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Dengvaxia
dengue tetravalent vaccine, live (DEN4CYD)
Adult Dosing .
Adult dosing is currently unavailable or not applicable for this drug.
Peds Dosing .
- Dosage forms: INJ
dengue disease prevention
- [9-16 yo]
- Dose: 0.5 mL SC x1 at mo 0, 6, and 12 for 3 total doses; Info: for patients living in endemic areas with laboratory-confirmed previous dengue virus infection; search 'immunization' for epocrates Child/Adolescent Immunization decision tool including links to CDC/ACIP schedules
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- patients without laboratory-confirmed dengue infection history
- immunocompromised patients
- HIV infection with CD4 <15%
- HIV infection with CD4 <200
- caution: HIV infection with CD4 >15% and CD4 >200
- caution: illness, acute moderate-severe
Drug Interactions .
Overview
dengue vaccine, live
live vaccine
- live vaccine
Contraindicated
- abatacept
- abemaciclib
- abrocitinib
- acalabrutinib
- adalimumab
- afamitresgene autoleucel
- aldesleukin
- alemtuzumab
- amivantamab
- anakinra
- anifrolumab
- anti-thymocyte globulin
- asciminib
- atezolizumab
- atidarsagene autotemcel
- avelumab
- axicabtagene ciloleucel
- azacitidine
- azathioprine
- baricitinib
- basiliximab
- belantamab mafodotin
- belatacept
- belimumab
- belinostat
- bendamustine
- betamethasone
- bimekizumab
- blinatumomab
- bortezomib
- brensocatib
- brentuximab vedotin
- brexucabtagene autoleucel
- brodalumab
- budesonide
- busulfan
- cabazitaxel
- canakinumab
- capecitabine
- carboplatin
- carfilzomib
- carmustine
- cemiplimab
- certolizumab pegol
- chlorambucil
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- cladribine oral
- clofarabine
- copanlisib
- corticotropin
- cortisone
- cosibelimab
- cyclophosphamide
- cyclosporine
- cytarabine
- dactinomycin
- daratumumab
- dasatinib
- daunorubicin
- decitabine
- deflazacort
- delgocitinib topical
- deucravacitinib
- deuruxolitinib
- dexamethasone
- dimethyl fumarate
- dinutuximab
- diroximel fumarate
- docetaxel
- dostarlimab
- doxorubicin
- dupilumab
- durvalumab
- duvelisib
- efgartigimod alfa
- elivaldogene autotemcel
- elotuzumab
- elranatamab
- emapalumab
- epcoritamab
- epirubicin
- erdafitinib
- eribulin
- etanercept
- etoposide
- etrasimod
- etuvetidigene autotemcel
- everolimus
- fingolimod
- floxuridine
- fludarabine
- fludrocortisone
- fluorouracil
- fruquintinib
- futibatinib
- gemcitabine
- gemtuzumab ozogamicin
- glofitamab
- golimumab
- guselkumab
- hydrocortisone
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- icotrokinra
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- imatinib
- inebilizumab
- infliximab
- inotuzumab ozogamicin
- ipilimumab
- irinotecan
- isatuximab
- ixabepilone
- ixekizumab
- lazertinib
- lebrikizumab
- leflunomide
- lenalidomide
- linvoseltamab
- lisocabtagene maraleucel
- lomustine
- loncastuximab tesirine
- lymphocyte immune globulin, anti-thymocyte globulin
- melphalan
- mercaptopurine
- methylprednisolone
- mirikizumab
- mitoxantrone
- mogamulizumab
- momelotinib
- monomethyl fumarate
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- natalizumab
- nelarabine
- nemolizumab
- nipocalimab
- nivolumab
- obinutuzumab
- ocrelizumab
- ofatumumab
- oxaliplatin
- ozanimod
- paclitaxel
- palbociclib
- peginterferon alfa 2a
- pembrolizumab
- pemetrexed
- penpulimab
- pentostatin
- pertuzumab
- pirtobrutinib
- polatuzumab vedotin
- pomalidomide
- ponatinib
- ponesimod
- prednisolone
- prednisone
- procarbazine
- regorafenib
- retifanlimab
- revumenib
- rilonacept
- rilzabrutinib
- risankizumab
- ritlecitinib
- rituximab
- romidepsin
- ropeginterferon alfa-2b
- rozanolixizumab
- rucaparib
- ruxolitinib
- sarilumab
- satralizumab
- secukinumab
- selinexor
- selumetinib
- sevabertinib
- sibeprenlimab
- siltuximab
- siponimod
- sirolimus
- sirolimus albumin-bound
- sirolimus topical
- sorafenib
- spesolimab
- sunitinib
- tacrolimus
- tafasitamab
- taletrectinib
- talquetamab
- tarlatamab
- teclistamab
- temozolomide
- temsirolimus
- teplizumab
- teriflunomide
- thioguanine
- thiotepa
- tildrakizumab
- tisagenlecleucel
- tislelizumab
- tocilizumab
- tofacitinib
- topotecan
- toripalimab
- trabectedin
- tralokinumab
- trastuzumab
- tremelimumab
- triamcinolone
- ublituximab
- upadacitinib
- ustekinumab
- vamorolone
- vedolizumab
- venetoclax
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- zanubrutinib
- ziftomenib
Avoid/Use Alternative
- ado-trastuzumab emtansine
- avutometinib
- belzutifan
- bevacizumab
- capmatinib
- cetuximab
- defactinib
- dordaviprone
- fam-trastuzumab deruxtecan
- interferon gamma 1b
- lurbinectedin
- margetuximab
- methotrexate
- mitomycin
- nilotinib
- obecabtagene autoleucel
- olaparib
- panitumumab
- remibrutinib
- ripretinib
- sunvozertinib
- telisotuzumab vedotin
- tezepelumab
- vandetanib
- zanidatamab
- zenocutuzumab
- zongertinib
Monitor/Modify Tx
- anthrax immune globulin
- botulism immune globulin
- budesonide rectal
- chikungunya vaccine, live
- cytomegalovirus immune globulin
- ebola vaccine, live
- glatiramer
- hepatitis B immune globulin
- immune globulin
- influenza nasal vaccine, live
- interferon beta 1a
- interferon beta 1b
- measles/mumps/rubella vaccine, live
- peginterferon beta 1a
- rabies immune globulin
- Rho(D) immune globulin
- smallpox vaccine, live
- smallpox/mpox vaccine, live
- tetanus immune globulin
- tuberculin purified protein derivative
- vaccinia immune globulin
- varicella vaccine, live
- varicella zoster immune globulin
- yellow fever vaccine, live
Caution Advised
- leniolisib
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
- asthma exacerbation
- vaccine viremia, transient
Common Reactions
- headache
- injection site reaction
- myalgia
- malaise
- asthenia
- fever
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available; no known risk of fetal harm based on animal data at recommended human dose
Pregnancy Registry
enroll patients or encourage patients to enroll in Dengvaxia Pregnancy Registry at 1-800-822-2463
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; possible risk of postnatal dengue virus transmission based on limited human data; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for dengue vaccine: unknown; CYP450: unknown
Excretion: for dengue vaccine: unknown; Half-life: unknown
Subclass: Dengue Vaccines ; Routine Pediatric Vaccines
Mechanism of Action
for dengue vaccine: exact mechanism of action unknown; elicits dengue-specific immune responses against 4 dengue virus serotypes
Formulary .
No Formulary Selected
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