Select a medication above to begin.
Poherdy (pertuzumab-dpzb)
pertuzumab
Black Box Warnings .
Cardiomyopathy
subclinical and clinical cardiac failure, manifesting as decr. LVEF and CHF can occur; evaluate left ventricular function prior to and during tx; D/C tx if clinically significant decr. left ventricular function
Embryo-Fetal Toxicity
exposure during pregnancy or w/in 7mo prior to conception can result in embryo-fetal death and birth defects, including oligohydramnios and delayed renal development; advise patients of risks and need for effective contraception
Adult Dosing .
Dosage forms: INJ
Special Note
- [equivalency or interchangeability info]
- Info: not interchangeable w/ SC pertuzumab/trastuzumab/hyaluronidase
- [drug name clarification]
- Info: nonproprietary name = pertuzumab-dpzb
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments
HER2-positive breast CA, metastatic
- [420 mg IV x1 on day 1 of 21-day cycle, starting cycle 2]
- Start: 840 mg IV x1 for cycle 1; Info: part of multi-drug chemo regimen
HER2-positive breast CA, early
- [neoadjuvant tx]
- Dose: 840 mg IV x1 on day 1 of 21-day cycle for cycle 1, then starting cycle 2, administer 420 mg IV x1 on day 1 of 21-day cycle; Info: for patients w/ locally advanced, inflammatory, or early stage disease w/ either >2cm in diameter or node positivity; give x3-6 cycles in neoadjuvant setting as part of multi-drug chemo regimen, then continue in adjuvant setting w/ trastuzumab or trastuzumab/hyaluronidase for total of 18 cycles
- [adjuvant tx]
- Dose: 840 mg IV x1 on day 1 of 21-day cycle for cycle 1, then starting cycle 2, administer 420 mg IV x1 on day 1 of 21-day cycle; Info: for patients w/ high recurrence risk; give x3-6 cycles as part of multi-drug chemo regimen, then continue w/ trastuzumab or trastuzumab/hyaluronidase for total of 18 cycles
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- avoid: breastfeeding during tx and x7mo after D/C
- caution: patients of childbearing potential
- caution: LVEF decr.
- caution: LVEF decr, trastuzumab-associated
- caution: CHF history
- caution: chest radiation history
- caution: anthracycline use history
- caution: HTN, uncontrolled
- caution: MI, recent
- caution: arrhythmia, serious
Drug Interactions .
Overview
pertuzumab
HER2/neu antagonist
- cardiotoxic effects
- immunomodulatory effects
Contraindicated
- adenovirus vaccine, live
- chikungunya vaccine, live
- cholera vaccine, live
- dengue vaccine, live
- influenza nasal vaccine, live
- measles/mumps/rubella vaccine, live
- rotavirus vaccine, live
- smallpox vaccine, live
- typhoid vaccine, live
- varicella vaccine, live
- yellow fever vaccine, live
Avoid/Use Alternative
- epirubicin
- idarubicin
- rabies vaccine
Monitor/Modify Tx
- adalimumab
- ado-trastuzumab emtansine
- aldesleukin
- alogliptin
- anagrelide
- anthrax vaccine
- asciminib
- avelumab
- axitinib
- bevacizumab
- bezlotoxumab
- binimetinib
- bortezomib
- bosutinib
- capecitabine
- carfilzomib
- certolizumab pegol
- chikungunya vaccine
- cilostazol
- clozapine
- cobimetinib
- COVID-19 vaccine
- cyclophosphamide
- dabrafenib
- daunorubicin
- diphtheria/tetanus vaccine
- diphtheria/tetanus/pertussis vaccine
- doxorubicin
- dronedarone
- ebola vaccine, live
- encorafenib
- entrectinib
- etanercept
- fam-trastuzumab deruxtecan
- fluorouracil
- golimumab
- Haemophilus b vaccine
- hepatitis A vaccine
- hepatitis B vaccine
- human papillomavirus vaccine
- hydroxychloroquine
- ibrutinib
- ifosfamide
- imatinib
- infliximab
- influenza H5N1 vaccine
- influenza vaccine
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- itraconazole
- Japanese encephalitis vaccine
- lapatinib
- lenvatinib
- linagliptin
- margetuximab
- mavacamten
- meningococcal vaccine
- mirdametinib
- mitoxantrone
- mobocertinib
- osimertinib
- pazopanib
- peginterferon beta 1a
- pioglitazone
- pneumococcal vaccine
- poliovirus vaccine
- ponatinib
- propafenone
- respiratory syncytial virus vaccine
- ripretinib
- ropeginterferon alfa-2b
- rosiglitazone
- saxagliptin
- selumetinib
- sitagliptin
- smallpox/mpox vaccine, live
- sorafenib
- sunitinib
- tick-borne encephalitis vaccine
- tivozanib
- trabectedin
- trametinib
- trastuzumab
- typhoid vaccine
- vandetanib
- zanidatamab
- zenocutuzumab
- zongertinib
Adverse Reactions .
Serious Reactions
- cardiac failure
- cardiomyopathy
- left ventricular dysfunction
- CHF
- infusion reaction, severe
- hypersensitivity reaction
- anaphylaxis
- angioedema
- anemia
- leukopenia
- neutropenia
- febrile neutropenia
Common Reactions
- diarrhea
- alopecia
- nausea
- fatigue
- peripheral neuropathy
- vomiting
- neutropenia
- constipation
- anemia
- stomatitis
- rash
- myalgia
- arthralgia
- appetite decr.
- dysgeusia
- asthenia
- headache
- fever
- insomnia
- peripheral edema
- hot flashes
- epistaxis
- cough
- lacrimation incr.
- dyspepsia
- xeroderma
- dyspnea
- nail disorder
- febrile neutropenia
- pruritus
- dizziness
- nasopharyngitis
- paresthesia
- abdominal pain
- radiation skin injury
- extremity pain
- leukopenia
- URI
- infusion reaction
- hypersensitivity reaction
Safety/Monitoring .
Monitoring Parameters
pregnancy test at baseline; LVEF at baseline, then regularly during tx; signs/symptoms of infusion reaction during and x60min after 1st infusion, then during and x30min after subsequent infusions
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; risk of oligohydramnios, delayed fetal renal development, and embryo-fetal death based on animal data at 2.5-20x recommended human dose
Pregnancy Reporting
report pregnancy during tx and w/in 7mo of last dose to Genentech Adverse Event Line at 1-888-835-2555
Individuals of Reproductive Potential
obtain pregnancy test before tx start; avoid pregnancy by using effective contraception during tx and x7mo after D/C in patients of childbearing potential
Lactation
Clinical Summary
avoid breastfeeding during tx and x7mo after D/C; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for pertuzumab: unknown; CYP450: unknown
Excretion: for pertuzumab: unknown; Half-life: 18 days
Subclass: HER2 Antagonists ; Immunotherapy, HER2 Inhibitors
Mechanism of Action
for pertuzumab: blocks HER2 heterodimerization, resulting in cell growth arrest and apoptosis; mediates antibody-dependent cell-mediated cytotoxicity
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.