Bromfed

Overview

brompheniramine

antihistamine, 1st generation

• anticholinergic effects
• CNS depression
• decreases central histamine effects
• tachycardia

phenylephrine

alpha-1 agonist

• hyperglycemic effects
• hypertensive effects
• tachycardia

• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• dihydroergotamine
Bromfed (brompheniramine/ phenylephrine)

+

dihydroergotamine

1 interaction

Contraindicated

phenylephrine + dihydroergotamine

contraindicated: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

• ergotamine
Bromfed (brompheniramine/ phenylephrine)

+

ergotamine

1 interaction

Contraindicated

phenylephrine + ergotamine

contraindicated: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

• isocarboxazid
Bromfed (brompheniramine/ phenylephrine)

+

isocarboxazid

2 interactions

Contraindicated

brompheniramine + isocarboxazid

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

phenylephrine + isocarboxazid

contraindicated w/in 14 days of isocarboxazid use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• phenelzine
Bromfed (brompheniramine/ phenylephrine)

+

phenelzine

2 interactions

Contraindicated

phenylephrine + phenelzine

contraindicated w/in 14 days of phenelzine use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Avoid/Use Alternative

brompheniramine + phenelzine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• potassium chloride
Bromfed (brompheniramine/ phenylephrine)

+

potassium chloride

1 interaction

Contraindicated

brompheniramine + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium citrate
Bromfed (brompheniramine/ phenylephrine)

+

potassium citrate

1 interaction

Contraindicated

brompheniramine + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• tranylcypromine
Bromfed (brompheniramine/ phenylephrine)

+

tranylcypromine

2 interactions

Contraindicated

brompheniramine + tranylcypromine

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

phenylephrine + tranylcypromine

contraindicated w/in 14 days of tranylcypromine use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Avoid/Use Alternative

• aclidinium inhaled
Bromfed (brompheniramine/ phenylephrine)

+

aclidinium inhaled

1 interaction

Avoid/Use Alternative

brompheniramine + aclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• albuterol
Bromfed (brompheniramine/ phenylephrine)

+

albuterol

1 interaction

Avoid/Use Alternative

phenylephrine + albuterol

use alternative or monitor BP, HR w/ oral albuterol; risk may be lower w/ inhaled albuterol: combo may incr. risk of HTN, tachycardia (additive effects)

• butalbital
Bromfed (brompheniramine/ phenylephrine)

+

butalbital

1 interaction

Avoid/Use Alternative

brompheniramine + butalbital

avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• chlorcyclizine
Bromfed (brompheniramine/ phenylephrine)

+

chlorcyclizine

1 interaction

Avoid/Use Alternative

brompheniramine + chlorcyclizine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects (additive effects, duplicate therapy)

• clonidine
Bromfed (brompheniramine/ phenylephrine)

+

clonidine

2 interactions

Avoid/Use Alternative

brompheniramine + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

phenylephrine + clonidine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clozapine
Bromfed (brompheniramine/ phenylephrine)

+

clozapine

1 interaction

Avoid/Use Alternative

brompheniramine + clozapine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (including life-threatening), other anticholinergic adverse effects (additive effects)

• cocaine
Bromfed (brompheniramine/ phenylephrine)

+

cocaine

1 interaction

Avoid/Use Alternative

phenylephrine + cocaine

use alternative or monitor BP, HR, ECG: combo may incr. risk of severe vasoconstriction, HTN, tachycardia, arrhythmias (additive effects)

• codeine
Bromfed (brompheniramine/ phenylephrine)

+

codeine

1 interaction

Avoid/Use Alternative

brompheniramine + codeine

avoid combo if antitussive use; otherwise monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• dexbrompheniramine
Bromfed (brompheniramine/ phenylephrine)

+

dexbrompheniramine

1 interaction

Avoid/Use Alternative

brompheniramine + dexbrompheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)

• doxylamine
Bromfed (brompheniramine/ phenylephrine)

+

doxylamine

1 interaction

Avoid/Use Alternative

brompheniramine + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dronabinol
Bromfed (brompheniramine/ phenylephrine)

+

dronabinol

2 interactions

Avoid/Use Alternative

brompheniramine + dronabinol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

phenylephrine + dronabinol

avoid combo: combo may incr. risk of HTN (additive effects)

• eluxadoline
Bromfed (brompheniramine/ phenylephrine)

+

eluxadoline

1 interaction

Avoid/Use Alternative

brompheniramine + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• ephedra
Bromfed (brompheniramine/ phenylephrine)

+

ephedra

1 interaction

Avoid/Use Alternative

phenylephrine + ephedra

avoid combo: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• epinephrine inhaled
Bromfed (brompheniramine/ phenylephrine)

+

epinephrine inhaled

1 interaction

Avoid/Use Alternative

phenylephrine + epinephrine inhaled

avoid combo: combo may incr. risk of HTN (including hypertensive crisis), tachycardia (additive effects)

• ethanol (alcoholic beverage)
Bromfed (brompheniramine/ phenylephrine)

+

ethanol (alcoholic beverage)

2 interactions

Avoid/Use Alternative

brompheniramine + ethanol (alcoholic beverage)

