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CagriSema
cagrilintide/ semaglutide
Adult Dosing .
Dosage forms: INJ (pen)
Investigational New Drug (IND)
- [pending FDA approval]
weight management, chronic
- [indication/patient population pending FDA approval]
- Info: cagrilintide binds amylin receptors, decreasing glucagon secretion, delaying gastric emptying, and modulating satiety; semaglutide activates glucagon-like-peptide-1 (GLP-1) receptor, regulating appetite and caloric restriction, increasing insulin secretion, decreasing glucagon secretion, and delaying gastric emptying (incretin mimetic)
Peds Dosing .
- Dosage forms: --
Investigational New Drug (IND)
- [pending FDA approval]
- Info: not anticipated to be applicable to Peds population
Contraindications / Cautions .
- pending FDA approval
Drug Interactions .
Overview
cagrilintide
amylin analog
- pending FDA approval
- pending FDA approval
semaglutide
GLP-1 agonist
- antidiabetic agent
- caution advised with oral drugs, especially narrow therapeutic index; oral/SC semaglutide delays gastric emptying, may alter absorption of concomitant oral drugs
- administer oral semaglutide at least 30 min before other oral drugs; combo may decr. oral semaglutide absorption, efficacy
Avoid/Use Alternative
Monitor/Modify Tx
Safety/Monitoring .
pending FDA approval
Pharmacology .
Metabolism: pending FDA approval
Excretion: pending FDA approval
Subclass: Obesity/Weight Management: Amylin Analog/GLP-1 Agonist Combos
Mechanism of Action
pending FDA approval
Formulary .
No Formulary Selected
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