caution advised with drugs metabolized by CYP450 liver enzymes; somatropin may increase CYP450 metabolic function, alter levels of concomitant drugs, incr. risk of adverse effects or decr. efficacy

lonapegsomatropin is a prodrug of somatropin; similar interactions anticipated

add MAO inhibitor to Interaction Check if recent (14 days) use

avoid combo with beverages or products containing ethanol and some ER methylphenidate formulations (including capsule, chewable, oral suspension, ODT); combo may incr. methylphenidate release rate, levels, risk of adverse effects, decr. duration of efficacy