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

phenylephrine + ethanol (alcoholic beverage)

monitor BP: combo may incr. risk of HTN (chronic alcohol use) (additive effects)

• ethanol injection
Bromfed (brompheniramine/ phenylephrine)

+

ethanol injection

1 interaction

Avoid/Use Alternative

brompheniramine + ethanol injection

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• furosemide
Bromfed (brompheniramine/ phenylephrine)

+

furosemide

1 interaction

Avoid/Use Alternative

phenylephrine + furosemide

use alternative or monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• glucagon
Bromfed (brompheniramine/ phenylephrine)

+

glucagon

1 interaction

Avoid/Use Alternative

brompheniramine + glucagon

avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)

• glycopyrronium topical
Bromfed (brompheniramine/ phenylephrine)

+

glycopyrronium topical

1 interaction

Avoid/Use Alternative

brompheniramine + glycopyrronium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• haloperidol
Bromfed (brompheniramine/ phenylephrine)

+

haloperidol

1 interaction

Avoid/Use Alternative

brompheniramine + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hydrocodone
Bromfed (brompheniramine/ phenylephrine)

+

hydrocodone

1 interaction

Avoid/Use Alternative

brompheniramine + hydrocodone

avoid combo if antitussive use; otherwise monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• hydroxyzine
Bromfed (brompheniramine/ phenylephrine)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

brompheniramine + hydroxyzine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects (additive effects, duplicate therapy)

• imipramine
Bromfed (brompheniramine/ phenylephrine)

+

imipramine

2 interactions

Avoid/Use Alternative

phenylephrine + imipramine

avoid combo: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + imipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• kava
Bromfed (brompheniramine/ phenylephrine)

+

kava

1 interaction

Avoid/Use Alternative

brompheniramine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Bromfed (brompheniramine/ phenylephrine)

+

kratom

1 interaction

Avoid/Use Alternative

brompheniramine + kratom

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• landiolol
Bromfed (brompheniramine/ phenylephrine)

+

landiolol

1 interaction

Avoid/Use Alternative

phenylephrine + landiolol

use alternative or monitor HR, BP: combo may decr. landiolol efficacy (antagonistic effects)

• linezolid
Bromfed (brompheniramine/ phenylephrine)

+

linezolid

1 interaction

Avoid/Use Alternative

phenylephrine + linezolid

avoid combo w/in 2wk of linezolid use: combo may incr. risk of HTN (additive effects)

• metaxalone
Bromfed (brompheniramine/ phenylephrine)

+

metaxalone

1 interaction

Avoid/Use Alternative

brompheniramine + metaxalone

use alternative or monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methylergonovine
Bromfed (brompheniramine/ phenylephrine)

+

methylergonovine

1 interaction

Avoid/Use Alternative

phenylephrine + methylergonovine

consider alternative or monitor BP: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

• metoclopramide
Bromfed (brompheniramine/ phenylephrine)

+

metoclopramide

2 interactions

Avoid/Use Alternative

brompheniramine + metoclopramide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

Monitor/Modify Tx

phenylephrine + metoclopramide

monitor BP: combo may incr. risk of HTN (additive effects)

• midazolam
Bromfed (brompheniramine/ phenylephrine)

+

midazolam

1 interaction

Avoid/Use Alternative

brompheniramine + midazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• midodrine
Bromfed (brompheniramine/ phenylephrine)

+

midodrine

1 interaction

Avoid/Use Alternative

phenylephrine + midodrine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

• olanzapine
Bromfed (brompheniramine/ phenylephrine)

+

olanzapine

1 interaction

Avoid/Use Alternative

brompheniramine + olanzapine

consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

• oxybate
Bromfed (brompheniramine/ phenylephrine)

+

oxybate

1 interaction

Avoid/Use Alternative

brompheniramine + oxybate

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

• ozanimod
Bromfed (brompheniramine/ phenylephrine)

+

ozanimod

1 interaction

Avoid/Use Alternative

phenylephrine + ozanimod

avoid combo w/in 14 days of ozanimod use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• phenylephrine
Bromfed (brompheniramine/ phenylephrine)

+

phenylephrine

1 interaction

Avoid/Use Alternative

phenylephrine + phenylephrine

avoid combo: combo may incr. risk of HTN, tachycardia (additive effects, duplicate therapy)

• pitolisant
Bromfed (brompheniramine/ phenylephrine)

+

pitolisant

1 interaction

Avoid/Use Alternative

brompheniramine + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

• pramlintide
Bromfed (brompheniramine/ phenylephrine)

+

pramlintide

2 interactions

Avoid/Use Alternative

brompheniramine + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

Monitor/Modify Tx

phenylephrine + pramlintide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• procarbazine
Bromfed (brompheniramine/ phenylephrine)

+

procarbazine

2 interactions

Avoid/Use Alternative

phenylephrine + procarbazine

use alternative or monitor BP: combo may incr. risk of HTN (additive effect)

Caution Advised

brompheniramine + procarbazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• promethazine
Bromfed (brompheniramine/ phenylephrine)

+

promethazine

1 interaction

Avoid/Use Alternative

brompheniramine + promethazine

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pseudoephedrine
Bromfed (brompheniramine/ phenylephrine)

