Select a medication above to begin.
Encelto (revakinagene taroretcel-lwey)
revakinagene taroretcel
Adult Dosing .
Dosage forms: IMPLANT: 200,000-440,000 retinal pigment epithelial cells
Special Note
- [formulation clarification]
- Info: nonproprietary name = revakinagene taroretcel-lwey
macular telangiectasia type 2
- [1 implant intravitreally x1]
- Info: use w/ topical antibiotic and corticosteroid, see pkg insert for dose
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to Endothelial Serum Free Media (Endo-SFM)
- ocular infection
- periocular infection
Drug Interactions .
Overview
revakinagene taroretcel
gene therapy
- antiplatelet/anticoagulant effects
Monitor/Modify Tx
- acalabrutinib
- ado-trastuzumab emtansine
- alteplase
- anacaulase topical
- anagrelide
- antithrombin
- apixaban
- argatroban
- asparaginase
- aspirin
- avapritinib
- axitinib
- bevacizumab
- binimetinib
- bivalirudin
- bromelain
- bromfenac ophthalmic
- cabozantinib
- calaspargase
- cangrelor
- caplacizumab
- carfilzomib
- celecoxib
- cilostazol
- citalopram
- clopidogrel
- dabigatran
- dalteparin
- danshen
- dasatinib
- defibrotide
- desvenlafaxine
- diclofenac
- diclofenac ophthalmic
- diclofenac topical
- diflunisal
- diosmin
- dipyridamole
- duloxetine
- edoxaban
- encorafenib
- enoxaparin
- epoprostenol
- eptifibatide
- escitalopram
- etodolac
- evening primrose oil
- fenoprofen
- fenugreek
- fluoxetine
- flurbiprofen
- flurbiprofen ophthalmic
- fluvoxamine
- fondaparinux
- fruquintinib
- garlic
- gemtuzumab ozogamicin
- ginkgo
- heparin
- ibrutinib
- ibuprofen
- ibuprofen lysine
- icosapent ethyl
- iloprost inhaled
- imatinib
- indomethacin
- ketoprofen
- ketorolac
- ketorolac ophthalmic
- lenvatinib
- levomilnacipran
- lifileucel
- meclofenamate
- mefenamic acid
- meloxicam
- methyl salicylate topical
- milnacipran
- mitotane
- nabumetone
- naproxen
- nattokinase
- nepafenac ophthalmic
- niacin (vitamin B3)
- nilotinib
- nintedanib
- nusinersen
- omega-3-acid
- oxaliplatin
- oxaprozin
- pacritinib
- paroxetine
- pazopanib
- pegaspargase
- penicillin G
- pentosan polysulfate sodium
- pentoxifylline
- piperacillin
- piroxicam
- pirtobrutinib
- plasminogen, human
- ponatinib
- pralsetinib
- prasugrel
- ramucirumab
- ranibizumab
- regorafenib
- resveratrol
- reteplase
- rivaroxaban
- saw palmetto
- selpercatinib
- selumetinib
- sertraline
- sirolimus albumin-bound
- sorafenib
- sotatercept
- sulindac
- sunitinib
- temsirolimus
- tenecteplase
- ticagrelor
- tipranavir
- tirofiban
- tisotumab vedotin
- tivozanib
- tolmetin
- tovorafenib
- trametinib
- trazodone
- treprostinil
- valproic acid
- vandetanib
- venlafaxine
- vilazodone
- vinpocetine
- vorapaxar
- vortioxetine
- warfarin
- willow bark
- zanubrutinib
- ziv-aflibercept
Adverse Reactions .
Serious Reactions
- vision loss, severe
- endophthalmitis
- retinal tear
- retinal detachment
- vitreous hemorrhage
- cataracts
- implant extrusion
Common Reactions
- conjunctival hemorrhage
- delayed dark adaptation
- foreign body sensation
- ocular pain
- miosis
- conjunctival hyperemia
- ocular pruritus
- ocular discomfort
- vitreous hemorrhage
- blurred vision
- headache
- dry eyes
- ocular irritation
- cataracts
- vitreous floaters
- vision loss, severe
- ocular discharge
- anterior chamber cells
- iridocyclitis
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on insignificant systemic absorption
Lactation
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on insignificant systemic absorption in breastfeeding pts
Pharmacology .
Metabolism: unknown; CYP450: unknown; Info: minimal systemic absorption
Excretion: unknown; Half-life: unknown
Subclass: Macular Diseases
Mechanism of Action
exact mechanism of action unknown; secretes recombinant human ciliary neurotrophic factor (rhCNTF), promoting photoreceptor survival
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.