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Yuvezzi
carbachol/ brimonidine ophthalmic
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- iritis
- caution: retinal disorder
- caution: depression
- caution: cerebral insufficiency
- caution: coronary insufficiency
- caution: Raynaud phenomenon
- caution: hypotension, orthostatic
- caution: thromboangiitis obliterans
- caution: CNS depressant use, concurrent
Drug Interactions .
Overview
brimonidine ophthalmic
alpha-2 agonist ophthalmic
- CNS depression
- hypotensive effects
carbachol ophthalmic
cholinergic agent
- cholinergic effects
- miosis agent
Avoid/Use Alternative
- apraclonidine ophthalmic
- butalbital
- clonidine
- codeine
- doxylamine
- ethanol (alcoholic beverage)
- ethanol injection
- hydrocodone
- isocarboxazid
- kratom
- metaxalone
- metoclopramide
- midazolam
- phenelzine
- promethazine
- ropeginterferon alfa-2b
- scopolamine
- tradipitant
- tranylcypromine
Monitor/Modify Tx
- acebutolol
- aldesleukin
- alfentanil
- alfuzosin
- aliskiren
- alprostadil intracavernous
- amantadine
- amifostine
- amiloride
- amitriptyline
- amlodipine
- amoxapine
- apomorphine
- aprocitentan
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- articaine
- asenapine
- atenolol
- avanafil
- azilsartan medoxomil
- benazepril
- berberine
- betaxolol
- betaxolol ophthalmic
- bethanechol
- bexagliflozin
- bisoprolol
- bortezomib
- brexpiprazole
- brimonidine topical
- bromocriptine
- bumetanide
- bupivacaine
- bupivacaine liposomal
- buprenorphine
- butorphanol
- cabergoline
- canagliflozin
- candesartan cilexetil
- cannabis
- captopril
- carbamazepine
- cariprazine
- carteolol ophthalmic
- carvedilol
- chloroprocaine
- chlorothiazide
- chlorpromazine
- chlorthalidone
- cilostazol
- clevidipine
- clofarabine
- clomipramine
- clozapine
- coenzyme Q-10
- dapagliflozin
- denileukin diftitox
- desflurane
- desipramine
- dexmedetomidine
- dexmedetomidine injection
- dihydrocodeine
- diltiazem
- dinutuximab
- dipyridamole
- doxazosin
- doxepin
- dronabinol
- duloxetine
- empagliflozin
- enalapril
- enalaprilat
- entacapone
- entrectinib
- eplerenone
- epoprostenol
- ertugliflozin
- esketamine
- esmolol
- ethacrynic acid
- ethanol (in some formulations)
- etomidate
- etripamil nasal
- felodipine
- fenoldopam
- fentanyl
- ferumoxytol
- flaxseed
- flibanserin
- fluphenazine
- fosinopril
- foslevodopa
- furosemide
- garlic
- gilteritinib
- guanfacine
- haloperidol
- hydralazine
- hydrochlorothiazide
- hydromorphone
- ifosfamide
- iloperidone
- iloprost
- imipramine
- indapamide
- irbesartan
- iron sucrose
- isoflurane
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- ketamine
- labetalol
- landiolol
- levobunolol ophthalmic
- levodopa
- levorphanol
- lidocaine
- lisinopril
- lofexidine
- losartan
- loxapine
- lubiprostone
- lumateperone
- lurasidone
- magnesium sulfate
- maraviroc
- meperidine
- mepivacaine
- methadone
- methohexital
- methyldopa
- methylene blue injection
- metolazone
- metoprolol
- milrinone
- milsaperidone
- minoxidil
- mirtazapine
- moexipril
- molindone
- morphine
- nadolol
- nalbuphine
- nattokinase
- naxitamab
- nebivolol
- nelarabine
- niacin (vitamin B3)
- nicardipine
- nifedipine
- nimodipine
- nisoldipine
- nitric oxide
- nitrite
- nitroglycerin
- nitroprusside
- nortriptyline
- obinutuzumab
- olanzapine
- oliceridine
- olmesartan medoxomil
- opicapone
- opium
- oxazepam
- oxycodone
- oxymorphone
- paliperidone
- palopegteriparatide
- pentamidine
- pentazocine
- pentobarbital
- perindopril
- perphenazine
- phenobarbital
- phenoxybenzamine
- phentolamine
- pindolol
- pramipexole
- prazosin
- primidone
- procarbazine
- prochlorperazine
- propafenone
- propofol
- propranolol
- protriptyline
- quetiapine
- quinapril
- ramipril
- rasagiline
- remifentanil
- remimazolam
- riociguat
- risperidone
- ropinirole
- ropivacaine
