Fintepla

Overview

fenfluramine

5-HT2B agonist

• CYP1A2 substrate
• CYP2B6 substrate
• CYP2D6 substrate
• CYP3A4 substrate
• affected by altered fat absorption
• antiepileptic agent
• CNS depression
• hypertensive effects
• serotonergic effects

• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• amifampridine
Fintepla (fenfluramine)

+

amifampridine

1 interaction

Contraindicated

fenfluramine + amifampridine

contraindicated: combo may alter seizure control (antagonistic effects, amifampridine may decr. seizure threshold)

• bupropion
Fintepla (fenfluramine)

+

bupropion

1 interaction

Contraindicated

fenfluramine + bupropion

contraindicated: combo may alter seizure control; may incr. fenfluramine levels, risk of HTN (incl. hypertensive crisis), serotonin syndrome, other adverse effects (antagonistic effects, bupropion may decr. seizure threshold; hepatic metab. inhibited, additive effects)

• dalfampridine
Fintepla (fenfluramine)

+

dalfampridine

1 interaction

Contraindicated

fenfluramine + dalfampridine

contraindicated: combo may alter seizure control (antagonistic effects, dalfampridine may decr. seizure threshold)

• isocarboxazid
Fintepla (fenfluramine)

+

isocarboxazid

1 interaction

Contraindicated

fenfluramine + isocarboxazid

contraindicated w/in 14 days of isocarboxazid use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, isocarboxazid may decr. seizure threshold)

• phenelzine
Fintepla (fenfluramine)

+

phenelzine

1 interaction

Contraindicated

fenfluramine + phenelzine

contraindicated w/in 14 days of phenelzine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, phenelzine may decr. seizure threshold)

• selegiline transdermal
Fintepla (fenfluramine)

+

selegiline transdermal

1 interaction

Contraindicated

fenfluramine + selegiline transdermal

contraindicated w/in 14 days of selegiline transdermal use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, selegiline transdermal may decr. seizure threshold)

• tranylcypromine
Fintepla (fenfluramine)

+

tranylcypromine

1 interaction

Contraindicated

fenfluramine + tranylcypromine

contraindicated w/in 14 days of tranylcypromine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, tranylcypromine may decr. seizure threshold)

Avoid/Use Alternative

• alfentanil
Fintepla (fenfluramine)

+

alfentanil

1 interaction

Avoid/Use Alternative

fenfluramine + alfentanil

use alternative or monitor BP, resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, profound CNS and resp. depression, psychomotor impairment, hypotension; may alter seizure control (additive effects; antagonistic effects, alfentanil may decr. seizure threshold)

• amphetamine
Fintepla (fenfluramine)

+

amphetamine

1 interaction

Avoid/Use Alternative

fenfluramine + amphetamine

consider alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; decr. amphetamine start dose: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, amphetamine may decr. seizure threshold)

• apalutamide
Fintepla (fenfluramine)

+

apalutamide

1 interaction

Avoid/Use Alternative

fenfluramine + apalutamide

use alternative or consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may alter seizure control (hepatic metab. induced; antagonistic effects, apalutamide may decr. seizure threshold)

• buprenorphine
Fintepla (fenfluramine)

+

buprenorphine

1 interaction

Avoid/Use Alternative

fenfluramine + buprenorphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, buprenorphine may decr. seizure threshold)

• butalbital
Fintepla (fenfluramine)

+

butalbital

1 interaction

Avoid/Use Alternative

fenfluramine + butalbital

avoid combo: combo may decr. fenfluramine levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment (hepatic metab. induced; additive effects)

• butorphanol
Fintepla (fenfluramine)

+

butorphanol

1 interaction

Avoid/Use Alternative

fenfluramine + butorphanol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, butorphanol may decr. seizure threshold)

• carbamazepine
Fintepla (fenfluramine)

+

carbamazepine

1 interaction

Avoid/Use Alternative

fenfluramine + carbamazepine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• citalopram
Fintepla (fenfluramine)

+

citalopram

1 interaction

Avoid/Use Alternative

fenfluramine + citalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, citalopram may decr. seizure threshold)

• clobazam
Fintepla (fenfluramine)

+

clobazam

1 interaction

Avoid/Use Alternative

fenfluramine + clobazam

monitor resp. rate; if combo w/ stiripentol plus clobazam, adjust max fenfluramine dose to 0.2 mg/kg bid (max 17 mg/day); if combo w/ stiripentol plus clobazam and hepatic impairment, adjust fenfluramine dose based on Child-Pugh score: Class A: adjust max fenfluramine dose to 13 mg/day; Class B or C: avoid combo w/ stiripentol plus clobazam: combo may incr. fenfluramine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• clomipramine
Fintepla (fenfluramine)

+

clomipramine

1 interaction

Avoid/Use Alternative

fenfluramine + clomipramine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, clomipramine may decr. seizure threshold)

• clonidine
Fintepla (fenfluramine)

+

clonidine

1 interaction

Avoid/Use Alternative

fenfluramine + clonidine

if ADHD use, avoid combo; otherwise, monitor BP: combo may decr. antihypertensive agent efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• codeine
Fintepla (fenfluramine)

+

codeine

1 interaction

Avoid/Use Alternative

fenfluramine + codeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• cyclobenzaprine
Fintepla (fenfluramine)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

fenfluramine + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, cyclobenzaprine may decr. seizure threshold)

• desipramine
Fintepla (fenfluramine)

+

desipramine

1 interaction

Avoid/Use Alternative

fenfluramine + desipramine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, desipramine may decr. seizure threshold)

• desvenlafaxine
Fintepla (fenfluramine)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

fenfluramine + desvenlafaxine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, desvenlafaxine may decr. seizure threshold)

• dextroamphetamine
Fintepla (fenfluramine)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

fenfluramine + dextroamphetamine

consider alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; decr. dextroamphetamine start dose: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, dextroamphetamine may decr. seizure threshold)

• dihydrocodeine
Fintepla (fenfluramine)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

fenfluramine + dihydrocodeine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, dihydrocodeine may decr. seizure threshold)

• doxylamine
Fintepla (fenfluramine)

+

doxylamine

1 interaction

Avoid/Use Alternative

fenfluramine + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• duloxetine
Fintepla (fenfluramine)

+

duloxetine

1 interaction

Avoid/Use Alternative

fenfluramine + duloxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, duloxetine may decr. seizure threshold)

• encorafenib
Fintepla (fenfluramine)

+

encorafenib

1 interaction

Avoid/Use Alternative

fenfluramine + encorafenib

use alternative or consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy (hepatic metab. induced)

• enzalutamide
Fintepla (fenfluramine)

+

enzalutamide

1 interaction

Avoid/Use Alternative

fenfluramine + enzalutamide

use alternative or monitor BP; consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, enzalutamide may decr. seizure threshold)

• epinephrine inhaled
Fintepla (fenfluramine)

+

epinephrine inhaled

1 interaction

Avoid/Use Alternative

fenfluramine + epinephrine inhaled

avoid combo: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• escitalopram
Fintepla (fenfluramine)

+

escitalopram

1 interaction

Avoid/Use Alternative

fenfluramine + escitalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• ethanol
Fintepla (fenfluramine)

+

ethanol

1 interaction

Avoid/Use Alternative

fenfluramine + ethanol

avoid combo: coingestion of oral alcohol w/ fenfluramine may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fentanyl
Fintepla (fenfluramine)

+

fentanyl

1 interaction

Avoid/Use Alternative

fenfluramine + fentanyl

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, fentanyl may decr. seizure threshold)

• fluoxetine
Fintepla (fenfluramine)

+

fluoxetine

1 interaction

Avoid/Use Alternative

fenfluramine + fluoxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluoxetine may decr. seizure threshold)

• fluvoxamine
Fintepla (fenfluramine)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

fenfluramine + fluvoxamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• fosphenytoin
Fintepla (fenfluramine)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

fenfluramine + fosphenytoin

use alternative or consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• furosemide
Fintepla (fenfluramine)

+

furosemide

1 interaction

Avoid/Use Alternative

fenfluramine + furosemide

use alternative or monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• gepirone
Fintepla (fenfluramine)

+

gepirone

1 interaction

Avoid/Use Alternative

fenfluramine + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• ginkgo
Fintepla (fenfluramine)

+

ginkgo

1 interaction

Avoid/Use Alternative

fenfluramine + ginkgo

avoid consumption of ginkgo seeds; otherwise, caution advised: combo may alter seizure control (antagonistic effects, ginkgotoxin may decr. seizure threshold)

• granisetron
Fintepla (fenfluramine)

+

granisetron

1 interaction

Avoid/Use Alternative

fenfluramine + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydrocodone
Fintepla (fenfluramine)

+

hydrocodone

1 interaction

Avoid/Use Alternative

fenfluramine + hydrocodone

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, hydrocodone may decr. seizure threshold)

• hydromorphone
Fintepla (fenfluramine)

