Reglan

Overview

metoclopramide

dopamine-2 antagonist; prokinetic

• CYP2D6 substrate
• CYP3A4 substrate
• affected by altered gastrointestinal motility
• CNS depression
• dopamine antagonist
• extrapyramidal effects
• hyperprolactinemic effects
• hypertensive effects
• increases gastrointestinal motility
• lowers seizure threshold
• methemoglobinemia
• serotonergic effects

Contraindicated

• lidocaine topical
Reglan (metoclopramide)

+

lidocaine topical

1 interaction

Contraindicated

metoclopramide + lidocaine topical

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

• prilocaine topical
Reglan (metoclopramide)

+

prilocaine topical

1 interaction

Contraindicated

metoclopramide + prilocaine topical

contraindicated if <1 yo; otherwise, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of methemoglobinemia (additive effects)

Avoid/Use Alternative

• 5-HTP
Reglan (metoclopramide)

+

5-HTP

1 interaction

Avoid/Use Alternative

metoclopramide + 5-HTP

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• aldesleukin
Reglan (metoclopramide)

+

aldesleukin

1 interaction

Avoid/Use Alternative

metoclopramide + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, seizures (additive effects)

• alfentanil
Reglan (metoclopramide)

+

alfentanil

1 interaction

Avoid/Use Alternative

metoclopramide + alfentanil

use alternative or monitor BP, resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• allopurinol
Reglan (metoclopramide)

+

allopurinol

1 interaction

Avoid/Use Alternative

metoclopramide + allopurinol

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• almotriptan
Reglan (metoclopramide)

+

almotriptan

1 interaction

Avoid/Use Alternative

metoclopramide + almotriptan

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• alprazolam
Reglan (metoclopramide)

+

alprazolam

1 interaction

Avoid/Use Alternative

metoclopramide + alprazolam

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• amantadine
Reglan (metoclopramide)

+

amantadine

1 interaction

Avoid/Use Alternative

metoclopramide + amantadine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• amifampridine
Reglan (metoclopramide)

+

amifampridine

1 interaction

Avoid/Use Alternative

metoclopramide + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• amitriptyline
Reglan (metoclopramide)

+

amitriptyline

1 interaction

Avoid/Use Alternative

metoclopramide + amitriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• amoxapine
Reglan (metoclopramide)

+

amoxapine

1 interaction

Avoid/Use Alternative

metoclopramide + amoxapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• amphetamine
Reglan (metoclopramide)

+

amphetamine

1 interaction

Avoid/Use Alternative

metoclopramide + amphetamine

consider alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; decr. amphetamine start dose: combo may incr. risk of HTN, serotonin syndrome (additive effects)

• apomorphine
Reglan (metoclopramide)

+

apomorphine

1 interaction

Avoid/Use Alternative

metoclopramide + apomorphine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• apraclonidine ophthalmic
Reglan (metoclopramide)

+

apraclonidine ophthalmic

1 interaction

Avoid/Use Alternative

metoclopramide + apraclonidine ophthalmic

use alternative if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole bimonthly injection
Reglan (metoclopramide)

+

aripiprazole bimonthly injection

1 interaction

Avoid/Use Alternative

metoclopramide + aripiprazole bimonthly injection

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• aripiprazole lauroxil
Reglan (metoclopramide)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

metoclopramide + aripiprazole lauroxil

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• aripiprazole monthly injection
Reglan (metoclopramide)

+

aripiprazole monthly injection

1 interaction

Avoid/Use Alternative

metoclopramide + aripiprazole monthly injection

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• aripiprazole oral
Reglan (metoclopramide)

+

aripiprazole oral

1 interaction

Avoid/Use Alternative

metoclopramide + aripiprazole oral

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• asenapine
Reglan (metoclopramide)

+

asenapine

1 interaction

Avoid/Use Alternative

metoclopramide + asenapine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• atovaquone
Reglan (metoclopramide)

+

atovaquone

1 interaction

Avoid/Use Alternative

metoclopramide + atovaquone

use alternative: combo may decr. atovaquone levels, efficacy (absorption decreased)

• baclofen
Reglan (metoclopramide)

+

baclofen

1 interaction

Avoid/Use Alternative

metoclopramide + baclofen

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen intrathecal
Reglan (metoclopramide)

+

baclofen intrathecal

1 interaction

Avoid/Use Alternative

metoclopramide + baclofen intrathecal

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• brexpiprazole
Reglan (metoclopramide)

+

brexpiprazole

1 interaction

Avoid/Use Alternative

metoclopramide + brexpiprazole

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• brimonidine topical
Reglan (metoclopramide)

+

brimonidine topical

1 interaction

Avoid/Use Alternative

metoclopramide + brimonidine topical

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brivaracetam
Reglan (metoclopramide)

+

brivaracetam

1 interaction

Avoid/Use Alternative

metoclopramide + brivaracetam

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• bromocriptine
Reglan (metoclopramide)

+

bromocriptine

1 interaction

Avoid/Use Alternative

metoclopramide + bromocriptine

avoid combo: combo may decr. efficacy of both drugs; may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• brompheniramine
Reglan (metoclopramide)

+

brompheniramine

1 interaction

Avoid/Use Alternative

metoclopramide + brompheniramine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• buprenorphine
Reglan (metoclopramide)

+

buprenorphine

1 interaction

Avoid/Use Alternative

metoclopramide + buprenorphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• bupropion
Reglan (metoclopramide)

+

bupropion

1 interaction

Avoid/Use Alternative

metoclopramide + bupropion

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: decr. metoclopramide dose 50%; consider lower bupropion doses; monitor BP: combo may incr. metoclopramide levels, risk of HTN, seizures, other adverse effects (hepatic metab. inhibited, additive effects)

• buspirone
Reglan (metoclopramide)

+

buspirone

1 interaction

Avoid/Use Alternative

metoclopramide + buspirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• butalbital
Reglan (metoclopramide)

+

butalbital

1 interaction

Avoid/Use Alternative

metoclopramide + butalbital

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may decr. metoclopramide levels, efficacy (additive effects; hepatic metab. induced)

• butorphanol
Reglan (metoclopramide)

+

butorphanol

1 interaction

Avoid/Use Alternative

metoclopramide + butorphanol

use alternative or monitor resp. rate, decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• cabergoline
Reglan (metoclopramide)

