Selected Drugs Clear All
MultiCheck Results
- 5
Interactions
Contraindicated |
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Kyxata
(carboplatin) + Vaxchora
(cholera vaccine, live oral) |
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Contraindicatedcarboplatin + cholera vaccine, live contraindicated; vaccinate at least 4wk before or 3mo after carboplatin tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects) |
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Avoid/Use Alternative |
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Recorlev
(levoketoconazole) + Sunlenca
(lenacapavir) |
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Avoid/Use Alternativelevoketoconazole + lenacapavir consider alternative x2wk before and during levoketoconazole tx; otherwise, monitor ECG during and x9mo after lenacapavir tx: combo may incr. levels of both drugs, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, P-gp-mediated transport inhibited) |
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Recorlev
(levoketoconazole) + Viagra
(sildenafil) |
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Avoid/Use Alternativelevoketoconazole + sildenafil PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION: monitor BP; consider decr. sildenafil start dose to 25 mg: combo may incr. sildenafil levels, risk of hypotension (including syncope), priapism, other adverse effects (hepatic metabolism inhibited) |
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Monitor/Modify Tx |
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Sunlenca
(lenacapavir) + Viagra
(sildenafil) |
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Monitor/Modify Txlenacapavir + sildenafil during and x9mo after lenacapavir tx, adjust sildenafil dose as follows: PULMONARY HTN: monitor BP; ERECTILE DYSFUNCTION: consider decr. sildenafil start dose to 25 mg: combo may incr. sildenafil levels, risk of hypotension (including syncope), priapism, other adverse effects (hepatic metabolism inhibited) |
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Caution Advised |
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Kyxata
(carboplatin) + Viagra
(sildenafil) |
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Caution Advisedcarboplatin + sildenafil caution advised: combo may incr. risk of auditory, vestibular adverse effects (additive effects) |
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Additional Considerations |
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lenacapavir
in Sunlenca
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lenacapavir is indicated for treatment of HIV infection (Sunlenca) and HIV pre-exposure prophylaxis (Yeztugo); drug interaction guidance with strong and moderate CYP3A4 inducers varies by indication; see individual drug interactions for specific details |
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levoketoconazole
in Recorlev
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avoid combo with alcoholic beverages or products containing ethanol; combo may incr. risk of disulfiram-like reaction |
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