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ketoprofen
generic
Black Box Warnings .
Cardiovascular Thrombotic Event
NSAIDs incr. risk of serious and potentially fatal cardiovascular thrombotic events, including MI and stroke; risk may occur early in tx and may incr. with duration of use; contraindicated in CABG periop setting
GI Bleeding, Ulceration, and Perforation
NSAIDs incr. risk of serious and potentially fatal GI adverse events including bleeding, ulcer, and stomach or intestine perforation; GI events may occur at any time during use and without warning symptoms; elderly patients and patients with history of PUD or GI bleeding at greater risk for serious GI events
Adult Dosing .
Dosage forms: CAP: 50 mg, 75 mg; ER CAP: 200 mg
pain, mild-moderate
- [50 mg PO q6-8h]
- Max: 300 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
osteoarthritis
- [75 mg PO tid]
- Alt: 50 mg PO qid; 200 mg ER PO qd; Max: 300 mg/day; 200 mg/day ER; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
rheumatoid arthritis
- [75 mg PO tid]
- Alt: 50 mg PO qid; 200 mg ER PO qd; Max: 300 mg/day; 200 mg/day ER; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
dysmenorrhea
- [50 mg PO q6-8h]
- Max: 300 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
for anti-inflammatory uses (off-label)
- [50-100 mg PO tid x7-14 days]
- Max: 300 mg/day; Info: use lowest effective dose, shortest effective tx duration; give with food if GI upset occurs
renal dosing
- [IR form]
- CrCl 60-89: max 150 mg/day; CrCl 25-59: not defined, caution advised; CrCl <25: avoid use; Alt: max 100 mg/day; advanced renal disease: avoid use
- HD: avoid use; Alt: max 100 mg/day; no supplement after dialysis; PD: avoid use; Alt: max 100 mg/day; no supplement
- [ER form]
- renal impairment: avoid use, dose adjustment not possible with ER cap; advanced renal disease: avoid use
- HD/PD: avoid use
hepatic dosing
- [adjust dose amount]
- hepatic impairment: max 100 mg/day
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to ASA
- hypersensitivity to NSAIDs
- asthma, ASA-induced
- asthma, NSAID-induced
- urticaria, ASA-induced
- urticaria, NSAID-induced
- aspirin triad
- CABG surgery periop use
- CrCl <25
- renal disease, advanced
- pregnancy starting at 30 wk gestation
- caution: pregnancy at <30 wk gestation
- caution: elderly patients
- caution: debilitated patients
- caution: renal impairment
- caution: hepatic impairment
- caution: asthma
- caution: MI, recent
- caution: cardiovascular disease
- caution: cardiac disease risk
- caution: HTN
- caution: CHF
- caution: fluid retention
- caution: coagulation disorder
- caution: GI bleeding history
- caution: GI ulcer history
- caution: dehydration
- caution: smokers
- caution: alcohol use, concurrent
- caution: prolonged use
- caution: patients of childbearing potential trying to conceive
Drug Interactions .
Overview
ketoprofen
NSAID
- OAT3 substrate
- affects growth hormone diagnostic test results
- alters gallbladder contraction/motility
- antiplatelet effects
- decreases renal perfusion/fxn
- GI mucosal injury/bleeding risk
- hyperkalemia
- hypertensive effects
- hyponatremia
- lowers seizure threshold
- thrombogenic effects
Contraindicated
- ketorolac
Avoid/Use Alternative
- amikacin
- aspirin
- bumetanide
- celecoxib
- clofarabine
- diclofenac
- diclofenac topical
- diflunisal
- enoxaparin
- epinephrine inhaled
- etodolac
- fenoprofen
- flurbiprofen
- fondaparinux
- ibuprofen
- ibuprofen lysine
- indomethacin
- ketoprofen
- lisinopril
- macimorelin
- magnesium salicylate
- meclofenamate
- mefenamic acid
- meloxicam
- methotrexate
- midodrine
- nabumetone
- naproxen
- oxaprozin
- pemetrexed
- piroxicam
- potassium chloride
- pralatrexate
- probenecid
- salsalate
- sulindac
