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Pyridium
phenazopyridine
Adult Dosing .
Dosage forms: TAB: 100 mg, 200 mg
dysuria
- [100-200 mg PO tid x2 days]
- Info: give after meals
renal dosing
- [adjust dose frequency]
- CrCl 50-80: give usual dose q12h; CrCl <50: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- severe hepatitis: contraindicated
Peds Dosing .
- Dosage forms: TAB: 100 mg, 200 mg
dysuria
- [6-12 yo]
- Dose: 4 mg/kg/dose PO tid x2 days; Info: give after meals
- [13 yo and older]
- Dose: 100-200 mg PO tid x2 days; Info: give after meals
renal dosing
- [adjust dose frequency]
- CrCl 50-80: give usual dose q12-16h; CrCl <50: contraindicated
- HD/PD: not defined
hepatic dosing
- [see below]
- severe hepatitis: contraindicated
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- breastfeeding
- glomerulonephritis
- hepatitis, severe
- uremia
- CrCl <50
- caution: renal impairment
- caution: G6PD deficiency
Drug Interactions .
Overview
phenazopyridine
urinary analgesic
- methemoglobinemia
Contraindicated
- lidocaine topical
- prilocaine topical
Avoid/Use Alternative
- acetaminophen
Caution Advised
- articaine
- benzocaine topical
- bupivacaine
- bupivacaine liposomal
- butamben
- chloroprocaine
- lidocaine
- mepivacaine
- procaine
- ropivacaine
- tetracaine
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylactoid rxn
- methemoglobinemia
- hemolytic anemia
- acute renal failure
- hepatitis
Common Reactions
- GI disturbance
- headache
- rash
- pruritus
- body fluid discoloration, red-orange
- contact lens staining
Safety/Monitoring .
Monitoring Parameters
Cr at baseline
Look/Sound-Alike Drug Names
Pyridium confused with: Imodium; pyridoxine
phenazopyridine confused with: cyclobenzaprine; phenoxybenzamine; phenytoin sodium; prochlorperazine; promethazine; pyridoxine
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; risk of fetal harm low based on human data
Lactation
Clinical Summary
avoid use while breastfeeding; no human data available to assess risk of infant harm, though possible drug excretion into milk based on drug properties; no human data available to assess effects on milk production
Pharmacology .
Metabolism: liver; CYP450: unknown; Info: active metabolite (acetaminophen)
Excretion: urine (65% unchanged); Half-life: unknown
Subclass: Analgesics, Urinary
Mechanism of Action
produces topical analgesia
Formulary .
No Formulary Selected
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