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captopril/ hydrochlorothiazide
generic
Black Box Warnings .
Fetal Toxicity
fetal/neonatal morbidity/mortality may occur when drugs that act directly on the renin-angiotensin system are used in pregnancy; D/C drug ASAP once pregnancy detected
Adult Dosing .
Dosage forms: TAB: 25 mg/15 mg, 25 mg/25 mg, 50 mg/15 mg, 50 mg/25 mg
HTN
- [1-3 tabs/day PO divided qd-tid]
- Start: 25 mg/15 mg PO qd; Max: 150 mg captopril/50 mg HCTZ/day; Info: give 1h before meals
renal dosing
- [see below]
- mild-moderate impairment: decr. usual dose or frequency to minimum effective dose; severe impairment: avoid use; anuria: contraindicated
- HD/PD: avoid use
hepatic dosing
- [see below]
- hepatic impairment/progressive hepatic dz: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.