+

cabergoline

1 interaction

Avoid/Use Alternative

metoclopramide + cabergoline

avoid combo: combo may decr. efficacy of both drugs (antagonistic effects)

• cannabidiol
Reglan (metoclopramide)

+

cannabidiol

1 interaction

Avoid/Use Alternative

metoclopramide + cannabidiol

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• cannabis
Reglan (metoclopramide)

+

cannabis

1 interaction

Avoid/Use Alternative

metoclopramide + cannabis

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, HTN (additive effects)

• carbamazepine
Reglan (metoclopramide)

+

carbamazepine

1 interaction

Avoid/Use Alternative

metoclopramide + carbamazepine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may decr. metoclopramide levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• carbinoxamine
Reglan (metoclopramide)

+

carbinoxamine

1 interaction

Avoid/Use Alternative

metoclopramide + carbinoxamine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• cariprazine
Reglan (metoclopramide)

+

cariprazine

1 interaction

Avoid/Use Alternative

metoclopramide + cariprazine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• carisoprodol
Reglan (metoclopramide)

+

carisoprodol

1 interaction

Avoid/Use Alternative

metoclopramide + carisoprodol

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cenobamate
Reglan (metoclopramide)

+

cenobamate

1 interaction

Avoid/Use Alternative

metoclopramide + cenobamate

use alternative: combo may decr. metoclopramide levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• cetirizine
Reglan (metoclopramide)

+

cetirizine

1 interaction

Avoid/Use Alternative

metoclopramide + cetirizine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chamomile, German
Reglan (metoclopramide)

+

chamomile, German

1 interaction

Avoid/Use Alternative

metoclopramide + chamomile, German

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Reglan (metoclopramide)

+

chlophedianol

1 interaction

Avoid/Use Alternative

metoclopramide + chlophedianol

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• chlordiazepoxide
Reglan (metoclopramide)

+

chlordiazepoxide

1 interaction

Avoid/Use Alternative

metoclopramide + chlordiazepoxide

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chloroquine
Reglan (metoclopramide)

+

chloroquine

1 interaction

Avoid/Use Alternative

metoclopramide + chloroquine

avoid combo: combo may incr. risk of extrapyramidal symptoms (additive effects)

• chlorpheniramine
Reglan (metoclopramide)

+

chlorpheniramine

1 interaction

Avoid/Use Alternative

metoclopramide + chlorpheniramine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• chlorpromazine
Reglan (metoclopramide)

+

chlorpromazine

1 interaction

Avoid/Use Alternative

metoclopramide + chlorpromazine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• chlorzoxazone
Reglan (metoclopramide)

+

chlorzoxazone

1 interaction

Avoid/Use Alternative

metoclopramide + chlorzoxazone

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• citalopram
Reglan (metoclopramide)

+

citalopram

1 interaction

Avoid/Use Alternative

metoclopramide + citalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• clemastine
Reglan (metoclopramide)

+

clemastine

1 interaction

Avoid/Use Alternative

metoclopramide + clemastine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• clobazam
Reglan (metoclopramide)

+

clobazam

1 interaction

Avoid/Use Alternative

metoclopramide + clobazam

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• clomipramine
Reglan (metoclopramide)

+

clomipramine

1 interaction

Avoid/Use Alternative

metoclopramide + clomipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, seizures, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• clonazepam
Reglan (metoclopramide)

+

clonazepam

1 interaction

Avoid/Use Alternative

metoclopramide + clonazepam

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• clonidine
Reglan (metoclopramide)

+

clonidine

1 interaction

Avoid/Use Alternative

metoclopramide + clonidine

if ADHD use, avoid combo; otherwise, use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• clorazepate
Reglan (metoclopramide)

+

clorazepate

1 interaction

Avoid/Use Alternative

metoclopramide + clorazepate

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• clozapine
Reglan (metoclopramide)

+

clozapine

1 interaction

Avoid/Use Alternative

metoclopramide + clozapine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, seizures, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• codeine
Reglan (metoclopramide)

+

codeine

1 interaction

Avoid/Use Alternative

metoclopramide + codeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• cyclobenzaprine
Reglan (metoclopramide)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

metoclopramide + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• cyproheptadine
Reglan (metoclopramide)

+

cyproheptadine

1 interaction

Avoid/Use Alternative

metoclopramide + cyproheptadine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• dacomitinib
Reglan (metoclopramide)

+

dacomitinib

1 interaction

Avoid/Use Alternative

metoclopramide + dacomitinib

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: decr. metoclopramide dose 50%: combo may incr. metoclopramide levels, risk of adverse effects (hepatic metab. inhibited)

• dantrolene
Reglan (metoclopramide)

+

dantrolene

1 interaction

Avoid/Use Alternative

metoclopramide + dantrolene

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• daridorexant
Reglan (metoclopramide)

+

daridorexant

1 interaction

Avoid/Use Alternative

metoclopramide + daridorexant

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Reglan (metoclopramide)

+

darifenacin

1 interaction

Avoid/Use Alternative

metoclopramide + darifenacin

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• desflurane
Reglan (metoclopramide)

+

desflurane

1 interaction

Avoid/Use Alternative

metoclopramide + desflurane

use alternative or monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• desipramine
Reglan (metoclopramide)

+

desipramine

1 interaction

Avoid/Use Alternative

metoclopramide + desipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• desvenlafaxine
Reglan (metoclopramide)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

metoclopramide + desvenlafaxine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, HTN, dystonia (additive effects)

• deutetrabenazine
Reglan (metoclopramide)

+

deutetrabenazine

1 interaction

Avoid/Use Alternative

metoclopramide + deutetrabenazine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Reglan (metoclopramide)

+

dexbrompheniramine

1 interaction

Avoid/Use Alternative

metoclopramide + dexbrompheniramine

use alternative: combo may decr. metoclopramide efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying; additive effects)

• dexchlorpheniramine
Reglan (metoclopramide)

+

dexchlorpheniramine

1 interaction

Avoid/Use Alternative

metoclopramide + dexchlorpheniramine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• dexmedetomidine
Reglan (metoclopramide)

