JAMA Neurol

Increased risk of mortality, severe disability in patients with poststroke seizures

September 22, 2023

Post-stroke seizures (PSS)—especially early seizures—were associated with increased mortality risk, poor functional outcomes, disability, and dementia in patients with history of stroke compared with patients without such seizures. 

• Researchers reviewed 71 eligible articles, including 20,110 patients with PSS and 1,166,085 patients without PSS in this systematic review and meta-analysis. 
• Of the participants with PSS, 1,967 (9.8%) had early seizures, and 10,605 (52.7%) had late seizures. 
• PSSs were associated with mortality risk (adds ratio [OR], 2.1), poor functional outcome (OR, 2.2), greater disability (standardized mean difference, 0.6), and increased dementia risk (OR, 3.1) compared with patients without PSS. 
• In subgroup analyses, early seizures but not late seizures were associated with mortality (OR, 2.4 vs. OR, 1.2; 95% confidence interval, 0.8-2.0) and both ischemic and hemorrhagic stroke subtypes were associated with mortality (OR, 2.2 vs. OR, 1.4). 
• Early and late seizures (OR, 2.4 vs. OR, 2.7) and stroke subtypes were associated with poor outcomes (OR, 2.6 vs. OR, 1.9).

Source:

Misra S, et al. (2023, September 18.) JAMA Neurol. Outcomes in Patients With Poststroke Seizures: A Systematic Review and Meta-Analysis. https://pubmed.ncbi.nlm.nih.gov/37721736/