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Tryvio
aprocitentan
Black Box Warnings .
Embryo-Fetal Toxicity
contraindicated in pregnancy due to risk of fetal harm; exclude pregnancy prior to tx initiation; avoid pregnancy by using effective methods of contraception prior to tx start, during tx, and x1mo after D/C; D/C ASAP if pregnancy detected
Adult Dosing .
Dosage forms: TAB: 12.5 mg
HTN, adjunct tx
- [12.5 mg PO qd]
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [see below]
- Child-Pugh Class B or C or baseline AST/ALT >3x ULN: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.