aprepitant + ethinyl estradiol (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after aprepitant tx; monitor thrombosis s/sx, especially if oral ethinyl estradiol dose >35 mcg/day: combo may decr. ethinyl estradiol levels, contraceptive efficacy; may initially incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (hepatic metabolism induced; hepatic metabolism inhibited)

aprepitant + levonorgestrel (contraceptive)

use additional non-hormonal or alternative contraception during and x28 days after aprepitant tx: combo may decr. levonorgestrel levels, contraceptive efficacy (hepatic metabolism induced)