+

pseudoephedrine

1 interaction

Avoid/Use Alternative

phenylephrine + pseudoephedrine

avoid combo: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects, duplicate therapy)

• pyrilamine
Bromfed (brompheniramine/ phenylephrine)

+

pyrilamine

1 interaction

Avoid/Use Alternative

brompheniramine + pyrilamine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

• rasagiline
Bromfed (brompheniramine/ phenylephrine)

+

rasagiline

2 interactions

Avoid/Use Alternative

phenylephrine + rasagiline

avoid combo w/in 14 days of rasagiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + rasagiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• revefenacin inhaled
Bromfed (brompheniramine/ phenylephrine)

+

revefenacin inhaled

1 interaction

Avoid/Use Alternative

brompheniramine + revefenacin inhaled

avoid combo: combo may incr. anticholinergic adverse effects (additive effects)

• rivastigmine
Bromfed (brompheniramine/ phenylephrine)

+

rivastigmine

1 interaction

Avoid/Use Alternative

brompheniramine + rivastigmine

use alternative: combo may decrease efficacy of both drugs (antagonistic effects)

• ropeginterferon alfa-2b
Bromfed (brompheniramine/ phenylephrine)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

brompheniramine + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• safinamide
Bromfed (brompheniramine/ phenylephrine)

+

safinamide

2 interactions

Avoid/Use Alternative

phenylephrine + safinamide

avoid combo w/in 14 days of safinamide use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + safinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• scopolamine
Bromfed (brompheniramine/ phenylephrine)

+

scopolamine

1 interaction

Avoid/Use Alternative

brompheniramine + scopolamine

use alternative: combo may increase risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• selegiline
Bromfed (brompheniramine/ phenylephrine)

+

selegiline

2 interactions

Avoid/Use Alternative

phenylephrine + selegiline

avoid combo w/in 14 days of selegiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + selegiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selegiline transdermal
Bromfed (brompheniramine/ phenylephrine)

+

selegiline transdermal

2 interactions

Avoid/Use Alternative

phenylephrine + selegiline transdermal

avoid combo w/in 14 days of selegiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + selegiline transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sofpironium topical
Bromfed (brompheniramine/ phenylephrine)

+

sofpironium topical

1 interaction

Avoid/Use Alternative

brompheniramine + sofpironium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• thalidomide
Bromfed (brompheniramine/ phenylephrine)

+

thalidomide

1 interaction

Avoid/Use Alternative

brompheniramine + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tradipitant
Bromfed (brompheniramine/ phenylephrine)

+

tradipitant

1 interaction

Avoid/Use Alternative

brompheniramine + tradipitant

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimethobenzamide
Bromfed (brompheniramine/ phenylephrine)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

brompheniramine + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• yohimbe
Bromfed (brompheniramine/ phenylephrine)

+

yohimbe

1 interaction

Avoid/Use Alternative

phenylephrine + yohimbe

use alternative or monitor HR, BP w/in 14 days of yohimbe use: combo may incr. risk of tachycardia, HTN (additive effects)

• zuranolone
Bromfed (brompheniramine/ phenylephrine)

+

zuranolone

1 interaction

Avoid/Use Alternative

brompheniramine + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• abiraterone acetate
Bromfed (brompheniramine/ phenylephrine)

+

abiraterone acetate

1 interaction

Monitor/Modify Tx

phenylephrine + abiraterone acetate

monitor BP: combo may incr. risk of HTN (additive effects)

• acarbose
Bromfed (brompheniramine/ phenylephrine)

+

acarbose

1 interaction

Monitor/Modify Tx

phenylephrine + acarbose

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• acebutolol
Bromfed (brompheniramine/ phenylephrine)

+

acebutolol

1 interaction

Monitor/Modify Tx

phenylephrine + acebutolol

monitor BP: combo may decr. antihypertensive efficacy, exaggerate HTN response (antagonistic effects)

• albuterol inhaled
Bromfed (brompheniramine/ phenylephrine)

+

albuterol inhaled

1 interaction

Monitor/Modify Tx

phenylephrine + albuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• aldesleukin
Bromfed (brompheniramine/ phenylephrine)

+

aldesleukin

1 interaction

Monitor/Modify Tx

brompheniramine + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alfentanil
Bromfed (brompheniramine/ phenylephrine)

+

alfentanil

1 interaction

Monitor/Modify Tx

brompheniramine + alfentanil

monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

• aliskiren
Bromfed (brompheniramine/ phenylephrine)

+

aliskiren

1 interaction

Monitor/Modify Tx

phenylephrine + aliskiren

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• almotriptan
Bromfed (brompheniramine/ phenylephrine)

+

almotriptan

2 interactions

Monitor/Modify Tx

phenylephrine + almotriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + almotriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alogliptin
Bromfed (brompheniramine/ phenylephrine)

+

alogliptin

1 interaction

Monitor/Modify Tx

phenylephrine + alogliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• alprazolam
Bromfed (brompheniramine/ phenylephrine)

+

alprazolam

1 interaction

Monitor/Modify Tx

brompheniramine + alprazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• amiloride
Bromfed (brompheniramine/ phenylephrine)

+

amiloride

1 interaction

Monitor/Modify Tx

phenylephrine + amiloride

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amitriptyline
Bromfed (brompheniramine/ phenylephrine)

