Remeron

Overview

mirtazapine

tetracyclic antidepressant

• CYP1A2 substrate
• CYP3A4 substrate
• anticholinergic effects
• CNS depression
• decreases central histamine effects
• hyponatremia
• hypotensive effects
• lowers seizure threshold
• prolongs QT interval (conditional)
• serotonergic effects

• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• isocarboxazid
Remeron (mirtazapine)

+

isocarboxazid

1 interaction

Contraindicated

mirtazapine + isocarboxazid

contraindicated w/in 14 days of isocarboxazid or mirtazapine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hypotension (incl. orthostasis), severe constipation, paralytic ileus, urinary retention (additive effects)

• linezolid
Remeron (mirtazapine)

+

linezolid

1 interaction

Contraindicated

mirtazapine + linezolid

contraindicated w/in 14 days of linezolid use; hold mirtazapine if urgent use; monitor sodium, serotonin syndrome sx x2wk after mirtazapine D/C or 24h after last linezolid dose: combo may incr. risk of serotonin syndrome, hyponatremia (additive effects, linezolid reversibly inhibits monoamine oxidase)

• methylene blue injection
Remeron (mirtazapine)

+

methylene blue injection

1 interaction

Contraindicated

mirtazapine + methylene blue injection

contraindicated w/in 14 days of methylene blue use; hold mirtazapine if emergency use; monitor BP, serotonin syndrome sx up to 4h after last methylene blue dose; may resume mirtazapine 72h after last methylene blue dose: combo may incr. risk of serotonin syndrome, hypotension, incl. orthostasis (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• phenelzine
Remeron (mirtazapine)

+

phenelzine

1 interaction

Contraindicated

mirtazapine + phenelzine

contraindicated w/in 14 days of phenelzine or mirtazapine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hypotension (incl. orthostasis), severe constipation, paralytic ileus, urinary retention (additive effects)

• pimozide
Remeron (mirtazapine)

+

pimozide

1 interaction

Contraindicated

mirtazapine + pimozide

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• potassium chloride
Remeron (mirtazapine)

+

potassium chloride

1 interaction

Contraindicated

mirtazapine + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium citrate
Remeron (mirtazapine)

+

potassium citrate

1 interaction

Contraindicated

mirtazapine + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• safinamide
Remeron (mirtazapine)

+

safinamide

1 interaction

Contraindicated

mirtazapine + safinamide

contraindicated w/in 14 days of safinamide use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• selegiline transdermal
Remeron (mirtazapine)

+

selegiline transdermal

1 interaction

Contraindicated

mirtazapine + selegiline transdermal

contraindicated w/in 14 days of selegiline or mirtazapine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• thioridazine
Remeron (mirtazapine)

+

thioridazine

1 interaction

Contraindicated

mirtazapine + thioridazine

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis), CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• tranylcypromine
Remeron (mirtazapine)

+

tranylcypromine

1 interaction

Contraindicated

mirtazapine + tranylcypromine

contraindicated w/in 14 days of tranylcypromine or mirtazapine use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hypotension (incl. orthostasis), severe constipation, paralytic ileus, urinary retention (additive effects)

Avoid/Use Alternative

• 5-HTP
Remeron (mirtazapine)

+

5-HTP

1 interaction

Avoid/Use Alternative

mirtazapine + 5-HTP

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• aclidinium inhaled
Remeron (mirtazapine)

+

aclidinium inhaled

1 interaction

Avoid/Use Alternative

mirtazapine + aclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• aldesleukin
Remeron (mirtazapine)

+

aldesleukin

1 interaction

Avoid/Use Alternative

mirtazapine + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, severe or life-threatening hypotension (incl. orthostasis), seizures (additive effects)

• alfentanil
Remeron (mirtazapine)

+

alfentanil

1 interaction

Avoid/Use Alternative

mirtazapine + alfentanil

use alternative or monitor BP, resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus, urinary retention (additive effects)

• almotriptan
Remeron (mirtazapine)

+

almotriptan

1 interaction

Avoid/Use Alternative

mirtazapine + almotriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• amifampridine
Remeron (mirtazapine)

+

amifampridine

1 interaction

Avoid/Use Alternative

mirtazapine + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• amitriptyline
Remeron (mirtazapine)

+

amitriptyline

1 interaction

Avoid/Use Alternative

mirtazapine + amitriptyline

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• amoxapine
Remeron (mirtazapine)

+

amoxapine

1 interaction

Avoid/Use Alternative

mirtazapine + amoxapine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• amphetamine
Remeron (mirtazapine)

+

amphetamine

1 interaction

Avoid/Use Alternative

mirtazapine + amphetamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; decr. amphetamine start dose: combo may incr. risk of serotonin syndrome (additive effects)

• arsenic trioxide
Remeron (mirtazapine)

+

arsenic trioxide

1 interaction

Avoid/Use Alternative

mirtazapine + arsenic trioxide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• bedaquiline
Remeron (mirtazapine)

+

bedaquiline

1 interaction

Avoid/Use Alternative

mirtazapine + bedaquiline

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• black cohosh
Remeron (mirtazapine)

+

black cohosh

1 interaction

Avoid/Use Alternative

mirtazapine + black cohosh

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• bromocriptine
Remeron (mirtazapine)

+

bromocriptine

1 interaction

Avoid/Use Alternative

mirtazapine + bromocriptine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, hypotension, incl. orthostasis, syncope (additive effects)

• buprenorphine
Remeron (mirtazapine)

+

buprenorphine

1 interaction

Avoid/Use Alternative

mirtazapine + buprenorphine

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus, urinary retention (additive effects)

• buspirone
Remeron (mirtazapine)

+

buspirone

1 interaction

Avoid/Use Alternative

mirtazapine + buspirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• butalbital
Remeron (mirtazapine)

+

butalbital

1 interaction

Avoid/Use Alternative

mirtazapine + butalbital

avoid combo: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment (hepatic metab. induced; additive effects)

• butorphanol
Remeron (mirtazapine)

+

butorphanol

1 interaction

Avoid/Use Alternative

mirtazapine + butorphanol

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• carbamazepine
Remeron (mirtazapine)

+

carbamazepine

1 interaction

Avoid/Use Alternative

mirtazapine + carbamazepine

use alternative or monitor BP, sodium, serotonin syndrome sx, especially during initiation/titration; consider mirtazapine adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. syncope), hyponatremia, serotonin syndrome; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• ceritinib
Remeron (mirtazapine)

+

ceritinib

1 interaction

Avoid/Use Alternative

mirtazapine + ceritinib

use alternative or monitor ECG, electrolytes: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, additive effects)

• cisapride
Remeron (mirtazapine)

+

cisapride

1 interaction

Avoid/Use Alternative

mirtazapine + cisapride

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. cisapride efficacy (additive effects; antagonistic effects)

• citalopram
Remeron (mirtazapine)

+

citalopram

1 interaction

Avoid/Use Alternative

mirtazapine + citalopram

use alternative or monitor ECG, sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, QT prolongation, cardiac arrhythmias, hyponatremia (additive effects)

• clomipramine
Remeron (mirtazapine)

+

clomipramine

1 interaction

Avoid/Use Alternative

mirtazapine + clomipramine

use alternative or monitor sodium, BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, seizures, serotonin syndrome, anticholinergic adverse effects, hyponatremia, hypotension, incl. orthostasis (additive effects)

• clonidine
Remeron (mirtazapine)

+

clonidine

1 interaction

Avoid/Use Alternative

mirtazapine + clonidine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• clozapine
Remeron (mirtazapine)

+

clozapine

1 interaction

Avoid/Use Alternative

mirtazapine + clozapine

use alternative or monitor BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, seizures, hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus (incl. life-threatening), other anticholinergic adverse effects (additive effects)

• cocaine
Remeron (mirtazapine)

+

cocaine

1 interaction

Avoid/Use Alternative

mirtazapine + cocaine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• codeine
Remeron (mirtazapine)

+

codeine

1 interaction

Avoid/Use Alternative

mirtazapine + codeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• crizotinib
Remeron (mirtazapine)

+

crizotinib

1 interaction

Avoid/Use Alternative

mirtazapine + crizotinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• cyclobenzaprine
Remeron (mirtazapine)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

mirtazapine + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, anticholinergic adverse effects (additive effects)

• desipramine
Remeron (mirtazapine)

+

desipramine

1 interaction

Avoid/Use Alternative

mirtazapine + desipramine

use alternative or monitor ECG, BP, sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis), hyponatremia, anticholinergic adverse effects (additive effects)

• desvenlafaxine
Remeron (mirtazapine)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

mirtazapine + desvenlafaxine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, hyponatremia (additive effects)

• dexmethylphenidate
Remeron (mirtazapine)

+

dexmethylphenidate

1 interaction

Avoid/Use Alternative

mirtazapine + dexmethylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextroamphetamine
Remeron (mirtazapine)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

mirtazapine + dextroamphetamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; decr. dextroamphetamine start dose: combo may incr. risk of serotonin syndrome (additive effects)

• dextromethorphan
Remeron (mirtazapine)

+

dextromethorphan

1 interaction

Avoid/Use Alternative

mirtazapine + dextromethorphan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dihydrocodeine
Remeron (mirtazapine)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

mirtazapine + dihydrocodeine

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• dihydroergotamine
Remeron (mirtazapine)

+

dihydroergotamine

1 interaction

Avoid/Use Alternative

mirtazapine + dihydroergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• domperidone
Remeron (mirtazapine)

+

domperidone

1 interaction

Avoid/Use Alternative

mirtazapine + domperidone

use alternative or monitor ECG, HR, electrolytes; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)

• doxepin
Remeron (mirtazapine)

+

doxepin

1 interaction

Avoid/Use Alternative

mirtazapine + doxepin

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• doxepin topical
Remeron (mirtazapine)

+

doxepin topical

1 interaction

Avoid/Use Alternative

mirtazapine + doxepin topical

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, anticholinergic adverse effects (additive effects)

• doxylamine
Remeron (mirtazapine)

+

doxylamine

1 interaction

Avoid/Use Alternative

mirtazapine + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dronedarone
Remeron (mirtazapine)

+

dronedarone

1 interaction

Avoid/Use Alternative

mirtazapine + dronedarone

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• duloxetine
Remeron (mirtazapine)

+

duloxetine

1 interaction

Avoid/Use Alternative

mirtazapine + duloxetine

use alternative or monitor sodium, BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, hyponatremia, hypotension, incl. orthostasis (additive effects)

• eletriptan
Remeron (mirtazapine)

+

eletriptan

1 interaction

Avoid/Use Alternative

mirtazapine + eletriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• eluxadoline
Remeron (mirtazapine)

+

eluxadoline

1 interaction

Avoid/Use Alternative

mirtazapine + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• ephedra
Remeron (mirtazapine)

+

ephedra

1 interaction

Avoid/Use Alternative

mirtazapine + ephedra

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ergotamine
Remeron (mirtazapine)

+

ergotamine

1 interaction

Avoid/Use Alternative

mirtazapine + ergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• eribulin
Remeron (mirtazapine)

+

eribulin

1 interaction

Avoid/Use Alternative

mirtazapine + eribulin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• escitalopram
Remeron (mirtazapine)

+

escitalopram

1 interaction

Avoid/Use Alternative

mirtazapine + escitalopram

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia (additive effects)