+

dexmedetomidine

1 interaction

Avoid/Use Alternative

metoclopramide + dexmedetomidine

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Reglan (metoclopramide)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

metoclopramide + dexmedetomidine injection

use alternative or monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dextroamphetamine
Reglan (metoclopramide)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

metoclopramide + dextroamphetamine

consider alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; decr. dextroamphetamine start dose: combo may incr. risk of HTN, serotonin syndrome (additive effects)

• diazepam
Reglan (metoclopramide)

+

diazepam

1 interaction

Avoid/Use Alternative

metoclopramide + diazepam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may alter seizure control; may incr. risk of profound CNS and resp. depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• dichlorphenamide
Reglan (metoclopramide)

+

dichlorphenamide

1 interaction

Avoid/Use Alternative

metoclopramide + dichlorphenamide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difelikefalin
Reglan (metoclopramide)

+

difelikefalin

1 interaction

Avoid/Use Alternative

metoclopramide + difelikefalin

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Reglan (metoclopramide)

+

difenoxin

1 interaction

Avoid/Use Alternative

metoclopramide + difenoxin

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. efficacy of both drugs (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• dihydrocodeine
Reglan (metoclopramide)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

metoclopramide + dihydrocodeine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• dimenhydrinate
Reglan (metoclopramide)

+

dimenhydrinate

1 interaction

Avoid/Use Alternative

metoclopramide + dimenhydrinate

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• diphenhydramine
Reglan (metoclopramide)

+

diphenhydramine

1 interaction

Avoid/Use Alternative

metoclopramide + diphenhydramine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• diphenoxylate
Reglan (metoclopramide)

+

diphenoxylate

1 interaction

Avoid/Use Alternative

metoclopramide + diphenoxylate

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. efficacy of both drugs (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• domperidone
Reglan (metoclopramide)

+

domperidone

1 interaction

Avoid/Use Alternative

metoclopramide + domperidone

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• doxepin
Reglan (metoclopramide)

+

doxepin

1 interaction

Avoid/Use Alternative

metoclopramide + doxepin

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• doxepin topical
Reglan (metoclopramide)

+

doxepin topical

1 interaction

Avoid/Use Alternative

metoclopramide + doxepin topical

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• doxylamine
Reglan (metoclopramide)

+

doxylamine

1 interaction

Avoid/Use Alternative

metoclopramide + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• dronabinol
Reglan (metoclopramide)

+

dronabinol

1 interaction

Avoid/Use Alternative

metoclopramide + dronabinol

use alternative or monitor BP, HR: combo may incr. risk of CNS depression, psychomotor impairment, HTN, tachycardia (additive effects)

• droperidol
Reglan (metoclopramide)

+

droperidol

1 interaction

Avoid/Use Alternative

metoclopramide + droperidol

use alternative or decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• duloxetine
Reglan (metoclopramide)

+

duloxetine

1 interaction

Avoid/Use Alternative

metoclopramide + duloxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• efavirenz
Reglan (metoclopramide)

+

efavirenz

1 interaction

Avoid/Use Alternative

metoclopramide + efavirenz

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide levels, efficacy (additive effects; hepatic metab. induced)

• eletriptan
Reglan (metoclopramide)

+

eletriptan

1 interaction

Avoid/Use Alternative

metoclopramide + eletriptan

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• entacapone
Reglan (metoclopramide)

+

entacapone

1 interaction

Avoid/Use Alternative

metoclopramide + entacapone

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entrectinib
Reglan (metoclopramide)

+

entrectinib

1 interaction

Avoid/Use Alternative

metoclopramide + entrectinib

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• epinephrine inhaled
Reglan (metoclopramide)

+

epinephrine inhaled

1 interaction

Avoid/Use Alternative

metoclopramide + epinephrine inhaled

avoid combo: combo may incr. risk of HTN, incl. hypertensive crisis (additive effects)

• escitalopram
Reglan (metoclopramide)

+

escitalopram

1 interaction

Avoid/Use Alternative

metoclopramide + escitalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• esketamine
Reglan (metoclopramide)

+

esketamine

1 interaction

Avoid/Use Alternative

metoclopramide + esketamine

use alternative or monitor BP, resp. rate: combo may incr. risk of HTN, CNS and resp. depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Reglan (metoclopramide)

+

eslicarbazepine acetate

1 interaction

Avoid/Use Alternative

metoclopramide + eslicarbazepine acetate

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• estazolam
Reglan (metoclopramide)

+

estazolam

1 interaction

Avoid/Use Alternative

metoclopramide + estazolam

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eszopiclone
Reglan (metoclopramide)

+

eszopiclone

1 interaction

Avoid/Use Alternative

metoclopramide + eszopiclone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethanol
Reglan (metoclopramide)

+

ethanol

1 interaction

Avoid/Use Alternative

metoclopramide + ethanol

avoid combo: combo may incr. rate of absorption and peak blood alcohol levels; may incr. risk of CNS and resp. depression, psychomotor impairment (enhanced gastric emptying rate; additive effects)

• ethanol (in some formulations)
Reglan (metoclopramide)

+

ethanol (in some formulations)

1 interaction

Avoid/Use Alternative

metoclopramide + ethanol (in some formulations)

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ethosuximide
Reglan (metoclopramide)

+

ethosuximide

1 interaction

Avoid/Use Alternative

metoclopramide + ethosuximide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• etomidate
Reglan (metoclopramide)

+

etomidate

1 interaction

Avoid/Use Alternative

metoclopramide + etomidate

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• felbamate
Reglan (metoclopramide)

+

felbamate

1 interaction

Avoid/Use Alternative

metoclopramide + felbamate

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• fenfluramine
Reglan (metoclopramide)

+

fenfluramine

1 interaction

Avoid/Use Alternative

metoclopramide + fenfluramine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may alter seizure control; may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• fentanyl
Reglan (metoclopramide)

+

fentanyl

1 interaction

Avoid/Use Alternative

metoclopramide + fentanyl

use alternative or monitor resp. rate, decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• fesoterodine
Reglan (metoclopramide)

+

fesoterodine

1 interaction

Avoid/Use Alternative

metoclopramide + fesoterodine

use alternative: combo may decr. metoclopramide efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying; additive effects)

• flibanserin
Reglan (metoclopramide)

