Javadin

Overview

clonidine

alpha-2 agonist, central

• affects growth hormone diagnostic test results
• antihypertensive agent
• bradycardia
• CNS depression
• delays atrioventricular conduction
• hyperglycemic effects
• hypoglycemic effects
• hypotensive effects

Avoid/Use Alternative

• 5-HTP
Javadin (clonidine)

+

5-HTP

1 interaction

Avoid/Use Alternative

clonidine + 5-HTP

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• acebutolol
Javadin (clonidine)

+

acebutolol

1 interaction

Avoid/Use Alternative

clonidine + acebutolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C acebutolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• adenosine
Javadin (clonidine)

+

adenosine

1 interaction

Avoid/Use Alternative

clonidine + adenosine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• aldesleukin
Javadin (clonidine)

+

aldesleukin

1 interaction

Avoid/Use Alternative

clonidine + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, severe or life-threatening hypotension, incl. orthostasis (additive effects)

• alfentanil
Javadin (clonidine)

+

alfentanil

1 interaction

Avoid/Use Alternative

clonidine + alfentanil

if ADHD use, avoid combo; otherwise, monitor BP, HR, resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, bradycardia, severe hypotension, incl. orthostasis, syncope (additive effects)

• allopurinol
Javadin (clonidine)

+

allopurinol

1 interaction

Avoid/Use Alternative

clonidine + allopurinol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• almotriptan
Javadin (clonidine)

+

almotriptan

1 interaction

Avoid/Use Alternative

clonidine + almotriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• alprazolam
Javadin (clonidine)

+

alprazolam

1 interaction

Avoid/Use Alternative

clonidine + alprazolam

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• amantadine
Javadin (clonidine)

+

amantadine

1 interaction

Avoid/Use Alternative

clonidine + amantadine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• amiodarone
Javadin (clonidine)

+

amiodarone

1 interaction

Avoid/Use Alternative

clonidine + amiodarone

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• amitriptyline
Javadin (clonidine)

+

amitriptyline

1 interaction

Avoid/Use Alternative

clonidine + amitriptyline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• amoxapine
Javadin (clonidine)

+

amoxapine

1 interaction

Avoid/Use Alternative

clonidine + amoxapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• apomorphine
Javadin (clonidine)

+

apomorphine

1 interaction

Avoid/Use Alternative

clonidine + apomorphine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• apraclonidine ophthalmic
Javadin (clonidine)

+

apraclonidine ophthalmic

1 interaction

Avoid/Use Alternative

clonidine + apraclonidine ophthalmic

if ADHD use, avoid combo; otherwise, monitor BP, HR if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia, hypotension, incl. orthostasis (additive effects)

• aripiprazole bimonthly injection
Javadin (clonidine)

+

aripiprazole bimonthly injection

1 interaction

Avoid/Use Alternative

clonidine + aripiprazole bimonthly injection

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole lauroxil
Javadin (clonidine)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

clonidine + aripiprazole lauroxil

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• aripiprazole monthly injection
Javadin (clonidine)

+

aripiprazole monthly injection

1 interaction

Avoid/Use Alternative

clonidine + aripiprazole monthly injection

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• aripiprazole oral
Javadin (clonidine)

+

aripiprazole oral

1 interaction

Avoid/Use Alternative

clonidine + aripiprazole oral

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• arsenic trioxide
Javadin (clonidine)

+

arsenic trioxide

1 interaction

Avoid/Use Alternative

clonidine + arsenic trioxide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• asenapine
Javadin (clonidine)

+

asenapine

1 interaction

Avoid/Use Alternative

clonidine + asenapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• atazanavir
Javadin (clonidine)

+

atazanavir

1 interaction

Avoid/Use Alternative

clonidine + atazanavir

if ADHD use, avoid combo; otherwise, monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• atenolol
Javadin (clonidine)

+

atenolol

1 interaction

Avoid/Use Alternative

clonidine + atenolol

if ADHD use, avoid combo; otherwise, monitor BP, HR; D/C atenolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• baclofen
Javadin (clonidine)

+

baclofen

1 interaction

Avoid/Use Alternative

clonidine + baclofen

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen intrathecal
Javadin (clonidine)

+

baclofen intrathecal

1 interaction

Avoid/Use Alternative

clonidine + baclofen intrathecal

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• betaxolol
Javadin (clonidine)

+

betaxolol

1 interaction

Avoid/Use Alternative

clonidine + betaxolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C betaxolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• bisoprolol
Javadin (clonidine)

+

bisoprolol

1 interaction

Avoid/Use Alternative

clonidine + bisoprolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C bisoprolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• brexpiprazole
Javadin (clonidine)

+

brexpiprazole

1 interaction

Avoid/Use Alternative

clonidine + brexpiprazole

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• brigatinib
Javadin (clonidine)

+

brigatinib

1 interaction

Avoid/Use Alternative

clonidine + brigatinib

use alternative or monitor BP, HR: combo may incr. risk of bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• brimonidine ophthalmic
Javadin (clonidine)

+

brimonidine ophthalmic

1 interaction

Avoid/Use Alternative

clonidine + brimonidine ophthalmic

if ADHD use, avoid combo; otherwise, monitor BP if elevated IOP use; OTC ocular redness use OK: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• brimonidine topical
Javadin (clonidine)

+

brimonidine topical

1 interaction

Avoid/Use Alternative

clonidine + brimonidine topical

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• brivaracetam
Javadin (clonidine)

+

brivaracetam

1 interaction

Avoid/Use Alternative

clonidine + brivaracetam

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• bromocriptine
Javadin (clonidine)

+

bromocriptine

1 interaction

Avoid/Use Alternative

clonidine + bromocriptine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• brompheniramine
Javadin (clonidine)

+

brompheniramine

1 interaction

Avoid/Use Alternative

clonidine + brompheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• buprenorphine
Javadin (clonidine)

+

buprenorphine

1 interaction

Avoid/Use Alternative

clonidine + buprenorphine

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• buspirone
Javadin (clonidine)

+

buspirone

1 interaction

Avoid/Use Alternative

clonidine + buspirone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• butalbital
Javadin (clonidine)