• ethanol
Remeron (mirtazapine)

+

ethanol

1 interaction

Avoid/Use Alternative

mirtazapine + ethanol

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis (additive effects)

• fenfluramine
Remeron (mirtazapine)

+

fenfluramine

1 interaction

Avoid/Use Alternative

mirtazapine + fenfluramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• fentanyl
Remeron (mirtazapine)

+

fentanyl

1 interaction

Avoid/Use Alternative

mirtazapine + fentanyl

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• fexinidazole
Remeron (mirtazapine)

+

fexinidazole

1 interaction

Avoid/Use Alternative

mirtazapine + fexinidazole

if possible, do not initiate fexinidazole until 5 half-lives after mirtazapine D/C; use alternative or monitor ECG during and x7 days after fexinidazole tx; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metab. induced; additive effects)

• fluoxetine
Remeron (mirtazapine)

+

fluoxetine

1 interaction

Avoid/Use Alternative

mirtazapine + fluoxetine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia (additive effects)

• fluvoxamine
Remeron (mirtazapine)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

mirtazapine + fluvoxamine

use alternative or monitor ECG, sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. mirtazapine levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, QT prolongation, cardiac arrhythmias, hyponatremia, other adverse effects (hepatic metab. inhibited, additive effects)

• frovatriptan
Remeron (mirtazapine)

+

frovatriptan

1 interaction

Avoid/Use Alternative

mirtazapine + frovatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• gepirone
Remeron (mirtazapine)

+

gepirone

1 interaction

Avoid/Use Alternative

mirtazapine + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• glucagon
Remeron (mirtazapine)

+

glucagon

1 interaction

Avoid/Use Alternative

mirtazapine + glucagon

avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)

• glycopyrronium topical
Remeron (mirtazapine)

+

glycopyrronium topical

1 interaction

Avoid/Use Alternative

mirtazapine + glycopyrronium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• granisetron
Remeron (mirtazapine)

+

granisetron

1 interaction

Avoid/Use Alternative

mirtazapine + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydrocodone
Remeron (mirtazapine)

+

hydrocodone

1 interaction

Avoid/Use Alternative

mirtazapine + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• hydromorphone
Remeron (mirtazapine)

+

hydromorphone

1 interaction

Avoid/Use Alternative

mirtazapine + hydromorphone

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• hydroxychloroquine
Remeron (mirtazapine)

+

hydroxychloroquine

1 interaction

Avoid/Use Alternative

mirtazapine + hydroxychloroquine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects)

• imipramine
Remeron (mirtazapine)

+

imipramine

1 interaction

Avoid/Use Alternative

mirtazapine + imipramine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• iohexol
Remeron (mirtazapine)

+

iohexol

1 interaction

Avoid/Use Alternative

mirtazapine + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• isoniazid
Remeron (mirtazapine)

+

isoniazid

1 interaction

Avoid/Use Alternative

mirtazapine + isoniazid

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, isoniazid inhibits monoamine oxidase)

• kava
Remeron (mirtazapine)

+

kava

1 interaction

Avoid/Use Alternative

mirtazapine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Remeron (mirtazapine)

+

kratom

1 interaction

Avoid/Use Alternative

mirtazapine + kratom

use alternative or monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lasmiditan
Remeron (mirtazapine)

+

lasmiditan

1 interaction

Avoid/Use Alternative

mirtazapine + lasmiditan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• lefamulin
Remeron (mirtazapine)

+

lefamulin

1 interaction

Avoid/Use Alternative

mirtazapine + lefamulin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levomilnacipran
Remeron (mirtazapine)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

mirtazapine + levomilnacipran

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, hyponatremia (additive effects)

• levorphanol
Remeron (mirtazapine)

+

levorphanol

1 interaction

Avoid/Use Alternative

mirtazapine + levorphanol

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• lisdexamfetamine
Remeron (mirtazapine)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

mirtazapine + lisdexamfetamine

use alternative or decr. lisdexamfetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lithium
Remeron (mirtazapine)

+

lithium

1 interaction

Avoid/Use Alternative

mirtazapine + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lofexidine
Remeron (mirtazapine)

+

lofexidine

1 interaction

Avoid/Use Alternative

mirtazapine + lofexidine

use alternative or monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• lonafarnib
Remeron (mirtazapine)

+

lonafarnib

1 interaction

Avoid/Use Alternative

mirtazapine + lonafarnib

use alternative or monitor HR, ECG, electrolytes: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, additive effects)

• meperidine
Remeron (mirtazapine)

+

meperidine

1 interaction

Avoid/Use Alternative

mirtazapine + meperidine

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• metaxalone
Remeron (mirtazapine)

+

metaxalone

1 interaction

Avoid/Use Alternative

mirtazapine + metaxalone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• methadone
Remeron (mirtazapine)

+

methadone

1 interaction

Avoid/Use Alternative

mirtazapine + methadone

use alternative or monitor resp. rate, ECG, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, QT prolongation, cardiac arrhythmias, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• methamphetamine
Remeron (mirtazapine)

+

methamphetamine

1 interaction

Avoid/Use Alternative

mirtazapine + methamphetamine

use alternative or decr. methamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylene blue oral
Remeron (mirtazapine)

+

methylene blue oral

1 interaction

Avoid/Use Alternative

mirtazapine + methylene blue oral

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylergonovine
Remeron (mirtazapine)

+

methylergonovine

1 interaction

Avoid/Use Alternative

mirtazapine + methylergonovine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylphenidate
Remeron (mirtazapine)

+

methylphenidate

1 interaction

Avoid/Use Alternative

mirtazapine + methylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• metoclopramide
Remeron (mirtazapine)

+

metoclopramide

1 interaction

Avoid/Use Alternative

mirtazapine + metoclopramide

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• midazolam
Remeron (mirtazapine)

+

midazolam

1 interaction

Avoid/Use Alternative

mirtazapine + midazolam

use alternative or monitor resp. rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• milnacipran
Remeron (mirtazapine)

+

milnacipran

1 interaction

Avoid/Use Alternative

mirtazapine + milnacipran

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia (additive effects)

• mobocertinib
Remeron (mirtazapine)

+

mobocertinib

1 interaction

Avoid/Use Alternative

mirtazapine + mobocertinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• morphine
Remeron (mirtazapine)

+

morphine

1 interaction

Avoid/Use Alternative

mirtazapine + morphine

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• nalbuphine
Remeron (mirtazapine)

+

nalbuphine

1 interaction

Avoid/Use Alternative

mirtazapine + nalbuphine

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• naratriptan
Remeron (mirtazapine)

+

naratriptan

1 interaction

Avoid/Use Alternative

mirtazapine + naratriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• nefazodone
Remeron (mirtazapine)

+

nefazodone

1 interaction

Avoid/Use Alternative

mirtazapine + nefazodone

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. mirtazapine levels, risk of CNS depression, psychomotor impairment, serotonin syndrome, QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, additive effects)

• nortriptyline
Remeron (mirtazapine)

+

nortriptyline

1 interaction

Avoid/Use Alternative

mirtazapine + nortriptyline

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• oliceridine
Remeron (mirtazapine)

+

oliceridine

1 interaction

Avoid/Use Alternative

mirtazapine + oliceridine

use alternative or monitor resp. rate, ECG, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• ondansetron
Remeron (mirtazapine)

+

ondansetron

1 interaction

Avoid/Use Alternative

mirtazapine + ondansetron

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias, serotonin syndrome (additive effects)

• opium
Remeron (mirtazapine)

+

opium

1 interaction

Avoid/Use Alternative

mirtazapine + opium

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• oxybate
Remeron (mirtazapine)

+

oxybate

1 interaction

Avoid/Use Alternative

mirtazapine + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Remeron (mirtazapine)

+

oxycodone

1 interaction

Avoid/Use Alternative

mirtazapine + oxycodone

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. oxycodone start dose by at least 50%, consider decr. mirtazapine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• oxymorphone
Remeron (mirtazapine)

+

oxymorphone

1 interaction

Avoid/Use Alternative

mirtazapine + oxymorphone

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. oxymorphone start dose by at least 50%, consider decr. mirtazapine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• palonosetron
Remeron (mirtazapine)

+

palonosetron

1 interaction

Avoid/Use Alternative

mirtazapine + palonosetron

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias, serotonin syndrome (additive effects)

• paroxetine
Remeron (mirtazapine)

+

paroxetine

1 interaction

Avoid/Use Alternative

mirtazapine + paroxetine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, hyponatremia (additive effects)

• pentazocine
Remeron (mirtazapine)

+

pentazocine

1 interaction

Avoid/Use Alternative

mirtazapine + pentazocine

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• pitolisant
Remeron (mirtazapine)

+

pitolisant

1 interaction

Avoid/Use Alternative

mirtazapine + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

• pramlintide
Remeron (mirtazapine)

+

pramlintide

1 interaction

Avoid/Use Alternative

mirtazapine + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• procarbazine
Remeron (mirtazapine)

+

procarbazine

1 interaction

Avoid/Use Alternative

mirtazapine + procarbazine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects, procarbazine inhibits monoamine oxidase)

• promethazine
Remeron (mirtazapine)

+

promethazine

1 interaction

Avoid/Use Alternative

mirtazapine + promethazine

use alternative or monitor resp. rate, BP; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, seizures, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• protriptyline
Remeron (mirtazapine)

+

protriptyline

1 interaction

Avoid/Use Alternative

mirtazapine + protriptyline

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• quizartinib
Remeron (mirtazapine)

+

quizartinib

1 interaction

Avoid/Use Alternative

mirtazapine + quizartinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rasagiline
Remeron (mirtazapine)

+

rasagiline

1 interaction

Avoid/Use Alternative

mirtazapine + rasagiline

avoid combo w/in 14 days of rasagiline use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• remifentanil
Remeron (mirtazapine)

+

remifentanil

1 interaction

Avoid/Use Alternative

mirtazapine + remifentanil

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• revefenacin inhaled
Remeron (mirtazapine)

+

revefenacin inhaled

1 interaction

Avoid/Use Alternative

mirtazapine + revefenacin inhaled

avoid combo: combo may incr. anticholinergic adverse effects (additive effects)

• rizatriptan
Remeron (mirtazapine)

+

rizatriptan

1 interaction

Avoid/Use Alternative

mirtazapine + rizatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• ropeginterferon alfa-2b
Remeron (mirtazapine)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

mirtazapine + ropeginterferon alfa-2b

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• SAMe
Remeron (mirtazapine)

+

SAMe

1 interaction

Avoid/Use Alternative

mirtazapine + SAMe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• selegiline
Remeron (mirtazapine)

+

selegiline

1 interaction

Avoid/Use Alternative

mirtazapine + selegiline

avoid combo w/in 14 days of selegiline use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• sertraline
Remeron (mirtazapine)

+

sertraline

1 interaction

Avoid/Use Alternative

mirtazapine + sertraline

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, hyponatremia (additive effects)

• sofpironium topical
Remeron (mirtazapine)

+

sofpironium topical

1 interaction

Avoid/Use Alternative

mirtazapine + sofpironium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• sotalol
Remeron (mirtazapine)

+

sotalol

1 interaction

Avoid/Use Alternative

mirtazapine + sotalol

use alternative or monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis (additive effects)

