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Conray
iothalamate meglumine
Adult Dosing .
Dosage forms: INJ: 282 mg per mL
Special Note
- [strength clarification]
- Info: strength expressed as iodine concentration
cerebral angiography
- [carotid or vertebral arteries]
- Dose: 6-10 mL intra-arterially x1; Info: may repeat dose prn
- [right brachial artery]
- Dose: 35-50 mL intra-arterially x1
peripheral arteriography
- [20-40 mL intra-arterially x1]
digital subtraction angiography
- [intra-arterial route, carotid or vertebral arteries]
- Dose: 3-8 mL intra-arterially x1
- [intra-arterial route, aortic arch]
- Dose: 15-25 mL intra-arterially x1
- [intra-arterial route, subclavian or brachial arteries]
- Dose: 5-15 mL intra-arterially x1
- [intra-arterial route, major aorta branches]
- Dose: 5-20 mL intra-arterially x1
- [intra-arterial route, lumbar aorta]
- Dose: 10-25 mL intra-arterially x1
- [IV route]
- Dose: 20-40 mL IV x1; Info: may repeat dose prn
computed tomography
- [head]
- Dose: 2 mL/kg/dose IV x1; Max: 150 mL/total dose
- [body, bolus regimen]
- Dose: 25-50 mL IV x1; Info: may repeat dose prn
- [body, infusion regimen]
- Dose: 150 mg IV x1
- [body, bolus and infusion regimen]
- Dose: 100-150 mL IV infusion x1, then 20-50 mL IV bolus x1; Info: may repeat bolus dose prn
cranial computerized angiotomography
- [bolus regimen]
- Dose: 0.5-1 mL/kg/dose IV x1; Max: 200 mL/total dose; Info: may repeat dose prn
- [bolus and infusion regimen]
- Dose: 50 mg IV bolus x1, then 150 mL IV infusion x1; Alt: 100 mg IV bolus x1, then 100 mL IV infusion x1
excretory urography
- [30-60 mL IV x1]
peripheral venography
- [20-40 mL IV x1]
arthrography
- [knee or hip]
- Dose: 5-15 mL intra-articularly x1
- [shoulder or ankle]
- Dose: 5-10 mL intra-articularly x1
- [other joint]
- Dose: 1-4 mL intra-articularly x1
direct cholangiography, operative or post-operative
- [10-25 mL intrabiliary x1]
- Info: may repeat operative dose prn
percutaneous transhepatic cholangiography
- [20-40 mL intrabiliary x1]
- Info: may repeat dose prn
endoscopic retrograde cholangiopancreatography
- [common bile duct]
- Dose: 10-100 mL intrabiliary x1
- [pancreatic duct]
- Dose: 2-10 mL intraductally x1
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ: 282 mg per mL
Special Note
- [strength clarification]
- Info: strength expressed as iodine concentration
cerebral angiography
- [individualize dose intra-arterially x1]
peripheral arteriography
- [individualize dose intra-arterially x1]
computed tomography, head
- [2 mL/kg/dose IV x1]
- Max: 150 mL/total dose
cranial computerized angiotomography
- [0.5-1 mL/kg/dose IV x1]
- Max: 200 mL/total dose; Info: may repeat dose prn
excretory urography
- [<14 yo]
- Dose: 0.5 mL/kg/dose IV x1
- [14 yo and older]
- Dose: 30-60 mL IV x1
peripheral venography
- [individualize dose IV x1]
arthrography
- [individualize dose intra-articularly x1]
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- intrathecal use
- myelography use
- joint infection (arthrography use)
- coagulation defects (percutaneous transhepatic cholangiography use)
- prolonged prothrombin times (percutaneous transhepatic cholangiography use)
- hypersensitivity to drug or ingredient
- caution: hypersensitivity to other iodinated contrast media
- caution: patients <3 yo
- caution: asthma
- caution: allergies, known
- caution: renal impairment
- caution: renal impairment risk
- caution: arterial disease, severe
- caution: venous disease, severe
- caution: hyperthyroidism
- caution: autonomously functioning thyroid nodule
- caution: cardiovascular disease
- caution: CHF
- caution: hepatorenal disease
- caution: cardiorenal disease
- caution: congenital cardiac conditions (peds patients)
- caution: thromboembolism risk (angiography use)
- caution: pheochromocytoma
- caution: myasthenia gravis
Drug Interactions .