+

hydromorphone

1 interaction

Avoid/Use Alternative

fenfluramine + hydromorphone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, hydromorphone may decr. seizure threshold)

• isoniazid
Fintepla (fenfluramine)

+

isoniazid

1 interaction

Avoid/Use Alternative

fenfluramine + isoniazid

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome; may alter seizure control (additive effects, isoniazid inhibits monoamine oxidase; antagonistic effects, isoniazid may decr. seizure threshold)

• ivosidenib
Fintepla (fenfluramine)

+

ivosidenib

1 interaction

Avoid/Use Alternative

fenfluramine + ivosidenib

use alternative or consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy (hepatic metab. induced)

• kava
Fintepla (fenfluramine)

+

kava

1 interaction

Avoid/Use Alternative

fenfluramine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Fintepla (fenfluramine)

+

kratom

1 interaction

Avoid/Use Alternative

fenfluramine + kratom

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, kratom may decr. seizure threshold)

• landiolol
Fintepla (fenfluramine)

+

landiolol

1 interaction

Avoid/Use Alternative

fenfluramine + landiolol

use alternative or monitor HR, BP: combo may decr. landiolol efficacy (antagonistic effects)

• levomilnacipran
Fintepla (fenfluramine)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

fenfluramine + levomilnacipran

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, levomilnacipran may decr. seizure threshold)

• levorphanol
Fintepla (fenfluramine)

+

levorphanol

1 interaction

Avoid/Use Alternative

fenfluramine + levorphanol

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, levorphanol may decr. seizure threshold)

• linezolid
Fintepla (fenfluramine)

+

linezolid

1 interaction

Avoid/Use Alternative

fenfluramine + linezolid

use alternative or hold fenfluramine if urgent use; monitor BP, serotonin syndrome sx x2wk after fenfluramine D/C or 24h after last linezolid dose: combo may incr. risk of serotonin syndrome, HTN, incl. hypertensive crisis; may alter seizure control (additive effects, linezolid reversibly inhibits monoamine oxidase; antagonistic effects, linezolid may decr. seizure threshold)

• lisdexamfetamine
Fintepla (fenfluramine)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

fenfluramine + lisdexamfetamine

consider alternative or decr. lisdexamfetamine start dose; monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, dextroamphetamine may decr. seizure threshold)

• lithium
Fintepla (fenfluramine)

+

lithium

1 interaction

Avoid/Use Alternative

fenfluramine + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, lithium may decr. seizure threshold)

• lumacaftor/ivacaftor
Fintepla (fenfluramine)

+

lumacaftor/ ivacaftor

1 interaction

Avoid/Use Alternative

fenfluramine + lumacaftor/ ivacaftor

use alternative or monitor BP; consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of HTN, incl. hypertensive crisis (hepatic metab. induced; additive effects)

• meperidine
Fintepla (fenfluramine)

+

meperidine

1 interaction

Avoid/Use Alternative

fenfluramine + meperidine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, meperidine may decr. seizure threshold)

• metaxalone
Fintepla (fenfluramine)

+

metaxalone

1 interaction

Avoid/Use Alternative

fenfluramine + metaxalone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• methadone
Fintepla (fenfluramine)

+

methadone

1 interaction

Avoid/Use Alternative

fenfluramine + methadone

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, methadone may decr. seizure threshold)

• methamphetamine
Fintepla (fenfluramine)

+

methamphetamine

1 interaction

Avoid/Use Alternative

fenfluramine + methamphetamine

consider alternative or decr. methamphetamine start dose; monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, methamphetamine may decr. seizure threshold)

• methylene blue oral
Fintepla (fenfluramine)

+

methylene blue oral

1 interaction

Avoid/Use Alternative

fenfluramine + methylene blue oral

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• metoclopramide
Fintepla (fenfluramine)

+

metoclopramide

1 interaction

Avoid/Use Alternative

fenfluramine + metoclopramide

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may alter seizure control; may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• midazolam
Fintepla (fenfluramine)

+

midazolam

1 interaction

Avoid/Use Alternative

fenfluramine + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• midodrine
Fintepla (fenfluramine)

+

midodrine

1 interaction

Avoid/Use Alternative

fenfluramine + midodrine

use alternative or monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• milnacipran
Fintepla (fenfluramine)

+

milnacipran

1 interaction

Avoid/Use Alternative

fenfluramine + milnacipran

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, milnacipran may decr. seizure threshold)

• mirtazapine
Fintepla (fenfluramine)

+

mirtazapine

1 interaction

Avoid/Use Alternative

fenfluramine + mirtazapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• mitotane
Fintepla (fenfluramine)

+

mitotane

1 interaction

Avoid/Use Alternative

fenfluramine + mitotane

use alternative or consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• morphine
Fintepla (fenfluramine)

+

morphine

1 interaction

Avoid/Use Alternative

fenfluramine + morphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, morphine may decr. seizure threshold)

• nalbuphine
Fintepla (fenfluramine)

+

nalbuphine

1 interaction

Avoid/Use Alternative

fenfluramine + nalbuphine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, nalbuphine may decr. seizure threshold)

• nortriptyline
Fintepla (fenfluramine)

+

nortriptyline

1 interaction

Avoid/Use Alternative

fenfluramine + nortriptyline

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, nortriptyline may decr. seizure threshold)

• oliceridine
Fintepla (fenfluramine)

+

oliceridine

1 interaction

Avoid/Use Alternative

fenfluramine + oliceridine

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; consider decr. oliceridine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and resp. depression, psychomotor impairment, hypotension; may alter seizure control (additive effects; antagonistic effects, oliceridine may decr. seizure threshold)

• ondansetron
Fintepla (fenfluramine)

+

ondansetron

1 interaction

Avoid/Use Alternative

fenfluramine + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opium
Fintepla (fenfluramine)

+

opium

1 interaction

Avoid/Use Alternative

fenfluramine + opium

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, morphine in opium may decr. seizure threshold)

• oxybate
Fintepla (fenfluramine)

+

oxybate

1 interaction

Avoid/Use Alternative

fenfluramine + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Fintepla (fenfluramine)

+

oxycodone

1 interaction

Avoid/Use Alternative

fenfluramine + oxycodone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. oxycodone start dose by at least 50%, consider decr. fenfluramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, oxycodone may decr. seizure threshold)

• oxymorphone
Fintepla (fenfluramine)

+

oxymorphone

1 interaction

Avoid/Use Alternative

fenfluramine + oxymorphone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. oxymorphone start dose by at least 50%, consider decr. fenfluramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, oxymorphone may decr. seizure threshold)

• paroxetine
Fintepla (fenfluramine)

+

paroxetine

1 interaction

Avoid/Use Alternative

fenfluramine + paroxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. inhibited, additive effects; antagonistic effects, paroxetine may decr. seizure threshold)

• pentazocine
Fintepla (fenfluramine)

+

pentazocine

1 interaction

Avoid/Use Alternative

fenfluramine + pentazocine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, pentazocine may decr. seizure threshold)

• pentobarbital
Fintepla (fenfluramine)

+

pentobarbital

1 interaction

Avoid/Use Alternative

fenfluramine + pentobarbital

use alternative or monitor resp. rate; consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment (hepatic metab. induced; additive effects)

• phenobarbital
Fintepla (fenfluramine)

+

phenobarbital

1 interaction

Avoid/Use Alternative

fenfluramine + phenobarbital

use alternative or monitor resp. rate; consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment (hepatic metab. induced; additive effects)

• phenytoin
Fintepla (fenfluramine)

+

phenytoin

1 interaction

Avoid/Use Alternative

fenfluramine + phenytoin

use alternative or consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• primidone
Fintepla (fenfluramine)

+

primidone

1 interaction

Avoid/Use Alternative

fenfluramine + primidone

use alternative or monitor resp. rate; consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment (hepatic metab. induced; additive effects)

• procarbazine
Fintepla (fenfluramine)

+

procarbazine

1 interaction

Avoid/Use Alternative

fenfluramine + procarbazine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration, w/in 14 days of procarbazine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects, procarbazine inhibits monoamine oxidase; antagonistic effects, procarbazine may decr. seizure threshold)

• promethazine
Fintepla (fenfluramine)

+

promethazine

1 interaction

Avoid/Use Alternative

fenfluramine + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, promethazine may decr. seizure threshold)

• rasagiline
Fintepla (fenfluramine)

+

rasagiline

1 interaction

Avoid/Use Alternative

fenfluramine + rasagiline

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis (additive effects)

• remifentanil
Fintepla (fenfluramine)

+

remifentanil

1 interaction

Avoid/Use Alternative

fenfluramine + remifentanil

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, remifentanil may decr. seizure threshold)

• rifabutin
Fintepla (fenfluramine)

+

rifabutin

1 interaction

Avoid/Use Alternative

fenfluramine + rifabutin

use alternative or consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy (hepatic metab. induced)

• rifampin
Fintepla (fenfluramine)