+

flibanserin

1 interaction

Avoid/Use Alternative

metoclopramide + flibanserin

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluoxetine
Reglan (metoclopramide)

+

fluoxetine

1 interaction

Avoid/Use Alternative

metoclopramide + fluoxetine

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: use alternative or decr. metoclopramide dose 50% and monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. metoclopramide levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• fluphenazine
Reglan (metoclopramide)

+

fluphenazine

1 interaction

Avoid/Use Alternative

metoclopramide + fluphenazine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• flurazepam
Reglan (metoclopramide)

+

flurazepam

1 interaction

Avoid/Use Alternative

metoclopramide + flurazepam

use alternative or monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fluvoxamine
Reglan (metoclopramide)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

metoclopramide + fluvoxamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• fosfomycin
Reglan (metoclopramide)

+

fosfomycin

1 interaction

Avoid/Use Alternative

metoclopramide + fosfomycin

consider alternative: combo may decr. fosfomycin levels, efficacy (absorption decreased)

• foslevodopa
Reglan (metoclopramide)

+

foslevodopa

1 interaction

Avoid/Use Alternative

metoclopramide + foslevodopa

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• fosphenytoin
Reglan (metoclopramide)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

metoclopramide + fosphenytoin

use alternative: combo may decr. metoclopramide levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• frovatriptan
Reglan (metoclopramide)

+

frovatriptan

1 interaction

Avoid/Use Alternative

metoclopramide + frovatriptan

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• furosemide
Reglan (metoclopramide)

+

furosemide

1 interaction

Avoid/Use Alternative

metoclopramide + furosemide

use alternative or monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• gabapentin
Reglan (metoclopramide)

+

gabapentin

1 interaction

Avoid/Use Alternative

metoclopramide + gabapentin

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• gabapentin enacarbil
Reglan (metoclopramide)

+

gabapentin enacarbil

1 interaction

Avoid/Use Alternative

metoclopramide + gabapentin enacarbil

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• galantamine
Reglan (metoclopramide)

+

galantamine

1 interaction

Avoid/Use Alternative

metoclopramide + galantamine

avoid combo: combo may incr. risk of extrapyramidal symptoms (additive effects)

• ganaxolone
Reglan (metoclopramide)

+

ganaxolone

1 interaction

Avoid/Use Alternative

metoclopramide + ganaxolone

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• gepirone
Reglan (metoclopramide)

+

gepirone

1 interaction

Avoid/Use Alternative

metoclopramide + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• glofitamab
Reglan (metoclopramide)

+

glofitamab

1 interaction

Avoid/Use Alternative

metoclopramide + glofitamab

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate
Reglan (metoclopramide)

+

glycopyrrolate

1 interaction

Avoid/Use Alternative

metoclopramide + glycopyrrolate

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• granisetron
Reglan (metoclopramide)

+

granisetron

1 interaction

Avoid/Use Alternative

metoclopramide + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• guanfacine
Reglan (metoclopramide)

+

guanfacine

1 interaction

Avoid/Use Alternative

metoclopramide + guanfacine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• haloperidol
Reglan (metoclopramide)

+

haloperidol

1 interaction

Avoid/Use Alternative

metoclopramide + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• hydrocodone
Reglan (metoclopramide)

+

hydrocodone

1 interaction

Avoid/Use Alternative

metoclopramide + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• hydromorphone
Reglan (metoclopramide)

+

hydromorphone

1 interaction

Avoid/Use Alternative

metoclopramide + hydromorphone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• hydroxyzine
Reglan (metoclopramide)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

metoclopramide + hydroxyzine

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• hyoscyamine
Reglan (metoclopramide)

+

hyoscyamine

1 interaction

Avoid/Use Alternative

metoclopramide + hyoscyamine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• ifosfamide
Reglan (metoclopramide)

+

ifosfamide

1 interaction

Avoid/Use Alternative

metoclopramide + ifosfamide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• iloperidone
Reglan (metoclopramide)

+

iloperidone

1 interaction

Avoid/Use Alternative

metoclopramide + iloperidone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• imipramine
Reglan (metoclopramide)

+

imipramine

1 interaction

Avoid/Use Alternative

metoclopramide + imipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• iohexol
Reglan (metoclopramide)

+

iohexol

1 interaction

Avoid/Use Alternative

metoclopramide + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• isocarboxazid
Reglan (metoclopramide)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

metoclopramide + isocarboxazid

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN (additive effects)

• isoflurane
Reglan (metoclopramide)

+

isoflurane

1 interaction

Avoid/Use Alternative

metoclopramide + isoflurane

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• isoniazid
Reglan (metoclopramide)

+

isoniazid

1 interaction

Avoid/Use Alternative

metoclopramide + isoniazid

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, isoniazid inhibits monoamine oxidase)

• kava
Reglan (metoclopramide)

+

kava

1 interaction

Avoid/Use Alternative

metoclopramide + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• ketamine
Reglan (metoclopramide)

+

ketamine

1 interaction

Avoid/Use Alternative

metoclopramide + ketamine

use alternative or monitor resp. rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment, HTN, other sympathomimetic adverse effects (additive effects)

• kratom
Reglan (metoclopramide)

+

kratom

1 interaction

Avoid/Use Alternative

metoclopramide + kratom

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lacosamide
Reglan (metoclopramide)

+

lacosamide

1 interaction

Avoid/Use Alternative

metoclopramide + lacosamide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• lamotrigine
Reglan (metoclopramide)

+

lamotrigine

1 interaction

Avoid/Use Alternative

metoclopramide + lamotrigine

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• lasmiditan
Reglan (metoclopramide)

+

lasmiditan

1 interaction

Avoid/Use Alternative

metoclopramide + lasmiditan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• lemborexant
Reglan (metoclopramide)

+

lemborexant

1 interaction

Avoid/Use Alternative

metoclopramide + lemborexant

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levetiracetam
Reglan (metoclopramide)

+

levetiracetam

1 interaction

Avoid/Use Alternative

metoclopramide + levetiracetam

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• levocetirizine
Reglan (metoclopramide)

+

levocetirizine

1 interaction

Avoid/Use Alternative

metoclopramide + levocetirizine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Reglan (metoclopramide)