+

butalbital

1 interaction

Avoid/Use Alternative

clonidine + butalbital

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• butorphanol
Javadin (clonidine)

+

butorphanol

1 interaction

Avoid/Use Alternative

clonidine + butorphanol

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• cannabidiol
Javadin (clonidine)

+

cannabidiol

1 interaction

Avoid/Use Alternative

clonidine + cannabidiol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cannabis
Javadin (clonidine)

+

cannabis

1 interaction

Avoid/Use Alternative

clonidine + cannabis

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may alter blood pressure control (additive effects, antagonistic effects)

• carbamazepine
Javadin (clonidine)

+

carbamazepine

1 interaction

Avoid/Use Alternative

clonidine + carbamazepine

if ADHD use, avoid combo; otherwise, monitor BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of PR interval prolongation, AV block, bradycardia, CNS depression, psychomotor impairment, hypotension, incl. syncope (additive effects)

• carbinoxamine
Javadin (clonidine)

+

carbinoxamine

1 interaction

Avoid/Use Alternative

clonidine + carbinoxamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cariprazine
Javadin (clonidine)

+

cariprazine

1 interaction

Avoid/Use Alternative

clonidine + cariprazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• carisoprodol
Javadin (clonidine)

+

carisoprodol

1 interaction

Avoid/Use Alternative

clonidine + carisoprodol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carteolol ophthalmic
Javadin (clonidine)

+

carteolol ophthalmic

1 interaction

Avoid/Use Alternative

clonidine + carteolol ophthalmic

if ADHD use, avoid combo; otherwise, monitor BP, HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension, incl. orthostasis (additive effects)

• carvedilol
Javadin (clonidine)

+

carvedilol

1 interaction

Avoid/Use Alternative

clonidine + carvedilol

if ADHD use, avoid combo; otherwise, monitor BP, HR; D/C carvedilol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• cenobamate
Javadin (clonidine)

+

cenobamate

1 interaction

Avoid/Use Alternative

clonidine + cenobamate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cetirizine
Javadin (clonidine)

+

cetirizine

1 interaction

Avoid/Use Alternative

clonidine + cetirizine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chamomile, German
Javadin (clonidine)

+

chamomile, German

1 interaction

Avoid/Use Alternative

clonidine + chamomile, German

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Javadin (clonidine)

+

chlophedianol

1 interaction

Avoid/Use Alternative

clonidine + chlophedianol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlordiazepoxide
Javadin (clonidine)

+

chlordiazepoxide

1 interaction

Avoid/Use Alternative

clonidine + chlordiazepoxide

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chlorpheniramine
Javadin (clonidine)

+

chlorpheniramine

1 interaction

Avoid/Use Alternative

clonidine + chlorpheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorpromazine
Javadin (clonidine)

+

chlorpromazine

1 interaction

Avoid/Use Alternative

clonidine + chlorpromazine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• chlorzoxazone
Javadin (clonidine)

+

chlorzoxazone

1 interaction

Avoid/Use Alternative

clonidine + chlorzoxazone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• citalopram
Javadin (clonidine)

+

citalopram

1 interaction

Avoid/Use Alternative

clonidine + citalopram

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clemastine
Javadin (clonidine)

+

clemastine

1 interaction

Avoid/Use Alternative

clonidine + clemastine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clobazam
Javadin (clonidine)

+

clobazam

1 interaction

Avoid/Use Alternative

clonidine + clobazam

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clomipramine
Javadin (clonidine)

+

clomipramine

1 interaction

Avoid/Use Alternative

clonidine + clomipramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• clonazepam
Javadin (clonidine)

+

clonazepam

1 interaction

Avoid/Use Alternative

clonidine + clonazepam

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clonidine
Javadin (clonidine)

+

clonidine

1 interaction

Avoid/Use Alternative

clonidine + clonidine

avoid combo: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, CNS depression, psychomotor impairment (duplicate tx; additive effects)

• clorazepate
Javadin (clonidine)

+

clorazepate

1 interaction

Avoid/Use Alternative

clonidine + clorazepate

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clozapine
Javadin (clonidine)

+

clozapine

1 interaction

Avoid/Use Alternative

clonidine + clozapine

if ADHD use, avoid combo; otherwise, monitor BP, HR: combo may incr. risk of severe bradycardia, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment (additive effects)

• codeine
Javadin (clonidine)

+

codeine

1 interaction

Avoid/Use Alternative

clonidine + codeine

avoid combo if ADHD or antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• cyclobenzaprine
Javadin (clonidine)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

clonidine + cyclobenzaprine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cyproheptadine
Javadin (clonidine)

+

cyproheptadine

1 interaction

Avoid/Use Alternative

clonidine + cyproheptadine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dantrolene
Javadin (clonidine)

+

dantrolene

1 interaction

Avoid/Use Alternative

clonidine + dantrolene

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• daridorexant
Javadin (clonidine)

+

daridorexant

1 interaction

Avoid/Use Alternative

clonidine + daridorexant

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Javadin (clonidine)

+

darifenacin

1 interaction

Avoid/Use Alternative

clonidine + darifenacin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• desipramine
Javadin (clonidine)

+

desipramine

1 interaction

Avoid/Use Alternative

clonidine + desipramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• desvenlafaxine
Javadin (clonidine)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

clonidine + desvenlafaxine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• deutetrabenazine
Javadin (clonidine)

+

deutetrabenazine

1 interaction

Avoid/Use Alternative

clonidine + deutetrabenazine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Javadin (clonidine)

+

dexbrompheniramine

1 interaction

Avoid/Use Alternative

clonidine + dexbrompheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Javadin (clonidine)

+

dexchlorpheniramine

1 interaction

Avoid/Use Alternative

clonidine + dexchlorpheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine
Javadin (clonidine)

+

dexmedetomidine

1 interaction

Avoid/Use Alternative

clonidine + dexmedetomidine

if ADHD use, avoid combo; otherwise, monitor BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia, hypotension, incl. orthostasis, syncope (additive effects)

• dexmedetomidine injection
Javadin (clonidine)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

clonidine + dexmedetomidine injection

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, bradycardia, severe or life-threatening hypotension, incl. orthostasis (additive effects)

• diazepam
Javadin (clonidine)