+

rifampin

1 interaction

Avoid/Use Alternative

fenfluramine + rifampin

use alternative or consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy (hepatic metab. induced)

• ropeginterferon alfa-2b
Fintepla (fenfluramine)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

fenfluramine + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• safinamide
Fintepla (fenfluramine)

+

safinamide

1 interaction

Avoid/Use Alternative

fenfluramine + safinamide

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis (additive effects)

• selegiline
Fintepla (fenfluramine)

+

selegiline

1 interaction

Avoid/Use Alternative

fenfluramine + selegiline

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis (additive effects)

• sertraline
Fintepla (fenfluramine)

+

sertraline

1 interaction

Avoid/Use Alternative

fenfluramine + sertraline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sertraline may decr. seizure threshold)

• St. John's wort
Fintepla (fenfluramine)

+

St. John's wort

1 interaction

Avoid/Use Alternative

fenfluramine + St. John's wort

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider fenfluramine dose adjustment: combo may decr. fenfluramine levels, efficacy; may incr. risk of serotonin syndrome (hepatic metab. induced; additive effects)

• stiripentol
Fintepla (fenfluramine)

+

stiripentol

1 interaction

Avoid/Use Alternative

fenfluramine + stiripentol

if combo w/ stiripentol plus clobazam, adjust max fenfluramine dose to 0.2 mg/kg bid (max 17 mg/day); if combo w/ stiripentol plus clobazam and hepatic impairment, adjust fenfluramine dose based on Child-Pugh score: Class A: adjust max fenfluramine dose to 13 mg/day; Class B or C: avoid combo w/ stiripentol plus clobazam: combo may incr. fenfluramine levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. possibly inhibited, additive effects)

• sufentanil
Fintepla (fenfluramine)

+

sufentanil

1 interaction

Avoid/Use Alternative

fenfluramine + sufentanil

use alternative or monitor resp. rate, decr. sufentanil start dose, consider decr. fenfluramine dose, use lowest effective doses; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, sufentanil may decr. seizure threshold)

• tapentadol
Fintepla (fenfluramine)

+

tapentadol

1 interaction

Avoid/Use Alternative

fenfluramine + tapentadol

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, tapentadol may decr. seizure threshold)

• thalidomide
Fintepla (fenfluramine)

+

thalidomide

1 interaction

Avoid/Use Alternative

fenfluramine + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thalidomide may decr. seizure threshold)

• tramadol
Fintepla (fenfluramine)

+

tramadol

1 interaction

Avoid/Use Alternative

fenfluramine + tramadol

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, tramadol may decr. seizure threshold)

• trimethobenzamide
Fintepla (fenfluramine)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

fenfluramine + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Fintepla (fenfluramine)

+

trimipramine

1 interaction

Avoid/Use Alternative

fenfluramine + trimipramine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, trimipramine may decr. seizure threshold)

• venlafaxine
Fintepla (fenfluramine)

+

venlafaxine

1 interaction

Avoid/Use Alternative

fenfluramine + venlafaxine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, venlafaxine may decr. seizure threshold)

• vilazodone
Fintepla (fenfluramine)

+

vilazodone

1 interaction

Avoid/Use Alternative

fenfluramine + vilazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, vilazodone may decr. seizure threshold)

• vortioxetine
Fintepla (fenfluramine)

+

vortioxetine

1 interaction

Avoid/Use Alternative

fenfluramine + vortioxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• yohimbe
Fintepla (fenfluramine)

+

yohimbe

1 interaction

Avoid/Use Alternative

fenfluramine + yohimbe

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN, incl. hypertensive crisis (additive effects, yohimbe inhibits monoamine oxidase)

• ziprasidone
Fintepla (fenfluramine)

+

ziprasidone

1 interaction

Avoid/Use Alternative

fenfluramine + ziprasidone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, ziprasidone may decr. seizure threshold)

• zuranolone
Fintepla (fenfluramine)

+

zuranolone

1 interaction

Avoid/Use Alternative

fenfluramine + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• 5-HTP
Fintepla (fenfluramine)

+

5-HTP

1 interaction

Monitor/Modify Tx

fenfluramine + 5-HTP

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• abiraterone acetate
Fintepla (fenfluramine)

+

abiraterone acetate

1 interaction

Monitor/Modify Tx

fenfluramine + abiraterone acetate

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• acebutolol
Fintepla (fenfluramine)

+

acebutolol

1 interaction

Monitor/Modify Tx

fenfluramine + acebutolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• albuterol
Fintepla (fenfluramine)

+

albuterol

1 interaction

Monitor/Modify Tx

fenfluramine + albuterol

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• albuterol inhaled
Fintepla (fenfluramine)

+

albuterol inhaled

1 interaction

Monitor/Modify Tx

fenfluramine + albuterol inhaled

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• aldesleukin
Fintepla (fenfluramine)

+

aldesleukin

1 interaction

Monitor/Modify Tx

fenfluramine + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, aldesleukin may decr. seizure threshold)

• aliskiren
Fintepla (fenfluramine)

+

aliskiren

1 interaction

Monitor/Modify Tx

fenfluramine + aliskiren

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• almotriptan
Fintepla (fenfluramine)

+

almotriptan

1 interaction

Monitor/Modify Tx

fenfluramine + almotriptan

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• alprazolam
Fintepla (fenfluramine)

+

alprazolam

1 interaction

Monitor/Modify Tx

fenfluramine + alprazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• amiloride
Fintepla (fenfluramine)

+

amiloride

1 interaction

Monitor/Modify Tx

fenfluramine + amiloride

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amitriptyline
Fintepla (fenfluramine)

+

amitriptyline

1 interaction

Monitor/Modify Tx

fenfluramine + amitriptyline

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, amitriptyline may decr. seizure threshold)

• amlodipine
Fintepla (fenfluramine)

+

amlodipine

1 interaction

Monitor/Modify Tx

fenfluramine + amlodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amoxapine
Fintepla (fenfluramine)

+

amoxapine

1 interaction

Monitor/Modify Tx

fenfluramine + amoxapine

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, amoxapine may decr. seizure threshold)

• angiotensin II
Fintepla (fenfluramine)

+

angiotensin II

1 interaction

Monitor/Modify Tx

fenfluramine + angiotensin II

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• aprocitentan
Fintepla (fenfluramine)

+

aprocitentan

1 interaction

Monitor/Modify Tx

fenfluramine + aprocitentan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• arformoterol inhaled
Fintepla (fenfluramine)

+

arformoterol inhaled

1 interaction

Monitor/Modify Tx

fenfluramine + arformoterol inhaled

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• armodafinil
Fintepla (fenfluramine)

+

armodafinil

1 interaction

Monitor/Modify Tx

fenfluramine + armodafinil

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• asciminib
Fintepla (fenfluramine)

+

asciminib

1 interaction

Monitor/Modify Tx

fenfluramine + asciminib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• atenolol
Fintepla (fenfluramine)

+

atenolol

1 interaction

Monitor/Modify Tx

fenfluramine + atenolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atogepant
Fintepla (fenfluramine)

+

atogepant

1 interaction

Monitor/Modify Tx

fenfluramine + atogepant

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• atomoxetine
Fintepla (fenfluramine)

+

atomoxetine

1 interaction

Monitor/Modify Tx

fenfluramine + atomoxetine

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• atropine ophthalmic
Fintepla (fenfluramine)

+

atropine ophthalmic

1 interaction

Monitor/Modify Tx

fenfluramine + atropine ophthalmic

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• axitinib
Fintepla (fenfluramine)

+

axitinib

1 interaction

Monitor/Modify Tx

fenfluramine + axitinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• azilsartan medoxomil
Fintepla (fenfluramine)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

fenfluramine + azilsartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• baclofen intrathecal
Fintepla (fenfluramine)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

fenfluramine + baclofen intrathecal

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, baclofen may decr. seizure threshold)

• benazepril
Fintepla (fenfluramine)

+

benazepril

1 interaction

Monitor/Modify Tx

fenfluramine + benazepril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• benzphetamine
Fintepla (fenfluramine)

+

benzphetamine

1 interaction

Monitor/Modify Tx

fenfluramine + benzphetamine

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, benzphetamine may decr. seizure threshold)

• betamethasone
Fintepla (fenfluramine)

+

betamethasone

1 interaction

Monitor/Modify Tx

fenfluramine + betamethasone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, betamethasone may decr. seizure threshold)

• betaxolol
Fintepla (fenfluramine)

+

betaxolol

1 interaction

Monitor/Modify Tx

fenfluramine + betaxolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bevacizumab
Fintepla (fenfluramine)

+

bevacizumab

1 interaction

Monitor/Modify Tx

fenfluramine + bevacizumab

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• bismuth subsalicylate
Fintepla (fenfluramine)

+

bismuth subsalicylate

1 interaction

Monitor/Modify Tx

fenfluramine + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

• bisoprolol
Fintepla (fenfluramine)

+

bisoprolol

1 interaction

Monitor/Modify Tx

fenfluramine + bisoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• black cohosh
Fintepla (fenfluramine)

