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Kyxata
carboplatin
Black Box Warnings .
Hypersensitivity and Anaphylaxis
serious and life-threatening rxns, incl. anaphylaxis can occur w/in minutes of admin. during any cycle; immediately D/C tx for severe rxns; admin. appropriate tx for management of hypersensitivity rxns
Adult Dosing .
Dosage forms: INJ
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments
- [dosing clarification]
- Info: use max GFR 125 mL/min in Calvert formula if estimated based on Cr measured by IDMS method; use measured value if actual GFR obtained; refer to institution protocols for target AUC of 4 to 6
ovarian CA, advanced
- [initial tx]
- Dose: 300 mg/m^2/dose IV x1 on day 1 of 28-day cycle for up to 6 cycles; Alt: Calvert formula dose (mg) = target AUC (4 to 6) x (GFR + 25) IV x1 on day 1 of 28-day cycle for up to 6 cycles; Info: use w/ cyclophosphamide; use Calvert formula dosing in elderly patients
- [recurrent dz]
- Dose: 360 mg/m^2/dose IV x1 on day 1 of 28-day cycle; Alt: Calvert formula dose (mg) = target AUC (4 to 6) x (GFR + 25) IV x1 on day 1 of 28-day cycle; Info: use Calvert formula dosing in elderly patients
renal dosing
- [adjust dose amount]
- CrCl 10-50: decr. usual BSA-based dose by 50%; CrCl <10: decr. usual BSA-based dose by 75%; Alt: use Calvert formula dose (mg) = target AUC (4 to 6) x (GFR + 25) to calculate each dose
- HD: decr. usual BSA-based dose by 50%, on dialysis days admin. 12-24h before dialysis; no supplement; Alt: use Calvert formula dose (mg) = target AUC (4 to 6) x 25 to calculate each dose, on dialysis days admin. 12-24h before dialysis; no supplement; PD: decr. usual BSA-based dose by 75%; no supplement; Alt: use Calvert formula dose (mg) = target AUC (4 to 6) x (GFR + 25) to calculate each dose; no supplement
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to mannitol (some generic forms)
- hypersensitivity to platinum compounds
- pregnancy 1st trimester
- myelosuppression
- bleeding, active
- avoid: breastfeeding during tx and x1wk after D/C
- caution: platinum compounds use history
- caution: neurotoxic agent use, concurrent
- caution: ototoxic agent use, concurrent
- caution: pregnancy 2nd trimester
- caution: pregnancy 3rd trimester
- caution: patients of childbearing potential
- caution: male patients of reproductive potential
- caution: elderly patients
- caution: renal impairment
- caution: hearing impairment
- caution: prolonged use
Drug Interactions .
Overview
carboplatin
platinum analog
- hypomagnesemia
- immunosuppressive oncologic agent
- myelosuppressive oncologic agent
- nephrotoxicity
- ototoxicity
- peripheral neuropathy
Contraindicated
- adenovirus vaccine, live
- BCG live intravesical
- chikungunya vaccine, live
- cholera vaccine, live
- cidofovir
- dengue vaccine, live
- influenza nasal vaccine, live
- measles/mumps/rubella vaccine, live
- rotavirus vaccine, live
- smallpox vaccine, live
- talimogene laherparepvec
- typhoid vaccine, live
- varicella vaccine, live
- yellow fever vaccine, live
Avoid/Use Alternative
- aldesleukin
- amikacin
- amikacin inhaled
- bumetanide
- carboplatin
- chloramphenicol
- cisplatin
- cladribine oral
- clofarabine
- deferiprone
- dexrazoxane
- ethacrynic acid
- etrasimod
- fexinidazole
- foscarnet
- furosemide
- ganciclovir
- gentamicin
- mannitol
- methotrexate
- neomycin
- oxaliplatin
- palifermin
- paromomycin
- penicillamine
- pentamidine
- pimecrolimus topical
- plazomicin
- polymyxin B
- primaquine
- rabies vaccine
- radium Ra 223 dichloride
- ropeginterferon alfa-2b
- streptomycin
- streptozocin
- tenofovir disoproxil
- tobramycin
- tobramycin inhaled
- valganciclovir
Monitor/Modify Tx
- acyclovir
- adefovir dipivoxil
- albendazole
- alectinib
- alemtuzumab
- aliskiren
- allopurinol
- amiloride
- amphotericin
- anthrax immune globulin
- anthrax vaccine
- anti-thymocyte globulin
- asenapine
- aspirin
- atidarsagene autotemcel
- auranofin
- axitinib
- azathioprine
