Interaction Check

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MultiCheck Results - 1 Interaction

Avoid/Use Alternative
Simpesse (levonorgestrel/ ethinyl estradiol) + Zanaflex (tizanidine)
Avoid/Use Alternative ethinyl estradiol (contraceptive) + tizanidine use alternative or monitor BP, HR: combo may incr. tizanidine levels, risk of hypotension (including orthostasis, syncope), bradycardia, CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)
Additional Considerations
quinidine (CYP2D6 inhibitor) in Nuedexta
low dose quinidine used as CYP2D6 'booster' has different interaction characteristics vs. antiarrhythmic dose quinidine
dextromethorphan in Nuedexta
add MAO inhibitor to Interaction Check if recent (14 days) use