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nystatin
generic
Adult Dosing .
Dosage forms: TAB: 500,000 units; SUSP: 100,000 units per mL
candidiasis, oropharyngeal
- [4-6 mL PO qid x7-14 days]
- Info: retain in mouth as long as possible
candidiasis, intestinal
- [1-2 tabs PO tid]
- Alt: 5-10 mL PO tid; Info: use x48h after sx resolve
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: SUSP: 100,000 units per mL
candidiasis, oral
- [premature or low birth wt neonates]
- Dose: 1 mL PO qid; Info: give 0.5 mL in each side of mouth; use x48h after sx resolve
- [infants]
- Dose: 2 mL PO qid; Info: give 1 mL in each side of mouth; use x48h after sx resolve
- [children]
- Dose: 4-6 mL PO qid; Info: retain in mouth as long as possible; use x48h after sx resolve
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
nystatin
polyene antifungal
-
None
Monitor/Modify Tx
- cyclosporine
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
Common Reactions
- nausea
- vomiting
- diarrhea
- abdominal pain
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
nystatin confused with: Dilantin; naftifine; niacin; nitroglycerin; phenytoin sodium
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; inadequate human data available, though risk of fetal harm not expected based on minimal systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on minimal systemic absorption in breastfeeding patients
Pharmacology .
Metabolism: none; CYP450: none; Info: minimal systemic absorption
Excretion: feces (100% unchanged); Half-life: unknown
Subclass: Antifungals ; Candidiasis, Oropharyngeal
Mechanism of Action
binds to cell membrane sterols, increasing permeability
Formulary .
No Formulary Selected
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