• sotorasib
Remeron (mirtazapine)

+

sotorasib

1 interaction

Avoid/Use Alternative

mirtazapine + sotorasib

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• St. John's wort
Remeron (mirtazapine)

+

St. John's wort

1 interaction

Avoid/Use Alternative

mirtazapine + St. John's wort

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of serotonin syndrome (hepatic metab. induced; additive effects)

• sufentanil
Remeron (mirtazapine)

+

sufentanil

1 interaction

Avoid/Use Alternative

mirtazapine + sufentanil

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. sufentanil start dose, consider decr. mirtazapine dose, use lowest effective doses: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• sumatriptan
Remeron (mirtazapine)

+

sumatriptan

1 interaction

Avoid/Use Alternative

mirtazapine + sumatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• tapentadol
Remeron (mirtazapine)

+

tapentadol

1 interaction

Avoid/Use Alternative

mirtazapine + tapentadol

use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• thalidomide
Remeron (mirtazapine)

+

thalidomide

1 interaction

Avoid/Use Alternative

mirtazapine + thalidomide

use alternative or monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• toremifene
Remeron (mirtazapine)

+

toremifene

1 interaction

Avoid/Use Alternative

mirtazapine + toremifene

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tramadol
Remeron (mirtazapine)

+

tramadol

1 interaction

Avoid/Use Alternative

mirtazapine + tramadol

use alternative or monitor sodium, resp. rate, ECG, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, seizures, serotonin syndrome, QT prolongation, cardiac arrhythmias, severe hyponatremia, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• trazodone
Remeron (mirtazapine)

+

trazodone

1 interaction

Avoid/Use Alternative

mirtazapine + trazodone

use alternative or monitor sodium, BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia, hypotension, incl. orthostasis, syncope (additive effects)

• trimethobenzamide
Remeron (mirtazapine)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

mirtazapine + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Remeron (mirtazapine)

+

trimipramine

1 interaction

Avoid/Use Alternative

mirtazapine + trimipramine

use alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• vandetanib
Remeron (mirtazapine)

+

vandetanib

1 interaction

Avoid/Use Alternative

mirtazapine + vandetanib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• venlafaxine
Remeron (mirtazapine)

+

venlafaxine

1 interaction

Avoid/Use Alternative

mirtazapine + venlafaxine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome, hyponatremia (additive effects)

• vilazodone
Remeron (mirtazapine)

+

vilazodone

1 interaction

Avoid/Use Alternative

mirtazapine + vilazodone

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia (additive effects)

• vortioxetine
Remeron (mirtazapine)

+

vortioxetine

1 interaction

Avoid/Use Alternative

mirtazapine + vortioxetine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of hyponatremia, serotonin syndrome (additive effects)

• yohimbe
Remeron (mirtazapine)

+

yohimbe

1 interaction

Avoid/Use Alternative

mirtazapine + yohimbe

use alternative or monitor BP, especially w/ high yohimbe doses, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, hypotension, incl. orthostasis (additive effects, yohimbe inhibits monoamine oxidase)

• ziprasidone
Remeron (mirtazapine)

+

ziprasidone

1 interaction

Avoid/Use Alternative

mirtazapine + ziprasidone

use alternative or monitor ECG, BP, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, serotonin syndrome, hyperthermia (additive effects)

• zolmitriptan
Remeron (mirtazapine)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

mirtazapine + zolmitriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• acebutolol
Remeron (mirtazapine)

+

acebutolol

1 interaction

Monitor/Modify Tx

mirtazapine + acebutolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• adagrasib
Remeron (mirtazapine)

+

adagrasib

1 interaction

Monitor/Modify Tx

mirtazapine + adagrasib

monitor ECG, electrolytes: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, additive effects)

• alfuzosin
Remeron (mirtazapine)

+

alfuzosin

1 interaction

Monitor/Modify Tx

mirtazapine + alfuzosin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• aliskiren
Remeron (mirtazapine)

+

aliskiren

1 interaction

Monitor/Modify Tx

mirtazapine + aliskiren

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• allopurinol
Remeron (mirtazapine)

+

allopurinol

1 interaction

Monitor/Modify Tx

mirtazapine + allopurinol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alprazolam
Remeron (mirtazapine)

+

alprazolam

1 interaction

Monitor/Modify Tx

mirtazapine + alprazolam

monitor resp. rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• amantadine
Remeron (mirtazapine)

+

amantadine

1 interaction

Monitor/Modify Tx

mirtazapine + amantadine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis, syncope (additive effects)

• amifostine
Remeron (mirtazapine)

+

amifostine

1 interaction

Monitor/Modify Tx

mirtazapine + amifostine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• amiloride
Remeron (mirtazapine)

+

amiloride

1 interaction

Monitor/Modify Tx

mirtazapine + amiloride

monitor sodium, BP: combo may incr. risk of hyponatremia, hypotension, incl. orthostasis (additive effects)

• amiodarone
Remeron (mirtazapine)

+

amiodarone

1 interaction

Monitor/Modify Tx

mirtazapine + amiodarone

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• amlodipine
Remeron (mirtazapine)

+

amlodipine

1 interaction

Monitor/Modify Tx

mirtazapine + amlodipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• anagrelide
Remeron (mirtazapine)

+

anagrelide

1 interaction

Monitor/Modify Tx

mirtazapine + anagrelide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• apalutamide
Remeron (mirtazapine)

+

apalutamide

1 interaction

Monitor/Modify Tx

mirtazapine + apalutamide

monitor ECG; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metab. induced; additive effects)

• apomorphine
Remeron (mirtazapine)

+

apomorphine

1 interaction

Monitor/Modify Tx

mirtazapine + apomorphine

monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, severe hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Remeron (mirtazapine)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

mirtazapine + apraclonidine ophthalmic

monitor BP, consider decr. dose of one or both drugs if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• aprocitentan
Remeron (mirtazapine)

+

aprocitentan

1 interaction

Monitor/Modify Tx

mirtazapine + aprocitentan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• aripiprazole bimonthly injection
Remeron (mirtazapine)

+

aripiprazole bimonthly injection

1 interaction

Monitor/Modify Tx

mirtazapine + aripiprazole bimonthly injection

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole lauroxil
Remeron (mirtazapine)

+

aripiprazole lauroxil

1 interaction

Monitor/Modify Tx

mirtazapine + aripiprazole lauroxil

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis (additive effects)

• aripiprazole monthly injection
Remeron (mirtazapine)

+

aripiprazole monthly injection

1 interaction

Monitor/Modify Tx

mirtazapine + aripiprazole monthly injection

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis (additive effects)

• aripiprazole oral
Remeron (mirtazapine)

+

aripiprazole oral

1 interaction

Monitor/Modify Tx

mirtazapine + aripiprazole oral

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis (additive effects)

• artemether/lumefantrine
Remeron (mirtazapine)

+

artemether/ lumefantrine

1 interaction

Monitor/Modify Tx

mirtazapine + artemether/ lumefantrine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• articaine
Remeron (mirtazapine)

+

articaine

1 interaction

Monitor/Modify Tx

mirtazapine + articaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• asenapine
Remeron (mirtazapine)

+

asenapine

1 interaction

Monitor/Modify Tx

mirtazapine + asenapine

monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, hyperthermia (additive effects)

• atazanavir
Remeron (mirtazapine)

+

atazanavir

1 interaction

Monitor/Modify Tx

mirtazapine + atazanavir

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• atenolol
Remeron (mirtazapine)

+

atenolol

1 interaction

Monitor/Modify Tx

mirtazapine + atenolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• avanafil
Remeron (mirtazapine)

+

avanafil

1 interaction

Monitor/Modify Tx

mirtazapine + avanafil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• azilsartan medoxomil
Remeron (mirtazapine)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

mirtazapine + azilsartan medoxomil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• azithromycin
Remeron (mirtazapine)

+

azithromycin

1 interaction

Monitor/Modify Tx

mirtazapine + azithromycin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• baclofen
Remeron (mirtazapine)

+

baclofen

1 interaction

Monitor/Modify Tx

mirtazapine + baclofen

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen intrathecal
Remeron (mirtazapine)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

mirtazapine + baclofen intrathecal

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• benazepril
Remeron (mirtazapine)

+

benazepril

1 interaction

Monitor/Modify Tx

mirtazapine + benazepril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• berberine
Remeron (mirtazapine)

+

berberine

1 interaction

Monitor/Modify Tx

mirtazapine + berberine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• betaxolol
Remeron (mirtazapine)

+

betaxolol

1 interaction

Monitor/Modify Tx

mirtazapine + betaxolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• betaxolol ophthalmic
Remeron (mirtazapine)

+

betaxolol ophthalmic

1 interaction

Monitor/Modify Tx

mirtazapine + betaxolol ophthalmic

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• bethanechol
Remeron (mirtazapine)

+

bethanechol

1 interaction

Monitor/Modify Tx

mirtazapine + bethanechol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• bexagliflozin
Remeron (mirtazapine)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

mirtazapine + bexagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• bisoprolol
Remeron (mirtazapine)

+

bisoprolol

1 interaction

Monitor/Modify Tx

mirtazapine + bisoprolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• bortezomib
Remeron (mirtazapine)

+

bortezomib

1 interaction

Monitor/Modify Tx

mirtazapine + bortezomib

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• bosentan
Remeron (mirtazapine)

+

bosentan

1 interaction

Monitor/Modify Tx

mirtazapine + bosentan

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• brexpiprazole
Remeron (mirtazapine)

+

brexpiprazole

1 interaction

Monitor/Modify Tx

mirtazapine + brexpiprazole

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• brimonidine ophthalmic
Remeron (mirtazapine)

+

brimonidine ophthalmic

1 interaction

Monitor/Modify Tx

mirtazapine + brimonidine ophthalmic

if elevated IOP use, monitor BP, consider decr. dose of one or both drugs; OTC ocular redness use OK: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• brimonidine topical
Remeron (mirtazapine)

+

brimonidine topical

1 interaction

Monitor/Modify Tx

mirtazapine + brimonidine topical

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• brivaracetam
Remeron (mirtazapine)

+

brivaracetam

1 interaction

Monitor/Modify Tx

mirtazapine + brivaracetam

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• brompheniramine
Remeron (mirtazapine)

+

brompheniramine

1 interaction

Monitor/Modify Tx

mirtazapine + brompheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• bumetanide
Remeron (mirtazapine)

+

bumetanide

1 interaction

Monitor/Modify Tx

mirtazapine + bumetanide

monitor sodium, BP: combo may incr. risk of hyponatremia, hypotension, incl. orthostasis (additive effects)

• bupivacaine
Remeron (mirtazapine)

+

bupivacaine

1 interaction

Monitor/Modify Tx

mirtazapine + bupivacaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• bupivacaine liposomal
Remeron (mirtazapine)

+

bupivacaine liposomal

1 interaction

Monitor/Modify Tx

mirtazapine + bupivacaine liposomal

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• bupropion
Remeron (mirtazapine)

+

bupropion

1 interaction

Monitor/Modify Tx

mirtazapine + bupropion

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• cabergoline
Remeron (mirtazapine)