+

amitriptyline

2 interactions

Monitor/Modify Tx

phenylephrine + amitriptyline

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + amitriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• amlodipine
Bromfed (brompheniramine/ phenylephrine)

+

amlodipine

1 interaction

Monitor/Modify Tx

phenylephrine + amlodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amoxapine
Bromfed (brompheniramine/ phenylephrine)

+

amoxapine

2 interactions

Monitor/Modify Tx

phenylephrine + amoxapine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + amoxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• amphetamine
Bromfed (brompheniramine/ phenylephrine)

+

amphetamine

1 interaction

Monitor/Modify Tx

phenylephrine + amphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, CNS stimulatory effects (additive effects)

• angiotensin II
Bromfed (brompheniramine/ phenylephrine)

+

angiotensin II

1 interaction

Monitor/Modify Tx

phenylephrine + angiotensin II

monitor BP: combo may incr. risk of HTN (additive effects)

• aprocitentan
Bromfed (brompheniramine/ phenylephrine)

+

aprocitentan

1 interaction

Monitor/Modify Tx

phenylephrine + aprocitentan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• arformoterol inhaled
Bromfed (brompheniramine/ phenylephrine)

+

arformoterol inhaled

1 interaction

Monitor/Modify Tx

phenylephrine + arformoterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• armodafinil
Bromfed (brompheniramine/ phenylephrine)

+

armodafinil

1 interaction

Monitor/Modify Tx

phenylephrine + armodafinil

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• asciminib
Bromfed (brompheniramine/ phenylephrine)

+

asciminib

1 interaction

Monitor/Modify Tx

phenylephrine + asciminib

monitor BP: combo may incr. risk of HTN (additive effects)

• atenolol
Bromfed (brompheniramine/ phenylephrine)

+

atenolol

1 interaction

Monitor/Modify Tx

phenylephrine + atenolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atogepant
Bromfed (brompheniramine/ phenylephrine)

+

atogepant

1 interaction

Monitor/Modify Tx

phenylephrine + atogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• atomoxetine
Bromfed (brompheniramine/ phenylephrine)

+

atomoxetine

1 interaction

Monitor/Modify Tx

phenylephrine + atomoxetine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• atropine ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

atropine ophthalmic

2 interactions

Monitor/Modify Tx

phenylephrine + atropine ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + atropine ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• axitinib
Bromfed (brompheniramine/ phenylephrine)

+

axitinib

1 interaction

Monitor/Modify Tx

phenylephrine + axitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• azilsartan medoxomil
Bromfed (brompheniramine/ phenylephrine)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

phenylephrine + azilsartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• benazepril
Bromfed (brompheniramine/ phenylephrine)

+

benazepril

1 interaction

Monitor/Modify Tx

phenylephrine + benazepril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• benzphetamine
Bromfed (brompheniramine/ phenylephrine)

+

benzphetamine

1 interaction

Monitor/Modify Tx

phenylephrine + benzphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• betamethasone
Bromfed (brompheniramine/ phenylephrine)

+

betamethasone

1 interaction

Monitor/Modify Tx

phenylephrine + betamethasone

monitor BP: combo may incr. risk of HTN (additive effects)

• betaxolol
Bromfed (brompheniramine/ phenylephrine)

+

betaxolol

1 interaction

Monitor/Modify Tx

phenylephrine + betaxolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bevacizumab
Bromfed (brompheniramine/ phenylephrine)

+

bevacizumab

1 interaction

Monitor/Modify Tx

phenylephrine + bevacizumab

monitor BP: combo may incr. risk of HTN (additive effects)

• bexagliflozin
Bromfed (brompheniramine/ phenylephrine)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

phenylephrine + bexagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• bismuth subsalicylate
Bromfed (brompheniramine/ phenylephrine)

+

bismuth subsalicylate

1 interaction

Monitor/Modify Tx

phenylephrine + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

• bisoprolol
Bromfed (brompheniramine/ phenylephrine)

+

bisoprolol

1 interaction

Monitor/Modify Tx

phenylephrine + bisoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• brigatinib
Bromfed (brompheniramine/ phenylephrine)

+

brigatinib

1 interaction

Monitor/Modify Tx

phenylephrine + brigatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• bromocriptine
Bromfed (brompheniramine/ phenylephrine)

+

bromocriptine

2 interactions

Monitor/Modify Tx

phenylephrine + bromocriptine

monitor BP, glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy; may incr. risk of HTN, tachycardia (antagonistic effects; mechanism unknown)

Caution Advised

brompheniramine + bromocriptine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• budesonide
Bromfed (brompheniramine/ phenylephrine)

+

budesonide

1 interaction

Monitor/Modify Tx

phenylephrine + budesonide

monitor BP: combo may incr. risk of HTN (additive effects)

• bumetanide
Bromfed (brompheniramine/ phenylephrine)

+

bumetanide

1 interaction

Monitor/Modify Tx

phenylephrine + bumetanide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• buprenorphine
Bromfed (brompheniramine/ phenylephrine)

+

buprenorphine

1 interaction

Monitor/Modify Tx

brompheniramine + buprenorphine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• bupropion
Bromfed (brompheniramine/ phenylephrine)

