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R-Gene 10
arginine
Adult Dosing .
Dosage forms: INJ
growth hormone deficiency, diagnosis
- [30 g IV x1]
- Start: morning after overnight fast; Max: 30 g/dose; Info: may repeat test after 1 day
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
growth hormone deficiency, diagnosis
- [0.5 g/kg/dose IV x1]
- Start: morning after overnight fast; Max: 30 g/dose; Info: may repeat test after 1 day
renal dosing
- [see below]
- renal impairment: not defined, caution advised
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- pregnancy
- caution: peds patients
- caution: renal impairment
- caution: electrolyte imbalance
Drug Interactions .
Overview
arginine
amino acid; diagnostic agent; herb/supplement
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
- tissue damage, extravasation-related
- thrombocytopenia
- hematuria including delayed onset
Common Reactions
- nausea
- vomiting
- headache
- flushing
- numbness
- local venous irritation
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
avoid use during pregnancy; inadequate human data available; no known risk of fetal harm based on animal data at 12x recommended human dose
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for arginine: liver, intestines; CYP450: unknown
Excretion: for arginine: urine; Half-life: 41.6min
Subclass: Diagnostic Agents, Endocrine
Mechanism of Action
for arginine: stimulates pituitary growth hormone release
Formulary .
No Formulary Selected
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