Modify Tx

clonidine + voclosporin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vosoritide
Javadin (clonidine)

+

vosoritide

1 interaction

Monitor/Modify Tx

clonidine + vosoritide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• zavegepant
Javadin (clonidine)

+

zavegepant

1 interaction

Monitor/Modify Tx

clonidine + zavegepant

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ziv-aflibercept
Javadin (clonidine)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

clonidine + ziv-aflibercept

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)