+

bupropion

1 interaction

Monitor/Modify Tx

phenylephrine + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

• butorphanol
Bromfed (brompheniramine/ phenylephrine)

+

butorphanol

1 interaction

Monitor/Modify Tx

brompheniramine + butorphanol

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• cabozantinib
Bromfed (brompheniramine/ phenylephrine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

phenylephrine + cabozantinib

monitor BP: combo may incr. risk of HTN (additive effects)

• caffeine
Bromfed (brompheniramine/ phenylephrine)

+

caffeine

1 interaction

Monitor/Modify Tx

phenylephrine + caffeine

monitor BP, HR; avoid excessive caffeine intake: combo may incr. risk of HTN, tachycardia (additive effects)

• caffeine citrate
Bromfed (brompheniramine/ phenylephrine)

+

caffeine citrate

1 interaction

Monitor/Modify Tx

phenylephrine + caffeine citrate

monitor BP: combo may incr. risk of HTN (additive effects)

• canagliflozin
Bromfed (brompheniramine/ phenylephrine)

+

canagliflozin

1 interaction

Monitor/Modify Tx

phenylephrine + canagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• candesartan cilexetil
Bromfed (brompheniramine/ phenylephrine)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

phenylephrine + candesartan cilexetil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• cannabis
Bromfed (brompheniramine/ phenylephrine)

+

cannabis

2 interactions

Monitor/Modify Tx

brompheniramine + cannabis

monitor HR: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

phenylephrine + cannabis

monitor BP: combo may incr. risk of HTN (additive effects)

• captopril
Bromfed (brompheniramine/ phenylephrine)

+

captopril

1 interaction

Monitor/Modify Tx

phenylephrine + captopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• carbamazepine
Bromfed (brompheniramine/ phenylephrine)

+

carbamazepine

1 interaction

Monitor/Modify Tx

brompheniramine + carbamazepine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carfilzomib
Bromfed (brompheniramine/ phenylephrine)

+

carfilzomib

1 interaction

Monitor/Modify Tx

phenylephrine + carfilzomib

monitor BP: combo may incr. risk of HTN (additive effects)

• carvedilol
Bromfed (brompheniramine/ phenylephrine)

+

carvedilol

1 interaction

Monitor/Modify Tx

phenylephrine + carvedilol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• celecoxib
Bromfed (brompheniramine/ phenylephrine)

+

celecoxib

1 interaction

Monitor/Modify Tx

phenylephrine + celecoxib

monitor BP: combo may incr. risk of HTN (additive effects)

• chlorothiazide
Bromfed (brompheniramine/ phenylephrine)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

phenylephrine + chlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• chlorpromazine
Bromfed (brompheniramine/ phenylephrine)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

brompheniramine + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorthalidone
Bromfed (brompheniramine/ phenylephrine)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

phenylephrine + chlorthalidone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clevidipine
Bromfed (brompheniramine/ phenylephrine)

+

clevidipine

1 interaction

Monitor/Modify Tx

phenylephrine + clevidipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clobazam
Bromfed (brompheniramine/ phenylephrine)

+

clobazam

1 interaction

Monitor/Modify Tx

brompheniramine + clobazam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clomipramine
Bromfed (brompheniramine/ phenylephrine)

+

clomipramine

2 interactions

Monitor/Modify Tx

brompheniramine + clomipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

phenylephrine + clomipramine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• clonazepam
Bromfed (brompheniramine/ phenylephrine)

+

clonazepam

1 interaction

Monitor/Modify Tx

brompheniramine + clonazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clorazepate
Bromfed (brompheniramine/ phenylephrine)

+

clorazepate

1 interaction

Monitor/Modify Tx

brompheniramine + clorazepate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• colesevelam
Bromfed (brompheniramine/ phenylephrine)

+

colesevelam

1 interaction

Monitor/Modify Tx

phenylephrine + colesevelam

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• copanlisib
Bromfed (brompheniramine/ phenylephrine)

+

copanlisib

1 interaction

Monitor/Modify Tx

phenylephrine + copanlisib

monitor BP: combo may incr. risk of HTN (additive effects, copanlisib may cause infusion-related HTN)

• corticotropin
Bromfed (brompheniramine/ phenylephrine)

+

corticotropin

1 interaction

Monitor/Modify Tx

phenylephrine + corticotropin

monitor BP: combo may incr. risk of HTN (additive effects)

• cortisone
Bromfed (brompheniramine/ phenylephrine)

+

cortisone

1 interaction

Monitor/Modify Tx

phenylephrine + cortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• cyclosporine
Bromfed (brompheniramine/ phenylephrine)

+

cyclosporine

1 interaction

Monitor/Modify Tx

phenylephrine + cyclosporine

monitor BP: combo may incr. risk of HTN (additive effects)

• danazol
Bromfed (brompheniramine/ phenylephrine)

+

danazol

1 interaction

Monitor/Modify Tx

phenylephrine + danazol

monitor BP: combo may incr. risk of HTN (additive effects)

• dapagliflozin
Bromfed (brompheniramine/ phenylephrine)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

phenylephrine + dapagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• darbepoetin alfa
Bromfed (brompheniramine/ phenylephrine)

