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Epioxa
riboflavin ophthalmic
Adult Dosing .
Dosage forms: SOL (kit): 0.177% syringe x1 and 0.239% (HD) syringe x1
keratoconus
- [corneal cross-linking procedure w/o epithelium removal]
- Dose: 2 gtt (0.239%) in eye(s) q60sec x4min, then 2 gtt (0.177%) in eye(s) q30sec x6min, then rinse w/ 5 mL BSS; measure corneal thickness; if corneal thickness <325 microns, do not perform irradiation; Start: after removal of mucin layer from corneal surface using cellulose spear sponge soaked w/ 0.239%; Info: use w/ O2n system and Boost Goggles, see pkg insert
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: SOL (kit): 0.177% syringe x1 and 0.239% (HD) syringe x1
keratoconus
- [corneal cross-linking procedure w/o epithelium removal, 13 yo and older]
- Dose: 2 gtt (0.239%) in eye(s) q60sec x4min, then 2 gtt (0.177%) in eye(s) q30sec x6min, then rinse w/ 5 mL BSS; measure corneal thickness; if corneal thickness <325 microns, do not perform irradiation; Start: after removal of mucin layer from corneal surface using cellulose spear sponge soaked w/ 0.239%; Info: use w/ O2n system and Boost Goggles, see pkg insert
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- aphakic patients
- pseudophakic patients
- caution: herpetic keratitis history
Drug Interactions .
Overview
riboflavin ophthalmic
photoenhancer ophthalmic
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- herpetic keratitis
Common Reactions
- ocular hyperemia
- corneal opacification
- photophobia
- punctate keratitis
- ocular pain
- ocular irritation
- lacrimation incr.
- corneal epithelial defect
- eyelid edema
- corneal striae
- visual acuity decr.
- dry eyes
- anterior chamber flare
Safety/Monitoring .
Monitoring Parameters
ophthalmic exam
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human or animal data available
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: unknown; CYP450: unknown
Excretion: unknown; Half-life: unknown
Subclass: Photodynamic Agents, Ophthalmic
Mechanism of Action
generates singlet oxygen, causing corneal cross-linking (photoenhancer)
Formulary .
No Formulary Selected
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