+

diazepam

1 interaction

Avoid/Use Alternative

clonidine + diazepam

if ADHD use, avoid combo; otherwise, monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dichlorphenamide
Javadin (clonidine)

+

dichlorphenamide

1 interaction

Avoid/Use Alternative

clonidine + dichlorphenamide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difelikefalin
Javadin (clonidine)

+

difelikefalin

1 interaction

Avoid/Use Alternative

clonidine + difelikefalin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Javadin (clonidine)

+

difenoxin

1 interaction

Avoid/Use Alternative

clonidine + difenoxin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dihydrocodeine
Javadin (clonidine)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

clonidine + dihydrocodeine

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• diltiazem
Javadin (clonidine)

+

diltiazem

1 interaction

Avoid/Use Alternative

clonidine + diltiazem

if ADHD use, avoid combo; otherwise, monitor HR, BP, consider monitoring ECG: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia (additive effects)

• dimenhydrinate
Javadin (clonidine)

+

dimenhydrinate

1 interaction

Avoid/Use Alternative

clonidine + dimenhydrinate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diphenhydramine
Javadin (clonidine)

+

diphenhydramine

1 interaction

Avoid/Use Alternative

clonidine + diphenhydramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diphenoxylate
Javadin (clonidine)

+

diphenoxylate

1 interaction

Avoid/Use Alternative

clonidine + diphenoxylate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• disopyramide
Javadin (clonidine)

+

disopyramide

1 interaction

Avoid/Use Alternative

clonidine + disopyramide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• domperidone
Javadin (clonidine)

+

domperidone

1 interaction

Avoid/Use Alternative

clonidine + domperidone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• donepezil
Javadin (clonidine)

+

donepezil

1 interaction

Avoid/Use Alternative

clonidine + donepezil

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• doxepin
Javadin (clonidine)

+

doxepin

1 interaction

Avoid/Use Alternative

clonidine + doxepin

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• doxepin topical
Javadin (clonidine)

+

doxepin topical

1 interaction

Avoid/Use Alternative

clonidine + doxepin topical

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• doxylamine
Javadin (clonidine)

+

doxylamine

1 interaction

Avoid/Use Alternative

clonidine + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting or clonidine use for ADHD; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dronabinol
Javadin (clonidine)

+

dronabinol

1 interaction

Avoid/Use Alternative

clonidine + dronabinol

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects, antagonistic effects)

• dronedarone
Javadin (clonidine)

+

dronedarone

1 interaction

Avoid/Use Alternative

clonidine + dronedarone

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• droperidol
Javadin (clonidine)

+

droperidol

1 interaction

Avoid/Use Alternative

clonidine + droperidol

if ADHD use, avoid combo; otherwise, decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dulaglutide
Javadin (clonidine)

+

dulaglutide

1 interaction

Avoid/Use Alternative

clonidine + dulaglutide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• duloxetine
Javadin (clonidine)

+

duloxetine

1 interaction

Avoid/Use Alternative

clonidine + duloxetine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• efavirenz
Javadin (clonidine)

+

efavirenz

1 interaction

Avoid/Use Alternative

clonidine + efavirenz

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eletriptan
Javadin (clonidine)

+

eletriptan

1 interaction

Avoid/Use Alternative

clonidine + eletriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• eliglustat
Javadin (clonidine)

+

eliglustat

1 interaction

Avoid/Use Alternative

clonidine + eliglustat

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• elinzanetant
Javadin (clonidine)

+

elinzanetant

1 interaction

Avoid/Use Alternative

clonidine + elinzanetant

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entacapone
Javadin (clonidine)

+

entacapone

1 interaction

Avoid/Use Alternative

clonidine + entacapone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• entrectinib
Javadin (clonidine)

+

entrectinib

1 interaction

Avoid/Use Alternative

clonidine + entrectinib

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• escitalopram
Javadin (clonidine)

+

escitalopram

1 interaction

Avoid/Use Alternative

clonidine + escitalopram

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• esketamine
Javadin (clonidine)

+

esketamine

1 interaction

Avoid/Use Alternative

clonidine + esketamine

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• eslicarbazepine acetate
Javadin (clonidine)

+

eslicarbazepine acetate

1 interaction

Avoid/Use Alternative

clonidine + eslicarbazepine acetate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• esmolol
Javadin (clonidine)

+

esmolol

1 interaction

Avoid/Use Alternative

clonidine + esmolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C esmolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• estazolam
Javadin (clonidine)

+

estazolam

1 interaction

Avoid/Use Alternative

clonidine + estazolam

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eszopiclone
Javadin (clonidine)

+

eszopiclone

1 interaction

Avoid/Use Alternative

clonidine + eszopiclone

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethanol
Javadin (clonidine)

+

ethanol

1 interaction

Avoid/Use Alternative

clonidine + ethanol

avoid combo: coingestion of oral alcohol w/ clonidine may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis (additive effects)

• ethanol (in some formulations)
Javadin (clonidine)

+

ethanol (in some formulations)

1 interaction

Avoid/Use Alternative

clonidine + ethanol (in some formulations)

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ethosuximide
Javadin (clonidine)

+

ethosuximide

1 interaction

Avoid/Use Alternative

clonidine + ethosuximide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• etrasimod
Javadin (clonidine)

+

etrasimod

1 interaction

Avoid/Use Alternative

clonidine + etrasimod

if ADHD use, avoid combo; otherwise, monitor BP, HR, especially when starting or restarting etrasimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• felbamate
Javadin (clonidine)

+

felbamate

1 interaction

Avoid/Use Alternative

clonidine + felbamate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fenfluramine
Javadin (clonidine)

+

fenfluramine

1 interaction

Avoid/Use Alternative

clonidine + fenfluramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may decr. antihypertensive agent efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• fentanyl
Javadin (clonidine)

+

fentanyl

1 interaction

Avoid/Use Alternative

clonidine + fentanyl

if ADHD use, avoid combo; otherwise, monitor HR, BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), bradycardia (additive effects)

• fesoterodine
Javadin (clonidine)

+

fesoterodine

1 interaction

Avoid/Use Alternative

clonidine + fesoterodine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fexinidazole
Javadin (clonidine)