Overview
iothalamate meglumine
contrast agent
- nephrotoxicity
- thrombogenic effects
- caution advised with radioactive iodine; iothalamate meglumine may decrease thyroid uptake of radioactive iodine, efficacy
Contraindicated
- cidofovir
Avoid/Use Alternative
- aldesleukin
- amikacin
- amikacin inhaled
- bumetanide
- clofarabine
- foscarnet
- ganciclovir
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate meglumine
- ioversol
- oxaliplatin
- pentamidine
- polymyxin B
- streptomycin
- streptozocin
- tobramycin
- tobramycin inhaled
- tranexamic acid
- vaccinia immune globulin
- valganciclovir
Monitor/Modify Tx
- abemaciclib
- abrocitinib
- acyclovir
- adefovir dipivoxil
- aflibercept
- alectinib
- aliskiren
- allopurinol
- amiloride
- aminocaproic acid
- amphotericin
- angiotensin II
- anthrax immune globulin
- anti-inhibitor coagulant complex
- antihemophilic factor (factor VIII)/von Willebrand factor complex
- asciminib
- asparaginase
- aspirin
- atidarsagene autotemcel
- auranofin
- avatrombopag
- axitinib
- azilsartan medoxomil
- balsalazide
- baricitinib
- bazedoxifene
- benazepril
- bevacizumab
- binimetinib
- bleomycin
- botulism immune globulin
- brolucizumab
- C1 esterase inhibitor
- cabozantinib
- calaspargase
- candesartan cilexetil
- capecitabine
- captopril
- carboplatin
- carfilzomib
- celecoxib
- chlorothiazide
- chlorthalidone
- chorionic gonadotropin
- cisplatin
- clindamycin
- clozapine
- coagulation factor IX
- coagulation factor VIIa
- coagulation factor XIII A-subunit
- colistimethate
- concizumab
- copper histidinate
- creatine
- cyclophosphamide
- cyclosporine
- cytomegalovirus immune globulin
- danazol
- darbepoetin alfa
- deferasirox
- deferoxamine
- deflazacort
- desogestrel (contraceptive)
- deuruxolitinib
- dexamethasone
- diclofenac
- diclofenac topical
- dienogest (contraceptive)
- diflunisal
- drospirenone (contraceptive)
- drospirenone (hormone replacement)
- eltrombopag
- enalapril
- enalaprilat
- epirubicin
- epoetin alfa
- estetrol (contraceptive)
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- ethacrynic acid
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- ethynodiol (contraceptive)
- etodolac
- etonogestrel (contraceptive)
- everolimus
- factor XIII concentrate
- faricimab
- fedratinib
- fenofibrate
- fenofibric acid
- fenoprofen
- fibrinogen (human)
- fitusiran
- flucytosine
- flurbiprofen
- follitropin
- fosinopril
- fruquintinib
- furosemide
- gentamicin
- hepatitis B immune globulin
- hydrochlorothiazide
- hydroxocobalamin IV
- ibuprofen
- ibuprofen lysine
- ifosfamide
- immune globulin
- indapamide
- indomethacin
- irbesartan
- ketoprofen
- ketorolac
- lazertinib
- lenalidomide
- lenvatinib
- levonorgestrel (contraceptive)
- levonorgestrel (hormone replacement)
- lifileucel
- lisinopril
- lithium
- lomustine
- losartan
- luspatercept
- lusutrombopag
- lutetium Lu 177 vipivotide tetraxetan
- magnesium citrate
- magnesium salicylate
- mannitol
- meclofenamate
- medroxyprogesterone (contraceptive)
- medroxyprogesterone (hormone replacement)
- mefenamic acid
- megestrol
- meloxicam
- menotropins
- mesalamine
- mesalamine rectal
- methotrexate
- methoxy polyethylene glycol-epoetin beta
- methyltestosterone
- metolazone
- mitomycin
- moexipril
- momelotinib
- nabumetone
- naproxen
- necitumumab
- neomycin
- nintedanib
- norelgestromin (contraceptive)
- norethindrone (contraceptive)
- norethindrone (hormone replacement)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- nusinersen
- obinutuzumab
- olaparib
- olmesartan medoxomil
- olsalazine
- ospemifene
- oxaprozin
- pacritinib
- pamidronate
- paromomycin
- pazopanib
- pegaspargase
- pemetrexed
- penicillamine
- pentostatin
- perindopril
- piroxicam
- plazomicin
- polyethylene glycol
- polyethylene glycol/electrolytes
- pomalidomide
- ponatinib
- porfimer
- progesterone (hormone replacement)
- progesterone vaginal (hormone replacement)
- prothrombin complex concentrate (human)
- quinapril
- raloxifene
- ramipril
- ramucirumab
- ranibizumab
- Rho(D) immune globulin
- ritlecitinib
- rituximab
- romiplostim
- ropeginterferon alfa-2b
- ruxolitinib
- ruxolitinib topical
- salsalate
- segesterone (contraceptive)
- sipuleucel-T
- sirolimus
- sitagliptin
- sodium tetradecyl sulfate
- sotatercept
- sparsentan
- spironolactone
- sulfate bowel prep
- sulindac
- sunitinib
- tacrolimus
- tamoxifen
- telavancin
- telmisartan
- temsirolimus
- tenofovir alafenamide
- tenofovir disoproxil
- testosterone
- thalidomide
- tiopronin
- tivozanib
- tofacitinib
- tolmetin
- toremifene
- torsemide
- trametinib
- trandolapril
- tretinoin
- triamterene
- upadacitinib
- vadadustat
- valacyclovir
- valoctocogene roxaparvovec
- valsartan
- vamorolone
- vancomycin
- varicella zoster immune globulin
- voclosporin
- von Willebrand factor
- vorinostat
- willow bark
- ziv-aflibercept
- zoledronic acid
- zonisamide
- zopapogene imadenovec
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
- cutaneous reaction, severe
- acute kidney injury
- hypotension
- shock
- cardiac arrest
- arrhythmia
- extravasation symptoms
- thromboembolism (angiography use)
- thyroid dysfunction (peds patients)
- seizures
- pulmonary edema
Common Reactions
may occur but none reported
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; inadequate human data available; no known risk of fetal harm based on animal data up to 6.6x recommended human dose
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on minimal drug excretion into milk; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for iothalamate: none; CYP450: none
Excretion: for iothalamate: urine primarily (100% unchanged); Half-life: 90min
Subclass: Contrast Agents
Mechanism of Action
for iothalamate: attenuates X-ray beams and opacifies vessels and anatomical structures, enhancing visualization of normal and pathological tissue (nonionic iodine-based contrast medium)
Formulary .
No Formulary Selected
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