Menest

Black Box Warnings .

Adult Dosing .

Dosage forms:  TAB: 0.3 mg, 0.625 mg, 1.25 mg

vasomotor symptoms, moderate-severe menopausal

[1.25 mg PO qd]

Info: cycle 21 days on, 7 days off; use lowest effective estrogen dose, shortest effective tx duration; add progestogen if intact uterus

vulvovaginal atrophy, menopausal

[0.3-1.25 mg PO qd]

Info: not preferred if local symptoms only; cycle 21 days on, 7 days off; use lowest effective estrogen dose, shortest effective tx duration; add progestogen if intact uterus

hypoestrogenism

[associated with hypogonadism]

Dose: 2.5-7.5 mg/day PO divided qd-tid; Info: cycle 20 days on, 10 days off; titrate to lowest effective maintenance dose; add progestogen on days 15-20 of cycle if no withdrawal bleeding

[associated with oopherectomy or primary ovarian failure]

Dose: 1.25 mg PO qd; Info: cycle 20 days on, 10 days off; titrate to lowest effective maintenance dose; add progestogen if intact uterus

metastatic breast CA, palliative tx

[10 mg PO tid for at least 3mo]

advanced prostate CA, palliative tx

[1.25-2.5 mg PO tid]

osteoporosis prevention, postmenopausal (off-label)

[0.3 mg PO qd]

Info: cycle 21 days on, 7 days off; add progestogen x10-14 days/28 day cycle if intact uterus; weigh estrogen tx risk/benefit

renal dosing

[see below]

renal disease: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[see below]

hepatic impairment/disease: contraindicated

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.