+

fexinidazole

1 interaction

Avoid/Use Alternative

clonidine + fexinidazole

if possible, do not initiate fexinidazole until 5 half-lives after clonidine D/C; use alternative or monitor ECG during and x7 days after fexinidazole tx: combo may incr. risk of QT prolongation, cardiac arrhythmias (bradycardia may incr. risk of QT prolongation)

• fingolimod
Javadin (clonidine)

+

fingolimod

1 interaction

Avoid/Use Alternative

clonidine + fingolimod

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR, ECG overnight, esp. during fingolimod initiation/titration: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• flecainide
Javadin (clonidine)

+

flecainide

1 interaction

Avoid/Use Alternative

clonidine + flecainide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• flibanserin
Javadin (clonidine)

+

flibanserin

1 interaction

Avoid/Use Alternative

clonidine + flibanserin

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• fluoxetine
Javadin (clonidine)

+

fluoxetine

1 interaction

Avoid/Use Alternative

clonidine + fluoxetine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluphenazine
Javadin (clonidine)

+

fluphenazine

1 interaction

Avoid/Use Alternative

clonidine + fluphenazine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• flurazepam
Javadin (clonidine)

+

flurazepam

1 interaction

Avoid/Use Alternative

clonidine + flurazepam

if ADHD use, avoid combo; otherwise, monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fluvoxamine
Javadin (clonidine)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

clonidine + fluvoxamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• foslevodopa
Javadin (clonidine)

+

foslevodopa

1 interaction

Avoid/Use Alternative

clonidine + foslevodopa

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• fosphenytoin
Javadin (clonidine)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

clonidine + fosphenytoin

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of CNS depression, psychomotor impairment, PR interval prolongation, AV block, bradycardia (additive effects)

• frovatriptan
Javadin (clonidine)

+

frovatriptan

1 interaction

Avoid/Use Alternative

clonidine + frovatriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• gabapentin
Javadin (clonidine)

+

gabapentin

1 interaction

Avoid/Use Alternative

clonidine + gabapentin

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Javadin (clonidine)

+

gabapentin enacarbil

1 interaction

Avoid/Use Alternative

clonidine + gabapentin enacarbil

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• galantamine
Javadin (clonidine)

+

galantamine

1 interaction

Avoid/Use Alternative

clonidine + galantamine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• ganaxolone
Javadin (clonidine)

+

ganaxolone

1 interaction

Avoid/Use Alternative

clonidine + ganaxolone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glofitamab
Javadin (clonidine)

+

glofitamab

1 interaction

Avoid/Use Alternative

clonidine + glofitamab

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate
Javadin (clonidine)

+

glycopyrrolate

1 interaction

Avoid/Use Alternative

clonidine + glycopyrrolate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• guanfacine
Javadin (clonidine)

+

guanfacine

1 interaction

Avoid/Use Alternative

clonidine + guanfacine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia (additive effects, duplicate tx)

• haloperidol
Javadin (clonidine)

+

haloperidol

1 interaction

Avoid/Use Alternative

clonidine + haloperidol

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• hydrocodone
Javadin (clonidine)

+

hydrocodone

1 interaction

Avoid/Use Alternative

clonidine + hydrocodone

avoid combo if ADHD or antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• hydromorphone
Javadin (clonidine)

+

hydromorphone

1 interaction

Avoid/Use Alternative

clonidine + hydromorphone

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• hydroxyzine
Javadin (clonidine)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

clonidine + hydroxyzine

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hyoscyamine
Javadin (clonidine)

+

hyoscyamine

1 interaction

Avoid/Use Alternative

clonidine + hyoscyamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ifosfamide
Javadin (clonidine)

+

ifosfamide

1 interaction

Avoid/Use Alternative

clonidine + ifosfamide

if ADHD use, avoid combo; otherwise, D/C one or both drugs if encephalopathy occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• iloperidone
Javadin (clonidine)

+

iloperidone

1 interaction

Avoid/Use Alternative

clonidine + iloperidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• imipramine
Javadin (clonidine)

+

imipramine

1 interaction

Avoid/Use Alternative

clonidine + imipramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• isocarboxazid
Javadin (clonidine)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

clonidine + isocarboxazid

if ADHD use, avoid combo; otherwise, use alternative or monitor BP during and x10 days after isocarboxazid use: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• ivabradine
Javadin (clonidine)

+

ivabradine

1 interaction

Avoid/Use Alternative

clonidine + ivabradine

if ADHD use, avoid combo; otherwise, monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• kava
Javadin (clonidine)

+

kava

1 interaction

Avoid/Use Alternative

clonidine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Javadin (clonidine)

+

kratom

1 interaction

Avoid/Use Alternative

clonidine + kratom

if ADHD use, avoid combo; otherwise, use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• labetalol
Javadin (clonidine)

+

labetalol

1 interaction

Avoid/Use Alternative

clonidine + labetalol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C labetalol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• lacosamide
Javadin (clonidine)

+

lacosamide

1 interaction

Avoid/Use Alternative

clonidine + lacosamide

if ADHD use, avoid combo; otherwise, monitor HR, ECG, especially during lacosamide initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, PR interval prolongation, AV block, bradycardia (additive effects)

• lamotrigine
Javadin (clonidine)

+

lamotrigine

1 interaction

Avoid/Use Alternative

clonidine + lamotrigine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia (additive effects)

• landiolol
Javadin (clonidine)

+

landiolol

1 interaction

Avoid/Use Alternative

clonidine + landiolol

avoid combo: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension, incl. orthostasis (additive effects)

• lasmiditan
Javadin (clonidine)

+

lasmiditan

1 interaction

Avoid/Use Alternative

clonidine + lasmiditan

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of bradycardia, CNS depression, psychomotor impairment (additive effects)

• lemborexant
Javadin (clonidine)

+

lemborexant

1 interaction

Avoid/Use Alternative

clonidine + lemborexant

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levetiracetam
Javadin (clonidine)

+

levetiracetam

1 interaction

Avoid/Use Alternative

clonidine + levetiracetam

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levocetirizine
Javadin (clonidine)

+

levocetirizine

1 interaction

Avoid/Use Alternative

clonidine + levocetirizine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Javadin (clonidine)

