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pyridoxine (vitamin B6)
generic
Adult Dosing .
Dosage forms: TAB: 25 mg, 50 mg, 100 mg, 250 mg, 500 mg; INJ: 100 mg per mL
neuropathy prevention, isoniazid-associated
- [25-50 mg PO qd]
- Info: to prevent neuropathy; consider 100 mg PO qd in patients with peripheral neuropathy
pyridoxine deficiency
- [2-5 mg PO qd]
- Start: 10-20 mg PO/IM/IV qd x3wk
dietary supplementation
- [individualize dose]
- Info: see Dietary Reference Intakes: Vitamin B6 (pyridoxine) table
premenstrual syndrome (off-label)
- [40-500 mg PO/IM/IV qd]
nausea/vomiting prevention, pregnancy-related (off-label)
- [10-25 mg PO tid-qid]
- Info: may give with doxylamine; adjust dose based on clinical response
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: TAB: 25 mg, 50 mg; INJ: 100 mg per mL
dietary supplementation
- [individualize dose]
- Info: see Dietary Reference Intakes: Vitamin B6 (pyridoxine) table
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: renal impairment (IM or IV use)
Drug Interactions .
Overview
pyridoxine (vitamin B6)
vitamin
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- numbness
- paresthesia
- unsteady gait
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
pyridoxine confused with: PARoxetine; phenazopyridine; predniSONE; primidone; Pyridium; pyridostigmine; pyrimethamine; thiamine
vitamin B6 confused with: vitamin B1
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; recommended dietary allowance 1.9 mg/day during pregnancy; drug of choice for mitigating neurologic complications from isoniazid use; no known risk of fetal harm based on human data
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding for premenstrual syndrome use, otherwise may use while breastfeeding; recommended dietary allowance 2 mg/day while breastfeeding; no known risk of infant harm based on human data; effects on milk production inconclusive based on conflicting human data
Pharmacology .
Metabolism: for vitamin B6: liver; CYP450: unknown
Excretion: for vitamin B6: urine; Half-life: 15-20 days
Subclass: Tuberculosis (TB) ; Vitamins/Nutritionals
Mechanism of Action
for vitamin B6: participates in carbohydrate, fat, and protein metabolism
Formulary .
No Formulary Selected
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