flame seedless

Reported Uses

• NOTE: see Herb & Supplement Effectiveness Rating Definitions table
• ADHD [Insufficient Evidence]
• age-related macular degeneration [Insufficient Evidence]
• aging skin [Insufficient Evidence]
• allergic rhinitis [Possibly Ineffective]
• aphthous ulcer (canker sores) [Insufficient Evidence]
• atherosclerosis [Insufficient Evidence]
• athletic performance [Insufficient Evidence]
• atopic dermatitis (eczema) [Insufficient Evidence]
• cardiovascular dz [Insufficient Evidence]
• chronic venous insufficiency [Possibly Effective]
• cognitive function [Insufficient Evidence]
• cognitive impairment [Insufficient Evidence]
• colorectal CA [Insufficient Evidence]
• constipation [Insufficient Evidence]
• dental caries [Insufficient Evidence]
• diabetes mellitus [Insufficient Evidence]
• diabetic retinopathy [Insufficient Evidence]
• erectile dysfxn [Insufficient Evidence]
• hemorrhoids [Insufficient Evidence]
• HTN [Insufficient Evidence]
• hypercholesterolemia [Insufficient Evidence]
• lower urinary tract sx [Possibly Ineffective]
• mastalgia [Possibly Ineffective]
• melasma [Insufficient Evidence]
• menopausal sx [Insufficient Evidence]
• metabolic syndrome [Insufficient Evidence]
• minor external bleeding [Insufficient Evidence]
• muscle soreness [Insufficient Evidence]
• nausea/vomiting, chemo-related [Possibly Ineffective]
• night vision [Insufficient Evidence]
• nonalcoholic fatty liver dz [Insufficient Evidence]
• obesity [Possibly Ineffective]
• ocular stress [Insufficient Evidence]
• premenstrual syndrome [Insufficient Evidence]
• wound healing [Insufficient Evidence]

Reported Doses

Safety/efficacy may not be established; reported doses may be derived from limited or potentially inadequate studies w/ variable regimens, multi-ingredient products, or where concentration of active ingredients may vary widely

Effectiveness Ratings

[see Herb & Supplement Effectiveness Rating Definitions table]

Special Note

[formulation clarification]

Info: may incl. whole fruit, juice, pomace, or extracts of fruit, seed, leaf or vine; extracts generally stdzd to polyphenol or proanthocyanidin content

aging skin

[Insufficient Evidence]

Dose: 10 mg fruit extract PO bid

atherosclerosis

[Insufficient Evidence]

Dose: 120 mg seed extract PO qd; Info: extract containing >95% proanthocyanidins

athletic performance

[Insufficient Evidence]

Dose: 400 mg fruit extract PO qd

chronic venous insufficiency

[Possibly Effective]

Dose: 360-720 mg red vine leaf extract PO qd

cognitive function

[Insufficient Evidence]

Dose: 250 mg fruit extract PO qd; Alt: 355 mL fruit juice PO qd

diabetes mellitus

[Insufficient Evidence]

Dose: 200 mg fruit extract PO qd-bid; Info: given 40min before meal

diabetic retinopathy

[Insufficient Evidence]

Dose: 50 mg seed extract PO tid; Info: extract containing proanthocyanidins

erectile dysfxn

[Insufficient Evidence]

Dose: 200 mg fruit extract PO qd; Info: given 40min before meal

HTN

[Insufficient Evidence]

Dose: 150 mg seed extract PO bid

melasma

[Insufficient Evidence]

Dose: 54 mg seed extract PO tid; Info: extract containing 81% proanthocyanidins

menopausal sx

[Insufficient Evidence]

Dose: 200 mg seed extract PO qd; Info: extract containing 81% proanthocyanidins

metabolic syndrome

[Insufficient Evidence]

Dose: 150-300 mg seed extract PO qd; Alt: 8 g pomace PO qd; 46 g polyphenol powder PO qd; 18 mL/kg/dose juice PO qd

minor external bleeding

[Insufficient Evidence]

Dose: apply 1 mL/spray topically x4; Info: product containing 8 mg/100 mL grape leaf extract

nonalcoholic fatty liver dz

[Insufficient Evidence]

Dose: 1000 mg seed extract PO bid

wound healing

[Insufficient Evidence]

Dose: apply 2% cream topically bid; Alt: apply 5% ointment topically bid; Info: products prepared w/ grape seed extract