+

levodopa

1 interaction

Avoid/Use Alternative

clonidine + levodopa

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• levomilnacipran
Javadin (clonidine)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

clonidine + levomilnacipran

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• levorphanol
Javadin (clonidine)

+

levorphanol

1 interaction

Avoid/Use Alternative

clonidine + levorphanol

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• linezolid
Javadin (clonidine)

+

linezolid

1 interaction

Avoid/Use Alternative

clonidine + linezolid

use alternative or monitor BP: combo may result in severe HTN followed by severe hypotension; may result in HTN crisis upon alpha-2 agonist D/C (complex effects on neuronal catecholamines, linezolid reversibly inhibits monoamine oxidase)

• linvoseltamab
Javadin (clonidine)

+

linvoseltamab

1 interaction

Avoid/Use Alternative

clonidine + linvoseltamab

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lofexidine
Javadin (clonidine)

+

lofexidine

1 interaction

Avoid/Use Alternative

clonidine + lofexidine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia, hypotension (incl. orthostasis, syncope), other adverse effects (additive effects, duplicate tx)

• lopinavir/ritonavir
Javadin (clonidine)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

clonidine + lopinavir/ ritonavir

if ADHD use, avoid combo; otherwise, monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• lorazepam
Javadin (clonidine)

+

lorazepam

1 interaction

Avoid/Use Alternative

clonidine + lorazepam

if ADHD use, avoid combo; otherwise, monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lorlatinib
Javadin (clonidine)

+

lorlatinib

1 interaction

Avoid/Use Alternative

clonidine + lorlatinib

if ADHD use, avoid combo; otherwise, monitor BP, HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• loxapine
Javadin (clonidine)

+

loxapine

1 interaction

Avoid/Use Alternative

clonidine + loxapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• lumateperone
Javadin (clonidine)

+

lumateperone

1 interaction

Avoid/Use Alternative

clonidine + lumateperone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• lurasidone
Javadin (clonidine)

+

lurasidone

1 interaction

Avoid/Use Alternative

clonidine + lurasidone

if ADHD use, avoid combo; otherwise, monitor BP; consider lowest lurasidone start dose, titrate slowly: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• macimorelin
Javadin (clonidine)

+

macimorelin

1 interaction

Avoid/Use Alternative

clonidine + macimorelin

avoid combo or D/C clonidine, allowing sufficient washout time before diagnostic test: combo may interfere w/ test results (clonidine may transiently incr. growth hormone levels)

• meclizine
Javadin (clonidine)

+

meclizine

1 interaction

Avoid/Use Alternative

clonidine + meclizine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mefloquine
Javadin (clonidine)

+

mefloquine

1 interaction

Avoid/Use Alternative

clonidine + mefloquine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• melatonin
Javadin (clonidine)

+

melatonin

1 interaction

Avoid/Use Alternative

clonidine + melatonin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meperidine
Javadin (clonidine)

+

meperidine

1 interaction

Avoid/Use Alternative

clonidine + meperidine

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• meprobamate
Javadin (clonidine)

+

meprobamate

1 interaction

Avoid/Use Alternative

clonidine + meprobamate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metaxalone
Javadin (clonidine)

+

metaxalone

1 interaction

Avoid/Use Alternative

clonidine + metaxalone

if ADHD use, avoid combo; otherwise, use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methadone
Javadin (clonidine)

+

methadone

1 interaction

Avoid/Use Alternative

clonidine + methadone

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• methocarbamol
Javadin (clonidine)

+

methocarbamol

1 interaction

Avoid/Use Alternative

clonidine + methocarbamol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methohexital
Javadin (clonidine)

+

methohexital

1 interaction

Avoid/Use Alternative

clonidine + methohexital

if ADHD use, avoid combo; otherwise, monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• methsuximide
Javadin (clonidine)

+

methsuximide

1 interaction

Avoid/Use Alternative

clonidine + methsuximide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methyldopa
Javadin (clonidine)

+

methyldopa

1 interaction

Avoid/Use Alternative

clonidine + methyldopa

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects, duplicate tx)

• metoclopramide
Javadin (clonidine)

+

metoclopramide

1 interaction

Avoid/Use Alternative

clonidine + metoclopramide

if ADHD use, avoid combo; otherwise, use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• metoprolol
Javadin (clonidine)

+

metoprolol

1 interaction

Avoid/Use Alternative

clonidine + metoprolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C metoprolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• metyrapone
Javadin (clonidine)

+

metyrapone

1 interaction

Avoid/Use Alternative

clonidine + metyrapone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Javadin (clonidine)

+

metyrosine

1 interaction

Avoid/Use Alternative

clonidine + metyrosine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• midazolam
Javadin (clonidine)

+

midazolam

1 interaction

Avoid/Use Alternative

clonidine + midazolam

if ADHD use, avoid combo; otherwise, use alternative or monitor resp. rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• milnacipran
Javadin (clonidine)

+

milnacipran

1 interaction

Avoid/Use Alternative

clonidine + milnacipran

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• mirtazapine
Javadin (clonidine)

+

mirtazapine

1 interaction

Avoid/Use Alternative

clonidine + mirtazapine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• mitotane
Javadin (clonidine)

+

mitotane

1 interaction

Avoid/Use Alternative

clonidine + mitotane

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• molindone
Javadin (clonidine)

+

molindone

1 interaction

Avoid/Use Alternative

clonidine + molindone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• morphine
Javadin (clonidine)

+

morphine

1 interaction

Avoid/Use Alternative

clonidine + morphine

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• mosunetuzumab
Javadin (clonidine)

+

mosunetuzumab

1 interaction

Avoid/Use Alternative

clonidine + mosunetuzumab

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Javadin (clonidine)

+

mycophenolate mofetil

1 interaction

Avoid/Use Alternative

clonidine + mycophenolate mofetil

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nadolol
Javadin (clonidine)

+

nadolol

1 interaction

Avoid/Use Alternative

clonidine + nadolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C nadolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• nalbuphine
Javadin (clonidine)

+

nalbuphine

1 interaction

Avoid/Use Alternative

clonidine + nalbuphine

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• naltrexone
Javadin (clonidine)