+

cabergoline

1 interaction

Monitor/Modify Tx

mirtazapine + cabergoline

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• cabozantinib
Remeron (mirtazapine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

mirtazapine + cabozantinib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• canagliflozin
Remeron (mirtazapine)

+

canagliflozin

1 interaction

Monitor/Modify Tx

mirtazapine + canagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• candesartan cilexetil
Remeron (mirtazapine)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

mirtazapine + candesartan cilexetil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• cannabidiol
Remeron (mirtazapine)

+

cannabidiol

1 interaction

Monitor/Modify Tx

mirtazapine + cannabidiol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• cannabis
Remeron (mirtazapine)

+

cannabis

1 interaction

Monitor/Modify Tx

mirtazapine + cannabis

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• captopril
Remeron (mirtazapine)

+

captopril

1 interaction

Monitor/Modify Tx

mirtazapine + captopril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• carbinoxamine
Remeron (mirtazapine)

+

carbinoxamine

1 interaction

Monitor/Modify Tx

mirtazapine + carbinoxamine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• cariprazine
Remeron (mirtazapine)

+

cariprazine

1 interaction

Monitor/Modify Tx

mirtazapine + cariprazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• carisoprodol
Remeron (mirtazapine)

+

carisoprodol

1 interaction

Monitor/Modify Tx

mirtazapine + carisoprodol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carteolol ophthalmic
Remeron (mirtazapine)

+

carteolol ophthalmic

1 interaction

Monitor/Modify Tx

mirtazapine + carteolol ophthalmic

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• carvedilol
Remeron (mirtazapine)

+

carvedilol

1 interaction

Monitor/Modify Tx

mirtazapine + carvedilol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• cenobamate
Remeron (mirtazapine)

+

cenobamate

1 interaction

Monitor/Modify Tx

mirtazapine + cenobamate

consider decr. dose of one or both drugs: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• cetirizine
Remeron (mirtazapine)

+

cetirizine

1 interaction

Monitor/Modify Tx

mirtazapine + cetirizine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chamomile, German
Remeron (mirtazapine)

+

chamomile, German

1 interaction

Monitor/Modify Tx

mirtazapine + chamomile, German

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Remeron (mirtazapine)

+

chlophedianol

1 interaction

Monitor/Modify Tx

mirtazapine + chlophedianol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chloramphenicol
Remeron (mirtazapine)

+

chloramphenicol

1 interaction

Monitor/Modify Tx

mirtazapine + chloramphenicol

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• chlordiazepoxide
Remeron (mirtazapine)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

mirtazapine + chlordiazepoxide

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chloroprocaine
Remeron (mirtazapine)

+

chloroprocaine

1 interaction

Monitor/Modify Tx

mirtazapine + chloroprocaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• chloroquine
Remeron (mirtazapine)

+

chloroquine

1 interaction

Monitor/Modify Tx

mirtazapine + chloroquine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• chlorothiazide
Remeron (mirtazapine)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

mirtazapine + chlorothiazide

monitor sodium, BP: combo may incr. risk of hyponatremia, seizures, hypotension, incl. orthostasis (additive effects)

• chlorpheniramine
Remeron (mirtazapine)

+

chlorpheniramine

1 interaction

Monitor/Modify Tx

mirtazapine + chlorpheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorpromazine
Remeron (mirtazapine)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

mirtazapine + chlorpromazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis, syncope (additive effects)

• chlorthalidone
Remeron (mirtazapine)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

mirtazapine + chlorthalidone

monitor sodium, BP: combo may incr. risk of hyponatremia, hypotension, incl. orthostasis (additive effects)

• chlorzoxazone
Remeron (mirtazapine)

+

chlorzoxazone

1 interaction

Monitor/Modify Tx

mirtazapine + chlorzoxazone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cilostazol
Remeron (mirtazapine)

+

cilostazol

1 interaction

Monitor/Modify Tx

mirtazapine + cilostazol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• cimetidine
Remeron (mirtazapine)

+

cimetidine

1 interaction

Monitor/Modify Tx

mirtazapine + cimetidine

monitor ECG, consider decr. mirtazapine dose: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• ciprofloxacin
Remeron (mirtazapine)

+

ciprofloxacin

1 interaction

Monitor/Modify Tx

mirtazapine + ciprofloxacin

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• cisplatin
Remeron (mirtazapine)

+

cisplatin

1 interaction

Monitor/Modify Tx

mirtazapine + cisplatin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• clarithromycin
Remeron (mirtazapine)

+

clarithromycin

1 interaction

Monitor/Modify Tx

mirtazapine + clarithromycin

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, additive effects)

• clemastine
Remeron (mirtazapine)

+

clemastine

1 interaction

Monitor/Modify Tx

mirtazapine + clemastine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clevidipine
Remeron (mirtazapine)

+

clevidipine

1 interaction

Monitor/Modify Tx

mirtazapine + clevidipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• clobazam
Remeron (mirtazapine)

+

clobazam

1 interaction

Monitor/Modify Tx

mirtazapine + clobazam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• clofarabine
Remeron (mirtazapine)

+

clofarabine

1 interaction

Monitor/Modify Tx

mirtazapine + clofarabine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis (additive effects)

• clofazimine
Remeron (mirtazapine)

+

clofazimine

1 interaction

Monitor/Modify Tx

mirtazapine + clofazimine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clonazepam
Remeron (mirtazapine)

+

clonazepam

1 interaction

Monitor/Modify Tx

mirtazapine + clonazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• clorazepate
Remeron (mirtazapine)

+

clorazepate

1 interaction

Monitor/Modify Tx

mirtazapine + clorazepate

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• cobicistat
Remeron (mirtazapine)

+

cobicistat

1 interaction

Monitor/Modify Tx

mirtazapine + cobicistat

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• coenzyme Q-10
Remeron (mirtazapine)

+

coenzyme Q-10

1 interaction

Monitor/Modify Tx

mirtazapine + coenzyme Q-10

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• cyclophosphamide
Remeron (mirtazapine)

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

mirtazapine + cyclophosphamide

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• cyproheptadine
Remeron (mirtazapine)

+

cyproheptadine

1 interaction

Monitor/Modify Tx

mirtazapine + cyproheptadine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dabrafenib
Remeron (mirtazapine)

+

dabrafenib

1 interaction

Monitor/Modify Tx

mirtazapine + dabrafenib

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• dantrolene
Remeron (mirtazapine)

+

dantrolene

1 interaction

Monitor/Modify Tx

mirtazapine + dantrolene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dapagliflozin
Remeron (mirtazapine)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

mirtazapine + dapagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• daridorexant
Remeron (mirtazapine)

+

daridorexant

1 interaction

Monitor/Modify Tx

mirtazapine + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Remeron (mirtazapine)

+

darifenacin

1 interaction

Monitor/Modify Tx

mirtazapine + darifenacin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• degarelix
Remeron (mirtazapine)

+

degarelix

1 interaction

Monitor/Modify Tx

mirtazapine + degarelix

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• denileukin diftitox
Remeron (mirtazapine)

+

denileukin diftitox

1 interaction

Monitor/Modify Tx

mirtazapine + denileukin diftitox

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• desflurane
Remeron (mirtazapine)

+

desflurane

1 interaction

Monitor/Modify Tx

mirtazapine + desflurane

monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis), CNS and resp. depression, psychomotor impairment (additive effects)

• desmopressin
Remeron (mirtazapine)

+

desmopressin

1 interaction

Monitor/Modify Tx

mirtazapine + desmopressin

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• deutetrabenazine
Remeron (mirtazapine)

+

deutetrabenazine

1 interaction

Monitor/Modify Tx

mirtazapine + deutetrabenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Remeron (mirtazapine)

+

dexbrompheniramine

1 interaction

Monitor/Modify Tx

mirtazapine + dexbrompheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexchlorpheniramine
Remeron (mirtazapine)

+

dexchlorpheniramine

1 interaction

Monitor/Modify Tx

mirtazapine + dexchlorpheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexmedetomidine
Remeron (mirtazapine)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

mirtazapine + dexmedetomidine

monitor BP, HR, ECG, electrolytes; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Remeron (mirtazapine)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

mirtazapine + dexmedetomidine injection

monitor ECG, BP, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and resp. depression, psychomotor impairment, severe or life-threatening hypotension, incl. orthostasis (additive effects)

• diazepam
Remeron (mirtazapine)

+

diazepam

1 interaction

Monitor/Modify Tx

mirtazapine + diazepam

monitor resp. rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• dichlorphenamide
Remeron (mirtazapine)

+

dichlorphenamide

1 interaction

Monitor/Modify Tx

mirtazapine + dichlorphenamide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difelikefalin
Remeron (mirtazapine)

+

difelikefalin

1 interaction

Monitor/Modify Tx

mirtazapine + difelikefalin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Remeron (mirtazapine)

+

difenoxin

1 interaction

Monitor/Modify Tx

mirtazapine + difenoxin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

• diltiazem
Remeron (mirtazapine)

+

diltiazem

1 interaction

Monitor/Modify Tx

mirtazapine + diltiazem

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• dimenhydrinate
Remeron (mirtazapine)

+

dimenhydrinate

1 interaction

Monitor/Modify Tx

mirtazapine + dimenhydrinate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dinutuximab
Remeron (mirtazapine)

+

dinutuximab

1 interaction

Monitor/Modify Tx

mirtazapine + dinutuximab

monitor sodium, BP: combo may incr. risk of severe hyponatremia, severe hypotension, incl. orthostasis (additive effects)

• diphenhydramine
Remeron (mirtazapine)

+

diphenhydramine

1 interaction

Monitor/Modify Tx

mirtazapine + diphenhydramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• diphenoxylate
Remeron (mirtazapine)

+

diphenoxylate

1 interaction

Monitor/Modify Tx

mirtazapine + diphenoxylate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dipyridamole
Remeron (mirtazapine)

+

dipyridamole

1 interaction

Monitor/Modify Tx

mirtazapine + dipyridamole

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis (additive effects)

• disopyramide
Remeron (mirtazapine)

+

disopyramide

1 interaction

Monitor/Modify Tx

mirtazapine + disopyramide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, anticholinergic adverse effects (additive effects)

• dofetilide
Remeron (mirtazapine)

+

dofetilide

1 interaction

Monitor/Modify Tx

mirtazapine + dofetilide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• donepezil
Remeron (mirtazapine)

+

donepezil

1 interaction

Monitor/Modify Tx

mirtazapine + donepezil

monitor ECG: combo may decr. efficacy of both drugs; may incr. risk of QT prolongation, cardiac arrhythmias (antagonistic effects; additive effects)

• dordaviprone
Remeron (mirtazapine)

+

dordaviprone

1 interaction

Monitor/Modify Tx

mirtazapine + dordaviprone

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• doxazosin
Remeron (mirtazapine)

+

doxazosin

1 interaction

Monitor/Modify Tx

mirtazapine + doxazosin

monitor BP, especially during doxazosin initiation/titration: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• dronabinol
Remeron (mirtazapine)

+

dronabinol

1 interaction

Monitor/Modify Tx

mirtazapine + dronabinol

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• droperidol
Remeron (mirtazapine)

+

droperidol

1 interaction

Monitor/Modify Tx

mirtazapine + droperidol

monitor ECG; decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• efavirenz
Remeron (mirtazapine)