- azilsartan medoxomil
- balsalazide
- baricitinib
- benazepril
- benznidazole
- betibeglogene autotemcel
- bevacizumab
- bleomycin
- botulism immune globulin
- cabozantinib
- candesartan cilexetil
- capecitabine
- captopril
- carfilzomib
- celecoxib
- cetuximab
- chikungunya vaccine
- chlorothiazide
- chlorthalidone
- clindamycin
- clozapine
- colchicine
- colistimethate
- COVID-19 vaccine
- creatine
- cyclophosphamide
- cyclosporine
- cytomegalovirus immune globulin
- dapsone
- deferasirox
- deferoxamine
- deuruxolitinib
- dexlansoprazole
- diclofenac
- diclofenac topical
- diflunisal
- digoxin
- diphtheria/tetanus vaccine
- diphtheria/tetanus/pertussis vaccine
- ebola vaccine, live
- efbemalenograstim alfa
- eflapegrastim (G-CSF)
- eflornithine
- elivaldogene autotemcel
- enalapril
- enalaprilat
- esomeprazole
- etodolac
- everolimus
- exagamglogene autotemcel
- fenoprofen
- filgrastim (G-CSF)
- flucytosine
- fluphenazine
- flurbiprofen
- fosinopril
- fosphenytoin
- fostamatinib
- givinostat
- Haemophilus b vaccine
- hepatitis A vaccine
- hepatitis B vaccine
- human papillomavirus vaccine
- hydrochlorothiazide
- hydroxocobalamin IV
- hydroxychloroquine
- hydroxyurea
- ibuprofen
- ibuprofen lysine
- ifosfamide
- immune globulin
- indapamide
- indomethacin
- influenza H5N1 vaccine
- influenza vaccine
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- iohexol
- iomeprol
- iopamidol
- irbesartan
- Japanese encephalitis vaccine
- ketoprofen
- ketorolac
- lansoprazole
- leflunomide
- lenvatinib
- lifileucel
- linezolid
- lisinopril
- lithium
- lonafarnib
- losartan
- lovotibeglogene autotemcel
- lumateperone
- lutetium Lu 177 vipivotide tetraxetan
- lymphocyte immune globulin, anti-thymocyte globulin
- magnesium citrate
- magnesium salicylate
- meclofenamate
- mefenamic acid
- meloxicam
- meningococcal vaccine
- mercaptopurine
- mesalamine
- mesalamine rectal
- metolazone
- mitomycin
- moexipril
- mycophenolate mofetil
- mycophenolic acid
- nabumetone
- naproxen
- necitumumab
- nusinersen
- olmesartan medoxomil
- olsalazine
- omeprazole
- oxaprozin
- pamidronate
- panitumumab
- pantoprazole
- patiromer
- pazopanib
- pegfilgrastim (G-CSF)
- peginterferon alfa 2a
- peginterferon beta 1a
- pemetrexed
- pentostatin
- perindopril
- phenytoin
- piroxicam
- pneumococcal vaccine
- poliovirus vaccine
- polyethylene glycol
- polyethylene glycol/electrolytes
- proguanil
- pyrimethamine
- quinapril
- rabeprazole
- ramipril
- ramucirumab
- respiratory syncytial virus vaccine
- Rho(D) immune globulin
- ribavirin
- rifabutin
- rituximab
- romidepsin
- ruxolitinib topical
- salsalate
- sargramostim (GM-CSF)
- sarilumab
- satralizumab
- sipuleucel-T
- sirolimus
- sitagliptin
- smallpox/mpox vaccine, live
- sodium polystyrene sulfonate
- sparsentan
- spironolactone
- stiripentol
- succimer
- sulfasalazine
- sulfate bowel prep
- sulindac
- sunitinib
- tacrolimus
- telavancin
- telmisartan
- temsirolimus
- tenofovir alafenamide
- teplizumab
- teprotumumab
- teriflunomide
- thalidomide
- tick-borne encephalitis vaccine
- tiopronin
- tivozanib
- tocilizumab
- tofacitinib
- tolmetin
- torsemide
- trandolapril
- triamterene
- trimethoprim
- typhoid vaccine
- upadacitinib
- vaccinia immune globulin
- valacyclovir
- valproic acid
- valsartan
- vancomycin
- voclosporin
- vonoprazan
- willow bark
- zidovudine
- ziv-aflibercept
- zoledronic acid
- zonisamide
Caution Advised
- abatacept
- abrocitinib
- adalimumab
- ado-trastuzumab emtansine
- amiodarone
- anakinra
- anifrolumab
- avacopan
- avanafil
- basiliximab
- beclomethasone inhaled
- beclomethasone nasal
- belatacept
- belimumab
- betamethasone
- bexarotene
- bimekizumab
- bortezomib
- brentuximab vedotin
- brodalumab
- budesonide
- budesonide inhaled
- budesonide nasal
- budesonide rectal
- cabazitaxel
- canakinumab
- certolizumab pegol
- chloroquine
- ciltacabtagene autoleucel
- ciprofloxacin
- clobetasol ophthalmic
- corticotropin
- cortisone
- crovalimab