+

naltrexone

1 interaction

Avoid/Use Alternative

clonidine + naltrexone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naratriptan
Javadin (clonidine)

+

naratriptan

1 interaction

Avoid/Use Alternative

clonidine + naratriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may decr. antihypertensive agent efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• nebivolol
Javadin (clonidine)

+

nebivolol

1 interaction

Avoid/Use Alternative

clonidine + nebivolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C nebivolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• nefazodone
Javadin (clonidine)

+

nefazodone

1 interaction

Avoid/Use Alternative

clonidine + nefazodone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nelarabine
Javadin (clonidine)

+

nelarabine

1 interaction

Avoid/Use Alternative

clonidine + nelarabine

if ADHD use, avoid combo; otherwise, withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nortriptyline
Javadin (clonidine)

+

nortriptyline

1 interaction

Avoid/Use Alternative

clonidine + nortriptyline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• olanzapine
Javadin (clonidine)

+

olanzapine

1 interaction

Avoid/Use Alternative

clonidine + olanzapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• oliceridine
Javadin (clonidine)

+

oliceridine

1 interaction

Avoid/Use Alternative

clonidine + oliceridine

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• opicapone
Javadin (clonidine)

+

opicapone

1 interaction

Avoid/Use Alternative

clonidine + opicapone

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• opium
Javadin (clonidine)

+

opium

1 interaction

Avoid/Use Alternative

clonidine + opium

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• orphenadrine
Javadin (clonidine)

+

orphenadrine

1 interaction

Avoid/Use Alternative

clonidine + orphenadrine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• oxazepam
Javadin (clonidine)

+

oxazepam

1 interaction

Avoid/Use Alternative

clonidine + oxazepam

if ADHD use, avoid combo; otherwise, monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• oxcarbazepine
Javadin (clonidine)

+

oxcarbazepine

1 interaction

Avoid/Use Alternative

clonidine + oxcarbazepine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• oxybate
Javadin (clonidine)

+

oxybate

1 interaction

Avoid/Use Alternative

clonidine + oxybate

if ADHD use, avoid combo; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxybutynin
Javadin (clonidine)

+

oxybutynin

1 interaction

Avoid/Use Alternative

clonidine + oxybutynin

if ADHD use, avoid combo; otherwise, decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxycodone
Javadin (clonidine)

+

oxycodone

1 interaction

Avoid/Use Alternative

clonidine + oxycodone

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. oxycodone start dose by at least 50%, consider decr. clonidine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• oxymorphone
Javadin (clonidine)

+

oxymorphone

1 interaction

Avoid/Use Alternative

clonidine + oxymorphone

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. oxymorphone start dose by at least 50%, consider decr. clonidine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• ozanimod
Javadin (clonidine)

+

ozanimod

1 interaction

Avoid/Use Alternative

clonidine + ozanimod

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR, ECG, especially when starting or restarting ozanimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• paliperidone
Javadin (clonidine)

+

paliperidone

1 interaction

Avoid/Use Alternative

clonidine + paliperidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• paltusotine
Javadin (clonidine)

+

paltusotine

1 interaction

Avoid/Use Alternative

clonidine + paltusotine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• paroxetine
Javadin (clonidine)

+

paroxetine

1 interaction

Avoid/Use Alternative

clonidine + paroxetine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• passion flower
Javadin (clonidine)

+

passion flower

1 interaction

Avoid/Use Alternative

clonidine + passion flower

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pentazocine
Javadin (clonidine)

+

pentazocine

1 interaction

Avoid/Use Alternative

clonidine + pentazocine

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• pentobarbital
Javadin (clonidine)

+

pentobarbital

1 interaction

Avoid/Use Alternative

clonidine + pentobarbital

if ADHD use, avoid combo; otherwise, monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• perampanel
Javadin (clonidine)

+

perampanel

1 interaction

Avoid/Use Alternative

clonidine + perampanel

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• perphenazine
Javadin (clonidine)

+

perphenazine

1 interaction

Avoid/Use Alternative

clonidine + perphenazine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• phenelzine
Javadin (clonidine)

+

phenelzine

1 interaction

Avoid/Use Alternative

clonidine + phenelzine

if ADHD use, avoid combo; otherwise, use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• pheniramine
Javadin (clonidine)

+

pheniramine

1 interaction

Avoid/Use Alternative

clonidine + pheniramine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• phenobarbital
Javadin (clonidine)

+

phenobarbital

1 interaction

Avoid/Use Alternative

clonidine + phenobarbital

if ADHD use, avoid combo; otherwise, monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• phenytoin
Javadin (clonidine)

+

phenytoin

1 interaction

Avoid/Use Alternative

clonidine + phenytoin

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of bradycardia, CNS depression, psychomotor impairment (additive effects)

• pimozide
Javadin (clonidine)

+

pimozide

1 interaction

Avoid/Use Alternative

clonidine + pimozide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pindolol
Javadin (clonidine)

+

pindolol

1 interaction

Avoid/Use Alternative

clonidine + pindolol

if ADHD use, avoid combo; otherwise monitor HR, BP; D/C pindolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• ponesimod
Javadin (clonidine)

+

ponesimod

1 interaction

Avoid/Use Alternative

clonidine + ponesimod

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR, ECG, especially when starting or restarting ponesimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• pramipexole
Javadin (clonidine)

+

pramipexole

1 interaction

Avoid/Use Alternative

clonidine + pramipexole

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• praziquantel
Javadin (clonidine)

+

praziquantel

1 interaction

Avoid/Use Alternative

clonidine + praziquantel

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• pregabalin
Javadin (clonidine)

+

pregabalin

1 interaction

Avoid/Use Alternative

clonidine + pregabalin

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• primidone
Javadin (clonidine)

+

primidone

1 interaction

Avoid/Use Alternative

clonidine + primidone

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• procainamide
Javadin (clonidine)

+

procainamide

1 interaction

Avoid/Use Alternative

clonidine + procainamide

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• procarbazine
Javadin (clonidine)

+

procarbazine

1 interaction

Avoid/Use Alternative

clonidine + procarbazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• prochlorperazine
Javadin (clonidine)

+

prochlorperazine

1 interaction

Avoid/Use Alternative

clonidine + prochlorperazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• promethazine
Javadin (clonidine)

