CaroSpir

Adult Dosing .

Dosage forms:  SUSPENSION: 25 mg per 5 mL

Dosage Form Details

[formulation clarification]

Info: suspension doses >100 mg may result in higher than expected concentration; use tab form for doses >100 mg

Special Note

[equivalency or interchangeability info]

Info: spironolactone tabs and suspension not bioequivalent; reassess dose if switching between products

heart failure with reduced ejection fraction, NYHA Class III-IV

[20-37.5 mg PO qd]

Start: 20 mg PO qd, may incr. to 37.5 mg PO qd after 4wk; Info: for patients with K <5.1 mEq/L; may decr. dose to 20 mg PO qod if hyperkalemia on 20 mg PO qd; D/C if K >5.5 mEq/L

HTN, adjunct tx

[20-75 mg/day PO divided qd-bid]

Info: may adjust dose q2wk

edema, cirrhosis-associated

[75-100 mg/day PO divided qd-bid]

Start: 75 mg/day PO divided qd-bid; Info: if given as monotherapy, may incr. dose after 5 days

renal dosing

[heart failure with reduced ejection fraction, NYHA Class III-IV]

eGFR 30-50: consider starting 10 mg qd; eGFR <30: avoid use

HD/PD: not defined

[all other indications]

eGFR <30: avoid use in patients 65 yo and older

HD/PD: not defined

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.