- danicopan
- daptomycin
- deflazacort
- delafloxacin
- delgocitinib topical
- deucravacitinib
- dexamethasone
- dexamethasone ophthalmic
- difluprednate ophthalmic
- dimethyl fumarate
- dinutuximab
- diroximel fumarate
- disulfiram
- docetaxel
- dupilumab
- eculizumab
- efgartigimod alfa
- elranatamab
- emapalumab
- enfortumab vedotin
- eribulin
- etanercept
- ethanol
- ethanol (in some formulations)
- fingolimod
- fludarabine
- fludrocortisone
- flunisolide nasal
- fluocinolone intravitreal
- fluorometholone ophthalmic
- fluticasone furoate
- fluticasone propionate
- galsulfase
- glofitamab
- golimumab
- guselkumab
- hydrocortisone
- hydrocortisone ophthalmic
- inebilizumab
- infliximab
- iptacopan
- isotretinoin
- itraconazole
- ixabepilone
- ixazomib
- ixekizumab
- lebrikizumab
- levofloxacin
- loteprednol ophthalmic
- methylprednisolone
- metronidazole
- miglustat
- mirikizumab
- mirvetuximab soravtansine
- mitoxantrone
- mometasone implant
- mometasone inhaled
- mometasone nasal
- monomethyl fumarate
- mosunetuzumab
- moxifloxacin
- nadofaragene firadenovec intravesical
- natalizumab
- naxitamab
- nelarabine
- neomycin otic
- nipocalimab
- ocrelizumab
- ofatumumab
- ofloxacin
- ozanimod
- paclitaxel
- pegcetacoplan
- polatuzumab vedotin
- pomalidomide
- ponatinib
- ponesimod
- pozelimab
- prednisolone
- prednisolone ophthalmic
- prednisone
- quinidine (antiarrhythmic)
- quinidine (CYP2D6 inhibitor)
- quinine
- ravulizumab
- rilonacept
- risankizumab
- ritlecitinib
- rozanolixizumab
- secukinumab
- sildenafil
- siltuximab
- siponimod
- spesolimab
- sutimlimab
- tadalafil
- talquetamab
- teclistamab
- telisotuzumab vedotin
- tezepelumab
- tildrakizumab
- tinidazole
- tisagenlecleucel
- tisotumab vedotin
- tralokinumab
- triamcinolone
- tuberculin purified protein derivative
- ublituximab
- ustekinumab
- vamorolone
- vardenafil
- vedolizumab
- vigabatrin
- vilobelimab
- vinblastine
- vincristine
- vinorelbine
- zilucoplan
Adverse Reactions .
Serious Reactions
- anaphylaxis
- myelosuppression
- infection
- hemorrhage
- nephrotoxicity
- ototoxicity
- peripheral neuropathy
- nausea, severe
- vomiting, severe
- vision loss
- extravasation necrosis
Common Reactions
- nausea
- anemia
- leukopenia
- vomiting
- neutropenia
- thrombocytopenia
- sodium decr.
- magnesium decr.
- alk phos elevated
- calcium decr.
- potassium decr.
- pain
- BUN or Cr elevated
- AST elevated
- asthenia
- peripheral neuropathy
- diarrhea
- constipation
- infection
- bleeding
- neurotoxicity
- bilirubin elevated
- hypersensitivity rxn
- alopecia
Safety/Monitoring .
Monitoring Parameters
Cr, pregnancy test at baseline; CBC w/ diff at baseline, before each cycle and as clinically indicated
Look/Sound-Alike Drug Names
CARBOplatin confused with: CISplatin
Pregnancy/Lactation .
Pregnancy
Clinical Summary
avoid use in 1st trimester, weigh risk/benefit in 2nd and 3rd trimesters; risk of teratogenicity in 1st trimester based on limited human data w/ cisplatin and drug's mechanism of action; risk of fetal harm low in 2nd and 3rd trimesters based on limited human data
Individuals of Reproductive Potential
obtain pregnancy test before tx start; avoid pregnancy by using effective contraception during tx and x6mo after D/C in patients of childbearing potential and during tx and x3mo after D/C in male patients
Lactation
Clinical Summary
avoid breastfeeding during tx and x1wk after D/C; no human data available to assess risk of infant harm, though possible drug excretion into milk based on drug properties; no human data available to assess effects on milk production
Pharmacology .
Metabolism: none; CYP450: none
Excretion: urine primarily; Half-life: 2.6-5.9h; Info: platinum irreversibly bound to plasma proteins is slowly eliminated w/ minimum half-life 5 days
Subclass: Alkylating Agents, Platinum Analogs
Mechanism of Action
binds and crosslinks DNA
Formulary .
No Formulary Selected
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