+

promethazine

1 interaction

Avoid/Use Alternative

clonidine + promethazine

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• propafenone
Javadin (clonidine)

+

propafenone

1 interaction

Avoid/Use Alternative

clonidine + propafenone

if ADHD use, avoid combo; otherwise, monitor HR, BP: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension, incl. orthostasis (additive effects)

• propranolol
Javadin (clonidine)

+

propranolol

1 interaction

Avoid/Use Alternative

clonidine + propranolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C propranolol prior to clonidine taper: combo may incr. risk of PR interval prolongation, AV block, bradycardia, altered BP, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• protriptyline
Javadin (clonidine)

+

protriptyline

1 interaction

Avoid/Use Alternative

clonidine + protriptyline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• pyrilamine
Javadin (clonidine)

+

pyrilamine

1 interaction

Avoid/Use Alternative

clonidine + pyrilamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• quazepam
Javadin (clonidine)

+

quazepam

1 interaction

Avoid/Use Alternative

clonidine + quazepam

if ADHD use, avoid combo; otherwise, monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• quetiapine
Javadin (clonidine)

+

quetiapine

1 interaction

Avoid/Use Alternative

clonidine + quetiapine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may decr. antihypertensive agent efficacy (peds patients) (additive effects, antagonistic effects)

• quinine
Javadin (clonidine)

+

quinine

1 interaction

Avoid/Use Alternative

clonidine + quinine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• ramelteon
Javadin (clonidine)

+

ramelteon

1 interaction

Avoid/Use Alternative

clonidine + ramelteon

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rasagiline
Javadin (clonidine)

+

rasagiline

1 interaction

Avoid/Use Alternative

clonidine + rasagiline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• regadenoson
Javadin (clonidine)

+

regadenoson

1 interaction

Avoid/Use Alternative

clonidine + regadenoson

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• remifentanil
Javadin (clonidine)

+

remifentanil

1 interaction

Avoid/Use Alternative

clonidine + remifentanil

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP, HR; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, bradycardia, severe hypotension, incl. orthostasis, syncope (additive effects)

• remimazolam
Javadin (clonidine)

+

remimazolam

1 interaction

Avoid/Use Alternative

clonidine + remimazolam

if ADHD use, avoid combo; otherwise, monitor BP, HR, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of hypotension (incl. orthostasis), bradycardia, profound CNS and resp. depression, psychomotor impairment (additive effects)

• repotrectinib
Javadin (clonidine)

+

repotrectinib

1 interaction

Avoid/Use Alternative

clonidine + repotrectinib

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• risperidone
Javadin (clonidine)

+

risperidone

1 interaction

Avoid/Use Alternative

clonidine + risperidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• ritonavir
Javadin (clonidine)

+

ritonavir

1 interaction

Avoid/Use Alternative

clonidine + ritonavir

if ADHD use, avoid combo; otherwise, monitor HR, consider monitoring ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• rizatriptan
Javadin (clonidine)

+

rizatriptan

1 interaction

Avoid/Use Alternative

clonidine + rizatriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• ropeginterferon alfa-2b
Javadin (clonidine)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

clonidine + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ropinirole
Javadin (clonidine)

+

ropinirole

1 interaction

Avoid/Use Alternative

clonidine + ropinirole

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects, antagonistic effects)

• rotigotine transdermal
Javadin (clonidine)

+

rotigotine transdermal

1 interaction

Avoid/Use Alternative

clonidine + rotigotine transdermal

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects)

• rufinamide
Javadin (clonidine)

+

rufinamide

1 interaction

Avoid/Use Alternative

clonidine + rufinamide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• safinamide
Javadin (clonidine)

+

safinamide

1 interaction

Avoid/Use Alternative

clonidine + safinamide

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• scopolamine
Javadin (clonidine)

+

scopolamine

1 interaction

Avoid/Use Alternative

clonidine + scopolamine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selegiline
Javadin (clonidine)

+

selegiline

1 interaction

Avoid/Use Alternative

clonidine + selegiline

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• selegiline transdermal
Javadin (clonidine)

+

selegiline transdermal

1 interaction

Avoid/Use Alternative

clonidine + selegiline transdermal

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• selinexor
Javadin (clonidine)

+

selinexor

1 interaction

Avoid/Use Alternative

clonidine + selinexor

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sertraline
Javadin (clonidine)

+

sertraline

1 interaction

Avoid/Use Alternative

clonidine + sertraline

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• siponimod
Javadin (clonidine)

+

siponimod

1 interaction

Avoid/Use Alternative

clonidine + siponimod

if ADHD use, avoid combo; otherwise, consider alternative or monitor BP, HR, ECG, especially when starting or restarting siponimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• solifenacin
Javadin (clonidine)

+

solifenacin

1 interaction

Avoid/Use Alternative

clonidine + solifenacin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sotalol
Javadin (clonidine)

+

sotalol

1 interaction

Avoid/Use Alternative

clonidine + sotalol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C sotalol prior to clonidine taper: combo may incr. risk of PR interval prolongation, AV block, bradycardia, hypotension (incl. orthostasis), severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• stiripentol
Javadin (clonidine)

+

stiripentol

1 interaction

Avoid/Use Alternative

clonidine + stiripentol

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sufentanil
Javadin (clonidine)

+

sufentanil

1 interaction

Avoid/Use Alternative

clonidine + sufentanil

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP, HR; decr. sufentanil start dose, consider decr. clonidine dose, use lowest effective doses: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, bradycardia, severe hypotension, incl. orthostasis, syncope (additive effects)

• sumatriptan
Javadin (clonidine)

+

sumatriptan

1 interaction

Avoid/Use Alternative

clonidine + sumatriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• suvorexant
Javadin (clonidine)

+

suvorexant

1 interaction

Avoid/Use Alternative

clonidine + suvorexant

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tapentadol
Javadin (clonidine)

+

tapentadol

1 interaction

Avoid/Use Alternative

clonidine + tapentadol

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• tasimelteon
Javadin (clonidine)

+

tasimelteon

1 interaction

Avoid/Use Alternative

clonidine + tasimelteon

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• temazepam
Javadin (clonidine)

