Select a medication above to begin.
Yuvezzi
carbachol/ brimonidine ophthalmic
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- iritis
- caution: retinal disorder
- caution: depression
- caution: cerebral insufficiency
- caution: coronary insufficiency
- caution: Raynaud phenomenon
- caution: hypotension, orthostatic
- caution: thromboangiitis obliterans
- caution: CNS depressant use, concurrent
Drug Interactions .
Overview
brimonidine ophthalmic
alpha-2 agonist ophthalmic
- CNS depression
- hypotensive effects
carbachol ophthalmic
cholinergic agent
- cholinergic effects
- miosis agent
Avoid/Use Alternative
- apraclonidine ophthalmic
- butalbital
- clonidine
- codeine
- doxylamine
- ethanol
- hydrocodone
- isocarboxazid
- kratom
- metaxalone
- metoclopramide
- midazolam
- phenelzine
- promethazine
- ropeginterferon alfa-2b
- scopolamine
- tradipitant
- tranylcypromine
Monitor/Modify Tx
- acebutolol
- aldesleukin
- alfentanil
- alfuzosin
- aliskiren
- amantadine
- amifostine
- amiloride
- amitriptyline
- amlodipine
- amoxapine
- apomorphine
- aprocitentan
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- articaine
- asenapine
- atenolol
- avanafil
- azilsartan medoxomil
- benazepril
- berberine
- betaxolol
- betaxolol ophthalmic
- bethanechol
- bexagliflozin
- bisoprolol
- bortezomib
- brexpiprazole
- brimonidine topical
- bromocriptine
- bumetanide
- bupivacaine
- bupivacaine liposomal
- buprenorphine
- butorphanol
- cabergoline
- canagliflozin
- candesartan cilexetil
- cannabis
- captopril
- carbamazepine
- cariprazine
- carteolol ophthalmic
- carvedilol
- chloroprocaine
- chlorothiazide
- chlorpromazine
- chlorthalidone
- cilostazol
- clevidipine
- clofarabine
- clomipramine
- clozapine
- coenzyme Q-10
- dapagliflozin
- denileukin diftitox
- desflurane
- desipramine
- dexmedetomidine
- dexmedetomidine injection
- dihydrocodeine
- diltiazem
- dinutuximab
- dipyridamole
- doxazosin
- doxepin
- dronabinol
- duloxetine
- empagliflozin
- enalapril
- enalaprilat
- entacapone
- entrectinib
- eplerenone
- epoprostenol
- ertugliflozin
- esketamine
- esmolol
- ethacrynic acid
- ethanol (in some formulations)
- etomidate
- etripamil nasal
- felodipine
- fenoldopam
- fentanyl
- ferumoxytol
- flaxseed
- flibanserin
- fluphenazine
- fosinopril
- foslevodopa
- furosemide
- garlic
- gilteritinib
- guanfacine
- haloperidol
- hydralazine
- hydrochlorothiazide
- hydromorphone
- ifosfamide
- iloperidone
- iloprost
- iloprost inhaled
- imipramine
- indapamide
- irbesartan
- iron sucrose
- isoflurane
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- ketamine
- labetalol
- landiolol
- levobunolol ophthalmic
- levodopa
- levorphanol
- lidocaine
- lisinopril
- lofexidine
- losartan
- loxapine
- lubiprostone
- lumateperone
- lurasidone
- magnesium sulfate
- maraviroc
- meperidine
- mepivacaine
- methadone
- methohexital
- methyldopa
- methylene blue injection
- metolazone
- metoprolol
- milrinone
- minoxidil
- mirtazapine
- moexipril
- molindone
- morphine
- nadolol
- nalbuphine
- nattokinase
- naxitamab
- nebivolol
- nelarabine
- niacin (vitamin B3)
- nicardipine
- nifedipine
- nimodipine
- nisoldipine
- nitric oxide
- nitrite
- nitroglycerin
- nitroprusside
- nortriptyline
- obinutuzumab
- olanzapine
- oliceridine
- olmesartan medoxomil
- opicapone
- opium
- oxazepam
- oxycodone
- oxymorphone
- paliperidone
- palopegteriparatide
- pentamidine
- pentazocine
- pentobarbital
- perindopril
- perphenazine
- phenobarbital
- phenoxybenzamine
- phentolamine
- pindolol
- pramipexole
- prazosin
- primidone
- procarbazine
- prochlorperazine
- propafenone
- propofol
- propranolol
- protriptyline
- quetiapine
- quinapril
- ramipril
- rasagiline
- remifentanil
- remimazolam
- riociguat
- risperidone
- ropinirole
- ropivacaine
- rotigotine transdermal
- sacubitril
