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Papzimeos (zopapogene imadenovec-drba)
zopapogene imadenovec
Adult Dosing .
Dosage forms: INJ
Special Note
- [drug name clarification]
- Info: nonproprietary name = zopapogene imadenovec-drba
recurrent respiratory papillomatosis
- [5 x10^11 particle units SC x1 at wk 0, 2, 6 and 12]
- Start: after establishing minimal residual disease by surgical debulking; Info: remove papilloma prior to 3rd and 4th doses if visible during tx
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
zopapogene imadenovec
gene therapy
- thrombogenic effects
Avoid/Use Alternative
- tranexamic acid
- vaccinia immune globulin
Monitor/Modify Tx
- abemaciclib
- abrocitinib
- aflibercept
- aminocaproic acid
- angiotensin II
- anthrax immune globulin
- anti-inhibitor coagulant complex
- antihemophilic factor (factor VIII)/von Willebrand factor complex
- asciminib
- asparaginase
- atidarsagene autotemcel
- avatrombopag
- axitinib
- baricitinib
- bazedoxifene
- bevacizumab
- binimetinib
- botulism immune globulin
- brolucizumab
- C1 esterase inhibitor
- cabozantinib
- calaspargase
- carfilzomib
- celecoxib
- chorionic gonadotropin
- clozapine
- coagulation factor IX
- coagulation factor VIIa
- coagulation factor XIII A-subunit
- concizumab
- cytomegalovirus immune globulin
- danazol
- darbepoetin alfa
- deflazacort
- desogestrel (contraceptive)
- deuruxolitinib
- dexamethasone
- diclofenac
- diclofenac topical
- dienogest (contraceptive)
- diflunisal
- drospirenone (contraceptive)
- drospirenone (hormone replacement)
- eltrombopag
- epirubicin
- epoetin alfa
- estetrol (contraceptive)
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- ethynodiol (contraceptive)
- etodolac
- etonogestrel (contraceptive)
- everolimus
- factor XIII concentrate
- faricimab
- fedratinib
- fenofibrate
- fenofibric acid
- fenoprofen
- fitusiran
- flurbiprofen
- follitropin
- fruquintinib
- hepatitis B immune globulin
- ibuprofen
- immune globulin
- indomethacin
- iohexol
- iomeprol
- iopamidol
- ketoprofen
- ketorolac
- lazertinib
- lenalidomide
- lenvatinib
- levonorgestrel (contraceptive)
- levonorgestrel (hormone replacement)
- luspatercept
- lusutrombopag
- meclofenamate
- medroxyprogesterone (contraceptive)
- medroxyprogesterone (hormone replacement)
- mefenamic acid
- megestrol
- meloxicam
- menotropins
- methoxy polyethylene glycol-epoetin beta
- methyltestosterone
- momelotinib
- nabumetone
- naproxen
- necitumumab
- nintedanib
- norelgestromin (contraceptive)
- norethindrone (contraceptive)
- norethindrone (hormone replacement)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- olaparib
- ospemifene
- oxaprozin
- pacritinib
- pazopanib
- pegaspargase
- piroxicam
- pomalidomide
- ponatinib
- porfimer
- progesterone (hormone replacement)
- progesterone vaginal (hormone replacement)
- prothrombin complex concentrate (human)
- raloxifene
- ramucirumab
- ranibizumab
- Rho(D) immune globulin
- ritlecitinib
- romiplostim
- ruxolitinib
- ruxolitinib topical
- salsalate
- segesterone (contraceptive)
- sipuleucel-T
- sodium tetradecyl sulfate
- sotatercept
- sulindac
- tamoxifen
- testosterone
- thalidomide
- tivozanib
- tofacitinib
- tolmetin
- toremifene
- trametinib
- tretinoin
- upadacitinib
- vadadustat
- valoctocogene roxaparvovec
- vamorolone
- varicella zoster immune globulin
- von Willebrand factor
- vorinostat
- ziv-aflibercept
Adverse Reactions .
Serious Reactions
- thrombosis
Common Reactions
- injection site rxn
- fatigue
- chills
- fever
- myalgia
- nausea
- headache
- tachycardia
- diarrhea
- vomiting
- hyperhidrosis
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human or animal data available
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: unknown; CYP450: unknown
Excretion: unknown; Half-life: unknown
Subclass: Immunotherapy, Human Papillomavirus
Mechanism of Action
expresses select regions of human papillomavirus (HPV) proteins, generating immune response to infected HPV-infected cells
Formulary .
No Formulary Selected
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