Priftin

Adult Dosing .

Dosage forms:  TAB: 150 mg

tuberculosis, active

[continuation phase, weekly regimen, non-HIV patients]

Dose: 10-20 mg/kg/dose PO qwk x18-31wk; Start: after completing initiation phase; Info: administer by directly observed tx; give with isoniazid 900 mg PO qwk; not 1st-line tx; refer to ATS/CDC/IDSA guidelines; give with food

[complete daily regimen, >40 kg (off-label)]

Dose: 1200 mg PO qd x4mo; Info: for susceptible pulmonary infection; administer by directly observed tx; give with moxifloxacin, isoniazid, and pyrazinamide for intensive phase x8wk; give with moxifloxacin and isoniazid for continuation phase to complete course; not 1st-line tx; refer to CDC guidelines; give with food

tuberculosis, latent

[32.1-49.9 kg]

Dose: 750 mg PO qwk x3mo; Info: for non-pregnant patients; give with weekly isoniazid; 1st-line tx; give with food

[>50 kg]

Dose: 900 mg PO qwk x3mo; Info: for non-pregnant patients; give with weekly isoniazid; 1st-line tx; give with food

[1 month daily regimen (off-label)]

Dose: 600 mg PO qd x1mo; Info: for non-pregnant patients; not 1st-line tx; may self-administer; give with daily isoniazid; refer to WHO guidelines; give with food

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 150 mg

tuberculosis, active

[continuation phase, weekly regimen, non-HIV patients, 12 yo and older]

Dose: 10-20 mg/kg/dose PO qwk x18-31wk; Start: after completing initiation phase; Info: administer by directly observed tx; give with isoniazid 900 mg PO qwk; not 1st-line tx, refer to ATS/CDC/IDSA guidelines; give with food

[complete daily regimen, 12 yo and older, >40 kg (off-label)]

Dose: 1200 mg PO qd x4mo; Info: for susceptible pulmonary infection; administer by directly observed tx; give with moxifloxacin, isoniazid, and pyrazinamide for intensive phase x8wk; give with moxifloxacin and isoniazid for continuation phase to complete course; not 1st-line tx; refer to CDC guidelines; give with food

tuberculosis, latent

[2 yo and older, 10-14 kg]

Dose: 300 mg PO qwk x3mo; Info: give with weekly isoniazid; 1st-line tx; give with food

[2 yo and older, 14.1-25 kg]

Dose: 450 mg PO qwk x3mo; Info: give with weekly isoniazid; 1st-line tx; give with food

[2 yo and older, 25.1-32 kg]

Dose: 600 mg PO qwk x3mo; Info: give with weekly isoniazid; 1st-line tx; give with food

[2 yo and older, 32.1-49.9 kg]

Dose: 750 mg PO qwk x3mo; Info: for non-pregnant patients; give with weekly isoniazid; 1st-line tx; give with food

[2 yo and older, >50 kg]

Dose: 900 mg PO qwk x3mo; Info: for non-pregnant patients; give with weekly isoniazid; 1st-line tx; give with food

[13 yo and older (off-label)]

Dose: 600 mg PO qd x1mo; Info: for non-pregnant patients; not 1st-line tx; may self-administer; give with daily isoniazid; refer to WHO guidelines; give with food

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised