Selected Drugs Clear All
MultiCheck Results
- 2
Interactions
Avoid/Use Alternative |
||
|
hydrocodone/acetaminophen
(generic) + Sabril
(vigabatrin) |
||
Avoid/Use Alternativehydrocodone + vigabatrin avoid combo if antitussive use; otherwise monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, hydrocodone may decr. seizure threshold) |
||
Monitor/Modify Tx |
||
|
Corzide
(nadolol/ bendroflumethiazide) + hydrocodone/acetaminophen
(generic) |
||
Monitor/Modify Txnadolol + hydrocodone monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects) |
||
Additional Considerations |
||
|
hydrocodone
in hydrocodone/acetaminophen
|
||
|
consider prescribing an opioid overdose reversal agent, especially with concomitant CNS depressant use benzhydrocodone (prodrug) rapidly converted to hydrocodone; similar interactions anticipated add MAO inhibitor to Interaction Check if recent (14 days) use avoid combo with beverages or products containing ethanol and some hydrocodone extended-release (ER) capsules; combo may incr. hydrocodone release rate, levels, risk of adverse effects, including life-threatening overdose, decr. duration of efficacy |
||
|
bendroflumethiazide
in Corzide
|
||
|
Discontinued in US |
||
|
sodium polystyrene sulfonate
in Kalexate
|
||
|
separate administration from other oral drugs at least 3h before or after sodium polystyrene sulfonate; if gastroparesis, separate administration from other oral drugs by 6h; sodium polystyrene sulfonate may decr. absorption of concomitant oral drugs some formulations of sodium polystyrene sulfonate contain sorbitol |
||