+

black cohosh

1 interaction

Monitor/Modify Tx

fenfluramine + black cohosh

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• brigatinib
Fintepla (fenfluramine)

+

brigatinib

1 interaction

Monitor/Modify Tx

fenfluramine + brigatinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• bromocriptine
Fintepla (fenfluramine)

+

bromocriptine

1 interaction

Monitor/Modify Tx

fenfluramine + bromocriptine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• budesonide
Fintepla (fenfluramine)

+

budesonide

1 interaction

Monitor/Modify Tx

fenfluramine + budesonide

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• bumetanide
Fintepla (fenfluramine)

+

bumetanide

1 interaction

Monitor/Modify Tx

fenfluramine + bumetanide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• buspirone
Fintepla (fenfluramine)

+

buspirone

1 interaction

Monitor/Modify Tx

fenfluramine + buspirone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• cabozantinib
Fintepla (fenfluramine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

fenfluramine + cabozantinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• caffeine
Fintepla (fenfluramine)

+

caffeine

1 interaction

Monitor/Modify Tx

fenfluramine + caffeine

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• caffeine citrate
Fintepla (fenfluramine)

+

caffeine citrate

1 interaction

Monitor/Modify Tx

fenfluramine + caffeine citrate

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• candesartan cilexetil
Fintepla (fenfluramine)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

fenfluramine + candesartan cilexetil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• cannabis
Fintepla (fenfluramine)

+

cannabis

1 interaction

Monitor/Modify Tx

fenfluramine + cannabis

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, cannabis may decr. seizure threshold)

• captopril
Fintepla (fenfluramine)

+

captopril

1 interaction

Monitor/Modify Tx

fenfluramine + captopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• carfilzomib
Fintepla (fenfluramine)

+

carfilzomib

1 interaction

Monitor/Modify Tx

fenfluramine + carfilzomib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• carvedilol
Fintepla (fenfluramine)

+

carvedilol

1 interaction

Monitor/Modify Tx

fenfluramine + carvedilol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• celecoxib
Fintepla (fenfluramine)

+

celecoxib

1 interaction

Monitor/Modify Tx

fenfluramine + celecoxib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• chlordiazepoxide
Fintepla (fenfluramine)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

fenfluramine + chlordiazepoxide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chlorothiazide
Fintepla (fenfluramine)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

fenfluramine + chlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• chlorpromazine
Fintepla (fenfluramine)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

fenfluramine + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, chlorpromazine may decr. seizure threshold)

• chlorthalidone
Fintepla (fenfluramine)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

fenfluramine + chlorthalidone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ciprofloxacin
Fintepla (fenfluramine)

+

ciprofloxacin

1 interaction

Monitor/Modify Tx

fenfluramine + ciprofloxacin

if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of adverse effects; may alter seizure control (hepatic metab. inhibited; antagonistic effects, ciprofloxacin may decr. seizure threshold)

• clevidipine
Fintepla (fenfluramine)

+

clevidipine

1 interaction

Monitor/Modify Tx

fenfluramine + clevidipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clonazepam
Fintepla (fenfluramine)

+

clonazepam

1 interaction

Monitor/Modify Tx

fenfluramine + clonazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clorazepate
Fintepla (fenfluramine)

+

clorazepate

1 interaction

Monitor/Modify Tx

fenfluramine + clorazepate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• cocaine
Fintepla (fenfluramine)

+

cocaine

1 interaction

Monitor/Modify Tx

fenfluramine + cocaine

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, cocaine may decr. seizure threshold)

• copanlisib
Fintepla (fenfluramine)

+

copanlisib

1 interaction

Monitor/Modify Tx

fenfluramine + copanlisib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects, copanlisib may cause infusion-related HTN)

• corticotropin
Fintepla (fenfluramine)

+

corticotropin

1 interaction

Monitor/Modify Tx

fenfluramine + corticotropin

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• cortisone
Fintepla (fenfluramine)

+

cortisone

1 interaction

Monitor/Modify Tx

fenfluramine + cortisone

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, cortisone may decr. seizure threshold)

• cyclosporine
Fintepla (fenfluramine)

+

cyclosporine

1 interaction

Monitor/Modify Tx

fenfluramine + cyclosporine

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, cyclosporine may decr. seizure threshold)

• dacomitinib
Fintepla (fenfluramine)

+

dacomitinib

1 interaction

Monitor/Modify Tx

fenfluramine + dacomitinib

if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of adverse effects (hepatic metab. inhibited)

• danazol
Fintepla (fenfluramine)

+

danazol

1 interaction

Monitor/Modify Tx

fenfluramine + danazol

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• darbepoetin alfa
Fintepla (fenfluramine)

+

darbepoetin alfa

1 interaction

Monitor/Modify Tx

fenfluramine + darbepoetin alfa

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, darbepoetin alfa may decr. seizure threshold)

• daridorexant
Fintepla (fenfluramine)

+

daridorexant

1 interaction

Monitor/Modify Tx

fenfluramine + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• deflazacort
Fintepla (fenfluramine)

+

deflazacort

1 interaction

Monitor/Modify Tx

fenfluramine + deflazacort

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, deflazacort may decr. seizure threshold)

• desflurane
Fintepla (fenfluramine)

+

desflurane

1 interaction

Monitor/Modify Tx

fenfluramine + desflurane

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• desmopressin
Fintepla (fenfluramine)

+

desmopressin

1 interaction

Monitor/Modify Tx

fenfluramine + desmopressin

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• dexamethasone
Fintepla (fenfluramine)

+

dexamethasone

1 interaction

Monitor/Modify Tx

fenfluramine + dexamethasone

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, dexamethasone may decr. seizure threshold)

• dexmedetomidine
Fintepla (fenfluramine)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

fenfluramine + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Fintepla (fenfluramine)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

fenfluramine + dexmedetomidine injection

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dexmethylphenidate
Fintepla (fenfluramine)

+

dexmethylphenidate

1 interaction

Monitor/Modify Tx

fenfluramine + dexmethylphenidate

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, (ser)dexmethylphenidate may decr. seizure threshold)

• dextromethorphan
Fintepla (fenfluramine)

+

dextromethorphan

1 interaction

Monitor/Modify Tx

fenfluramine + dextromethorphan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• diazepam
Fintepla (fenfluramine)

+

diazepam

1 interaction

Monitor/Modify Tx

fenfluramine + diazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• diclofenac
Fintepla (fenfluramine)

+

diclofenac

1 interaction

Monitor/Modify Tx

fenfluramine + diclofenac

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• diclofenac topical
Fintepla (fenfluramine)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

fenfluramine + diclofenac topical

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• diethylpropion
Fintepla (fenfluramine)

+

diethylpropion

1 interaction

Monitor/Modify Tx

fenfluramine + diethylpropion

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, diethylpropion may decr. seizure threshold)

• diflunisal
Fintepla (fenfluramine)

+

diflunisal

1 interaction

Monitor/Modify Tx

fenfluramine + diflunisal

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• dihydroergotamine
Fintepla (fenfluramine)

+

dihydroergotamine

1 interaction

Monitor/Modify Tx

fenfluramine + dihydroergotamine

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of severe HTN (incl. hypertensive crisis), vasospasm, ischemia, serotonin syndrome (additive effects)

• diltiazem
Fintepla (fenfluramine)

+

diltiazem

1 interaction

Monitor/Modify Tx

fenfluramine + diltiazem

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dobutamine
Fintepla (fenfluramine)

+

dobutamine

1 interaction

Monitor/Modify Tx

fenfluramine + dobutamine

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• dopamine
Fintepla (fenfluramine)

+

dopamine

1 interaction

Monitor/Modify Tx

fenfluramine + dopamine

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• doxapram
Fintepla (fenfluramine)

+

doxapram

1 interaction

Monitor/Modify Tx

fenfluramine + doxapram

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• doxazosin
Fintepla (fenfluramine)

+

doxazosin

1 interaction

Monitor/Modify Tx

fenfluramine + doxazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• doxepin
Fintepla (fenfluramine)

+

doxepin

1 interaction

Monitor/Modify Tx

fenfluramine + doxepin

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, doxepin may decr. seizure threshold)

• doxepin topical
Fintepla (fenfluramine)

+

doxepin topical

1 interaction

Monitor/Modify Tx

fenfluramine + doxepin topical

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• dronabinol
Fintepla (fenfluramine)

+

dronabinol

1 interaction

Monitor/Modify Tx

fenfluramine + dronabinol

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, dronabinol may decr. seizure threshold)

• droperidol
Fintepla (fenfluramine)

+

droperidol

1 interaction

Monitor/Modify Tx

fenfluramine + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• droxidopa
Fintepla (fenfluramine)

+

droxidopa

1 interaction

Monitor/Modify Tx

fenfluramine + droxidopa

monitor BP: combo may incr. risk of supine HTN, incl. hypertensive crisis (additive effects)

• eletriptan
Fintepla (fenfluramine)

