Select a medication above to begin.
Kebilidi (eladocagene exuparvovec-tneq)
eladocagene exuparvovec
Adult Dosing .
Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = eladocagene exuparvovec-tneq
aromatic L-amino acid decarboxylase deficiency
- [1.8 x10^11 vector genomes intraputaminally divided equally in 4 sites x1]
- Start: w/in 6h of starting product thaw; Info: for pts w/ biallelic mutations in DDC gene; see pkg insert for detailed instructions
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
Special Note
- [formulation clarification]
- Info: nonproprietary name = eladocagene exuparvovec-tneq
aromatic L-amino acid decarboxylase deficiency
- [1.8 x10^11 vector genomes intraputaminally divided equally in 4 sites x1]
- Start: w/in 6h of starting product thaw; Info: for pts w/ biallelic mutations in DDC gene and skull maturity; see pkg insert for detailed instructions
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- skull immaturity
- pregnancy
- caution: pts of childbearing potential
Drug Interactions .
Overview
eladocagene exuparvovec
gene therapy
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- respiratory arrest
- cardiac arrest
- cerebral infarction
- intracranial bleeding
- dyskinesia
Common Reactions
- dyskinesia
- fever
- hypotension
- anemia
- sialorrhea
- hypokalemia
- hypophosphatemia
- insomnia
- hypomagnesemia
- procedural complications
Safety/Monitoring .
Monitoring Parameters
neuroimaging, pregnancy test before tx start; cardiac and respiratory fxn continuously in hospital after procedure
Pregnancy/Lactation .
Pregnancy
Clinical Summary
avoid use during pregnancy; no human or animal data available
Individuals of Reproductive Potential
obtain negative pregnancy test before tx start
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: unknown; CYP450: unknown
Excretion: unknown; Half-life: unknown
Subclass: Inherited Metabolic Disorders
Mechanism of Action
recombinant adeno-associated viral vector delivers functional copy of DDC gene encoding aromatic L-amino acid decarboxylase (AACD) enzyme, increasing enzyme expression and dopamine production
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.