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Rezenopy
naloxone nasal
Adult Dosing .
Dosage forms: SPRAY: 10 mg per actuation
opioid overdose
- [1 actuation in one nostril x1]
- Info: may repeat dose in alternate nostrils q2-3min until pt responsive or EMS arrives
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: SPRAY: 10 mg per actuation
opioid overdose
- [1 actuation in one nostril x1]
- Info: may repeat dose in alternate nostrils q2-3min until pt responsive or EMS arrives
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: peds pts
- caution: cardiovascular dz
- caution: opioid dependence
Drug Interactions .
Overview
naloxone
opioid antagonist, central
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- ventricular tachycardia
- ventricular fibrillation
- cardiac arrest
- hypotension, severe
- pulmonary edema
- seizures
- opioid withdrawal, severe
Common Reactions
- BP incr.
- constipation
- toothache
- muscle spasms
- musculoskeletal pain
- headache
- nasal dryness
- nasal edema
- nasal congestion
- nasal inflammation
- rhinalgia
- xeroderma
- withdrawal sx
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
naloxone confused with: Lanoxin; nalbuphine; nalmefene
Pregnancy/Lactation .
Pregnancy
Clinical Summary
benefits outweigh risks during pregnancy; inadequate human data available; no known risk of teratogenicity or embryo-fetal toxicity based on animal data at 2x and 4x recommended human dose; risk of fetal and neonatal opioid withdrawal based on drug's mechanism of action
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on drug properties; no known adverse effects on milk production based on limited human data
Pharmacology .
Metabolism: liver; CYP450: unknown; UGT: 1A8, 2B7 substrate
Excretion: urine; Half-life: 1.33h
Subclass: Toxicity: Drugs
Mechanism of Action
antagonizes various opioid receptors (opioid antagonist)
Formulary .
No Formulary Selected
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