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Sdamlo
amlodipine
Adult Dosing .
Dosage forms: SOL: 2.5 mg per 15 mL, 5 mg per 15 mL, 10 mg per 15 mL
HTN
- [5-10 mg PO qd]
- Start: 5 mg PO qd; Max: 10 mg/day; Info: start 2.5 mg PO qd in small, fragile, or elderly pts, or if used as secondary agent; may adjust dose q1-2wk
CAD
- [5-10 mg PO qd]
- Max: 10 mg/day; Info: for pts w/ chronic stable angina, vasospastic angina, or angiographically documented CAD; start 5 mg PO qd in elderly pts
pulmonary arterial HTN (off-label)
- [15-30 mg/day PO divided qd-bid]
- Start: 5 mg PO qd; Max: 30 mg/day; Info: for pts w/ positive vasoreactivity test
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [HTN]
- hepatic impairment: start 2.5 mg qd; Info: titrate slowly if severe impairment
- [all other indications]
- hepatic impairment: start 5 mg qd; Info: titrate slowly if severe impairment
Peds Dosing .
- Dosage forms: SOL: 2.5 mg per 15 mL, 5 mg per 15 mL, 10 mg per 15 mL
HTN
- [6-17 yo]
- Dose: 2.5-5 mg PO qd; Max: 10 mg/day
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [not defined]
- hepatic impairment: consider adult hepatic dosing for guidance
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: elderly pts
- caution: hepatic impairment
- caution: CHF
- caution: CAD, severe obstructive
- caution: aortic stenosis, severe
Drug Interactions .
Overview
amlodipine
CCB, dihydropyridine
- CYP3A4 substrate
- CYP3A4 inhibitor, weak
- alters gallbladder contraction/motility
- angioedema
- antihypertensive agent
- binds to cation exchange resin/polymer
- levamlodipine is the active isomer of racemic amlodipine; similar interactions anticipated
Contraindicated
- cisapride
- eliglustat
- isocarboxazid
Avoid/Use Alternative
- aldesleukin
- alprazolam
- aripiprazole lauroxil
- ceritinib
- codeine
- colchicine
- dantrolene
- diltiazem
- felodipine
- hydrocodone
- isradipine
- lofexidine
- meperidine
- methadone
- nicardipine
- nifedipine
- nisoldipine
- oxycodone
- pimozide
- pralsetinib
- propafenone
- simvastatin
- verapamil
Monitor/Modify Tx
- abemaciclib
- abiraterone acetate
- acalabrutinib
- adagrasib
- albuterol
- albuterol inhaled
- alfentanil
- alfuzosin
- almotriptan
- amantadine
- amifostine
- amiodarone
- amitriptyline
- amoxapine
- amphetamine
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- arformoterol inhaled
- aripiprazole bimonthly injection
- aripiprazole monthly injection
- aripiprazole oral
- armodafinil
- artemether/lumefantrine
- articaine
- asciminib
- asenapine
- aspirin
- atazanavir
- atogepant
- atomoxetine
- atropine ophthalmic
- avanafil
- avapritinib
- axitinib
- belzutifan
- benzphetamine
- berberine
- betamethasone
- betaxolol ophthalmic
- bethanechol
- bevacizumab
- bexagliflozin
- bexarotene
- bismuth subsalicylate
- bortezomib
- bosentan
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- bromocriptine
- budesonide
- bupivacaine
- bupivacaine liposomal
- buprenorphine
- bupropion
- butalbital
- butorphanol
- cabergoline
- cabozantinib
- caffeine
- caffeine citrate
- canagliflozin
- cannabis
- capivasertib
- carbamazepine
- carfilzomib
- cariprazine
- carteolol ophthalmic
- celecoxib
- cenobamate
- chloramphenicol
- chloroprocaine
- chlorpromazine
- cilostazol
- clarithromycin
- clobazam
- clofarabine
- clomipramine
- clonidine
- clozapine
- cobicistat
- cocaine
- coenzyme Q-10
- copanlisib
- corticotropin
- cortisone
- cyclosporine
- dabrafenib
- danazol
- danshen
- dapagliflozin
- darbepoetin alfa
- darolutamide
- darunavir
- deflazacort