+

darbepoetin alfa

1 interaction

Monitor/Modify Tx

phenylephrine + darbepoetin alfa

monitor BP: combo may incr. risk of HTN (additive effects)

• daridorexant
Bromfed (brompheniramine/ phenylephrine)

+

daridorexant

1 interaction

Monitor/Modify Tx

brompheniramine + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• deflazacort
Bromfed (brompheniramine/ phenylephrine)

+

deflazacort

1 interaction

Monitor/Modify Tx

phenylephrine + deflazacort

monitor BP: combo may incr. risk of HTN (additive effects)

• desflurane
Bromfed (brompheniramine/ phenylephrine)

+

desflurane

1 interaction

Monitor/Modify Tx

brompheniramine + desflurane

consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• desipramine
Bromfed (brompheniramine/ phenylephrine)

+

desipramine

2 interactions

Monitor/Modify Tx

brompheniramine + desipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

phenylephrine + desipramine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• desmopressin
Bromfed (brompheniramine/ phenylephrine)

+

desmopressin

1 interaction

Monitor/Modify Tx

phenylephrine + desmopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• desvenlafaxine
Bromfed (brompheniramine/ phenylephrine)

+

desvenlafaxine

2 interactions

Monitor/Modify Tx

phenylephrine + desvenlafaxine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + desvenlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexamethasone
Bromfed (brompheniramine/ phenylephrine)

+

dexamethasone

1 interaction

Monitor/Modify Tx

phenylephrine + dexamethasone

monitor BP: combo may incr. risk of HTN (additive effects)

• dexmedetomidine
Bromfed (brompheniramine/ phenylephrine)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

brompheniramine + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Bromfed (brompheniramine/ phenylephrine)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

brompheniramine + dexmedetomidine injection

monitor respiratory rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• dexmethylphenidate
Bromfed (brompheniramine/ phenylephrine)

+

dexmethylphenidate

1 interaction

Monitor/Modify Tx

phenylephrine + dexmethylphenidate

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• dextroamphetamine
Bromfed (brompheniramine/ phenylephrine)

+

dextroamphetamine

1 interaction

Monitor/Modify Tx

phenylephrine + dextroamphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects)

• diazepam
Bromfed (brompheniramine/ phenylephrine)

+

diazepam

1 interaction

Monitor/Modify Tx

brompheniramine + diazepam

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• diclofenac
Bromfed (brompheniramine/ phenylephrine)

+

diclofenac

1 interaction

Monitor/Modify Tx

phenylephrine + diclofenac

monitor BP: combo may incr. risk of HTN (additive effects)

• diclofenac topical
Bromfed (brompheniramine/ phenylephrine)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

phenylephrine + diclofenac topical

monitor BP: combo may incr. risk of HTN (additive effects)

• diethylpropion
Bromfed (brompheniramine/ phenylephrine)

+

diethylpropion

1 interaction

Monitor/Modify Tx

phenylephrine + diethylpropion

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• diflunisal
Bromfed (brompheniramine/ phenylephrine)

+

diflunisal

1 interaction

Monitor/Modify Tx

phenylephrine + diflunisal

monitor BP: combo may incr. risk of HTN (additive effects)

• dihydrocodeine
Bromfed (brompheniramine/ phenylephrine)

+

dihydrocodeine

1 interaction

Monitor/Modify Tx

brompheniramine + dihydrocodeine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• diltiazem
Bromfed (brompheniramine/ phenylephrine)

+

diltiazem

1 interaction

Monitor/Modify Tx

phenylephrine + diltiazem

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dobutamine
Bromfed (brompheniramine/ phenylephrine)

+

dobutamine

1 interaction

Monitor/Modify Tx

phenylephrine + dobutamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• dopamine
Bromfed (brompheniramine/ phenylephrine)

+

dopamine

1 interaction

Monitor/Modify Tx

phenylephrine + dopamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• doxapram
Bromfed (brompheniramine/ phenylephrine)

+

doxapram

1 interaction

Monitor/Modify Tx

phenylephrine + doxapram

monitor BP: combo may incr. risk of HTN (additive effects)

• doxazosin
Bromfed (brompheniramine/ phenylephrine)

+

doxazosin

2 interactions

Monitor/Modify Tx

phenylephrine + doxazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

brompheniramine + doxazosin

caution advised w/ doxazosin ER dosage form: combo may incr. doxazosin levels, risk of adverse effects (absorption increased, slower GI transit due to anticholinergic effects)

• doxepin
Bromfed (brompheniramine/ phenylephrine)

+

doxepin

2 interactions

Monitor/Modify Tx

phenylephrine + doxepin

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + doxepin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• droperidol
Bromfed (brompheniramine/ phenylephrine)

+

droperidol

1 interaction

Monitor/Modify Tx

brompheniramine + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• droxidopa
Bromfed (brompheniramine/ phenylephrine)

+

droxidopa

1 interaction

Monitor/Modify Tx

phenylephrine + droxidopa

monitor BP: combo may incr. risk of supine HTN (additive effects)

• dulaglutide
Bromfed (brompheniramine/ phenylephrine)

+

dulaglutide

1 interaction

Monitor/Modify Tx

phenylephrine + dulaglutide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• eletriptan
Bromfed (brompheniramine/ phenylephrine)

