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Adbry (tralokinumab-ldrm)
tralokinumab
Adult Dosing .
Dosage forms: INJ (auto-injector): 300 mg; INJ (pre-filled syringe): 150 mg per mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = tralokinumab-ldrm
atopic dermatitis, moderate-severe
- [300 mg SC q2wk]
- Start: 600 mg SC x1; Info: may consider 300 mg SC q4wk after 16wk if wt <100 kg
renal dosing
- [see below]
- mild-moderate impairment: no adjustment; severe impairment: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- mild impairment: no adjustment; moderate-severe impairment: not defined
Peds Dosing .
- Dosage forms: INJ (pre-filled syringe): 150 mg per mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = tralokinumab-ldrm
atopic dermatitis, moderate-severe
- [12-17 yo]
- Dose: 150 mg SC q2wk; Start: 300 mg SC x1
renal dosing
- [not defined]
- renal impairment: consider adult renal dosing for guidance
- HD/PD: not defined
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- helminth infection
Drug Interactions .
Overview
tralokinumab
IL-13 antagonist
- immunomodulatory effects
Contraindicated
Avoid/Use Alternative
Monitor/Modify Tx
Caution Advised
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
- angioedema
- keratitis
Common Reactions
- URI
- conjunctivitis
- injection site reaction
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available, though likely to cross placenta based on human data with other monoclonal antibodies; no known risk of teratogenicity or embryo-fetal toxicity based on animal data up to 10x MRHD
Pregnancy Registry
enroll patients or encourage patients to enroll in MotherToBaby Pregnancy Study at 1-877-311-8972 or www.mothertobaby.org/ongoing-study/adbry-tralokinumab/
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for tralokinumab: catabolism; CYP450: unknown
Excretion: for tralokinumab: unknown; Half-life: 3wk
Subclass: Atopic Dermatitis, Systemic Nonsteroidal Agents ; Interleukin-13 (IL-13) Antagonists
Mechanism of Action
for tralokinumab: binds to interleukin-13 and inhibits interleukin-13 cytokine-induced responses including release of pro-inflammatory cytokines, chemokines, and IgE (monoclonal antibody)
Formulary .
No Formulary Selected
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