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J Am Coll Cardiol

ACC clarifies when DOACs should—and shouldn’t—be used

New scientific statement highlights where direct oral anticoagulants fit best—and where caution is still warranted. . .

JAMA Dermatol

GLP-1s tied to sharply lower death, systemic risk in hidradenitis suppurativa

Use of the drugs was associated with lower all-cause mortality with parallel drops in cardiovascular events and serious infections in a large retrospective cohort. . .

Drug Alcohol Depend

Illicit fentanyl users take 100x daily opioid guideline dose

Regular consumers on average take in the daily equivalent of nearly 9,000 mg of oral morphine, dwarfing both the doses guidelines allow and the those used to treat them. . .

N Engl J Med.

New adjuvant renal cell carcinoma combo lowers recurrence risk

Adding belzutifan lowered recurrence risk after surgery but increased high-grade adverse events. . .

Clin Gastroenterol Hepatol

Coffee tied to lower cirrhosis, liver cancer risk

Benefits rose with intake, peaking at five or more cups daily, with decaffeinated coffee performing as well as caffeinated. . .

Curr Atheroscler Rep

Sugar substitutes tied to higher insulin, HbA1c

Long assumed metabolically neutral, sugar substitutes may instead disrupt glucose control through the gut microbiome. . .

FDA

FDA expands Casgevy label to younger children with sickle cell disease

First gene therapy approved for children as young as 2 years with sickle cell disease and transfusion-dependent β-thalassemia. . .

PLoS Med

Swapping light activity for sitting tied to lower cancer mortality

Prolonged unbroken sedentary time was tied to higher cancer mortality, while interrupted sitting tracked the other way. . .

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