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flutamide
generic
Black Box Warnings .
Hepatotoxicity
hospitalization and rarely death due to flutamide-assoc. hepatic failure; hepatic injury incl. elev. AST/ALT, jaundice, hepatic encephalopathy, and death related to acute hepatic failure; hepatic injury reversible in some pts after D/C tx; approx. 50% cases occur w/in 1st 3mo of tx; measure baseline AST/ALT, avoid use if ALT >2x ULN; monitor AST/ALT qmo x4mo, then periodically; measure LFTs if s/sx hepatic impairment; immediately D/C tx if jaundice or ALT >2x ULN and follow LFTs until normal
Adult Dosing .
Dosage forms: CAP: 125 mg
prostate CA, stage B2-C or metastatic
- [250 mg PO q8h]
- Info: use w/ LHRH analog
renal dosing
- [see below]
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
hepatic dosing
- [see below]
- severe impairment: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.