- denileukin diftitox
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- dexamethasone
- dexmedetomidine
- dexmedetomidine injection
- dexmethylphenidate
- dextroamphetamine
- diazoxide
- diclofenac
- diclofenac topical
- dicloxacillin
- diethylpropion
- diflunisal
- dihydrocodeine
- dihydroergotamine
- dinutuximab
- dipyridamole
- disopyramide
- docetaxel
- dofetilide
- domperidone
- doxapram
- doxazosin
- doxepin
- dronabinol
- dronedarone
- droxidopa
- duloxetine
- echinacea
- efavirenz
- elafibranor
- elagolix
- eletriptan
- empagliflozin
- enasidenib
- encorafenib
- entacapone
- entrectinib
- enzalutamide
- ephedra
- ephedrine injection
- ephedrine oral
- epinephrine
- epinephrine inhaled
- epoetin alfa
- epoprostenol
- eptinezumab
- erenumab
- ergotamine
- ertugliflozin
- erythromycin
- esketamine
- eslicarbazepine acetate
- estetrol (contraceptive)
- estradiol (contraceptive)
- ethanol
- ethinyl estradiol (contraceptive)
- etodolac
- etrasimod
- etravirine
- everolimus
- fedratinib
- felbamate
- fenfluramine
- fenoprofen
- fentanyl
- ferumoxytol
- fexinidazole
- finerenone
- fingolimod
- flaxseed
- flibanserin
- fluconazole
- fludrocortisone
- fluphenazine
- flurbiprofen
- formoterol inhaled
- fosamprenavir
- foslevodopa
- fosphenytoin
- fostamatinib
- fremanezumab
- frovatriptan
- fruquintinib
- galcanezumab
- garlic
- gepirone
- gilteritinib
- ginkgo
- ginseng, Asian
- glycerol phenylbutyrate
- griseofulvin
- guanfacine
- haloperidol
- hoodia
- hydralazine
- hydrocortisone
- hydromorphone
- ibrutinib
- ibuprofen
- idelalisib
- iloperidone
- iloprost
- iloprost inhaled
- imatinib
- imipramine
- indomethacin
- iron sucrose
- isoflurane
- isosorbide dinitrate
- isosorbide mononitrate
- itraconazole
- ivabradine
- ivosidenib
- ixabepilone
- ketamine
- ketoconazole
- ketoprofen
- ketorolac
- landiolol
- lanreotide
- leflunomide
- lemborexant
- lenvatinib
- levalbuterol inhaled
- levobunolol ophthalmic
- levodopa
- levoketoconazole
- levomilnacipran
- levorphanol
- levothyroxine
- licorice
- lidocaine
- liothyronine
- lisdexamfetamine
- lomitapide
- lonafarnib
- lopinavir/ritonavir
- lorlatinib
- lovastatin
- loxapine
- lubiprostone
- lumacaftor/ivacaftor
- lumateperone
- lurasidone
- lurbinectedin
- luspatercept
- magnesium salicylate
- magnesium sulfate
- maraviroc
- mavacamten
- meclofenamate
- mefenamic acid
- meloxicam
- mepivacaine
- meropenem
- methamphetamine
- methohexital
- methoxy polyethylene glycol-epoetin beta
- methylene blue injection
- methylergonovine
- methylphenidate
- methylprednisolone
- methyltestosterone
- metoclopramide
- midazolam
- midodrine
- mifepristone
- milnacipran
- milrinone
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- molindone
- morphine
- nabumetone
- nafcillin
- nalbuphine
- naphazoline ophthalmic
- naproxen
- naratriptan
- nattokinase
- naxitamab
- nefazodone
- nelfinavir
- nevirapine
- niacin (vitamin B3)
- nimodipine
- niraparib
- nitric oxide
- nitrite
- nitroglycerin
- nitroprusside
- nortriptyline
- obinutuzumab
- odevixibat
- olanzapine
- oliceridine
- olodaterol inhaled
- olutasidenib
- omaveloxolone
- opicapone
- opium
- osilodrostat
- oxaprozin
- oxazepam
- oxcarbazepine
- oxymetazoline nasal
- oxymetazoline ophthalmic
- oxymetazoline topical
- oxymorphone
- oxytocin
- ozanimod
- pacritinib
- paliperidone
- palopegteriparatide
- pazopanib
- pemigatinib
- pentamidine
- pentazocine
- pentobarbital
- pentoxifylline
- perampanel
- perphenazine
- pexidartinib
- phendimetrazine
- phenelzine
- phenobarbital
- phentermine