+

temazepam

1 interaction

Avoid/Use Alternative

clonidine + temazepam

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tetrabenazine
Javadin (clonidine)

+

tetrabenazine

1 interaction

Avoid/Use Alternative

clonidine + tetrabenazine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thalidomide
Javadin (clonidine)

+

thalidomide

1 interaction

Avoid/Use Alternative

clonidine + thalidomide

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, bradycardia, hypotension, incl. orthostasis (additive effects)

• thioridazine
Javadin (clonidine)

+

thioridazine

1 interaction

Avoid/Use Alternative

clonidine + thioridazine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• thiotepa
Javadin (clonidine)

+

thiotepa

1 interaction

Avoid/Use Alternative

clonidine + thiotepa

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiothixene
Javadin (clonidine)

+

thiothixene

1 interaction

Avoid/Use Alternative

clonidine + thiothixene

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• tiagabine
Javadin (clonidine)

+

tiagabine

1 interaction

Avoid/Use Alternative

clonidine + tiagabine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ticagrelor
Javadin (clonidine)

+

ticagrelor

1 interaction

Avoid/Use Alternative

clonidine + ticagrelor

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• timolol
Javadin (clonidine)

+

timolol

1 interaction

Avoid/Use Alternative

clonidine + timolol

if ADHD use, avoid combo; otherwise, monitor HR, BP; D/C timolol prior to clonidine taper: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia, severe rebound HTN on alpha-2 agonist withdrawal (additive effects; antagonistic effects, unopposed alpha adrenergic stimulation)

• tizanidine
Javadin (clonidine)

+

tizanidine

1 interaction

Avoid/Use Alternative

clonidine + tizanidine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), other adverse effects (additive effects, duplicate tx)

• tolcapone
Javadin (clonidine)

+

tolcapone

1 interaction

Avoid/Use Alternative

clonidine + tolcapone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• tolterodine
Javadin (clonidine)

+

tolterodine

1 interaction

Avoid/Use Alternative

clonidine + tolterodine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• topiramate
Javadin (clonidine)

+

topiramate

1 interaction

Avoid/Use Alternative

clonidine + topiramate

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tramadol
Javadin (clonidine)

+

tramadol

1 interaction

Avoid/Use Alternative

clonidine + tramadol

if ADHD use, avoid combo; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• tranylcypromine
Javadin (clonidine)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

clonidine + tranylcypromine

if ADHD use, avoid combo; otherwise, use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• trazodone
Javadin (clonidine)

+

trazodone

1 interaction

Avoid/Use Alternative

clonidine + trazodone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• triazolam
Javadin (clonidine)

+

triazolam

1 interaction

Avoid/Use Alternative

clonidine + triazolam

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• trifluoperazine
Javadin (clonidine)

+

trifluoperazine

1 interaction

Avoid/Use Alternative

clonidine + trifluoperazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, incl. orthostasis (additive effects)

• trihexyphenidyl
Javadin (clonidine)

+

trihexyphenidyl

1 interaction

Avoid/Use Alternative

clonidine + trihexyphenidyl

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimethobenzamide
Javadin (clonidine)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

clonidine + trimethobenzamide

if ADHD use, avoid combo; otherwise, use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Javadin (clonidine)

+

trimipramine

1 interaction

Avoid/Use Alternative

clonidine + trimipramine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, altered BP (additive effects; antagonistic effects)

• triprolidine
Javadin (clonidine)

+

triprolidine

1 interaction

Avoid/Use Alternative

clonidine + triprolidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trospium
Javadin (clonidine)

+

trospium

1 interaction

Avoid/Use Alternative

clonidine + trospium

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valbenazine
Javadin (clonidine)

+

valbenazine

1 interaction

Avoid/Use Alternative

clonidine + valbenazine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Javadin (clonidine)

+

valerian

1 interaction

Avoid/Use Alternative

clonidine + valerian

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
Javadin (clonidine)

+

valproic acid

1 interaction

Avoid/Use Alternative

clonidine + valproic acid

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• venlafaxine
Javadin (clonidine)

+

venlafaxine

1 interaction

Avoid/Use Alternative

clonidine + venlafaxine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• verapamil
Javadin (clonidine)

+

verapamil

1 interaction

Avoid/Use Alternative

clonidine + verapamil

if ADHD use, avoid combo; otherwise, use alternative or monitor BP, HR: combo may incr. risk of hypotension (incl. orthostasis), PR interval prolongation, AV block, bradycardia (additive effects)

• vigabatrin
Javadin (clonidine)

+

vigabatrin

1 interaction

Avoid/Use Alternative

clonidine + vigabatrin

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vilazodone
Javadin (clonidine)

+

vilazodone

1 interaction

Avoid/Use Alternative

clonidine + vilazodone

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• viloxazine
Javadin (clonidine)

+

viloxazine

1 interaction

Avoid/Use Alternative

clonidine + viloxazine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• yohimbe
Javadin (clonidine)

+

yohimbe

1 interaction

Avoid/Use Alternative

clonidine + yohimbe

avoid combo: combo may decr. efficacy of both drugs (antagonistic effects)

• zaleplon
Javadin (clonidine)

+

zaleplon

1 interaction

Avoid/Use Alternative

clonidine + zaleplon

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziconotide
Javadin (clonidine)

+

ziconotide

1 interaction

Avoid/Use Alternative

clonidine + ziconotide

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziprasidone
Javadin (clonidine)

+

ziprasidone

1 interaction

Avoid/Use Alternative

clonidine + ziprasidone

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• zolmitriptan
Javadin (clonidine)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

clonidine + zolmitriptan

if ADHD use, avoid combo; otherwise, monitor BP: combo may decr. antihypertensive agent efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• zolpidem
Javadin (clonidine)

+

zolpidem

1 interaction

Avoid/Use Alternative

clonidine + zolpidem

if ADHD use, avoid combo; otherwise, consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
Javadin (clonidine)

+

zonisamide

1 interaction

Avoid/Use Alternative

clonidine + zonisamide

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zuranolone
Javadin (clonidine)

+

zuranolone

1 interaction

Avoid/Use Alternative

clonidine + zuranolone

if ADHD use, avoid combo; otherwise, use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)