+

eletriptan

1 interaction

Monitor/Modify Tx

fenfluramine + eletriptan

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• enalapril
Fintepla (fenfluramine)

+

enalapril

1 interaction

Monitor/Modify Tx

fenfluramine + enalapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• enalaprilat
Fintepla (fenfluramine)

+

enalaprilat

1 interaction

Monitor/Modify Tx

fenfluramine + enalaprilat

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• enasidenib
Fintepla (fenfluramine)

+

enasidenib

1 interaction

Monitor/Modify Tx

fenfluramine + enasidenib

if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of adverse effects (hepatic metab. inhibited)

• ephedra
Fintepla (fenfluramine)

+

ephedra

1 interaction

Monitor/Modify Tx

fenfluramine + ephedra

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, ephedra may decr. seizure threshold)

• ephedrine injection
Fintepla (fenfluramine)

+

ephedrine injection

1 interaction

Monitor/Modify Tx

fenfluramine + ephedrine injection

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ephedrine oral
Fintepla (fenfluramine)

+

ephedrine oral

1 interaction

Monitor/Modify Tx

fenfluramine + ephedrine oral

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• epinephrine
Fintepla (fenfluramine)

+

epinephrine

1 interaction

Monitor/Modify Tx

fenfluramine + epinephrine

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• eplerenone
Fintepla (fenfluramine)

+

eplerenone

1 interaction

Monitor/Modify Tx

fenfluramine + eplerenone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epoetin alfa
Fintepla (fenfluramine)

+

epoetin alfa

1 interaction

Monitor/Modify Tx

fenfluramine + epoetin alfa

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, epoetin alfa may decr. seizure threshold)

• eptinezumab
Fintepla (fenfluramine)

+

eptinezumab

1 interaction

Monitor/Modify Tx

fenfluramine + eptinezumab

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• erenumab
Fintepla (fenfluramine)

+

erenumab

1 interaction

Monitor/Modify Tx

fenfluramine + erenumab

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ergotamine
Fintepla (fenfluramine)

+

ergotamine

1 interaction

Monitor/Modify Tx

fenfluramine + ergotamine

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of severe HTN (incl. hypertensive crisis), vasospasm, ischemia, serotonin syndrome (additive effects)

• esketamine
Fintepla (fenfluramine)

+

esketamine

1 interaction

Monitor/Modify Tx

fenfluramine + esketamine

monitor BP, resp. rate: combo may incr. risk of HTN (incl. hypertensive crisis), CNS and resp. depression, psychomotor impairment (additive effects)

• esmolol
Fintepla (fenfluramine)

+

esmolol

1 interaction

Monitor/Modify Tx

fenfluramine + esmolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• estazolam
Fintepla (fenfluramine)

+

estazolam

1 interaction

Monitor/Modify Tx

fenfluramine + estazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• estetrol (contraceptive)
Fintepla (fenfluramine)

+

estetrol (contraceptive)

1 interaction

Monitor/Modify Tx

fenfluramine + estetrol (contraceptive)

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• estradiol (contraceptive)
Fintepla (fenfluramine)

+

estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

fenfluramine + estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• eszopiclone
Fintepla (fenfluramine)

+

eszopiclone

1 interaction

Monitor/Modify Tx

fenfluramine + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Fintepla (fenfluramine)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

fenfluramine + ethacrynic acid

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ethanol (in some formulations)
Fintepla (fenfluramine)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

fenfluramine + ethanol (in some formulations)

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ethinyl estradiol (contraceptive)
Fintepla (fenfluramine)

+

ethinyl estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

fenfluramine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• etodolac
Fintepla (fenfluramine)

+

etodolac

1 interaction

Monitor/Modify Tx

fenfluramine + etodolac

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• etomidate
Fintepla (fenfluramine)

+

etomidate

1 interaction

Monitor/Modify Tx

fenfluramine + etomidate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• etrasimod
Fintepla (fenfluramine)

+

etrasimod

1 interaction

Monitor/Modify Tx

fenfluramine + etrasimod

monitor BP: combo may incr. risk of HTN (additive effects)

• felodipine
Fintepla (fenfluramine)

+

felodipine

1 interaction

Monitor/Modify Tx

fenfluramine + felodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenoldopam
Fintepla (fenfluramine)

+

fenoldopam

1 interaction

Monitor/Modify Tx

fenfluramine + fenoldopam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenoprofen
Fintepla (fenfluramine)

+

fenoprofen

1 interaction

Monitor/Modify Tx

fenfluramine + fenoprofen

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• fingolimod
Fintepla (fenfluramine)

+

fingolimod

1 interaction

Monitor/Modify Tx

fenfluramine + fingolimod

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• fludrocortisone
Fintepla (fenfluramine)

+

fludrocortisone

1 interaction

Monitor/Modify Tx

fenfluramine + fludrocortisone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• fluphenazine
Fintepla (fenfluramine)

+

fluphenazine

1 interaction

Monitor/Modify Tx

fenfluramine + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• flurazepam
Fintepla (fenfluramine)

+

flurazepam

1 interaction

Monitor/Modify Tx

fenfluramine + flurazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• flurbiprofen
Fintepla (fenfluramine)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

fenfluramine + flurbiprofen

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• formoterol inhaled
Fintepla (fenfluramine)

+

formoterol inhaled

1 interaction

Monitor/Modify Tx

fenfluramine + formoterol inhaled

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• fosinopril
Fintepla (fenfluramine)

+

fosinopril

1 interaction

Monitor/Modify Tx

fenfluramine + fosinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fostamatinib
Fintepla (fenfluramine)

+

fostamatinib

1 interaction

Monitor/Modify Tx

fenfluramine + fostamatinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• fremanezumab
Fintepla (fenfluramine)

+

fremanezumab

1 interaction

Monitor/Modify Tx

fenfluramine + fremanezumab

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• frovatriptan
Fintepla (fenfluramine)

+

frovatriptan

1 interaction

Monitor/Modify Tx

fenfluramine + frovatriptan

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• fruquintinib
Fintepla (fenfluramine)

+

fruquintinib

1 interaction

Monitor/Modify Tx

fenfluramine + fruquintinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• gabapentin
Fintepla (fenfluramine)

+

gabapentin

1 interaction

Monitor/Modify Tx

fenfluramine + gabapentin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Fintepla (fenfluramine)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

fenfluramine + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• galcanezumab
Fintepla (fenfluramine)

+

galcanezumab

1 interaction

Monitor/Modify Tx

fenfluramine + galcanezumab

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• guanfacine
Fintepla (fenfluramine)

+

guanfacine

1 interaction

Monitor/Modify Tx

fenfluramine + guanfacine

monitor BP: combo may decr. antihypertensive agent efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• hoodia
Fintepla (fenfluramine)

+

hoodia

1 interaction

Monitor/Modify Tx

fenfluramine + hoodia

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• hydralazine
Fintepla (fenfluramine)

+

hydralazine

1 interaction

Monitor/Modify Tx

fenfluramine + hydralazine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrochlorothiazide
Fintepla (fenfluramine)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

fenfluramine + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrocortisone
Fintepla (fenfluramine)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

fenfluramine + hydrocortisone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• hydroxocobalamin IV
Fintepla (fenfluramine)

+

hydroxocobalamin IV

1 interaction

Monitor/Modify Tx

fenfluramine + hydroxocobalamin IV

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• hydroxyzine
Fintepla (fenfluramine)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

fenfluramine + hydroxyzine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ibrutinib
Fintepla (fenfluramine)

+

ibrutinib

1 interaction

Monitor/Modify Tx

fenfluramine + ibrutinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ibuprofen
Fintepla (fenfluramine)

+

ibuprofen

1 interaction

Monitor/Modify Tx

fenfluramine + ibuprofen

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ifosfamide
Fintepla (fenfluramine)

+

ifosfamide

1 interaction

Monitor/Modify Tx

fenfluramine + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, ifosfamide may decr. seizure threshold)

• imipramine
Fintepla (fenfluramine)

+

imipramine

1 interaction

Monitor/Modify Tx

fenfluramine + imipramine

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, imipramine may decr. seizure threshold)

• indapamide
Fintepla (fenfluramine)

+

indapamide

1 interaction

Monitor/Modify Tx

fenfluramine + indapamide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• indomethacin
Fintepla (fenfluramine)

+

indomethacin

1 interaction

Monitor/Modify Tx

fenfluramine + indomethacin

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• irbesartan
Fintepla (fenfluramine)

+

irbesartan

1 interaction

Monitor/Modify Tx

fenfluramine + irbesartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• isoflurane
Fintepla (fenfluramine)

+

isoflurane

1 interaction

Monitor/Modify Tx

fenfluramine + isoflurane

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• isradipine
Fintepla (fenfluramine)

+

isradipine

1 interaction

Monitor/Modify Tx

fenfluramine + isradipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ketamine
Fintepla (fenfluramine)