+

levodopa

1 interaction

Avoid/Use Alternative

metoclopramide + levodopa

avoid combo: combo may decr. efficacy of both drugs; may incr. levodopa bioavailability, risk of CNS depression, psychomotor impairment, other adverse effects (antagonistic effects; absorption increased, additive effects)

• levomilnacipran
Reglan (metoclopramide)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

metoclopramide + levomilnacipran

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• levorphanol
Reglan (metoclopramide)

+

levorphanol

1 interaction

Avoid/Use Alternative

metoclopramide + levorphanol

use alternative or monitor resp. rate, decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• linezolid
Reglan (metoclopramide)

+

linezolid

1 interaction

Avoid/Use Alternative

metoclopramide + linezolid

use alternative or hold metoclopramide if urgent use; monitor BP, serotonin syndrome sx x2wk after metoclopramide D/C or 24h after last linezolid dose: combo may incr. risk of serotonin syndrome, HTN (additive effects, linezolid reversibly inhibits monoamine oxidase)

• linvoseltamab
Reglan (metoclopramide)

+

linvoseltamab

1 interaction

Avoid/Use Alternative

metoclopramide + linvoseltamab

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lisdexamfetamine
Reglan (metoclopramide)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

metoclopramide + lisdexamfetamine

consider alternative or decr. lisdexamfetamine start dose; monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN (additive effects)

• lithium
Reglan (metoclopramide)

+

lithium

1 interaction

Avoid/Use Alternative

metoclopramide + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lofexidine
Reglan (metoclopramide)

+

lofexidine

1 interaction

Avoid/Use Alternative

metoclopramide + lofexidine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lorazepam
Reglan (metoclopramide)

+

lorazepam

1 interaction

Avoid/Use Alternative

metoclopramide + lorazepam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may alter seizure control; may incr. risk of profound CNS and resp. depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• loxapine
Reglan (metoclopramide)

+

loxapine

1 interaction

Avoid/Use Alternative

metoclopramide + loxapine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• lumateperone
Reglan (metoclopramide)

+

lumateperone

1 interaction

Avoid/Use Alternative

metoclopramide + lumateperone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• lurasidone
Reglan (metoclopramide)

+

lurasidone

1 interaction

Avoid/Use Alternative

metoclopramide + lurasidone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• mavorixafor
Reglan (metoclopramide)

+

mavorixafor

1 interaction

Avoid/Use Alternative

metoclopramide + mavorixafor

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: decr. metoclopramide dose 50%: combo may incr. metoclopramide levels, risk of adverse effects (hepatic metab. inhibited)

• meclizine
Reglan (metoclopramide)

+

meclizine

1 interaction

Avoid/Use Alternative

metoclopramide + meclizine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• melatonin
Reglan (metoclopramide)

+

melatonin

1 interaction

Avoid/Use Alternative

metoclopramide + melatonin

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meperidine
Reglan (metoclopramide)

+

meperidine

1 interaction

Avoid/Use Alternative

metoclopramide + meperidine

use alternative or monitor resp. rate, decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• meprobamate
Reglan (metoclopramide)

+

meprobamate

1 interaction

Avoid/Use Alternative

metoclopramide + meprobamate

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metaxalone
Reglan (metoclopramide)

+

metaxalone

1 interaction

Avoid/Use Alternative

metoclopramide + metaxalone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• methadone
Reglan (metoclopramide)

+

methadone

1 interaction

Avoid/Use Alternative

metoclopramide + methadone

use alternative or monitor resp. rate, decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• methamphetamine
Reglan (metoclopramide)

+

methamphetamine

1 interaction

Avoid/Use Alternative

metoclopramide + methamphetamine

consider alternative or decr. methamphetamine start dose; monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, HTN (additive effects)

• methocarbamol
Reglan (metoclopramide)

+

methocarbamol

1 interaction

Avoid/Use Alternative

metoclopramide + methocarbamol

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methohexital
Reglan (metoclopramide)

+

methohexital

1 interaction

Avoid/Use Alternative

metoclopramide + methohexital

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methsuximide
Reglan (metoclopramide)

+

methsuximide

1 interaction

Avoid/Use Alternative

metoclopramide + methsuximide

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• methyldopa
Reglan (metoclopramide)

+

methyldopa

1 interaction

Avoid/Use Alternative

metoclopramide + methyldopa

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment; may decr. antihypertensive agent efficacy (additive effects; antagonistic effects)

• methylene blue oral
Reglan (metoclopramide)

+

methylene blue oral

1 interaction

Avoid/Use Alternative

metoclopramide + methylene blue oral

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• metyrapone
Reglan (metoclopramide)

+

metyrapone

1 interaction

Avoid/Use Alternative

metoclopramide + metyrapone

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Reglan (metoclopramide)

+

metyrosine

1 interaction

Avoid/Use Alternative

metoclopramide + metyrosine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• midazolam
Reglan (metoclopramide)

+

midazolam

1 interaction

Avoid/Use Alternative

metoclopramide + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may alter seizure control; may incr. risk of profound CNS and resp. depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• midodrine
Reglan (metoclopramide)

+

midodrine

1 interaction

Avoid/Use Alternative

metoclopramide + midodrine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

• milnacipran
Reglan (metoclopramide)

+

milnacipran

1 interaction

Avoid/Use Alternative

metoclopramide + milnacipran

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, HTN, dystonia (additive effects)

• mirtazapine
Reglan (metoclopramide)

+

mirtazapine

1 interaction

Avoid/Use Alternative

metoclopramide + mirtazapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• mitotane
Reglan (metoclopramide)

+

mitotane

1 interaction

Avoid/Use Alternative

metoclopramide + mitotane

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide levels, efficacy (additive effects; hepatic metab. induced)

• molindone
Reglan (metoclopramide)

+

molindone

1 interaction

Avoid/Use Alternative

metoclopramide + molindone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• morphine
Reglan (metoclopramide)

+

morphine

1 interaction

Avoid/Use Alternative

metoclopramide + morphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• mosunetuzumab
Reglan (metoclopramide)

+

mosunetuzumab

1 interaction

Avoid/Use Alternative

metoclopramide + mosunetuzumab

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Reglan (metoclopramide)

+

mycophenolate mofetil

1 interaction

Avoid/Use Alternative

metoclopramide + mycophenolate mofetil

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nalbuphine
Reglan (metoclopramide)