+

efavirenz

1 interaction

Monitor/Modify Tx

mirtazapine + efavirenz

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• empagliflozin
Remeron (mirtazapine)

+

empagliflozin

1 interaction

Monitor/Modify Tx

mirtazapine + empagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• enalapril
Remeron (mirtazapine)

+

enalapril

1 interaction

Monitor/Modify Tx

mirtazapine + enalapril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• enalaprilat
Remeron (mirtazapine)

+

enalaprilat

1 interaction

Monitor/Modify Tx

mirtazapine + enalaprilat

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• enasidenib
Remeron (mirtazapine)

+

enasidenib

1 interaction

Monitor/Modify Tx

mirtazapine + enasidenib

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• encorafenib
Remeron (mirtazapine)

+

encorafenib

1 interaction

Monitor/Modify Tx

mirtazapine + encorafenib

monitor ECG, electrolytes; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metab. induced; additive effects)

• entacapone
Remeron (mirtazapine)

+

entacapone

1 interaction

Monitor/Modify Tx

mirtazapine + entacapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• entrectinib
Remeron (mirtazapine)

+

entrectinib

1 interaction

Monitor/Modify Tx

mirtazapine + entrectinib

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• enzalutamide
Remeron (mirtazapine)

+

enzalutamide

1 interaction

Monitor/Modify Tx

mirtazapine + enzalutamide

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• epirubicin
Remeron (mirtazapine)

+

epirubicin

1 interaction

Monitor/Modify Tx

mirtazapine + epirubicin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• eplerenone
Remeron (mirtazapine)

+

eplerenone

1 interaction

Monitor/Modify Tx

mirtazapine + eplerenone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• epoprostenol
Remeron (mirtazapine)

+

epoprostenol

1 interaction

Monitor/Modify Tx

mirtazapine + epoprostenol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis (additive effects)

• ertugliflozin
Remeron (mirtazapine)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

mirtazapine + ertugliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• erythromycin
Remeron (mirtazapine)

+

erythromycin

1 interaction

Monitor/Modify Tx

mirtazapine + erythromycin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. erythromycin efficacy when used for GI promotility (additive effects; antagonistic effects)

• esketamine
Remeron (mirtazapine)

+

esketamine

1 interaction

Monitor/Modify Tx

mirtazapine + esketamine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Remeron (mirtazapine)

+

eslicarbazepine acetate

1 interaction

Monitor/Modify Tx

mirtazapine + eslicarbazepine acetate

monitor sodium; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyponatremia (incl. life-threatening), seizures (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• esmolol
Remeron (mirtazapine)

+

esmolol

1 interaction

Monitor/Modify Tx

mirtazapine + esmolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• estazolam
Remeron (mirtazapine)

+

estazolam

1 interaction

Monitor/Modify Tx

mirtazapine + estazolam

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eszopiclone
Remeron (mirtazapine)

+

eszopiclone

1 interaction

Monitor/Modify Tx

mirtazapine + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Remeron (mirtazapine)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

mirtazapine + ethacrynic acid

monitor sodium, BP: combo may incr. risk of hyponatremia, hypotension, incl. orthostasis (additive effects)

• ethanol (in some formulations)
Remeron (mirtazapine)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

mirtazapine + ethanol (in some formulations)

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ethosuximide
Remeron (mirtazapine)

+

ethosuximide

1 interaction

Monitor/Modify Tx

mirtazapine + ethosuximide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• etomidate
Remeron (mirtazapine)

+

etomidate

1 interaction

Monitor/Modify Tx

mirtazapine + etomidate

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• etravirine
Remeron (mirtazapine)

+

etravirine

1 interaction

Monitor/Modify Tx

mirtazapine + etravirine

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• felbamate
Remeron (mirtazapine)

+

felbamate

1 interaction

Monitor/Modify Tx

mirtazapine + felbamate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• felodipine
Remeron (mirtazapine)

+

felodipine

1 interaction

Monitor/Modify Tx

mirtazapine + felodipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• fenoldopam
Remeron (mirtazapine)

+

fenoldopam

1 interaction

Monitor/Modify Tx

mirtazapine + fenoldopam

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• ferumoxytol
Remeron (mirtazapine)

+

ferumoxytol

1 interaction

Monitor/Modify Tx

mirtazapine + ferumoxytol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• fesoterodine
Remeron (mirtazapine)

+

fesoterodine

1 interaction

Monitor/Modify Tx

mirtazapine + fesoterodine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• flaxseed
Remeron (mirtazapine)

+

flaxseed

1 interaction

Monitor/Modify Tx

mirtazapine + flaxseed

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• flecainide
Remeron (mirtazapine)

+

flecainide

1 interaction

Monitor/Modify Tx

mirtazapine + flecainide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• flibanserin
Remeron (mirtazapine)

+

flibanserin

1 interaction

Monitor/Modify Tx

mirtazapine + flibanserin

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• fluorouracil
Remeron (mirtazapine)

+

fluorouracil

1 interaction

Monitor/Modify Tx

mirtazapine + fluorouracil

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fluphenazine
Remeron (mirtazapine)

+

fluphenazine

1 interaction

Monitor/Modify Tx

mirtazapine + fluphenazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• flurazepam
Remeron (mirtazapine)

+

flurazepam

1 interaction

Monitor/Modify Tx

mirtazapine + flurazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fosinopril
Remeron (mirtazapine)

+

fosinopril

1 interaction

Monitor/Modify Tx

mirtazapine + fosinopril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• foslevodopa
Remeron (mirtazapine)

+

foslevodopa

1 interaction

Monitor/Modify Tx

mirtazapine + foslevodopa

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• fosphenytoin
Remeron (mirtazapine)

+

fosphenytoin

1 interaction

Monitor/Modify Tx

mirtazapine + fosphenytoin

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• furosemide
Remeron (mirtazapine)

+

furosemide

1 interaction

Monitor/Modify Tx

mirtazapine + furosemide

monitor sodium, BP: combo may incr. risk of hyponatremia, hypotension, incl. orthostasis (additive effects)

• gabapentin
Remeron (mirtazapine)

+

gabapentin

1 interaction

Monitor/Modify Tx

mirtazapine + gabapentin

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• gabapentin enacarbil
Remeron (mirtazapine)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

mirtazapine + gabapentin enacarbil

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ganaxolone
Remeron (mirtazapine)

+

ganaxolone

1 interaction

Monitor/Modify Tx

mirtazapine + ganaxolone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• garlic
Remeron (mirtazapine)

+

garlic

1 interaction

Monitor/Modify Tx

mirtazapine + garlic

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• gilteritinib
Remeron (mirtazapine)

+

gilteritinib

1 interaction

Monitor/Modify Tx

mirtazapine + gilteritinib

monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis (additive effects)

• glasdegib
Remeron (mirtazapine)

+

glasdegib

1 interaction

Monitor/Modify Tx

mirtazapine + glasdegib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• glofitamab
Remeron (mirtazapine)

+

glofitamab

1 interaction

Monitor/Modify Tx

mirtazapine + glofitamab

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate
Remeron (mirtazapine)

+

glycopyrrolate

1 interaction

Monitor/Modify Tx

mirtazapine + glycopyrrolate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• goserelin
Remeron (mirtazapine)

+

goserelin

1 interaction

Monitor/Modify Tx

mirtazapine + goserelin

PROSTATE CANCER: monitor ECG, electrolytes; ALL OTHER INDICATIONS: consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• guanfacine
Remeron (mirtazapine)

+

guanfacine

1 interaction

Monitor/Modify Tx

mirtazapine + guanfacine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• haloperidol
Remeron (mirtazapine)

+

haloperidol

1 interaction

Monitor/Modify Tx

mirtazapine + haloperidol

monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis), CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• histrelin
Remeron (mirtazapine)

+

histrelin

1 interaction

Monitor/Modify Tx

mirtazapine + histrelin

consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• hydralazine
Remeron (mirtazapine)

+

hydralazine

1 interaction

Monitor/Modify Tx

mirtazapine + hydralazine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• hydrochlorothiazide
Remeron (mirtazapine)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

mirtazapine + hydrochlorothiazide

monitor sodium, BP: combo may incr. hydrochlorothiazide levels, risk of hyponatremia, hypotension (incl. orthostasis), other adverse effects (absorption increased, additive effects)

• hydroxyzine
Remeron (mirtazapine)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

mirtazapine + hydroxyzine

monitor ECG; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• hyoscyamine
Remeron (mirtazapine)

+

hyoscyamine

1 interaction

Monitor/Modify Tx

mirtazapine + hyoscyamine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ibutilide
Remeron (mirtazapine)

+

ibutilide

1 interaction

Monitor/Modify Tx

mirtazapine + ibutilide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• idelalisib
Remeron (mirtazapine)

+

idelalisib

1 interaction

Monitor/Modify Tx

mirtazapine + idelalisib

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• ifosfamide
Remeron (mirtazapine)

+

ifosfamide

1 interaction

Monitor/Modify Tx

mirtazapine + ifosfamide

monitor sodium; consider decr. mirtazapine dose, D/C one or both drugs if encephalopathy occurs: combo may incr. risk of hyponatremia, CNS depression, psychomotor impairment (additive effects)

• iloperidone
Remeron (mirtazapine)

+

iloperidone

1 interaction

Monitor/Modify Tx

mirtazapine + iloperidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• iloprost
Remeron (mirtazapine)

+

iloprost

1 interaction

Monitor/Modify Tx

mirtazapine + iloprost

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis (additive effects)

• iloprost inhaled
Remeron (mirtazapine)

+

iloprost inhaled

1 interaction

Monitor/Modify Tx

mirtazapine + iloprost inhaled

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• indapamide
Remeron (mirtazapine)

+

indapamide

1 interaction

Monitor/Modify Tx

mirtazapine + indapamide

monitor sodium, BP: combo may incr. risk of severe hyponatremia, hypotension, incl. orthostasis (additive effects)

• inotuzumab ozogamicin
Remeron (mirtazapine)

+

inotuzumab ozogamicin

1 interaction

Monitor/Modify Tx

mirtazapine + inotuzumab ozogamicin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• iopamidol
Remeron (mirtazapine)

+

iopamidol

1 interaction

Monitor/Modify Tx

mirtazapine + iopamidol

caution advised if intrathecal iopamidol use; consider holding mirtazapine at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• irbesartan
Remeron (mirtazapine)

+

irbesartan

1 interaction

Monitor/Modify Tx

mirtazapine + irbesartan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• iron sucrose
Remeron (mirtazapine)

+

iron sucrose

1 interaction

Monitor/Modify Tx

mirtazapine + iron sucrose

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• isoflurane
Remeron (mirtazapine)

+

isoflurane

1 interaction

Monitor/Modify Tx

mirtazapine + isoflurane

monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis), CNS and resp. depression, psychomotor impairment (additive effects)

• isosorbide dinitrate
Remeron (mirtazapine)

+

isosorbide dinitrate

1 interaction

Monitor/Modify Tx

mirtazapine + isosorbide dinitrate

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• isosorbide mononitrate
Remeron (mirtazapine)

+

isosorbide mononitrate

1 interaction

Monitor/Modify Tx

mirtazapine + isosorbide mononitrate

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• isradipine
Remeron (mirtazapine)

+

isradipine

1 interaction

Monitor/Modify Tx

mirtazapine + isradipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• itraconazole
Remeron (mirtazapine)