+

ketamine

1 interaction

Monitor/Modify Tx

fenfluramine + ketamine

monitor resp. rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment, HTN (incl. hypertensive crisis), other sympathomimetic adverse effects; may alter seizure control (additive effects; antagonistic effects, ketamine may decr. seizure threshold)

• ketoprofen
Fintepla (fenfluramine)

+

ketoprofen

1 interaction

Monitor/Modify Tx

fenfluramine + ketoprofen

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ketorolac
Fintepla (fenfluramine)

+

ketorolac

1 interaction

Monitor/Modify Tx

fenfluramine + ketorolac

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, ketorolac may decr. seizure threshold)

• labetalol
Fintepla (fenfluramine)

+

labetalol

1 interaction

Monitor/Modify Tx

fenfluramine + labetalol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lanreotide
Fintepla (fenfluramine)

+

lanreotide

1 interaction

Monitor/Modify Tx

fenfluramine + lanreotide

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• lasmiditan
Fintepla (fenfluramine)

+

lasmiditan

1 interaction

Monitor/Modify Tx

fenfluramine + lasmiditan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• leflunomide
Fintepla (fenfluramine)

+

leflunomide

1 interaction

Monitor/Modify Tx

fenfluramine + leflunomide

monitor BP: combo may decr. fenfluramine levels, efficacy; may incr. risk of HTN, incl. hypertensive crisis (hepatic metab. induced; additive effects)

• lemborexant
Fintepla (fenfluramine)

+

lemborexant

1 interaction

Monitor/Modify Tx

fenfluramine + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenvatinib
Fintepla (fenfluramine)

+

lenvatinib

1 interaction

Monitor/Modify Tx

fenfluramine + lenvatinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• levalbuterol inhaled
Fintepla (fenfluramine)

+

levalbuterol inhaled

1 interaction

Monitor/Modify Tx

fenfluramine + levalbuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, other cardiovascular adverse effects (additive effects)

• levothyroxine
Fintepla (fenfluramine)

+

levothyroxine

1 interaction

Monitor/Modify Tx

fenfluramine + levothyroxine

monitor BP: combo may incr. risk of HTN (additive effects)

• licorice
Fintepla (fenfluramine)

+

licorice

1 interaction

Monitor/Modify Tx

fenfluramine + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• liothyronine
Fintepla (fenfluramine)

+

liothyronine

1 interaction

Monitor/Modify Tx

fenfluramine + liothyronine

monitor BP: combo may incr. risk of HTN (additive effects)

• lisinopril
Fintepla (fenfluramine)

+

lisinopril

1 interaction

Monitor/Modify Tx

fenfluramine + lisinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lorazepam
Fintepla (fenfluramine)

+

lorazepam

1 interaction

Monitor/Modify Tx

fenfluramine + lorazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lorlatinib
Fintepla (fenfluramine)

+

lorlatinib

1 interaction

Monitor/Modify Tx

fenfluramine + lorlatinib

monitor BP: combo may decr. fenfluramine levels, efficacy; may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, lorlatinib may decr. seizure threshold)

• losartan
Fintepla (fenfluramine)

+

losartan

1 interaction

Monitor/Modify Tx

fenfluramine + losartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• luspatercept
Fintepla (fenfluramine)

+

luspatercept

1 interaction

Monitor/Modify Tx

fenfluramine + luspatercept

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• magnesium salicylate
Fintepla (fenfluramine)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

fenfluramine + magnesium salicylate

monitor BP w/ high-dose magnesium salicylate: combo may incr. risk of HTN (additive effects)

• mavorixafor
Fintepla (fenfluramine)

+

mavorixafor

1 interaction

Monitor/Modify Tx

fenfluramine + mavorixafor

if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of adverse effects (hepatic metab. inhibited)

• meclofenamate
Fintepla (fenfluramine)

+

meclofenamate

1 interaction

Monitor/Modify Tx

fenfluramine + meclofenamate

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• mefenamic acid
Fintepla (fenfluramine)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

fenfluramine + mefenamic acid

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• meloxicam
Fintepla (fenfluramine)

+

meloxicam

1 interaction

Monitor/Modify Tx

fenfluramine + meloxicam

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• methohexital
Fintepla (fenfluramine)

+

methohexital

1 interaction

Monitor/Modify Tx

fenfluramine + methohexital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methoxy polyethylene glycol-epoetin beta
Fintepla (fenfluramine)

+

methoxy polyethylene glycol-epoetin beta

1 interaction

Monitor/Modify Tx

fenfluramine + methoxy polyethylene glycol-epoetin beta

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, methoxy polyethylene glycol-epoetin beta may decr. seizure threshold)

• methyldopa
Fintepla (fenfluramine)

+

methyldopa

1 interaction

Monitor/Modify Tx

fenfluramine + methyldopa

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• methylene blue injection
Fintepla (fenfluramine)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

fenfluramine + methylene blue injection

hold fenfluramine if emergency use; monitor serotonin syndrome sx up to 4h after last methylene blue dose; may resume fenfluramine 72h after last methylene blue dose: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylergonovine
Fintepla (fenfluramine)

+

methylergonovine

1 interaction

Monitor/Modify Tx

fenfluramine + methylergonovine

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of severe HTN (incl. hypertensive crisis), vasospasm, ischemia, serotonin syndrome (additive effects)

• methylphenidate
Fintepla (fenfluramine)

+

methylphenidate

1 interaction

Monitor/Modify Tx

fenfluramine + methylphenidate

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, methylphenidate may decr. seizure threshold)

• methylprednisolone
Fintepla (fenfluramine)

+

methylprednisolone

1 interaction

Monitor/Modify Tx

fenfluramine + methylprednisolone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• methyltestosterone
Fintepla (fenfluramine)

+

methyltestosterone

1 interaction

Monitor/Modify Tx

fenfluramine + methyltestosterone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• metolazone
Fintepla (fenfluramine)

+

metolazone

1 interaction

Monitor/Modify Tx

fenfluramine + metolazone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• metoprolol
Fintepla (fenfluramine)

+

metoprolol

1 interaction

Monitor/Modify Tx

fenfluramine + metoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• minoxidil
Fintepla (fenfluramine)

+

minoxidil

1 interaction

Monitor/Modify Tx

fenfluramine + minoxidil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• mirabegron
Fintepla (fenfluramine)

+

mirabegron

1 interaction

Monitor/Modify Tx

fenfluramine + mirabegron

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• modafinil
Fintepla (fenfluramine)

+

modafinil

1 interaction

Monitor/Modify Tx

fenfluramine + modafinil

monitor BP: combo may decr. fenfluramine levels, efficacy; may incr. risk of HTN, incl. hypertensive crisis (hepatic metab. induced; additive effects)

• moexipril
Fintepla (fenfluramine)

+

moexipril

1 interaction

Monitor/Modify Tx

fenfluramine + moexipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nabumetone
Fintepla (fenfluramine)

+

nabumetone

1 interaction

Monitor/Modify Tx

fenfluramine + nabumetone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• nadolol
Fintepla (fenfluramine)

+

nadolol

1 interaction

Monitor/Modify Tx

fenfluramine + nadolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• naproxen
Fintepla (fenfluramine)

+

naproxen

1 interaction

Monitor/Modify Tx

fenfluramine + naproxen

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• naratriptan
Fintepla (fenfluramine)

+

naratriptan

1 interaction

Monitor/Modify Tx

fenfluramine + naratriptan

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• naxitamab
Fintepla (fenfluramine)

+

naxitamab

1 interaction

Monitor/Modify Tx

fenfluramine + naxitamab

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• nebivolol
Fintepla (fenfluramine)

+

nebivolol

1 interaction

Monitor/Modify Tx

fenfluramine + nebivolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nefazodone
Fintepla (fenfluramine)

+

nefazodone

1 interaction

Monitor/Modify Tx

fenfluramine + nefazodone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, nefazodone may decr. seizure threshold)

• nelarabine
Fintepla (fenfluramine)

+

nelarabine

1 interaction

Monitor/Modify Tx

fenfluramine + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, nelarabine may decr. seizure threshold)

• nicardipine
Fintepla (fenfluramine)

+

nicardipine

1 interaction

Monitor/Modify Tx

fenfluramine + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nifedipine
Fintepla (fenfluramine)

+

nifedipine

1 interaction

Monitor/Modify Tx

fenfluramine + nifedipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nimodipine
Fintepla (fenfluramine)

+

nimodipine

1 interaction

Monitor/Modify Tx

fenfluramine + nimodipine

monitor BP: combo may decr. nimodipine efficacy (antagonistic effects)

• niraparib
Fintepla (fenfluramine)

+

niraparib

1 interaction

Monitor/Modify Tx

fenfluramine + niraparib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• nisoldipine
Fintepla (fenfluramine)

+

nisoldipine

1 interaction

Monitor/Modify Tx

fenfluramine + nisoldipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• norepinephrine
Fintepla (fenfluramine)