- tacrolimus
- tenofovir disoproxil
- tolmetin
- tranexamic acid
- vaccinia immune globulin
- valsartan
- willow bark
Monitor/Modify Tx
- abemaciclib
- abiraterone acetate
- abrocitinib
- acalabrutinib
- acebutolol
- acyclovir
- adefovir dipivoxil
- ado-trastuzumab emtansine
- afatinib
- aflibercept
- albuterol
- albuterol inhaled
- aldesleukin
- alendronate
- aliskiren
- allopurinol
- almotriptan
- alpha-tocopherol (vitamin E)
- alprostadil intracavernous
- alprostadil intravenous
- alteplase
- amikacin inhaled
- amiloride
- aminocaproic acid
- amlodipine
- amphetamine
- amphotericin
- anacaulase topical
- anagrelide
- angiotensin II
- anthrax immune globulin
- anti-inhibitor coagulant complex
- antihemophilic factor (factor VIII)/von Willebrand factor complex
- antithrombin
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- aprocitentan
- arformoterol inhaled
- argatroban
- armodafinil
- asciminib
- asparaginase
- atenolol
- atidarsagene autotemcel
- atogepant
- atomoxetine
- atropine ophthalmic
- auranofin
- avapritinib
- avatrombopag
- axitinib
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- balsalazide
- baricitinib
- bazedoxifene
- benazepril
- benzphetamine
- betamethasone
- betaxolol
- bevacizumab
- binimetinib
- bismuth subsalicylate
- bisoprolol
- bivalirudin
- botulism immune globulin
- brentuximab vedotin
- brigatinib
- brolucizumab
- bromelain
- bromfenac ophthalmic
- budesonide
- bupropion
- C1 esterase inhibitor
- cabazitaxel
- cabotegravir
- cabozantinib
- caffeine
- caffeine citrate
- calaspargase
- candesartan cilexetil
- cangrelor
- cannabis
- capecitabine
- caplacizumab
- captopril
- carboplatin
- carfilzomib
- carvedilol
- chlorothiazide
- chlorthalidone
- chorionic gonadotropin
- cidofovir
- cilostazol
- cinacalcet
- cisplatin
- citalopram
- clevidipine
- clindamycin
- clonidine
- clopidogrel
- clozapine
- coagulation factor IX
- coagulation factor VIIa
- coagulation factor XIII A-subunit
- cocaine
- colistimethate
- collagenase clostridium histolyticum
- concizumab
- copanlisib
- copper histidinate
- corticotropin
- cortisone
- creatine
- cyclophosphamide
- cyclosporine
- cysteamine
- cytomegalovirus immune globulin
- dabigatran
- dalteparin
- danazol
- danshen
- darbepoetin alfa
- dasatinib
- decitabine
- deferasirox
- deferoxamine
- defibrotide
- deflazacort
- desmopressin
- desogestrel (contraceptive)
- desvenlafaxine
- deuruxolitinib
- dexamethasone
- dexmethylphenidate
- dextroamphetamine
- diclofenac ophthalmic
- dienogest (contraceptive)
- diethylpropion
- dihydroergotamine
- diltiazem
- dimethyl fumarate
- diosmin
- dipyridamole
- diroximel fumarate
- dobutamine
- donepezil
- dopamine
- doxapram
- doxazosin
- dronabinol
- drospirenone (contraceptive)
- drospirenone (hormone replacement)
- droxidopa
- duloxetine
- edoxaban
- eletriptan
- eltrombopag
- enalapril
- enalaprilat
- encorafenib
- ephedra
- ephedrine injection
- ephedrine oral
- epinephrine
- epirubicin
- eplerenone
- epoetin alfa
- epoprostenol
- eptifibatide
- eptinezumab
- erenumab
- ergotamine
- erlotinib
- escitalopram
- esketamine
- esmolol
- estetrol (contraceptive)
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- etelcalcetide
- ethacrynic acid
- ethanol (alcoholic beverage)
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- ethynodiol (contraceptive)
- etonogestrel (contraceptive)
- etrasimod
- evening primrose oil
- everolimus
- factor XIII concentrate
- faricimab
- fedratinib
- felodipine
- fenfluramine
- fenofibrate
- fenofibric acid
- fenoldopam
- fenugreek
- fexinidazole
- fibrinogen (human)
- finerenone
- fingolimod
- fitusiran
- flucytosine
- fludrocortisone
- fluoxetine
- flurbiprofen ophthalmic
- fluvoxamine
- follitropin
- formoterol inhaled
- foscarnet