- phenylephrine
- phenylephrine injection
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine rectal
- phenytoin
- pioglitazone
- piroxicam
- ponatinib
- ponesimod
- posaconazole
- pramipexole
- prazosin
- prednisolone
- prednisone
- primidone
- procarbazine
- prochlorperazine
- promethazine
- propofol
- protriptyline
- pseudoephedrine
- quetiapine
- quinidine (antiarrhythmic)
- ramucirumab
- rasagiline
- red yeast rice
- regorafenib
- remifentanil
- remimazolam
- repotrectinib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rimegepant
- riociguat
- ripretinib
- risperidone
- ritonavir
- rizatriptan
- ropinirole
- ropivacaine
- rotigotine transdermal
- rufinamide
- sacubitril
- safinamide
- salmeterol inhaled
- salsalate
- sarilumab
- selegiline
- selegiline transdermal
- selpercatinib
- selumetinib
- sevoflurane
- sildenafil
- silodosin
- sincalide
- siponimod
- sirolimus
- sirolimus albumin-bound
- sodium ferric gluconate complex
- sodium polystyrene sulfonate
- sorafenib
- sotagliflozin
- sotalol
- sotorasib
- sparsentan
- St. John's wort
- stiripentol
- sufentanil
- sulindac
- sumatriptan
- sunitinib
- sunvozertinib
- suzetrigine
- tacrolimus
- tadalafil
- tagraxofusp
- tamsulosin
- tapentadol
- taurine
- tazemetostat
- tecovirimat
- telotristat ethyl
- temsirolimus
- terazosin
- terbutaline
- teriflunomide
- testosterone
- tetrahydrozoline ophthalmic
- thalidomide
- thioridazine
- thiothixene
- thyroid
- timolol ophthalmic
- tipranavir
- tivozanib
- tizanidine
- tocilizumab
- tolcapone
- tolmetin
- tolvaptan
- topiramate
- tovorafenib
- tramadol
- trametinib
- tranylcypromine
- trazodone
- treprostinil
- triamcinolone
- triazolam
- trifluoperazine
- trimipramine
- tucatinib
- ubrogepant
- vaborbactam
- vadadustat
- vamorolone
- vandetanib
- vardenafil
- vasopressin
- vemurafenib
- venetoclax
- venlafaxine
- vilanterol inhaled
- viloxazine
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- vorasidenib
- voriconazole
- vosoritide
- warfarin
- yohimbe
- zanubrutinib
- zavegepant
- ziprasidone
- ziv-aflibercept
- zolmitriptan
Caution Advised
- cobimetinib
- conivaptan
- cyclophosphamide
- daridorexant
- eplerenone
- lithium
- palovarotene
- pimecrolimus topical
- roflumilast
- roflumilast topical
- sirolimus topical
- tacrolimus topical
- verteporfin
Adverse Reactions .
Serious Reactions
- angina exacerbation
- MI
- hypotension
- hepatitis
- hypersensitivity rxn
- erythema multiforme
Common Reactions
- peripheral edema
- palpitations
- fatigue
- dizziness
- nausea
- flushing
- eczematous eruptions (chronic use in elderly pts)
Safety/Monitoring .
Monitoring Parameters
BP at baseline, then periodically; HR
Look/Sound-Alike Drug Names
amLODIPine confused with: aMILoride; amiodarone; amitriptyline; felodipine; memantine
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available; no known risk of teratogenicity, though risk of embryo-fetal death based on animal data at 10x and 20x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no known risk of infant harm based on limited human data; no human data available to assess effects on milk production
Pharmacology .
Metabolism: liver extensively; CYP450: 3A4 substrate
Excretion: urine 59-62% (5-10% unchanged), bile/feces 20-25%; Half-life: 30-50h, 56h (hepatic impairment)
Subclass: Antianginals ; Calcium Channel Blockers (CCBs), Dihydropyridines
Mechanism of Action
inhibits calcium ion influx into vascular smooth muscle and myocardium
Formulary .
No Formulary Selected
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