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Perjeta
pertuzumab
Black Box Warnings .
Cardiomyopathy
subclinical and clinical cardiac failure, manifesting as decr. LVEF and CHF can occur; evaluate left ventricular function prior to and during tx; D/C tx if clinically significant decr. left ventricular function
Embryo-Fetal Toxicity
exposure during pregnancy or within 7mo prior to conception can result in embryo-fetal death and birth defects, including oligohydramnios and delayed renal development; advise patients of risks and need for effective contraception
Adult Dosing .
Dosage forms: INJ
Special Note
- [equivalency or interchangeability info]
- Info: not interchangeable with SC pertuzumab/trastuzumab/hyaluronidase
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments
HER2-positive breast CA, metastatic
- [420 mg IV x1 on day 1 of 21-day cycle, starting cycle 2]
- Start: 840 mg IV x1 for cycle 1; Info: part of multi-drug chemo regimen
HER2-positive breast CA, early
- [neoadjuvant tx]
- Dose: 840 mg IV x1 on day 1 of 21-day cycle for cycle 1, then starting cycle 2, administer 420 mg IV x1 on day 1 of 21-day cycle; Info: for patients with locally advanced, inflammatory, or early stage disease with either >2cm in diameter or node positivity; give x3-6 cycles in neoadjuvant setting as part of multi-drug chemo regimen, then continue in adjuvant setting with trastuzumab or trastuzumab/hyaluronidase for total of 18 cycles
- [adjuvant tx]
- Dose: 840 mg IV x1 on day 1 of 21-day cycle for cycle 1, then starting cycle 2, administer 420 mg IV x1 on day 1 of 21-day cycle; Info: for patients with high recurrence risk; give x3-6 cycles as part of multi-drug chemo regimen, then continue with trastuzumab or trastuzumab/hyaluronidase for total of 18 cycles
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.