+

itraconazole

1 interaction

Monitor/Modify Tx

mirtazapine + itraconazole

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• ivosidenib
Remeron (mirtazapine)

+

ivosidenib

1 interaction

Monitor/Modify Tx

mirtazapine + ivosidenib

monitor ECG, electrolytes; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metab. induced; additive effects)

• ketamine
Remeron (mirtazapine)

+

ketamine

1 interaction

Monitor/Modify Tx

mirtazapine + ketamine

monitor resp. rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment (additive effects)

• ketoconazole
Remeron (mirtazapine)

+

ketoconazole

1 interaction

Monitor/Modify Tx

mirtazapine + ketoconazole

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• labetalol
Remeron (mirtazapine)

+

labetalol

1 interaction

Monitor/Modify Tx

mirtazapine + labetalol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• lacosamide
Remeron (mirtazapine)

+

lacosamide

1 interaction

Monitor/Modify Tx

mirtazapine + lacosamide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• lamotrigine
Remeron (mirtazapine)

+

lamotrigine

1 interaction

Monitor/Modify Tx

mirtazapine + lamotrigine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• landiolol
Remeron (mirtazapine)

+

landiolol

1 interaction

Monitor/Modify Tx

mirtazapine + landiolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• lemborexant
Remeron (mirtazapine)

+

lemborexant

1 interaction

Monitor/Modify Tx

mirtazapine + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• leuprolide
Remeron (mirtazapine)

+

leuprolide

1 interaction

Monitor/Modify Tx

mirtazapine + leuprolide

PROSTATE CANCER: monitor ECG, electrolytes; ALL OTHER INDICATIONS: consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• levetiracetam
Remeron (mirtazapine)

+

levetiracetam

1 interaction

Monitor/Modify Tx

mirtazapine + levetiracetam

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• levobunolol ophthalmic
Remeron (mirtazapine)

+

levobunolol ophthalmic

1 interaction

Monitor/Modify Tx

mirtazapine + levobunolol ophthalmic

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• levocetirizine
Remeron (mirtazapine)

+

levocetirizine

1 interaction

Monitor/Modify Tx

mirtazapine + levocetirizine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Remeron (mirtazapine)

+

levodopa

1 interaction

Monitor/Modify Tx

mirtazapine + levodopa

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• levofloxacin
Remeron (mirtazapine)

+

levofloxacin

1 interaction

Monitor/Modify Tx

mirtazapine + levofloxacin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levoketoconazole
Remeron (mirtazapine)

+

levoketoconazole

1 interaction

Monitor/Modify Tx

mirtazapine + levoketoconazole

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, additive effects)

• lidocaine
Remeron (mirtazapine)

+

lidocaine

1 interaction

Monitor/Modify Tx

mirtazapine + lidocaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• linvoseltamab
Remeron (mirtazapine)

+

linvoseltamab

1 interaction

Monitor/Modify Tx

mirtazapine + linvoseltamab

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lisinopril
Remeron (mirtazapine)

+

lisinopril

1 interaction

Monitor/Modify Tx

mirtazapine + lisinopril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• lopinavir/ritonavir
Remeron (mirtazapine)

+

lopinavir/ ritonavir

1 interaction

Monitor/Modify Tx

mirtazapine + lopinavir/ ritonavir

monitor ECG; consider mirtazapine dose adjustment: combo may incr. or decr. mirtazapine levels, incr. risk of QT prolongation, cardiac arrhythmias, other adverse effects or decr. efficacy (hepatic metab. altered)

• lorazepam
Remeron (mirtazapine)

+

lorazepam

1 interaction

Monitor/Modify Tx

mirtazapine + lorazepam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• lorlatinib
Remeron (mirtazapine)

+

lorlatinib

1 interaction

Monitor/Modify Tx

mirtazapine + lorlatinib

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• losartan
Remeron (mirtazapine)

+

losartan

1 interaction

Monitor/Modify Tx

mirtazapine + losartan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• loxapine
Remeron (mirtazapine)

+

loxapine

1 interaction

Monitor/Modify Tx

mirtazapine + loxapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis, syncope (additive effects)

• lubiprostone
Remeron (mirtazapine)

+

lubiprostone

1 interaction

Monitor/Modify Tx

mirtazapine + lubiprostone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• lumacaftor/ivacaftor
Remeron (mirtazapine)

+

lumacaftor/ ivacaftor

1 interaction

Monitor/Modify Tx

mirtazapine + lumacaftor/ ivacaftor

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• lumateperone
Remeron (mirtazapine)

+

lumateperone

1 interaction

Monitor/Modify Tx

mirtazapine + lumateperone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• lurasidone
Remeron (mirtazapine)

+

lurasidone

1 interaction

Monitor/Modify Tx

mirtazapine + lurasidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, hyperthermia (additive effects)

• macimorelin
Remeron (mirtazapine)

+

macimorelin

1 interaction

Monitor/Modify Tx

mirtazapine + macimorelin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• magnesium citrate
Remeron (mirtazapine)

+

magnesium citrate

1 interaction

Monitor/Modify Tx

mirtazapine + magnesium citrate

monitor sodium, especially if magnesium citrate bowel prep use: combo may incr. risk of hyponatremia, seizures (additive effects)

• magnesium sulfate
Remeron (mirtazapine)

+

magnesium sulfate

1 interaction

Monitor/Modify Tx

mirtazapine + magnesium sulfate

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• mannitol
Remeron (mirtazapine)

+

mannitol

1 interaction

Monitor/Modify Tx

mirtazapine + mannitol

monitor sodium: combo may incr. risk of hyponatremia (incl. life-threatening), seizures (additive effects)

• maraviroc
Remeron (mirtazapine)

+

maraviroc

1 interaction

Monitor/Modify Tx

mirtazapine + maraviroc

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• mavacamten
Remeron (mirtazapine)

+

mavacamten

1 interaction

Monitor/Modify Tx

mirtazapine + mavacamten

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• meclizine
Remeron (mirtazapine)

+

meclizine

1 interaction

Monitor/Modify Tx

mirtazapine + meclizine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• melatonin
Remeron (mirtazapine)

+

melatonin

1 interaction

Monitor/Modify Tx

mirtazapine + melatonin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mepivacaine
Remeron (mirtazapine)

+

mepivacaine

1 interaction

Monitor/Modify Tx

mirtazapine + mepivacaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• meprobamate
Remeron (mirtazapine)

+

meprobamate

1 interaction

Monitor/Modify Tx

mirtazapine + meprobamate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methocarbamol
Remeron (mirtazapine)

+

methocarbamol

1 interaction

Monitor/Modify Tx

mirtazapine + methocarbamol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methohexital
Remeron (mirtazapine)

+

methohexital

1 interaction

Monitor/Modify Tx

mirtazapine + methohexital

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• methsuximide
Remeron (mirtazapine)

+

methsuximide

1 interaction

Monitor/Modify Tx

mirtazapine + methsuximide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• methyldopa
Remeron (mirtazapine)

+

methyldopa

1 interaction

Monitor/Modify Tx

mirtazapine + methyldopa

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• metolazone
Remeron (mirtazapine)

+

metolazone

1 interaction

Monitor/Modify Tx

mirtazapine + metolazone

monitor sodium, BP: combo may incr. risk of hyponatremia (incl. life-threatening), hypotension, incl. orthostasis (additive effects)

• metoprolol
Remeron (mirtazapine)

+

metoprolol

1 interaction

Monitor/Modify Tx

mirtazapine + metoprolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• metyrapone
Remeron (mirtazapine)

+

metyrapone

1 interaction

Monitor/Modify Tx

mirtazapine + metyrapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Remeron (mirtazapine)

+

metyrosine

1 interaction

Monitor/Modify Tx

mirtazapine + metyrosine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mifepristone
Remeron (mirtazapine)

+

mifepristone

1 interaction

Monitor/Modify Tx

mirtazapine + mifepristone

monitor ECG during and x14 days after daily mifepristone use: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• milrinone
Remeron (mirtazapine)

+

milrinone

1 interaction

Monitor/Modify Tx

mirtazapine + milrinone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• minoxidil
Remeron (mirtazapine)

+

minoxidil

1 interaction

Monitor/Modify Tx

mirtazapine + minoxidil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• mitapivat
Remeron (mirtazapine)

+

mitapivat

1 interaction

Monitor/Modify Tx

mirtazapine + mitapivat

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• mitotane
Remeron (mirtazapine)

+

mitotane

1 interaction

Monitor/Modify Tx

mirtazapine + mitotane

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• modafinil
Remeron (mirtazapine)

+

modafinil

1 interaction

Monitor/Modify Tx

mirtazapine + modafinil

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• moexipril
Remeron (mirtazapine)

+

moexipril

1 interaction

Monitor/Modify Tx

mirtazapine + moexipril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• molindone
Remeron (mirtazapine)

+

molindone

1 interaction

Monitor/Modify Tx

mirtazapine + molindone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• mosunetuzumab
Remeron (mirtazapine)

+

mosunetuzumab

1 interaction

Monitor/Modify Tx

mirtazapine + mosunetuzumab

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• moxifloxacin
Remeron (mirtazapine)

+

moxifloxacin

1 interaction

Monitor/Modify Tx

mirtazapine + moxifloxacin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• mycophenolate mofetil
Remeron (mirtazapine)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

mirtazapine + mycophenolate mofetil

consider decr. mirtazapine dose: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nadolol
Remeron (mirtazapine)

+

nadolol

1 interaction

Monitor/Modify Tx

mirtazapine + nadolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nafcillin
Remeron (mirtazapine)

+

nafcillin

1 interaction

Monitor/Modify Tx

mirtazapine + nafcillin

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• naltrexone
Remeron (mirtazapine)

+

naltrexone

1 interaction

Monitor/Modify Tx

mirtazapine + naltrexone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nattokinase
Remeron (mirtazapine)

+

nattokinase

1 interaction

Monitor/Modify Tx

mirtazapine + nattokinase

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• naxitamab
Remeron (mirtazapine)

+

naxitamab

1 interaction

Monitor/Modify Tx

mirtazapine + naxitamab

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nebivolol
Remeron (mirtazapine)

+

nebivolol

1 interaction

Monitor/Modify Tx

mirtazapine + nebivolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nelarabine
Remeron (mirtazapine)

+

nelarabine

1 interaction

Monitor/Modify Tx

mirtazapine + nelarabine

consider decr. mirtazapine dose; withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nelfinavir
Remeron (mirtazapine)

+

nelfinavir

1 interaction

Monitor/Modify Tx

mirtazapine + nelfinavir

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• niacin (vitamin B3)
Remeron (mirtazapine)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

mirtazapine + niacin (vitamin B3)

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nicardipine
Remeron (mirtazapine)

+

nicardipine

1 interaction

Monitor/Modify Tx

mirtazapine + nicardipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nifedipine
Remeron (mirtazapine)

+

nifedipine

1 interaction

Monitor/Modify Tx

mirtazapine + nifedipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nilotinib
Remeron (mirtazapine)

+

nilotinib

1 interaction

Monitor/Modify Tx

mirtazapine + nilotinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, hyponatremia (additive effects)

• nimodipine
Remeron (mirtazapine)

