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MiraLAX
polyethylene glycol 3350
Dosing .
<17 yo, <20 kg (off-label)
- [ oral powder ]
- Dose: 0.2-0.8 g/kg/dose PO qd; Start: 0.4 g/kg/dose PO qd; Max: 17 g/day; Info: dissolve in 4-8 oz of liquid; treat x2 mo minimum and x1 mo minimum after symptom resolution; taper dose gradually to D/C
<17 yo, >20 kg (off-label)
- [ oral powder ]
- Dose: 1 capful or packet PO qd prn; Max: 1 capful or packet/day; Info: dissolve in 4-8 oz of liquid; may take 1-3 days to produce BM; use shortest effective tx duration
17 yo and older
- [ oral powder ]
- Dose: 1 capful or packet PO qd prn; Max: 1 capful or packet/day; Info: dissolve in 4-8 oz of liquid; may take 1-3 days to produce BM; use shortest effective tx duration
renal dosing
- [ see below ]
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
hepatic dosing
- [ not defined ]
Formulations .
oral powder
- [active ingredients per capful or packet]
- polyethylene glycol 3350 17 g
- [flavors/selected other ingredients]
- orange flavor contains sucralose, no alcohol, no dye, no phenylalanine, no saccharin, no sugar
- unflavored formulation contains no alcohol, no dye, no phenylalanine, no saccharin, no sucralose, no sugar
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- GI obstruction, known or suspected
- caution: elderly patients
- caution: renal impairment
Drug Interactions .
Overview
polyethylene glycol
osmotic laxative; bowel prep
Interaction Characteristics:
- colonic mucosal ulceration
- decreases renal perfusion/fxn
- fluid/electrolyte loss
- hypokalemia
- hyponatremia
- lowers seizure threshold
- separate administration from other oral drugs by at least 1h; polyethylene glycol when used for bowel prep may decr. absorption of concomitant oral drugs
Avoid/Use Alternative
- aldesleukin
- amifampridine
- amikacin
- arsenic trioxide
- bisacodyl
- bisacodyl rectal
- castor oil
- clofarabine
- ginkgo
- iodixanol
- iohexol
- iomeprol
- iopromide
- ioversol
- irinotecan
- magnesium citrate
- polyethylene glycol/electrolytes
- sennosides
- sodium phosphate rectal
- sodium picosulfate
- sulfate bowel prep
Monitor/Modify Tx
- abiraterone acetate
- acetazolamide
- acyclovir
- adefovir dipivoxil
- albuterol
- albuterol inhaled
- aliskiren
- aloe
- amikacin inhaled
- amiloride
- amphotericin
- anthrax immune globulin
- apremilast
- arformoterol inhaled
- asparaginase
- aspirin
- auranofin
- azilsartan medoxomil
- balsalazide
- benazepril
- betamethasone
- botulism immune globulin
- budesonide
- bumetanide
- bupropion
- candesartan cilexetil
- capecitabine
- captopril
- carbamazepine
- carboplatin
- carfilzomib
- celecoxib
- cetuximab
- chlorothiazide
- chlorthalidone
- cidofovir
- cisplatin
- citalopram
- clindamycin
- clomipramine
- colistimethate
- copper histidinate
- corticotropin
- cortisone
- creatine
- crizotinib
- cyclophosphamide
- cyclosporine
- cytomegalovirus immune globulin
- decitabine
- deferasirox
- deferoxamine
- deflazacort
- desipramine
- desmopressin
- desvenlafaxine
- dexamethasone
- dichlorphenamide
- diclofenac
- diclofenac topical
- diflunisal
- digoxin
- dinutuximab
- duloxetine
- emapalumab
- enalapril
- enalaprilat
- epinephrine
- escitalopram
- eslicarbazepine acetate
- ethacrynic acid
- etodolac
- fenoprofen
- flucytosine
- fludrocortisone
- fluoxetine
- flurbiprofen
- fluvoxamine
- formoterol inhaled
- foscarnet
- fosfomycin injection
- fosinopril
- furosemide
- ganciclovir
- gentamicin
- hydrochlorothiazide
- hydrocortisone
- ibuprofen
- ibuprofen lysine
- ifosfamide
- immune globulin
- indapamide
- indomethacin
- insulin
- iopamidol
- iothalamate meglumine
- irbesartan
- isoproterenol
- ketoprofen
- ketorolac
- lenalidomide
- levalbuterol inhaled
- levomilnacipran
- licorice
- linezolid
- lisinopril
- lithium
- lomustine
- losartan
- lutetium Lu 177 vipivotide tetraxetan
- magnesium salicylate
- mannitol
- meclofenamate
- mefenamic acid
- meloxicam
- mesalamine
- mesalamine rectal
- methazolamide
- methotrexate
- methylprednisolone
- metolazone
- mifepristone
- milnacipran
- mirtazapine
- mitomycin
- moexipril
- motixafortide
- nabumetone
- naproxen
- necitumumab
- neomycin
- nilotinib
- nusinersen
- olmesartan medoxomil
- olodaterol inhaled
- olsalazine
- osilodrostat
- oxaliplatin
- oxaprozin
- oxcarbazepine
- oxytocin
- pamidronate
- panitumumab