+

norepinephrine

1 interaction

Monitor/Modify Tx

fenfluramine + norepinephrine

monitor BP: combo may incr. risk of severe HTN, incl. hypertensive crisis (additive effects)

• obinutuzumab
Fintepla (fenfluramine)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

fenfluramine + obinutuzumab

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• olanzapine
Fintepla (fenfluramine)

+

olanzapine

1 interaction

Monitor/Modify Tx

fenfluramine + olanzapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis; may alter seizure control (additive effects; antagonistic effects, olanzapine may decr. seizure threshold)

• olmesartan medoxomil
Fintepla (fenfluramine)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

fenfluramine + olmesartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• olodaterol inhaled
Fintepla (fenfluramine)

+

olodaterol inhaled

1 interaction

Monitor/Modify Tx

fenfluramine + olodaterol inhaled

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• opicapone
Fintepla (fenfluramine)

+

opicapone

1 interaction

Monitor/Modify Tx

fenfluramine + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• osilodrostat
Fintepla (fenfluramine)

+

osilodrostat

1 interaction

Monitor/Modify Tx

fenfluramine + osilodrostat

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• oxaprozin
Fintepla (fenfluramine)

+

oxaprozin

1 interaction

Monitor/Modify Tx

fenfluramine + oxaprozin

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• oxazepam
Fintepla (fenfluramine)

+

oxazepam

1 interaction

Monitor/Modify Tx

fenfluramine + oxazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• oxybutynin
Fintepla (fenfluramine)

+

oxybutynin

1 interaction

Monitor/Modify Tx

fenfluramine + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxymetazoline nasal
Fintepla (fenfluramine)

+

oxymetazoline nasal

1 interaction

Monitor/Modify Tx

fenfluramine + oxymetazoline nasal

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• oxytocin
Fintepla (fenfluramine)

+

oxytocin

1 interaction

Monitor/Modify Tx

fenfluramine + oxytocin

monitor BP: combo may incr. risk of HTN, incl. life-threatening (additive effects)

• ozanimod
Fintepla (fenfluramine)

+

ozanimod

1 interaction

Monitor/Modify Tx

fenfluramine + ozanimod

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• palonosetron
Fintepla (fenfluramine)

+

palonosetron

1 interaction

Monitor/Modify Tx

fenfluramine + palonosetron

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• pazopanib
Fintepla (fenfluramine)

+

pazopanib

1 interaction

Monitor/Modify Tx

fenfluramine + pazopanib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• perindopril
Fintepla (fenfluramine)

+

perindopril

1 interaction

Monitor/Modify Tx

fenfluramine + perindopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• perphenazine
Fintepla (fenfluramine)

+

perphenazine

1 interaction

Monitor/Modify Tx

fenfluramine + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, perphenazine may decr. seizure threshold)

• pexidartinib
Fintepla (fenfluramine)

+

pexidartinib

1 interaction

Monitor/Modify Tx

fenfluramine + pexidartinib

monitor BP: combo may decr. fenfluramine levels, efficacy; may incr. risk of HTN, incl. hypertensive crisis (hepatic metab. induced; additive effects)

• phendimetrazine
Fintepla (fenfluramine)

+

phendimetrazine

1 interaction

Monitor/Modify Tx

fenfluramine + phendimetrazine

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, phendimetrazine may decr. seizure threshold)

• phenoxybenzamine
Fintepla (fenfluramine)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

fenfluramine + phenoxybenzamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phentermine
Fintepla (fenfluramine)

+

phentermine

1 interaction

Monitor/Modify Tx

fenfluramine + phentermine

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, phentermine may decr. seizure threshold)

• phentolamine
Fintepla (fenfluramine)

+

phentolamine

1 interaction

Monitor/Modify Tx

fenfluramine + phentolamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phenylephrine
Fintepla (fenfluramine)

+

phenylephrine

1 interaction

Monitor/Modify Tx

fenfluramine + phenylephrine

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• phenylephrine injection
Fintepla (fenfluramine)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

fenfluramine + phenylephrine injection

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• phenylephrine nasal
Fintepla (fenfluramine)

+

phenylephrine nasal

1 interaction

Monitor/Modify Tx

fenfluramine + phenylephrine nasal

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• phenylephrine ophthalmic
Fintepla (fenfluramine)

+

phenylephrine ophthalmic

1 interaction

Monitor/Modify Tx

fenfluramine + phenylephrine ophthalmic

monitor BP; HTN risk may be lower w/ phenylephrine ophthalmic 2.5%: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• phenylephrine rectal
Fintepla (fenfluramine)

+

phenylephrine rectal

1 interaction

Monitor/Modify Tx

fenfluramine + phenylephrine rectal

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• pindolol
Fintepla (fenfluramine)

+

pindolol

1 interaction

Monitor/Modify Tx

fenfluramine + pindolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• piroxicam
Fintepla (fenfluramine)

+

piroxicam

1 interaction

Monitor/Modify Tx

fenfluramine + piroxicam

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ponatinib
Fintepla (fenfluramine)

+

ponatinib

1 interaction

Monitor/Modify Tx

fenfluramine + ponatinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ponesimod
Fintepla (fenfluramine)

+

ponesimod

1 interaction

Monitor/Modify Tx

fenfluramine + ponesimod

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• pralsetinib
Fintepla (fenfluramine)

+

pralsetinib

1 interaction

Monitor/Modify Tx

fenfluramine + pralsetinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• prazosin
Fintepla (fenfluramine)

+

prazosin

1 interaction

Monitor/Modify Tx

fenfluramine + prazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• prednisolone
Fintepla (fenfluramine)

+

prednisolone

1 interaction

Monitor/Modify Tx

fenfluramine + prednisolone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• prednisone
Fintepla (fenfluramine)

+

prednisone

1 interaction

Monitor/Modify Tx

fenfluramine + prednisone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• pregabalin
Fintepla (fenfluramine)

+

pregabalin

1 interaction

Monitor/Modify Tx

fenfluramine + pregabalin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• propofol
Fintepla (fenfluramine)

+

propofol

1 interaction

Monitor/Modify Tx

fenfluramine + propofol

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, propofol may decr. seizure threshold)

• propranolol
Fintepla (fenfluramine)

+

propranolol

1 interaction

Monitor/Modify Tx

fenfluramine + propranolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• protriptyline
Fintepla (fenfluramine)

+

protriptyline

1 interaction

Monitor/Modify Tx

fenfluramine + protriptyline

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, protriptyline may decr. seizure threshold)

• pseudoephedrine
Fintepla (fenfluramine)

+

pseudoephedrine

1 interaction

Monitor/Modify Tx

fenfluramine + pseudoephedrine

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• quazepam
Fintepla (fenfluramine)

+

quazepam

1 interaction

Monitor/Modify Tx

fenfluramine + quazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• quetiapine
Fintepla (fenfluramine)

+

quetiapine

1 interaction

Monitor/Modify Tx

fenfluramine + quetiapine

monitor BP, especially in pts <18 yo: combo may incr. risk of CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis (peds patients); may alter seizure control (additive effects; antagonistic effects, quetiapine may decr. seizure threshold)

• quinapril
Fintepla (fenfluramine)

+

quinapril

1 interaction

Monitor/Modify Tx

fenfluramine + quinapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• quinidine (antiarrhythmic)
Fintepla (fenfluramine)

+

quinidine (antiarrhythmic)

1 interaction

Monitor/Modify Tx

fenfluramine + quinidine (antiarrhythmic)

if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of adverse effects (hepatic metab. inhibited)

• quinidine (CYP2D6 inhibitor)
Fintepla (fenfluramine)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Monitor/Modify Tx

fenfluramine + quinidine (CYP2D6 inhibitor)

if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of adverse effects (hepatic metab. inhibited)

• ramipril
Fintepla (fenfluramine)

+

ramipril

1 interaction

Monitor/Modify Tx

fenfluramine + ramipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ramucirumab
Fintepla (fenfluramine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

fenfluramine + ramucirumab

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• regorafenib
Fintepla (fenfluramine)

+

regorafenib

1 interaction

Monitor/Modify Tx

fenfluramine + regorafenib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• remimazolam
Fintepla (fenfluramine)

+

remimazolam

1 interaction

Monitor/Modify Tx

fenfluramine + remimazolam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• rimegepant
Fintepla (fenfluramine)

+

rimegepant

1 interaction

Monitor/Modify Tx

fenfluramine + rimegepant

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ripretinib
Fintepla (fenfluramine)

+

ripretinib

1 interaction

Monitor/Modify Tx

fenfluramine + ripretinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• rizatriptan
Fintepla (fenfluramine)

+

rizatriptan

1 interaction

Monitor/Modify Tx

fenfluramine + rizatriptan

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• ropinirole
Fintepla (fenfluramine)

+

ropinirole

1 interaction

Monitor/Modify Tx

fenfluramine + ropinirole

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis), CNS depression, psychomotor impairment (additive effects)

• rotigotine transdermal
Fintepla (fenfluramine)