+

eletriptan

2 interactions

Monitor/Modify Tx

phenylephrine + eletriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + eletriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• empagliflozin
Bromfed (brompheniramine/ phenylephrine)

+

empagliflozin

1 interaction

Monitor/Modify Tx

phenylephrine + empagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• enalapril
Bromfed (brompheniramine/ phenylephrine)

+

enalapril

1 interaction

Monitor/Modify Tx

phenylephrine + enalapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• enalaprilat
Bromfed (brompheniramine/ phenylephrine)

+

enalaprilat

1 interaction

Monitor/Modify Tx

phenylephrine + enalaprilat

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ephedrine injection
Bromfed (brompheniramine/ phenylephrine)

+

ephedrine injection

1 interaction

Monitor/Modify Tx

phenylephrine + ephedrine injection

monitor BP, HR: combo may incr. risk of HTN, arrhythmias, tachycardia (additive effects)

• ephedrine oral
Bromfed (brompheniramine/ phenylephrine)

+

ephedrine oral

1 interaction

Monitor/Modify Tx

phenylephrine + ephedrine oral

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• epinephrine
Bromfed (brompheniramine/ phenylephrine)

+

epinephrine

2 interactions

Monitor/Modify Tx

brompheniramine + epinephrine

monitor HR, ECG: combo may incr. risk of tachycardia, cardiac arrhythmias (additive effects)

phenylephrine + epinephrine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• eplerenone
Bromfed (brompheniramine/ phenylephrine)

+

eplerenone

1 interaction

Monitor/Modify Tx

phenylephrine + eplerenone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epoetin alfa
Bromfed (brompheniramine/ phenylephrine)

+

epoetin alfa

1 interaction

Monitor/Modify Tx

phenylephrine + epoetin alfa

monitor BP: combo may incr. risk of HTN (additive effects)

• eptinezumab
Bromfed (brompheniramine/ phenylephrine)

+

eptinezumab

1 interaction

Monitor/Modify Tx

phenylephrine + eptinezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• erenumab
Bromfed (brompheniramine/ phenylephrine)

+

erenumab

2 interactions

Monitor/Modify Tx

phenylephrine + erenumab

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + erenumab

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• ertugliflozin
Bromfed (brompheniramine/ phenylephrine)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

phenylephrine + ertugliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• esketamine
Bromfed (brompheniramine/ phenylephrine)

+

esketamine

2 interactions

Monitor/Modify Tx

brompheniramine + esketamine

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

phenylephrine + esketamine

monitor BP: combo may incr. risk of HTN (additive effects)

• esmolol
Bromfed (brompheniramine/ phenylephrine)

+

esmolol

1 interaction

Monitor/Modify Tx

phenylephrine + esmolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• estetrol (contraceptive)
Bromfed (brompheniramine/ phenylephrine)

+

estetrol (contraceptive)

1 interaction

Monitor/Modify Tx

phenylephrine + estetrol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• estradiol (contraceptive)
Bromfed (brompheniramine/ phenylephrine)

+

estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

phenylephrine + estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• eszopiclone
Bromfed (brompheniramine/ phenylephrine)

+

eszopiclone

1 interaction

Monitor/Modify Tx

brompheniramine + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Bromfed (brompheniramine/ phenylephrine)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

phenylephrine + ethacrynic acid

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ethinyl estradiol (contraceptive)
Bromfed (brompheniramine/ phenylephrine)

+

ethinyl estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

phenylephrine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• etodolac
Bromfed (brompheniramine/ phenylephrine)

+

etodolac

1 interaction

Monitor/Modify Tx

phenylephrine + etodolac

monitor BP: combo may incr. risk of HTN (additive effects)

• etomidate
Bromfed (brompheniramine/ phenylephrine)

+

etomidate

1 interaction

Monitor/Modify Tx

brompheniramine + etomidate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• etrasimod
Bromfed (brompheniramine/ phenylephrine)

+

etrasimod

1 interaction

Monitor/Modify Tx

phenylephrine + etrasimod

monitor BP: combo may incr. risk of HTN (additive effects)

• exenatide
Bromfed (brompheniramine/ phenylephrine)

+

exenatide

1 interaction

Monitor/Modify Tx

phenylephrine + exenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• felodipine
Bromfed (brompheniramine/ phenylephrine)

+

felodipine

1 interaction

Monitor/Modify Tx

phenylephrine + felodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenfluramine
Bromfed (brompheniramine/ phenylephrine)

+

fenfluramine

2 interactions

Monitor/Modify Tx

phenylephrine + fenfluramine

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + fenfluramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fenoldopam
Bromfed (brompheniramine/ phenylephrine)

+

fenoldopam

1 interaction

Monitor/Modify Tx

phenylephrine + fenoldopam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenoprofen
Bromfed (brompheniramine/ phenylephrine)

+

fenoprofen

1 interaction

Monitor/Modify Tx

phenylephrine + fenoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• fentanyl
Bromfed (brompheniramine/ phenylephrine)

+

fentanyl

1 interaction

Monitor/Modify Tx

brompheniramine + fentanyl

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• fingolimod
Bromfed (brompheniramine/ phenylephrine)

