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Andembry (garadacimab-gxii)
garadacimab
Adult Dosing .
Dosage forms: INJ (auto-injector): 200 mg; INJ (pre-filled syringe): 200 mg per 1.2 mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = garadacimab-gxii
hereditary angioedema prophylaxis
- [200 mg SC qmo]
- Start: 400 mg SC x1 dose
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ (auto-injector): 200 mg; INJ (pre-filled syringe): 200 mg per 1.2 mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = garadacimab-gxii
hereditary angioedema prophylaxis
- [12 yo and older]
- Dose: 200 mg SC qmo; Start: 400 mg SC x1 dose
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
garadacimab
factor XIIa inhibitor
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- injection site rxn
- nasopharyngitis
- abdominal pain
- prolonged aPTT
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 76x and 100x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: catabolism; CYP450: unknown
Excretion: unknown; Half-life: 17.4 days
Subclass: Hereditary Angioedema
Mechanism of Action
binds to activated FXII, inhibiting kallikrein-kinin system and preventing bradykinin generation
Formulary .
No Formulary Selected
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