+

nimodipine

1 interaction

Monitor/Modify Tx

mirtazapine + nimodipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nisoldipine
Remeron (mirtazapine)

+

nisoldipine

1 interaction

Monitor/Modify Tx

mirtazapine + nisoldipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nitric oxide
Remeron (mirtazapine)

+

nitric oxide

1 interaction

Monitor/Modify Tx

mirtazapine + nitric oxide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nitrite
Remeron (mirtazapine)

+

nitrite

1 interaction

Monitor/Modify Tx

mirtazapine + nitrite

monitor BP: combo may incr. risk of severe or life-threatening hypotension, incl. syncope (additive effects)

• nitroglycerin
Remeron (mirtazapine)

+

nitroglycerin

1 interaction

Monitor/Modify Tx

mirtazapine + nitroglycerin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nitroprusside
Remeron (mirtazapine)

+

nitroprusside

1 interaction

Monitor/Modify Tx

mirtazapine + nitroprusside

monitor BP: combo may incr. risk of severe or life-threatening hypotension, incl. orthostasis (additive effects)

• obinutuzumab
Remeron (mirtazapine)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

mirtazapine + obinutuzumab

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• olanzapine
Remeron (mirtazapine)

+

olanzapine

1 interaction

Monitor/Modify Tx

mirtazapine + olanzapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus (incl. life-threatening), other anticholinergic adverse effects (additive effects)

• olmesartan medoxomil
Remeron (mirtazapine)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

mirtazapine + olmesartan medoxomil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• opicapone
Remeron (mirtazapine)

+

opicapone

1 interaction

Monitor/Modify Tx

mirtazapine + opicapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• orphenadrine
Remeron (mirtazapine)

+

orphenadrine

1 interaction

Monitor/Modify Tx

mirtazapine + orphenadrine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• osimertinib
Remeron (mirtazapine)

+

osimertinib

1 interaction

Monitor/Modify Tx

mirtazapine + osimertinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oxazepam
Remeron (mirtazapine)

+

oxazepam

1 interaction

Monitor/Modify Tx

mirtazapine + oxazepam

monitor resp. rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• oxcarbazepine
Remeron (mirtazapine)

+

oxcarbazepine

1 interaction

Monitor/Modify Tx

mirtazapine + oxcarbazepine

monitor sodium; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyponatremia, seizures (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• oxybutynin
Remeron (mirtazapine)

+

oxybutynin

1 interaction

Monitor/Modify Tx

mirtazapine + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxytocin
Remeron (mirtazapine)

+

oxytocin

1 interaction

Monitor/Modify Tx

mirtazapine + oxytocin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• pacritinib
Remeron (mirtazapine)

+

pacritinib

1 interaction

Monitor/Modify Tx

mirtazapine + pacritinib

monitor ECG, electrolytes; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metab. induced; additive effects)

• paliperidone
Remeron (mirtazapine)

+

paliperidone

1 interaction

Monitor/Modify Tx

mirtazapine + paliperidone

monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, hyperthermia (additive effects)

• palopegteriparatide
Remeron (mirtazapine)

+

palopegteriparatide

1 interaction

Monitor/Modify Tx

mirtazapine + palopegteriparatide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• panobinostat
Remeron (mirtazapine)

+

panobinostat

1 interaction

Monitor/Modify Tx

mirtazapine + panobinostat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pasireotide
Remeron (mirtazapine)

+

pasireotide

1 interaction

Monitor/Modify Tx

mirtazapine + pasireotide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• passion flower
Remeron (mirtazapine)

+

passion flower

1 interaction

Monitor/Modify Tx

mirtazapine + passion flower

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pentamidine
Remeron (mirtazapine)

+

pentamidine

1 interaction

Monitor/Modify Tx

mirtazapine + pentamidine

monitor ECG, BP; risk may be lower w/ nebulized pentamidine: combo may incr. risk of QT prolongation, cardiac arrhythmias, severe or life-threatening hypotension, incl. orthostasis (additive effects)

• pentobarbital
Remeron (mirtazapine)

+

pentobarbital

1 interaction

Monitor/Modify Tx

mirtazapine + pentobarbital

monitor BP, resp. rate; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (hepatic metab. induced; additive effects)

• perampanel
Remeron (mirtazapine)

+

perampanel

1 interaction

Monitor/Modify Tx

mirtazapine + perampanel

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• perindopril
Remeron (mirtazapine)

+

perindopril

1 interaction

Monitor/Modify Tx

mirtazapine + perindopril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• perphenazine
Remeron (mirtazapine)

+

perphenazine

1 interaction

Monitor/Modify Tx

mirtazapine + perphenazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, severe hypotension, incl. orthostasis, syncope (additive effects)

• pexidartinib
Remeron (mirtazapine)

+

pexidartinib

1 interaction

Monitor/Modify Tx

mirtazapine + pexidartinib

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• pheniramine
Remeron (mirtazapine)

+

pheniramine

1 interaction

Monitor/Modify Tx

mirtazapine + pheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• phenobarbital
Remeron (mirtazapine)

+

phenobarbital

1 interaction

Monitor/Modify Tx

mirtazapine + phenobarbital

monitor BP, resp. rate; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• phenoxybenzamine
Remeron (mirtazapine)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

mirtazapine + phenoxybenzamine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• phentolamine
Remeron (mirtazapine)

+

phentolamine

1 interaction

Monitor/Modify Tx

mirtazapine + phentolamine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• phenytoin
Remeron (mirtazapine)

+

phenytoin

1 interaction

Monitor/Modify Tx

mirtazapine + phenytoin

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• pindolol
Remeron (mirtazapine)

+

pindolol

1 interaction

Monitor/Modify Tx

mirtazapine + pindolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• polyethylene glycol
Remeron (mirtazapine)

+

polyethylene glycol

1 interaction

Monitor/Modify Tx

mirtazapine + polyethylene glycol

monitor sodium, especially if polyethylene glycol bowel prep use: combo may incr. risk of hyponatremia, seizures (additive effects)

• polyethylene glycol/electrolytes
Remeron (mirtazapine)

+

polyethylene glycol/ electrolytes

1 interaction

Monitor/Modify Tx

mirtazapine + polyethylene glycol/ electrolytes

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• posaconazole
Remeron (mirtazapine)

+

posaconazole

1 interaction

Monitor/Modify Tx

mirtazapine + posaconazole

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• pramipexole
Remeron (mirtazapine)

+

pramipexole

1 interaction

Monitor/Modify Tx

mirtazapine + pramipexole

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• prazosin
Remeron (mirtazapine)

+

prazosin

1 interaction

Monitor/Modify Tx

mirtazapine + prazosin

monitor BP, especially during prazosin initiation/titration: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• pregabalin
Remeron (mirtazapine)

+

pregabalin

1 interaction

Monitor/Modify Tx

mirtazapine + pregabalin

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• primidone
Remeron (mirtazapine)

+

primidone

1 interaction

Monitor/Modify Tx

mirtazapine + primidone

monitor resp. rate; consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• procainamide
Remeron (mirtazapine)

+

procainamide

1 interaction

Monitor/Modify Tx

mirtazapine + procainamide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• prochlorperazine
Remeron (mirtazapine)

+

prochlorperazine

1 interaction

Monitor/Modify Tx

mirtazapine + prochlorperazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis (additive effects)

• propafenone
Remeron (mirtazapine)

+

propafenone

1 interaction

Monitor/Modify Tx

mirtazapine + propafenone

monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis (additive effects)

• propofol
Remeron (mirtazapine)

+

propofol

1 interaction

Monitor/Modify Tx

mirtazapine + propofol

monitor resp. rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis (additive effects)

• propranolol
Remeron (mirtazapine)

+

propranolol

1 interaction

Monitor/Modify Tx

mirtazapine + propranolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• pyrilamine
Remeron (mirtazapine)

+

pyrilamine

1 interaction

Monitor/Modify Tx

mirtazapine + pyrilamine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• quazepam
Remeron (mirtazapine)

+

quazepam

1 interaction

Monitor/Modify Tx

mirtazapine + quazepam

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• quetiapine
Remeron (mirtazapine)

+

quetiapine

1 interaction

Monitor/Modify Tx

mirtazapine + quetiapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis, syncope (additive effects)

• quinapril
Remeron (mirtazapine)

+

quinapril

1 interaction

Monitor/Modify Tx

mirtazapine + quinapril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• quinidine (antiarrhythmic)
Remeron (mirtazapine)

+

quinidine (antiarrhythmic)

1 interaction

Monitor/Modify Tx

mirtazapine + quinidine (antiarrhythmic)

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, anticholinergic adverse effects (additive effects)

• quinidine (CYP2D6 inhibitor)
Remeron (mirtazapine)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Monitor/Modify Tx

mirtazapine + quinidine (CYP2D6 inhibitor)

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, anticholinergic adverse effects (additive effects)

• quinine
Remeron (mirtazapine)

+

quinine

1 interaction

Monitor/Modify Tx

mirtazapine + quinine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ramelteon
Remeron (mirtazapine)

+

ramelteon

1 interaction

Monitor/Modify Tx

mirtazapine + ramelteon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ramipril
Remeron (mirtazapine)

+

ramipril

1 interaction

Monitor/Modify Tx

mirtazapine + ramipril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• ramucirumab
Remeron (mirtazapine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

mirtazapine + ramucirumab

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• remimazolam
Remeron (mirtazapine)

+

remimazolam

1 interaction

Monitor/Modify Tx

mirtazapine + remimazolam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• repotrectinib
Remeron (mirtazapine)

+

repotrectinib

1 interaction

Monitor/Modify Tx

mirtazapine + repotrectinib

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• resveratrol
Remeron (mirtazapine)

+

resveratrol

1 interaction

Monitor/Modify Tx

mirtazapine + resveratrol

monitor ECG; consider decr. mirtazapine dose: combo may incr. mirtazapine levels, risk of adverse effects (hepatic metab. inhibited)

• revumenib
Remeron (mirtazapine)

+

revumenib

1 interaction

Monitor/Modify Tx

mirtazapine + revumenib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ribociclib
Remeron (mirtazapine)

+

ribociclib

1 interaction

Monitor/Modify Tx

mirtazapine + ribociclib

monitor ECG, electrolytes: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, additive effects)

• rifabutin
Remeron (mirtazapine)

+

rifabutin

1 interaction

Monitor/Modify Tx

mirtazapine + rifabutin

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• rifampin
Remeron (mirtazapine)

+

rifampin

1 interaction

Monitor/Modify Tx

mirtazapine + rifampin

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• rifapentine
Remeron (mirtazapine)

+

rifapentine

1 interaction

Monitor/Modify Tx

mirtazapine + rifapentine

consider mirtazapine dose adjustment: combo may decr. mirtazapine levels, efficacy (hepatic metab. induced)

• riociguat
Remeron (mirtazapine)

+

riociguat

1 interaction

Monitor/Modify Tx

mirtazapine + riociguat

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis (additive effects)

• risperidone
Remeron (mirtazapine)

+

risperidone

1 interaction

Monitor/Modify Tx

mirtazapine + risperidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• ritonavir
Remeron (mirtazapine)

+

ritonavir

1 interaction

Monitor/Modify Tx

mirtazapine + ritonavir

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• romidepsin
Remeron (mirtazapine)