+

rotigotine transdermal

1 interaction

Monitor/Modify Tx

fenfluramine + rotigotine transdermal

monitor BP, HR: combo may incr. risk of HTN (incl. hypertensive crisis), tachycardia, CNS depression, psychomotor impairment (additive effects)

• salmeterol inhaled
Fintepla (fenfluramine)

+

salmeterol inhaled

1 interaction

Monitor/Modify Tx

fenfluramine + salmeterol inhaled

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• salsalate
Fintepla (fenfluramine)

+

salsalate

1 interaction

Monitor/Modify Tx

fenfluramine + salsalate

monitor BP w/ high-dose salsalate: combo may incr. risk of HTN (additive effects)

• SAMe
Fintepla (fenfluramine)

+

SAMe

1 interaction

Monitor/Modify Tx

fenfluramine + SAMe

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• selpercatinib
Fintepla (fenfluramine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

fenfluramine + selpercatinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• sevoflurane
Fintepla (fenfluramine)

+

sevoflurane

1 interaction

Monitor/Modify Tx

fenfluramine + sevoflurane

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sevoflurane may decr. seizure threshold)

• siponimod
Fintepla (fenfluramine)

+

siponimod

1 interaction

Monitor/Modify Tx

fenfluramine + siponimod

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• solriamfetol
Fintepla (fenfluramine)

+

solriamfetol

1 interaction

Monitor/Modify Tx

fenfluramine + solriamfetol

monitor BP, HR: combo may incr. risk of HTN (incl. hypertensive crisis), tachycardia (additive effects)

• sorafenib
Fintepla (fenfluramine)

+

sorafenib

1 interaction

Monitor/Modify Tx

fenfluramine + sorafenib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• spironolactone
Fintepla (fenfluramine)

+

spironolactone

1 interaction

Monitor/Modify Tx

fenfluramine + spironolactone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• sulindac
Fintepla (fenfluramine)

+

sulindac

1 interaction

Monitor/Modify Tx

fenfluramine + sulindac

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• sumatriptan
Fintepla (fenfluramine)

+

sumatriptan

1 interaction

Monitor/Modify Tx

fenfluramine + sumatriptan

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sumatriptan may decr. seizure threshold)

• sunitinib
Fintepla (fenfluramine)

+

sunitinib

1 interaction

Monitor/Modify Tx

fenfluramine + sunitinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• suvorexant
Fintepla (fenfluramine)

+

suvorexant

1 interaction

Monitor/Modify Tx

fenfluramine + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tacrolimus
Fintepla (fenfluramine)

+

tacrolimus

1 interaction

Monitor/Modify Tx

fenfluramine + tacrolimus

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, tacrolimus may decr. seizure threshold)

• tagraxofusp
Fintepla (fenfluramine)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

fenfluramine + tagraxofusp

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• telmisartan
Fintepla (fenfluramine)

+

telmisartan

1 interaction

Monitor/Modify Tx

fenfluramine + telmisartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• temazepam
Fintepla (fenfluramine)

+

temazepam

1 interaction

Monitor/Modify Tx

fenfluramine + temazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• terazosin
Fintepla (fenfluramine)

+

terazosin

1 interaction

Monitor/Modify Tx

fenfluramine + terazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• terbinafine
Fintepla (fenfluramine)

+

terbinafine

1 interaction

Monitor/Modify Tx

fenfluramine + terbinafine

if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of adverse effects (hepatic metab. inhibited)

• terbutaline
Fintepla (fenfluramine)

+

terbutaline

1 interaction

Monitor/Modify Tx

fenfluramine + terbutaline

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, terbutaline may decr. seizure threshold)

• teriflunomide
Fintepla (fenfluramine)

+

teriflunomide

1 interaction

Monitor/Modify Tx

fenfluramine + teriflunomide

monitor BP: combo may decr. fenfluramine levels, efficacy; may incr. risk of HTN, incl. hypertensive crisis (hepatic metab. induced; additive effects)

• testosterone
Fintepla (fenfluramine)

+

testosterone

1 interaction

Monitor/Modify Tx

fenfluramine + testosterone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• thioridazine
Fintepla (fenfluramine)

+

thioridazine

1 interaction

Monitor/Modify Tx

fenfluramine + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thioridazine may decr. seizure threshold)

• thiothixene
Fintepla (fenfluramine)

+

thiothixene

1 interaction

Monitor/Modify Tx

fenfluramine + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thiothixene may decr. seizure threshold)

• thyroid
Fintepla (fenfluramine)

+

thyroid

1 interaction

Monitor/Modify Tx

fenfluramine + thyroid

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• timolol
Fintepla (fenfluramine)

+

timolol

1 interaction

Monitor/Modify Tx

fenfluramine + timolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tivozanib
Fintepla (fenfluramine)

+

tivozanib

1 interaction

Monitor/Modify Tx

fenfluramine + tivozanib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• tolmetin
Fintepla (fenfluramine)

+

tolmetin

1 interaction

Monitor/Modify Tx

fenfluramine + tolmetin

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• torsemide
Fintepla (fenfluramine)

+

torsemide

1 interaction

Monitor/Modify Tx

fenfluramine + torsemide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• trametinib
Fintepla (fenfluramine)

+

trametinib

1 interaction

Monitor/Modify Tx

fenfluramine + trametinib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• trandolapril
Fintepla (fenfluramine)

+

trandolapril

1 interaction

Monitor/Modify Tx

fenfluramine + trandolapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• trazodone
Fintepla (fenfluramine)

+

trazodone

1 interaction

Monitor/Modify Tx

fenfluramine + trazodone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• triamcinolone
Fintepla (fenfluramine)

+

triamcinolone

1 interaction

Monitor/Modify Tx

fenfluramine + triamcinolone

monitor BP: combo may incr. risk of HTN (incl. hypertensive crisis); may alter seizure control (additive effects; antagonistic effects, triamcinolone may decr. seizure threshold)

• triamterene
Fintepla (fenfluramine)

+

triamterene

1 interaction

Monitor/Modify Tx

fenfluramine + triamterene

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triazolam
Fintepla (fenfluramine)

+

triazolam

1 interaction

Monitor/Modify Tx

fenfluramine + triazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ubrogepant
Fintepla (fenfluramine)

+

ubrogepant

1 interaction

Monitor/Modify Tx

fenfluramine + ubrogepant

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• vadadustat
Fintepla (fenfluramine)

+

vadadustat

1 interaction

Monitor/Modify Tx

fenfluramine + vadadustat

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis; may alter seizure control (additive effects; antagonistic effects, vadadustat may decr. seizure threshold)

• valsartan
Fintepla (fenfluramine)

+

valsartan

1 interaction

Monitor/Modify Tx

fenfluramine + valsartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vamorolone
Fintepla (fenfluramine)

+

vamorolone

1 interaction

Monitor/Modify Tx

fenfluramine + vamorolone

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• vandetanib
Fintepla (fenfluramine)

+

vandetanib

1 interaction

Monitor/Modify Tx

fenfluramine + vandetanib

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• vasopressin
Fintepla (fenfluramine)

+

vasopressin

1 interaction

Monitor/Modify Tx

fenfluramine + vasopressin

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• verapamil
Fintepla (fenfluramine)

+

verapamil

1 interaction

Monitor/Modify Tx

fenfluramine + verapamil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vilanterol inhaled
Fintepla (fenfluramine)

+

vilanterol inhaled

1 interaction

Monitor/Modify Tx

fenfluramine + vilanterol inhaled

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• viloxazine
Fintepla (fenfluramine)

+

viloxazine

1 interaction

Monitor/Modify Tx

fenfluramine + viloxazine

monitor BP; if also combined w/ stiripentol, adjust max fenfluramine dose to 17 mg/day; otherwise, adjust max fenfluramine dose to 20 mg/day: combo may incr. fenfluramine levels, risk of CNS depression, psychomotor impairment, HTN (incl. hypertensive crisis), other adverse effects (hepatic metab. inhibited, additive effects)

• voclosporin
Fintepla (fenfluramine)

+

voclosporin

1 interaction

Monitor/Modify Tx

fenfluramine + voclosporin

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• zaleplon
Fintepla (fenfluramine)

+

zaleplon

1 interaction

Monitor/Modify Tx

fenfluramine + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zavegepant
Fintepla (fenfluramine)

+

zavegepant

1 interaction

Monitor/Modify Tx

fenfluramine + zavegepant

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• ziconotide
Fintepla (fenfluramine)

+

ziconotide

1 interaction

Monitor/Modify Tx

fenfluramine + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziv-aflibercept
Fintepla (fenfluramine)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

fenfluramine + ziv-aflibercept

monitor BP: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• zolmitriptan
Fintepla (fenfluramine)

+

zolmitriptan

1 interaction

Monitor/Modify Tx

fenfluramine + zolmitriptan

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN (incl. hypertensive crisis), serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• zolpidem
Fintepla (fenfluramine)

+

zolpidem

1 interaction

Monitor/Modify Tx

fenfluramine + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)