- rotigotine transdermal
- sacubitril
- safinamide
- selegiline
- selegiline transdermal
- sevoflurane
- sildenafil
- silodosin
- sodium ferric gluconate complex
- sotagliflozin
- sotalol
- sparsentan
- spironolactone
- sufentanil
- tadalafil
- tagraxofusp
- tamsulosin
- tapentadol
- taurine
- telmisartan
- terazosin
- thalidomide
- thioridazine
- thiothixene
- timolol
- timolol ophthalmic
- tizanidine
- tolcapone
- torsemide
- tramadol
- trandolapril
- trazodone
- treprostinil
- triamterene
- trifluoperazine
- trimipramine
- valsartan
- vardenafil
- verapamil
- vosoritide
- yohimbe
- ziprasidone
Caution Advised
- 5-HTP
- allopurinol
- almotriptan
- alprazolam
- atropine ophthalmic
- baclofen
- baclofen intrathecal
- brivaracetam
- bromfenac ophthalmic
- brompheniramine
- buspirone
- cannabidiol
- carbinoxamine
- carisoprodol
- cenobamate
- cetirizine
- chamomile, German
- chlophedianol
- chlorcyclizine
- chlordiazepoxide
- chlorpheniramine
- chlorzoxazone
- citalopram
- clemastine
- clobazam
- clonazepam
- clorazepate
- cyclobenzaprine
- cyclopentolate ophthalmic
- cyproheptadine
- dantrolene
- daridorexant
- darifenacin
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- diazepam
- dichlorphenamide
- diclofenac ophthalmic
- difelikefalin
- difenoxin
- dimenhydrinate
- diphenhydramine
- diphenoxylate
- domperidone
- doxepin topical
- droperidol
- efavirenz
- eletriptan
- elinzanetant
- escitalopram
- eslicarbazepine acetate
- estazolam
- eszopiclone
- ethosuximide
- felbamate
- fenfluramine
- fesoterodine
- fluoxetine
- flurazepam
- flurbiprofen ophthalmic
- fluvoxamine
- fosphenytoin
- frovatriptan
- gabapentin
- gabapentin enacarbil
- ganaxolone
- glofitamab
- glycopyrrolate
- hydroxyzine
- hyoscyamine
- kava
- ketorolac ophthalmic
- lacosamide
- lamotrigine
- lemborexant
- levetiracetam
- levocetirizine
- levomilnacipran
- linezolid
- linvoseltamab
- lorazepam
- meclizine
- melatonin
- meprobamate
- methocarbamol
- methsuximide
- metyrapone
- metyrosine
- milnacipran
- mitotane
- mosunetuzumab
- mycophenolate mofetil
- naltrexone
- naratriptan
- nefazodone
- nepafenac ophthalmic
- orphenadrine
- oxcarbazepine
- oxybate
- oxybutynin
- paroxetine
- passion flower
- perampanel
- pheniramine
- phenytoin
- pimozide
- pregabalin
- pyrilamine
- quazepam
- ramelteon
- repotrectinib
- rizatriptan
- rufinamide
- selinexor
- sertraline
- solifenacin
- stiripentol
- sumatriptan
- suvorexant
- tasimelteon
- temazepam
- tetrabenazine
- thiotepa
- tiagabine
- tolterodine
- topiramate
- triazolam
- trihexyphenidyl
- trimethobenzamide
- triprolidine
- tropicamide ophthalmic
- trospium
- valbenazine
- valerian
- valproic acid
- venlafaxine
- vigabatrin
- vilazodone
- viloxazine
- zaleplon
- ziconotide
- zolmitriptan
- zolpidem
- zonisamide
- zuranolone
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- retinal tear
- retinal detachment
- iritis
- vascular insufficiency
Common Reactions
- ocular irritation
- headache
- ocular pain
- visual impairment
Safety/Monitoring .
Monitoring Parameters
retinal exam at baseline
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on limited systemic absorption
Lactation
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on limited systemic absorption in breastfeeding patients
Pharmacology .
Metabolism: for carbachol: unknown; CYP450: unknown; for brimonidine: liver primarily; CYP450: unknown; Info: limited systemic absorption
Excretion: for carbachol: unknown; Half-life: unknown; for brimonidine: urine 74%; Half-life: 2h
Subclass: Cholinergics/Miotics
Mechanism of Action
for carbachol: stimulates cholinergic receptors, reducing pupil size to improve near visual acuity; for brimonidine: stimulates alpha-2 adrenergic receptors, inhibiting iris dilator and ciliary muscle contraction
Formulary .
No Formulary Selected
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