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ethacrynic acid
generic
Black Box Warnings .
Fluid and Electrolyte Depletion
potent diuretic in excessive amounts can cause profound diuresis with water and electrolyte depletion; medical supervision required; individualize dose and schedule to patient needs
Adult Dosing .
Dosage forms: TAB: 25 mg; INJ: various
edema
- [PO route]
- Dose: 50-200 mg/day PO divided qd-bid; Start: 50 mg PO qd, then may incr. by 25-50 mg/day; Max: 400 mg/day; Info: for patients with CHF, hepatic disease or renal disease; maintenance dose may be given intermittently
- [IV route]
- Dose: 50 mg IV x1; Max: 100 mg/dose; Alt: 0.5-1 mg/kg/dose IV x1; Info: for patients with CHF, hepatic disease or renal disease; may repeat dose x1
ascites, short-term tx
- [PO route]
- Dose: 50-200 mg/day PO divided qd-bid; Start: 50 mg PO qd, then may incr. by 25-50 mg/day; Max: 400 mg/day; Info: for patients with malignancy, idiopathic edema or lymphedema
- [IV route]
- Dose: 50 mg IV x1; Max: 100 mg/dose; Alt: 0.5-1 mg/kg/dose IV x1; Info: for patients with malignancy, idiopathic edema or lymphedema; may repeat dose x1
HTN (off-label)
- [25-100 mg/day PO divided qd-tid]
- Start: 25 mg PO qd; Max: 100 mg/day
renal dosing
- [see below]
- renal impairment: not defined, caution advised; anuria: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- advanced cirrhosis: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 25 mg
edema, short-term tx
- [2 yo and older]
- Dose: individualize dose PO qd-bid; Start: 25 mg PO qd, then may incr. by 25 mg/day; Max: 400 mg/day; Alt: 0.5-1 mg/kg/dose PO q6-12h, max 3 mg/kg/day; Info: for hospitalized patients with congenital heart disease or nephrotic syndrome
renal dosing
- [see below]
- renal impairment: not defined, caution advised; anuria: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- advanced cirrhosis: not defined, caution advised