- fosinopril
- fostamatinib
- fremanezumab
- frovatriptan
- fruquintinib
- furosemide
- galantamine
- galcanezumab
- ganciclovir
- garlic
- gefitinib
- gemfibrozil
- gemtuzumab ozogamicin
- gentamicin
- ginkgo
- guanfacine
- heparin
- hepatitis B immune globulin
- hoodia
- hydralazine
- hydrochlorothiazide
- hydrocortisone
- hydroxocobalamin IV
- ibandronate
- ibrutinib
- icosapent ethyl
- ifosfamide
- imatinib
- immune globulin
- indapamide
- iodixanol
- iohexol
- iomeprol
- iopamidol
- iopromide
- iothalamate meglumine
- ioversol
- irbesartan
- isradipine
- ketamine
- ketorolac ophthalmic
- labetalol
- landiolol
- lanreotide
- lanthanum
- lazertinib
- leflunomide
- lenalidomide
- lenvatinib
- levalbuterol inhaled
- levomilnacipran
- levonorgestrel (contraceptive)
- levonorgestrel (hormone replacement)
- licorice
- lifileucel
- lisdexamfetamine
- lithium
- lomustine
- lorlatinib
- losartan
- lumacaftor/ivacaftor
- luspatercept
- lusutrombopag
- lutetium Lu 177 vipivotide tetraxetan
- magnesium citrate
- mannitol
- medroxyprogesterone (contraceptive)
- medroxyprogesterone (hormone replacement)
- megestrol
- menotropins
- meropenem
- mesalamine
- mesalamine rectal
- methamphetamine
- methoxy polyethylene glycol-epoetin beta
- methyl salicylate topical
- methyldopa
- methylergonovine
- methylphenidate
- methylprednisolone
- methyltestosterone
- metoclopramide
- metolazone
- metoprolol
- milnacipran
- minoxidil
- mirabegron
- mitomycin
- mitotane
- modafinil
- moexipril
- momelotinib
- monomethyl fumarate
- mycophenolate mofetil
- mycophenolic acid
- nadolol
- naratriptan
- nattokinase
- naxitamab
- nebivolol
- necitumumab
- neomycin
- nepafenac ophthalmic
- niacin (vitamin B3)
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nintedanib
- niraparib
- nisoldipine
- nitisinone
- norelgestromin (contraceptive)
- norepinephrine
- norethindrone (contraceptive)
- norethindrone (hormone replacement)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- nusinersen
- obinutuzumab
- olaparib
- olmesartan medoxomil
- olodaterol inhaled
- olsalazine
- omega-3-acid
- osilodrostat
- ospemifene
- oxaliplatin
- oxymetazoline nasal
- oxytocin
- ozanimod
- pacritinib
- pamidronate
- paromomycin
- paroxetine
- pazopanib
- pegaspargase
- penicillamine
- penicillin G
- pentamidine
- pentosan polysulfate sodium
- pentostatin
- pentoxifylline
- perindopril
- pexidartinib
- phendimetrazine
- phenoxybenzamine
- phentermine
- phentolamine
- phenylephrine
- phenylephrine injection
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine rectal
- pindolol
- piperacillin
- pirtobrutinib
- plasminogen, human
- plazomicin
- polyethylene glycol
- polyethylene glycol/electrolytes
- polymyxin B
- pomalidomide
- ponatinib
- ponesimod
- porfimer
- potassium acid phosphate
- potassium bicarbonate
- potassium citrate
- potassium iodide
- potassium phosphate
- pralsetinib
- prasugrel
- prazosin
- prednisolone
- prednisone
- pretomanid
- progesterone (hormone replacement)
- progesterone vaginal (hormone replacement)
- propranolol
- prothrombin complex concentrate (human)
- pseudoephedrine
- pyridostigmine
- quetiapine
- quinapril
- raloxifene
- ramipril
- ramucirumab
- ranibizumab
- regorafenib
- remibrutinib
- resveratrol
- reteplase
- revakinagene taroretcel
- Rho(D) immune globulin
- rimegepant
- ripretinib
- risedronate
- ritlecitinib
- rituximab
- rivaroxaban
- rivastigmine
- rizatriptan
- romiplostim
- ropeginterferon alfa-2b
- ropinirole
- rotigotine transdermal
- ruxolitinib
- ruxolitinib topical
- salmeterol inhaled
- saw palmetto
- segesterone (contraceptive)
- selpercatinib
- selumetinib
- sepiapterin
- sertraline
- sincalide
- siponimod
- sipuleucel-T
- sirolimus
- sirolimus albumin-bound
- sitagliptin
- sodium tetradecyl sulfate