- safinamide
- selegiline
- selegiline transdermal
- sevoflurane
- sildenafil
- silodosin
- sodium ferric gluconate complex
- sotagliflozin
- sotalol
- sparsentan
- spironolactone
- sufentanil
- tadalafil
- tagraxofusp
- tamsulosin
- tapentadol
- taurine
- telmisartan
- terazosin
- thalidomide
- thioridazine
- thiothixene
- timolol
- timolol ophthalmic
- tizanidine
- tolcapone
- torsemide
- tramadol
- trandolapril
- trazodone
- treprostinil
- triamterene
- trifluoperazine
- trimipramine
- valsartan
- vardenafil
- verapamil
- vosoritide
- yohimbe
- ziprasidone
Caution Advised
- 5-HTP
- allopurinol
- almotriptan
- alprazolam
- atropine ophthalmic
- baclofen
- baclofen intrathecal
- brivaracetam
- bromfenac ophthalmic
- brompheniramine
- buspirone
- cannabidiol
- carbinoxamine
- carisoprodol
- cenobamate
- cetirizine
- chamomile, German
- chlophedianol
- chlorcyclizine
- chlordiazepoxide
- chlorpheniramine
- chlorzoxazone
- citalopram
- clemastine
- clobazam
- clonazepam
- clorazepate
- cyclobenzaprine
- cyclopentolate ophthalmic
- cyproheptadine
- dantrolene
- daridorexant
- darifenacin
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- diazepam
- dichlorphenamide
- diclofenac ophthalmic
- difelikefalin
- difenoxin
- dimenhydrinate
- diphenhydramine
- diphenoxylate
- domperidone
- doxepin topical
- droperidol
- efavirenz
- eletriptan
- elinzanetant
- escitalopram
- eslicarbazepine acetate
- estazolam
- eszopiclone
- ethosuximide
- felbamate
- fenfluramine
- fesoterodine
- fluoxetine
- flurazepam
- flurbiprofen ophthalmic
- fluvoxamine
- fosphenytoin
- frovatriptan
- gabapentin
- gabapentin enacarbil
- ganaxolone
- glofitamab
- glycopyrrolate
- hydroxyzine
- hyoscyamine
- kava
- ketorolac ophthalmic
- lacosamide
- lamotrigine
- lasmiditan
- lemborexant
- levetiracetam
- levocetirizine
- levomilnacipran
- linezolid
- linvoseltamab
- lorazepam
- meclizine
- melatonin
- meprobamate
- methocarbamol
- methsuximide
- metyrapone
- metyrosine
- milnacipran
- mitotane
- mosunetuzumab
- mycophenolate mofetil
- naltrexone
- naratriptan
- nefazodone
- nepafenac ophthalmic
- orphenadrine
- oxcarbazepine
- oxybate
- oxybutynin
- paroxetine
- passion flower
- perampanel
- pheniramine
- phenytoin
- pimozide
- pregabalin
- pyrilamine
- quazepam
- ramelteon
- repotrectinib
- rizatriptan
- rufinamide
- selinexor
- sertraline
- solifenacin
- stiripentol
- sumatriptan
- suvorexant
- tasimelteon
- temazepam
- tetrabenazine
- thiotepa
- tiagabine
- tolterodine
- topiramate
- triazolam
- trihexyphenidyl
- trimethobenzamide
- triprolidine
- tropicamide ophthalmic
- trospium
- valbenazine
- valerian
- valproic acid
- venlafaxine
- vigabatrin
- vilazodone
- viloxazine
- zaleplon
- ziconotide
- zolmitriptan
- zolpidem
- zonisamide
- zuranolone
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- retinal tear
- retinal detachment
- iritis
- vascular insufficiency
Common Reactions
- ocular irritation
- headache
- ocular pain
- visual impairment
Safety/Monitoring .
Monitoring Parameters
retinal exam at baseline
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on limited systemic absorption
Lactation
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on limited systemic absorption in breastfeeding patients
Pharmacology .
Metabolism: for carbachol: unknown; CYP450: unknown; for brimonidine: liver primarily; CYP450: unknown; Info: limited systemic absorption
Excretion: for carbachol: unknown; Half-life: unknown; for brimonidine: urine 74%; Half-life: 2h
Subclass: Cholinergics/Miotics
Mechanism of Action
for carbachol: stimulates cholinergic receptors, reducing pupil size to improve near visual acuity; for brimonidine: stimulates alpha-2 adrenergic receptors, inhibiting iris dilator and ciliary muscle contraction
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.