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Migergot
ergotamine/ caffeine rectal
Black Box Warnings .
Peripheral Ischemia w/ Concomitant Strong CYP3A4 Inhibitor Use
serious and/or life-threatening peripheral ischemia possible when given in combo w/ strong CYP3A4 inhibitors incl. protease inhibitors and macrolide antibiotics; CYP3A4 inhibition incr. serum levels and risk for vasospasm leading to cerebral ischemia and/or ischemia of extremities; concomitant use w/ strong CYP3A4 inhibitors contraindicated
Adult Dosing .
Dosage forms: SUPP: 2 mg/100 mg
migraine, acute
- [1 supp PR x1]
- Max: 4 mg/episode, 10 mg/wk ergotamine; Info: may repeat dose x1 after 1h
renal dosing
- [see below]
- renal impairment: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.