+

romidepsin

1 interaction

Monitor/Modify Tx

mirtazapine + romidepsin

monitor ECG, sodium: combo may incr. risk of QT prolongation, cardiac arrhythmias, hyponatremia (additive effects)

• ropinirole
Remeron (mirtazapine)

+

ropinirole

1 interaction

Monitor/Modify Tx

mirtazapine + ropinirole

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• ropivacaine
Remeron (mirtazapine)

+

ropivacaine

1 interaction

Monitor/Modify Tx

mirtazapine + ropivacaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• rotigotine transdermal
Remeron (mirtazapine)

+

rotigotine transdermal

1 interaction

Monitor/Modify Tx

mirtazapine + rotigotine transdermal

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• rucaparib
Remeron (mirtazapine)

+

rucaparib

1 interaction

Monitor/Modify Tx

mirtazapine + rucaparib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rufinamide
Remeron (mirtazapine)

+

rufinamide

1 interaction

Monitor/Modify Tx

mirtazapine + rufinamide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• sacubitril
Remeron (mirtazapine)

+

sacubitril

1 interaction

Monitor/Modify Tx

mirtazapine + sacubitril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• scopolamine
Remeron (mirtazapine)

+

scopolamine

1 interaction

Monitor/Modify Tx

mirtazapine + scopolamine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• selinexor
Remeron (mirtazapine)

+

selinexor

1 interaction

Monitor/Modify Tx

mirtazapine + selinexor

monitor sodium; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyponatremia, incl. life-threatening (additive effects)

• selpercatinib
Remeron (mirtazapine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

mirtazapine + selpercatinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• sevoflurane
Remeron (mirtazapine)

+

sevoflurane

1 interaction

Monitor/Modify Tx

mirtazapine + sevoflurane

monitor ECG, BP, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis), CNS and resp. depression, psychomotor impairment (additive effects)

• sildenafil
Remeron (mirtazapine)

+

sildenafil

1 interaction

Monitor/Modify Tx

mirtazapine + sildenafil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• silodosin
Remeron (mirtazapine)

+

silodosin

1 interaction

Monitor/Modify Tx

mirtazapine + silodosin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• sodium ferric gluconate complex
Remeron (mirtazapine)

+

sodium ferric gluconate complex

1 interaction

Monitor/Modify Tx

mirtazapine + sodium ferric gluconate complex

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• solifenacin
Remeron (mirtazapine)

+

solifenacin

1 interaction

Monitor/Modify Tx

mirtazapine + solifenacin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• sotagliflozin
Remeron (mirtazapine)

+

sotagliflozin

1 interaction

Monitor/Modify Tx

mirtazapine + sotagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• sparsentan
Remeron (mirtazapine)

+

sparsentan

1 interaction

Monitor/Modify Tx

mirtazapine + sparsentan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• spironolactone
Remeron (mirtazapine)

+

spironolactone

1 interaction

Monitor/Modify Tx

mirtazapine + spironolactone

monitor sodium, BP: combo may incr. risk of hyponatremia, hypotension, incl. orthostasis (additive effects)

• stiripentol
Remeron (mirtazapine)

+

stiripentol

1 interaction

Monitor/Modify Tx

mirtazapine + stiripentol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• sulfate bowel prep
Remeron (mirtazapine)

+

sulfate bowel prep

1 interaction

Monitor/Modify Tx

mirtazapine + sulfate bowel prep

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• suvorexant
Remeron (mirtazapine)

+

suvorexant

1 interaction

Monitor/Modify Tx

mirtazapine + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tadalafil
Remeron (mirtazapine)

+

tadalafil

1 interaction

Monitor/Modify Tx

mirtazapine + tadalafil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• tagraxofusp
Remeron (mirtazapine)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

mirtazapine + tagraxofusp

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• taletrectinib
Remeron (mirtazapine)

+

taletrectinib

1 interaction

Monitor/Modify Tx

mirtazapine + taletrectinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tamsulosin
Remeron (mirtazapine)

+

tamsulosin

1 interaction

Monitor/Modify Tx

mirtazapine + tamsulosin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• tasimelteon
Remeron (mirtazapine)

+

tasimelteon

1 interaction

Monitor/Modify Tx

mirtazapine + tasimelteon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• taurine
Remeron (mirtazapine)

+

taurine

1 interaction

Monitor/Modify Tx

mirtazapine + taurine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• telavancin
Remeron (mirtazapine)

+

telavancin

1 interaction

Monitor/Modify Tx

mirtazapine + telavancin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• telmisartan
Remeron (mirtazapine)

+

telmisartan

1 interaction

Monitor/Modify Tx

mirtazapine + telmisartan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• temazepam
Remeron (mirtazapine)

+

temazepam

1 interaction

Monitor/Modify Tx

mirtazapine + temazepam

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• terazosin
Remeron (mirtazapine)

+

terazosin

1 interaction

Monitor/Modify Tx

mirtazapine + terazosin

monitor BP, especially during terazosin initiation/titration: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• tetrabenazine
Remeron (mirtazapine)

+

tetrabenazine

1 interaction

Monitor/Modify Tx

mirtazapine + tetrabenazine

monitor ECG; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• thiotepa
Remeron (mirtazapine)

+

thiotepa

1 interaction

Monitor/Modify Tx

mirtazapine + thiotepa

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiothixene
Remeron (mirtazapine)

+

thiothixene

1 interaction

Monitor/Modify Tx

mirtazapine + thiothixene

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, incl. orthostasis, syncope (additive effects)

• tiagabine
Remeron (mirtazapine)

+

tiagabine

1 interaction

Monitor/Modify Tx

mirtazapine + tiagabine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• timolol
Remeron (mirtazapine)

+

timolol

1 interaction

Monitor/Modify Tx

mirtazapine + timolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• timolol ophthalmic
Remeron (mirtazapine)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

mirtazapine + timolol ophthalmic

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• tipranavir
Remeron (mirtazapine)

+

tipranavir

1 interaction

Monitor/Modify Tx

mirtazapine + tipranavir

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• tizanidine
Remeron (mirtazapine)

+

tizanidine

1 interaction

Monitor/Modify Tx

mirtazapine + tizanidine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• tolcapone
Remeron (mirtazapine)

+

tolcapone

1 interaction

Monitor/Modify Tx

mirtazapine + tolcapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• tolterodine
Remeron (mirtazapine)

+

tolterodine

1 interaction

Monitor/Modify Tx

mirtazapine + tolterodine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• topiramate
Remeron (mirtazapine)

+

topiramate

1 interaction

Monitor/Modify Tx

mirtazapine + topiramate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• torsemide
Remeron (mirtazapine)

+

torsemide

1 interaction

Monitor/Modify Tx

mirtazapine + torsemide

monitor sodium, BP: combo may incr. risk of hyponatremia, hypotension, incl. orthostasis (additive effects)

• trandolapril
Remeron (mirtazapine)

+

trandolapril

1 interaction

Monitor/Modify Tx

mirtazapine + trandolapril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• treprostinil
Remeron (mirtazapine)

+

treprostinil

1 interaction

Monitor/Modify Tx

mirtazapine + treprostinil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• triamterene
Remeron (mirtazapine)

+

triamterene

1 interaction

Monitor/Modify Tx

mirtazapine + triamterene

monitor sodium, BP: combo may incr. risk of hyponatremia, hypotension, incl. orthostasis (additive effects)

• triazolam
Remeron (mirtazapine)

+

triazolam

1 interaction

Monitor/Modify Tx

mirtazapine + triazolam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• triclabendazole
Remeron (mirtazapine)

+

triclabendazole

1 interaction

Monitor/Modify Tx

mirtazapine + triclabendazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• trifluoperazine
Remeron (mirtazapine)

+

trifluoperazine

1 interaction

Monitor/Modify Tx

mirtazapine + trifluoperazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, severe hypotension, incl. orthostasis (additive effects)

• trifluridine
Remeron (mirtazapine)

+

trifluridine

1 interaction

Monitor/Modify Tx

mirtazapine + trifluridine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• trihexyphenidyl
Remeron (mirtazapine)

+

trihexyphenidyl

1 interaction

Monitor/Modify Tx

mirtazapine + trihexyphenidyl

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• triprolidine
Remeron (mirtazapine)

+

triprolidine

1 interaction

Monitor/Modify Tx

mirtazapine + triprolidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• triptorelin
Remeron (mirtazapine)

+

triptorelin

1 interaction

Monitor/Modify Tx

mirtazapine + triptorelin

PROSTATE CANCER: monitor ECG, electrolytes; ALL OTHER INDICATIONS: consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• trospium
Remeron (mirtazapine)

+

trospium

1 interaction

Monitor/Modify Tx

mirtazapine + trospium

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• tucatinib
Remeron (mirtazapine)

+

tucatinib

1 interaction

Monitor/Modify Tx

mirtazapine + tucatinib

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• valbenazine
Remeron (mirtazapine)

+

valbenazine

1 interaction

Monitor/Modify Tx

mirtazapine + valbenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Remeron (mirtazapine)

+

valerian

1 interaction

Monitor/Modify Tx

mirtazapine + valerian

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
Remeron (mirtazapine)

+

valproic acid

1 interaction

Monitor/Modify Tx

mirtazapine + valproic acid

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• valsartan
Remeron (mirtazapine)

+

valsartan

1 interaction

Monitor/Modify Tx

mirtazapine + valsartan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• vardenafil
Remeron (mirtazapine)

+

vardenafil

1 interaction

Monitor/Modify Tx

mirtazapine + vardenafil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• vasopressin
Remeron (mirtazapine)

+

vasopressin

1 interaction

Monitor/Modify Tx

mirtazapine + vasopressin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• vemurafenib
Remeron (mirtazapine)

+

vemurafenib

1 interaction

Monitor/Modify Tx

mirtazapine + vemurafenib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• verapamil
Remeron (mirtazapine)

+

verapamil

1 interaction

Monitor/Modify Tx

mirtazapine + verapamil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• vigabatrin
Remeron (mirtazapine)

+

vigabatrin

1 interaction

Monitor/Modify Tx

mirtazapine + vigabatrin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• viloxazine
Remeron (mirtazapine)

+

viloxazine

1 interaction

Monitor/Modify Tx

mirtazapine + viloxazine

monitor ECG; consider decr. dose of one or both drugs: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• voriconazole
Remeron (mirtazapine)

+

voriconazole

1 interaction

Monitor/Modify Tx

mirtazapine + voriconazole

monitor ECG: combo may incr. mirtazapine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• vosoritide
Remeron (mirtazapine)

+

vosoritide

1 interaction

Monitor/Modify Tx

mirtazapine + vosoritide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• zaleplon
Remeron (mirtazapine)

+

zaleplon

1 interaction

Monitor/Modify Tx

mirtazapine + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziconotide
Remeron (mirtazapine)

+

ziconotide

1 interaction

Monitor/Modify Tx

mirtazapine + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
Remeron (mirtazapine)

+

zolpidem

1 interaction

Monitor/Modify Tx

mirtazapine + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
Remeron (mirtazapine)

+

zonisamide

1 interaction

Monitor/Modify Tx

mirtazapine + zonisamide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• zuranolone
Remeron (mirtazapine)

+

zuranolone

1 interaction

Monitor/Modify Tx

mirtazapine + zuranolone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)