- paromomycin
- paroxetine
- pegvaliase
- pemetrexed
- penicillamine
- pentamidine
- pentostatin
- perindopril
- piroxicam
- plazomicin
- polymyxin B
- posaconazole
- prednisolone
- prednisone
- quinapril
- ramipril
- ramucirumab
- Rho(D) immune globulin
- rituximab
- romidepsin
- ropeginterferon alfa-2b
- sacituzumab govitecan
- salmeterol inhaled
- salsalate
- selinexor
- sertraline
- sirolimus
- sirolimus albumin-bound
- sitagliptin
- sodium benzoate
- sodium phenylacetate
- sodium phenylbutyrate
- sodium polystyrene sulfonate
- sodium thiosulfate
- sparsentan
- spironolactone
- streptomycin
- streptozocin
- sulindac
- tacrolimus
- tafasitamab
- telavancin
- telmisartan
- temsirolimus
- tenofovir alafenamide
- tenofovir disoproxil
- terbutaline
- tiopronin
- tobramycin
- tobramycin inhaled
- tolmetin
- topiramate
- torsemide
- tramadol
- trandolapril
- trazodone
- triamcinolone
- triamterene
- trofinetide
- vaccinia immune globulin
- valacyclovir
- valganciclovir
- valsartan
- vamorolone
- vancomycin
- vasopressin
- venlafaxine
- vilanterol inhaled
- vilazodone
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- vortioxetine
- willow bark
- zoledronic acid
- zonisamide
Caution Advised
- alfentanil
- aminophylline
- amitriptyline
- amoxapine
- amoxicillin
- amphetamine
- ampicillin
- apalutamide
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- asenapine
- axicabtagene ciloleucel
- baclofen
- baclofen intrathecal
- benzphetamine
- brexpiprazole
- brexucabtagene autoleucel
- brivaracetam
- buprenorphine
- busulfan
- butorphanol
- cannabidiol
- cannabis
- cariprazine
- cefazolin
- cefepime
- cefiderocol
- ceftaroline
- ceftazidime
- ceftobiprole
- cenobamate
- charcoal, activated
- chlorambucil
- chloroquine
- chlorpromazine
- ciltacabtagene autoleucel
- ciprofloxacin
- cisatracurium
- clobazam
- clonazepam
- clorazepate
- clozapine
- cocaine
- codeine
- cyclobenzaprine
- cycloserine
- dalfampridine
- darbepoetin alfa
- darolutamide
- delafloxacin
- dexmethylphenidate
- dextroamphetamine
- diazepam
- dicloxacillin
- diethylpropion
- dihydrocodeine
- donepezil
- doxepin
- dronabinol
- elinzanetant
- elivaldogene autotemcel
- enzalutamide
- ephedra
- epoetin alfa
- ertapenem
- ethosuximide
- felbamate
- fenfluramine
- fentanyl
- fluphenazine
- fosphenytoin
- gabapentin
- galantamine
- ganaxolone
- goserelin
- haloperidol
- histrelin
- hydrocodone
- hydromorphone
- hydroxychloroquine
- idecabtagene vicleucel
- iloperidone
- imipenem
- imipramine
- interferon beta 1a
- interferon beta 1b
- isocarboxazid
- isoniazid
- ketamine
- kratom
- lacosamide
- lamotrigine
- leuprolide
- levetiracetam
- levocarnitine
- levofloxacin
- levorphanol
- lidocaine
- lidocaine topical
- lisdexamfetamine
- lisocabtagene maraleucel
- lorazepam
- lorlatinib
- loxapine
- lumateperone
- lurasidone
- mefloquine
- melatonin
- meperidine
- meropenem
- methadone
- methamphetamine
- methocarbamol
- methoxy polyethylene glycol-epoetin beta
- methsuximide
- metoclopramide
- metronidazole
- mexiletine
- midazolam
- milsaperidone
- molindone
- morphine
- moxifloxacin
- nafarelin nasal
- nafcillin
- nalbuphine
- nefazodone
- nelarabine
- nortriptyline
- obecabtagene autoleucel
- ofloxacin
- olanzapine
- oliceridine
- oxacillin
- oxycodone
- oxymorphone
- paliperidone
- peginterferon beta 1a
- penicillin G
- penicillin V
- pentazocine
- perampanel
- perphenazine
- phendimetrazine
- phenelzine
- phenobarbital
- phentermine
- phenytoin
- pimozide
- piperacillin
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- promethazine
- propofol
- protriptyline
- pyridostigmine
- pyrimethamine
- quetiapine
- quinine
- regadenoson
- remifentanil
- risperidone
- rivastigmine
- rufinamide
- scopolamine
- selegiline transdermal
- sevoflurane
- stiripentol
- sufentanil
- sumatriptan
- tapentadol
- teclistamab
- thalidomide
- theophylline
- thioridazine
- thiotepa
- thiothixene
- tiagabine
- tinidazole
- tisagenlecleucel
- tranexamic acid
- tranylcypromine
- treosulfan
- trifluoperazine
- trimipramine
- triptorelin
- vadadustat
- valproic acid
- varenicline
- vigabatrin
- ziprasidone
Adverse Reactions .
Serious Reactions
- electrolyte disorders (prolonged or excessive use)
- laxative dependence (prolonged or excessive use)
Common Reactions
- nausea
- abdominal distension
- cramping
- flatulence
- diarrhea
- urticaria