+

nalbuphine

1 interaction

Avoid/Use Alternative

metoclopramide + nalbuphine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• naltrexone
Reglan (metoclopramide)

+

naltrexone

1 interaction

Avoid/Use Alternative

metoclopramide + naltrexone

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naratriptan
Reglan (metoclopramide)

+

naratriptan

1 interaction

Avoid/Use Alternative

metoclopramide + naratriptan

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• nefazodone
Reglan (metoclopramide)

+

nefazodone

1 interaction

Avoid/Use Alternative

metoclopramide + nefazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• nelarabine
Reglan (metoclopramide)

+

nelarabine

1 interaction

Avoid/Use Alternative

metoclopramide + nelarabine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nortriptyline
Reglan (metoclopramide)

+

nortriptyline

1 interaction

Avoid/Use Alternative

metoclopramide + nortriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• olanzapine
Reglan (metoclopramide)

+

olanzapine

1 interaction

Avoid/Use Alternative

metoclopramide + olanzapine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis), neuroleptic malignant syndrome, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• oliceridine
Reglan (metoclopramide)

+

oliceridine

1 interaction

Avoid/Use Alternative

metoclopramide + oliceridine

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• ondansetron
Reglan (metoclopramide)

+

ondansetron

1 interaction

Avoid/Use Alternative

metoclopramide + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opicapone
Reglan (metoclopramide)

+

opicapone

1 interaction

Avoid/Use Alternative

metoclopramide + opicapone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• opium
Reglan (metoclopramide)

+

opium

1 interaction

Avoid/Use Alternative

metoclopramide + opium

use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• orphenadrine
Reglan (metoclopramide)

+

orphenadrine

1 interaction

Avoid/Use Alternative

metoclopramide + orphenadrine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• oxazepam
Reglan (metoclopramide)

+

oxazepam

1 interaction

Avoid/Use Alternative

metoclopramide + oxazepam

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• oxcarbazepine
Reglan (metoclopramide)

+

oxcarbazepine

1 interaction

Avoid/Use Alternative

metoclopramide + oxcarbazepine

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• oxybate
Reglan (metoclopramide)

+

oxybate

1 interaction

Avoid/Use Alternative

metoclopramide + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxybutynin
Reglan (metoclopramide)

+

oxybutynin

1 interaction

Avoid/Use Alternative

metoclopramide + oxybutynin

use alternative or decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment; somnolence less likely w/ oxybutynin transdermal patch; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• oxycodone
Reglan (metoclopramide)

+

oxycodone

1 interaction

Avoid/Use Alternative

metoclopramide + oxycodone

use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• oxymorphone
Reglan (metoclopramide)

+

oxymorphone

1 interaction

Avoid/Use Alternative

metoclopramide + oxymorphone

use alternative or monitor resp. rate; decr. oxymorphone start dose by at least 50%, consider decr. metoclopramide dose, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• paliperidone
Reglan (metoclopramide)

+

paliperidone

1 interaction

Avoid/Use Alternative

metoclopramide + paliperidone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• paroxetine
Reglan (metoclopramide)

+

paroxetine

1 interaction

Avoid/Use Alternative

metoclopramide + paroxetine

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: use alternative or decr. metoclopramide dose 50% and monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. metoclopramide levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• passion flower
Reglan (metoclopramide)

+

passion flower

1 interaction

Avoid/Use Alternative

metoclopramide + passion flower

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pentazocine
Reglan (metoclopramide)

+

pentazocine

1 interaction

Avoid/Use Alternative

metoclopramide + pentazocine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• pentobarbital
Reglan (metoclopramide)

+

pentobarbital

1 interaction

Avoid/Use Alternative

metoclopramide + pentobarbital

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may decr. metoclopramide levels, efficacy (additive effects; hepatic metab. induced)

• perampanel
Reglan (metoclopramide)

+

perampanel

1 interaction

Avoid/Use Alternative

metoclopramide + perampanel

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• perphenazine
Reglan (metoclopramide)

+

perphenazine

1 interaction

Avoid/Use Alternative

metoclopramide + perphenazine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• phenelzine
Reglan (metoclopramide)

+

phenelzine

1 interaction

Avoid/Use Alternative

metoclopramide + phenelzine

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis (additive effects)

• pheniramine
Reglan (metoclopramide)

+

pheniramine

1 interaction

Avoid/Use Alternative

metoclopramide + pheniramine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• phenobarbital
Reglan (metoclopramide)

+

phenobarbital

1 interaction

Avoid/Use Alternative

metoclopramide + phenobarbital

use alternative or monitor resp. rate: combo may decr. metoclopramide levels, efficacy; may incr. risk of CNS depression and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• phenytoin
Reglan (metoclopramide)

+

phenytoin

1 interaction

Avoid/Use Alternative

metoclopramide + phenytoin

use alternative: combo may decr. metoclopramide levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• pimozide
Reglan (metoclopramide)

+

pimozide

1 interaction

Avoid/Use Alternative

metoclopramide + pimozide

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• pramipexole
Reglan (metoclopramide)

+

pramipexole

1 interaction

Avoid/Use Alternative

metoclopramide + pramipexole

avoid combo: combo may decr. efficacy of both drugs; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• pramlintide
Reglan (metoclopramide)

+

pramlintide

1 interaction

Avoid/Use Alternative

metoclopramide + pramlintide

consider alternative: combo may decr. efficacy of both drugs (antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• pregabalin
Reglan (metoclopramide)

+

pregabalin

1 interaction

Avoid/Use Alternative

metoclopramide + pregabalin

use alternative or monitor resp. rate: combo may alter seizure control; may incr. risk of profound CNS and resp. depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• primidone
Reglan (metoclopramide)

+

primidone

1 interaction

Avoid/Use Alternative

metoclopramide + primidone

use alternative or monitor resp. rate: combo may decr. metoclopramide levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, metoclopramide may decr. seizure threshold)

• procarbazine
Reglan (metoclopramide)

+

procarbazine

1 interaction

Avoid/Use Alternative

metoclopramide + procarbazine

avoid combo: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• prochlorperazine
Reglan (metoclopramide)

