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Zolymbus
bimatoprost ophthalmic
Adult Dosing .
Dosage forms: GEL: 0.01%
elevated IOP
- [1 gtt in eye(s) qpm]
- Max: 1 dose/24h; Info: for patients w/ open-angle glaucoma or ocular HTN
Peds Dosing .
- Dosage forms: GEL: 0.01%
elevated IOP
- [16 yo and older]
- Dose: 1 gtt in eye(s) qpm; Max: 1 dose/24h; Info: for patients w/ open-angle glaucoma or ocular HTN
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: intraocular inflammation, active
- caution: aphakia
- caution: pseudophakia w/ torn posterior lens capsule
- caution: macular edema risk
Drug Interactions .
Overview
bimatoprost ophthalmic
prostaglandin F2-alpha analog
- alters intraocular pressure
Avoid/Use Alternative
- bimatoprost ophthalmic
- latanoprost ophthalmic
Monitor/Modify Tx
- latanoprostene bunod ophthalmic
- tafluprost ophthalmic
- travoprost ophthalmic
Adverse Reactions .
Serious Reactions
- macular edema
- superficial punctate keratitis
- uveitis
- iritis
- cataracts
- periorbital fat atrophy
- enophthalmos
Common Reactions
- conjunctival hyperemia
- eyelash growth
- ocular pruritus
- dry eyes
- visual disturbance
- ocular burning
- foreign body sensation
- ocular pain
- periorbital skin darkening
- blepharitis
- cataracts
- superficial punctate keratitis
- eyelid erythema
- ocular irritation
- eyelash darkening
- ocular discharge
- lacrimation
- photophobia
- allergic conjunctivitis
- asthenopia
- iris hyperpigmentation
- conjunctival edema
- hypertrichosis
- subconjunctival hemorrhage
- URI
- headache
- asthenia
- ocular hypersensitivity rxn
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
bimatoprost ophthalmic confused with: brimonidine; latanoprost
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on insignificant systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on insignificant systemic absorption in breastfeeding patients
Pharmacology .
Metabolism: oxidation, n-deethylation, and glucuronidation; CYP450: unknown; Info: minimal systemic absorption
Excretion: urine 67%, feces 25%; Half-life: 45min
Subclass: Glaucoma/Elevated IOP: Prostaglandin Agonists
Mechanism of Action
increases aqueous humor outflow through trabecular meshwork and uveoscleral routes, reducing IOP
Formulary .
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