- solriamfetol
- sorafenib
- sotatercept
- sparsentan
- spironolactone
- streptomycin
- streptozocin
- succinylcholine
- sulfate bowel prep
- sumatriptan
- sunitinib
- tagraxofusp
- tamoxifen
- telavancin
- telmisartan
- temsirolimus
- tenecteplase
- tenofovir alafenamide
- terazosin
- terbutaline
- teriflunomide
- testosterone
- thalidomide
- ticagrelor
- timolol
- tiopronin
- tipranavir
- tirofiban
- tisotumab vedotin
- tivozanib
- tobramycin
- tobramycin inhaled
- tocilizumab
- tofacitinib
- tolvaptan
- toremifene
- torsemide
- tovorafenib
- trametinib
- trandolapril
- trazodone
- treprostinil
- tretinoin
- triamcinolone
- triamterene
- trimethoprim
- ubrogepant
- upadacitinib
- vaborbactam
- vadadustat
- valacyclovir
- valganciclovir
- valoctocogene roxaparvovec
- valproic acid
- vamorolone
- vancomycin
- vandetanib
- varicella zoster immune globulin
- vasopressin
- venlafaxine
- verapamil
- vilanterol inhaled
- vilazodone
- viloxazine
- vinpocetine
- voclosporin
- von Willebrand factor
- vorapaxar
- vorinostat
- vortioxetine
- warfarin
- yohimbe
- zanubrutinib
- zavegepant
- ziv-aflibercept
- zoledronic acid
- zolmitriptan
- zonisamide
- zopapogene imadenovec
Caution Advised
- ciprofloxacin
- delafloxacin
- emtricitabine
- levofloxacin
- moxifloxacin
- ofloxacin
Adverse Reactions .
Serious Reactions
- GI bleeding
- GI perforation
- GI ulcer
- MI
- stroke
- thromboembolism
- HTN
- CHF
- renal papillary necrosis
- nephrotoxicity
- hepatotoxicity
- anaphylactoid reaction
- bronchospasm
- exfoliative dermatitis
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- drug reaction with eosinophilia and systemic symptoms
- generalized bullous fixed drug eruption
- anemia
- blood dyscrasia
- prolonged bleeding time
- hyperkalemia
Common Reactions
- dyspepsia
- nausea
- abdominal pain
- constipation
- headache
- dizziness
- somnolence
- rash
- ALT or AST elevated
- peripheral edema
- fluid retention
- tinnitus
- ecchymosis
- photosensitivity
- delayed ovulation
Safety/Monitoring .
Monitoring Parameters
Cr at baseline, then if renal or hepatic impairment, CHF, elderly or long-term tx, continue periodically; BP at baseline, then periodically; CBC, chemistry profile if long-term tx
Look/Sound-Alike Drug Names
ketoprofen confused with: ketoconazole
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit if <30 wk gestation, especially at 20-29 wk gestation, avoid use starting at 30 wk gestation; if must use at 20-29 wk gestation, limit dose and duration, and consider monitoring amniotic fluid if use >48h; risk of embryo-fetal toxicity and death low in 1st trimester based on conflicting human data; risk of fetal harm, including renal dysfunction and oligohydramnios, starting at 20 wk gestation and premature ductus arteriosus closure, starting at 30 wk gestation, based on human data with NSAID class and drug's mechanism of action
Individuals of Reproductive Potential
weigh risk/benefit in patients of childbearing potential trying to conceive, especially if long-term use; NSAIDs may reversibly delay ovulation during tx based on limited human or animal data and drug's mechanism of action
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; inadequate human data available, though possible risk of infant renal and GI adverse effects; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for ketoprofen: liver extensively, tissues; CYP450: unknown
Excretion: for ketoprofen: urine 80% (<10% unchanged); Half-life: 2.1h
Subclass: Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Mechanism of Action
for ketoprofen: exact mechanism of action unknown; inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis
Formulary .
No Formulary Selected
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