+

prochlorperazine

1 interaction

Avoid/Use Alternative

metoclopramide + prochlorperazine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• promethazine
Reglan (metoclopramide)

+

promethazine

1 interaction

Avoid/Use Alternative

metoclopramide + promethazine

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment, extrapyramidal symptoms, seizures; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• propofol
Reglan (metoclopramide)

+

propofol

1 interaction

Avoid/Use Alternative

metoclopramide + propofol

use alternative or monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• protriptyline
Reglan (metoclopramide)

+

protriptyline

1 interaction

Avoid/Use Alternative

metoclopramide + protriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• pyrilamine
Reglan (metoclopramide)

+

pyrilamine

1 interaction

Avoid/Use Alternative

metoclopramide + pyrilamine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• quazepam
Reglan (metoclopramide)

+

quazepam

1 interaction

Avoid/Use Alternative

metoclopramide + quazepam

use alternative or monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• quetiapine
Reglan (metoclopramide)

+

quetiapine

1 interaction

Avoid/Use Alternative

metoclopramide + quetiapine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms, HTN; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• quinidine (antiarrhythmic)
Reglan (metoclopramide)

+

quinidine (antiarrhythmic)

1 interaction

Avoid/Use Alternative

metoclopramide + quinidine (antiarrhythmic)

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: decr. metoclopramide dose 50%: combo may incr. metoclopramide levels, risk of adverse effects (hepatic metab. inhibited)

• quinidine (CYP2D6 inhibitor)
Reglan (metoclopramide)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Avoid/Use Alternative

metoclopramide + quinidine (CYP2D6 inhibitor)

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: decr. metoclopramide dose 50%: combo may incr. metoclopramide levels, risk of adverse effects (hepatic metab. inhibited)

• ramelteon
Reglan (metoclopramide)

+

ramelteon

1 interaction

Avoid/Use Alternative

metoclopramide + ramelteon

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rasagiline
Reglan (metoclopramide)

+

rasagiline

1 interaction

Avoid/Use Alternative

metoclopramide + rasagiline

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• remifentanil
Reglan (metoclopramide)

+

remifentanil

1 interaction

Avoid/Use Alternative

metoclopramide + remifentanil

use alternative or monitor resp. rate, decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• remimazolam
Reglan (metoclopramide)

+

remimazolam

1 interaction

Avoid/Use Alternative

metoclopramide + remimazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• repotrectinib
Reglan (metoclopramide)

+

repotrectinib

1 interaction

Avoid/Use Alternative

metoclopramide + repotrectinib

use alternative: combo may decr. metoclopramide levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• risperidone
Reglan (metoclopramide)

+

risperidone

1 interaction

Avoid/Use Alternative

metoclopramide + risperidone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• rivastigmine
Reglan (metoclopramide)

+

rivastigmine

1 interaction

Avoid/Use Alternative

metoclopramide + rivastigmine

avoid combo: combo may incr. risk of extrapyramidal symptoms (additive effects)

• rizatriptan
Reglan (metoclopramide)

+

rizatriptan

1 interaction

Avoid/Use Alternative

metoclopramide + rizatriptan

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• ropeginterferon alfa-2b
Reglan (metoclopramide)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

metoclopramide + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ropinirole
Reglan (metoclopramide)

+

ropinirole

1 interaction

Avoid/Use Alternative

metoclopramide + ropinirole

avoid combo: combo may decr. efficacy of both drugs; may incr. risk of CNS depression, psychomotor impairment, HTN (antagonistic effects; additive effects)

• rotigotine transdermal
Reglan (metoclopramide)

+

rotigotine transdermal

1 interaction

Avoid/Use Alternative

metoclopramide + rotigotine transdermal

avoid combo: combo may decr. efficacy of both drugs; may incr. risk of CNS depression, psychomotor impairment, HTN (antagonistic effects; additive effects)

• rufinamide
Reglan (metoclopramide)

+

rufinamide

1 interaction

Avoid/Use Alternative

metoclopramide + rufinamide

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• safinamide
Reglan (metoclopramide)

+

safinamide

1 interaction

Avoid/Use Alternative

metoclopramide + safinamide

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• scopolamine
Reglan (metoclopramide)

+

scopolamine

1 interaction

Avoid/Use Alternative

metoclopramide + scopolamine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• selegiline
Reglan (metoclopramide)

+

selegiline

1 interaction

Avoid/Use Alternative

metoclopramide + selegiline

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• selegiline transdermal
Reglan (metoclopramide)

+

selegiline transdermal

1 interaction

Avoid/Use Alternative

metoclopramide + selegiline transdermal

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• selinexor
Reglan (metoclopramide)

+

selinexor

1 interaction

Avoid/Use Alternative

metoclopramide + selinexor

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sertraline
Reglan (metoclopramide)

+

sertraline

1 interaction

Avoid/Use Alternative

metoclopramide + sertraline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• sevoflurane
Reglan (metoclopramide)

+

sevoflurane

1 interaction

Avoid/Use Alternative

metoclopramide + sevoflurane

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• solifenacin
Reglan (metoclopramide)

+

solifenacin

1 interaction

Avoid/Use Alternative

metoclopramide + solifenacin

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• solriamfetol
Reglan (metoclopramide)

+

solriamfetol

1 interaction

Avoid/Use Alternative

metoclopramide + solriamfetol

avoid combo: combo may decr. efficacy of both drugs; may incr. risk of HTN, tachycardia (antagonistic effects; additive effects)

• stiripentol
Reglan (metoclopramide)

+

stiripentol

1 interaction

Avoid/Use Alternative

metoclopramide + stiripentol

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• sufentanil
Reglan (metoclopramide)

+

sufentanil

1 interaction

Avoid/Use Alternative

metoclopramide + sufentanil

use alternative or monitor resp. rate, decr. sufentanil start dose, consider decr. metoclopramide dose, use lowest effective doses; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• sumatriptan
Reglan (metoclopramide)

+

sumatriptan

1 interaction

Avoid/Use Alternative

metoclopramide + sumatriptan

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• suvorexant
Reglan (metoclopramide)

+

suvorexant

1 interaction

Avoid/Use Alternative

metoclopramide + suvorexant

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tapentadol
Reglan (metoclopramide)

