leuprolide

Adult Dosing .

Dosage forms:  INJ (pre-filled syringe): 22.5 mg; INJ (vial): 1 mg per 0.2 mL

prostate CA

[advanced disease, pre-filled syringe form]

Dose: 22.5 mg IM q3mo; Info: for regional or metastatic, castration-sensitive or castration-resistant disease

[advanced disease, vial form]

Dose: 1 mg SC qd; Info: for palliative tx or for regional or metastatic, castration-sensitive or castration-resistant disease

[localized disease, pre-filled syringe form (off-label)]

Dose: 22.5 mg IM q3mo; Info: for clinically localized disease as neoadjuvant, concurrent and/or adjuvant tx with XRT

[localized disease, vial form (off-label)]

Dose: 1 mg SC qd; Info: for clinically localized disease as neoadjuvant, concurrent and/or adjuvant tx with XRT

premature ovulation prevention (off-label)

[individualize dose SC qd]

Info: for inhibition of premature LH surge during controlled ovarian stimulation with Assisted Reproductive Technology treatment; refer to institution protocols for dose and duration

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ: 1 mg per 0.2 mL

central precocious puberty (off-label)

[individualize dose SC qd]

Start: 50 mcg/kg/dose SC qd, may incr. by 10 mcg/kg/day until total downregulation; Info: D/C at appropriate age of puberty onset

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]