+

tapentadol

1 interaction

Avoid/Use Alternative

metoclopramide + tapentadol

use alternative or monitor resp. rate, decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• tasimelteon
Reglan (metoclopramide)

+

tasimelteon

1 interaction

Avoid/Use Alternative

metoclopramide + tasimelteon

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• temazepam
Reglan (metoclopramide)

+

temazepam

1 interaction

Avoid/Use Alternative

metoclopramide + temazepam

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• terbinafine
Reglan (metoclopramide)

+

terbinafine

1 interaction

Avoid/Use Alternative

metoclopramide + terbinafine

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: decr. metoclopramide dose 50%: combo may incr. metoclopramide levels, risk of adverse effects (hepatic metab. inhibited)

• tetrabenazine
Reglan (metoclopramide)

+

tetrabenazine

1 interaction

Avoid/Use Alternative

metoclopramide + tetrabenazine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thalidomide
Reglan (metoclopramide)

+

thalidomide

1 interaction

Avoid/Use Alternative

metoclopramide + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thioridazine
Reglan (metoclopramide)

+

thioridazine

1 interaction

Avoid/Use Alternative

metoclopramide + thioridazine

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• thiotepa
Reglan (metoclopramide)

+

thiotepa

1 interaction

Avoid/Use Alternative

metoclopramide + thiotepa

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiothixene
Reglan (metoclopramide)

+

thiothixene

1 interaction

Avoid/Use Alternative

metoclopramide + thiothixene

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• tiagabine
Reglan (metoclopramide)

+

tiagabine

1 interaction

Avoid/Use Alternative

metoclopramide + tiagabine

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• tizanidine
Reglan (metoclopramide)

+

tizanidine

1 interaction

Avoid/Use Alternative

metoclopramide + tizanidine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolcapone
Reglan (metoclopramide)

+

tolcapone

1 interaction

Avoid/Use Alternative

metoclopramide + tolcapone

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolterodine
Reglan (metoclopramide)

+

tolterodine

1 interaction

Avoid/Use Alternative

metoclopramide + tolterodine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• topiramate
Reglan (metoclopramide)

+

topiramate

1 interaction

Avoid/Use Alternative

metoclopramide + topiramate

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• tramadol
Reglan (metoclopramide)

+

tramadol

1 interaction

Avoid/Use Alternative

metoclopramide + tramadol

use alternative or monitor resp. rate, decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, seizures; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• tranylcypromine
Reglan (metoclopramide)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

metoclopramide + tranylcypromine

avoid combo: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, HTN, incl. hypertensive crisis (additive effects)

• trazodone
Reglan (metoclopramide)

+

trazodone

1 interaction

Avoid/Use Alternative

metoclopramide + trazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• triazolam
Reglan (metoclopramide)

+

triazolam

1 interaction

Avoid/Use Alternative

metoclopramide + triazolam

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• trifluoperazine
Reglan (metoclopramide)

+

trifluoperazine

1 interaction

Avoid/Use Alternative

metoclopramide + trifluoperazine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• trihexyphenidyl
Reglan (metoclopramide)

+

trihexyphenidyl

1 interaction

Avoid/Use Alternative

metoclopramide + trihexyphenidyl

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• trimethobenzamide
Reglan (metoclopramide)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

metoclopramide + trimethobenzamide

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• trimipramine
Reglan (metoclopramide)

+

trimipramine

1 interaction

Avoid/Use Alternative

metoclopramide + trimipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• triprolidine
Reglan (metoclopramide)

+

triprolidine

1 interaction

Avoid/Use Alternative

metoclopramide + triprolidine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• trospium
Reglan (metoclopramide)

+

trospium

1 interaction

Avoid/Use Alternative

metoclopramide + trospium

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• valbenazine
Reglan (metoclopramide)

+

valbenazine

1 interaction

Avoid/Use Alternative

metoclopramide + valbenazine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Reglan (metoclopramide)

+

valerian

1 interaction

Avoid/Use Alternative

metoclopramide + valerian

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
Reglan (metoclopramide)

+

valproic acid

1 interaction

Avoid/Use Alternative

metoclopramide + valproic acid

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• venlafaxine
Reglan (metoclopramide)

+

venlafaxine

1 interaction

Avoid/Use Alternative

metoclopramide + venlafaxine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment, dystonia (additive effects)

• vigabatrin
Reglan (metoclopramide)

+

vigabatrin

1 interaction

Avoid/Use Alternative

metoclopramide + vigabatrin

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• vilazodone
Reglan (metoclopramide)

+

vilazodone

1 interaction

Avoid/Use Alternative

metoclopramide + vilazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• viloxazine
Reglan (metoclopramide)

+

viloxazine

1 interaction

Avoid/Use Alternative

metoclopramide + viloxazine

use alternative or monitor BP, HR: combo may incr. risk of HTN, tachycardia, CNS depression, psychomotor impairment (additive effects)

• vortioxetine
Reglan (metoclopramide)

+

vortioxetine

1 interaction

Avoid/Use Alternative

metoclopramide + vortioxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• yohimbe
Reglan (metoclopramide)

+

yohimbe

1 interaction

Avoid/Use Alternative

metoclopramide + yohimbe

avoid combo: combo may incr. risk of serotonin syndrome, HTN (additive effects, yohimbe inhibits monoamine oxidase)

• zaleplon
Reglan (metoclopramide)

+

zaleplon

1 interaction

Avoid/Use Alternative

metoclopramide + zaleplon

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziconotide
Reglan (metoclopramide)

+

ziconotide

1 interaction

Avoid/Use Alternative

metoclopramide + ziconotide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziprasidone
Reglan (metoclopramide)

+

ziprasidone

1 interaction

Avoid/Use Alternative

metoclopramide + ziprasidone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• zolmitriptan
Reglan (metoclopramide)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

metoclopramide + zolmitriptan

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• zolpidem
Reglan (metoclopramide)

+

zolpidem

1 interaction

Avoid/Use Alternative

metoclopramide + zolpidem

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
Reglan (metoclopramide)

+

zonisamide

1 interaction

Avoid/Use Alternative

metoclopramide + zonisamide

use alternative: combo may alter seizure control; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• zuranolone
Reglan (metoclopramide)

+

zuranolone

1 interaction

Avoid/Use Alternative

metoclopramide + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)