+

fingolimod

1 interaction

Monitor/Modify Tx

phenylephrine + fingolimod

monitor BP: combo may incr. risk of HTN (additive effects)

• fludrocortisone
Bromfed (brompheniramine/ phenylephrine)

+

fludrocortisone

1 interaction

Monitor/Modify Tx

phenylephrine + fludrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• fluphenazine
Bromfed (brompheniramine/ phenylephrine)

+

fluphenazine

1 interaction

Monitor/Modify Tx

brompheniramine + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• flurazepam
Bromfed (brompheniramine/ phenylephrine)

+

flurazepam

1 interaction

Monitor/Modify Tx

brompheniramine + flurazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• flurbiprofen
Bromfed (brompheniramine/ phenylephrine)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

phenylephrine + flurbiprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• formoterol inhaled
Bromfed (brompheniramine/ phenylephrine)

+

formoterol inhaled

1 interaction

Monitor/Modify Tx

phenylephrine + formoterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• fosinopril
Bromfed (brompheniramine/ phenylephrine)

+

fosinopril

1 interaction

Monitor/Modify Tx

phenylephrine + fosinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fostamatinib
Bromfed (brompheniramine/ phenylephrine)

+

fostamatinib

1 interaction

Monitor/Modify Tx

phenylephrine + fostamatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• fremanezumab
Bromfed (brompheniramine/ phenylephrine)

+

fremanezumab

1 interaction

Monitor/Modify Tx

phenylephrine + fremanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• frovatriptan
Bromfed (brompheniramine/ phenylephrine)

+

frovatriptan

2 interactions

Monitor/Modify Tx

phenylephrine + frovatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + frovatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fruquintinib
Bromfed (brompheniramine/ phenylephrine)

+

fruquintinib

1 interaction

Monitor/Modify Tx

phenylephrine + fruquintinib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• gabapentin
Bromfed (brompheniramine/ phenylephrine)

+

gabapentin

1 interaction

Monitor/Modify Tx

brompheniramine + gabapentin

monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Bromfed (brompheniramine/ phenylephrine)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

brompheniramine + gabapentin enacarbil

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• galcanezumab
Bromfed (brompheniramine/ phenylephrine)

+

galcanezumab

1 interaction

Monitor/Modify Tx

phenylephrine + galcanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• glimepiride
Bromfed (brompheniramine/ phenylephrine)

+

glimepiride

1 interaction

Monitor/Modify Tx

phenylephrine + glimepiride

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glipizide
Bromfed (brompheniramine/ phenylephrine)

+

glipizide

1 interaction

Monitor/Modify Tx

phenylephrine + glipizide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glyburide
Bromfed (brompheniramine/ phenylephrine)

+

glyburide

1 interaction

Monitor/Modify Tx

phenylephrine + glyburide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glycopyrrolate
Bromfed (brompheniramine/ phenylephrine)

+

glycopyrrolate

1 interaction

Monitor/Modify Tx

brompheniramine + glycopyrrolate

monitor HR: combo may incr. risk of tachycardia, CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• guanfacine
Bromfed (brompheniramine/ phenylephrine)

+

guanfacine

2 interactions

Monitor/Modify Tx

phenylephrine + guanfacine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

brompheniramine + guanfacine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hoodia
Bromfed (brompheniramine/ phenylephrine)

+

hoodia

1 interaction

Monitor/Modify Tx

phenylephrine + hoodia

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• hydralazine
Bromfed (brompheniramine/ phenylephrine)

+

hydralazine

1 interaction

Monitor/Modify Tx

phenylephrine + hydralazine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrochlorothiazide
Bromfed (brompheniramine/ phenylephrine)

+

hydrochlorothiazide

2 interactions

Monitor/Modify Tx

phenylephrine + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

brompheniramine + hydrochlorothiazide

caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased)

• hydrocortisone
Bromfed (brompheniramine/ phenylephrine)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

phenylephrine + hydrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• hydromorphone
Bromfed (brompheniramine/ phenylephrine)

+

hydromorphone

1 interaction

Monitor/Modify Tx

brompheniramine + hydromorphone

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• hydroxocobalamin IV
Bromfed (brompheniramine/ phenylephrine)

+

hydroxocobalamin IV

1 interaction

Monitor/Modify Tx

phenylephrine + hydroxocobalamin IV

monitor BP: combo may incr. risk of HTN (additive effects)

• ibrutinib
Bromfed (brompheniramine/ phenylephrine)

+

ibrutinib

1 interaction

Monitor/Modify Tx

phenylephrine + ibrutinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ibuprofen
Bromfed (brompheniramine/ phenylephrine)

+

ibuprofen

1 interaction

Monitor/Modify Tx

phenylephrine + ibuprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• ifosfamide
Bromfed (brompheniramine/ phenylephrine)

+

ifosfamide

1 interaction

Monitor/Modify Tx

brompheniramine + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• indapamide
Bromfed (brompheniramine/ phenylephrine)

+

indapamide

1 interaction

Monitor/Modify Tx

phenylephrine + indapamide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• indomethacin
Bromfed (brompheniramine/ phenylephrine)

+

indomethacin

1 interaction

Monitor/Modify Tx

phenylephrine + indomethacin

monitor BP: combo may incr. risk of HTN (additive effects)

• insulin
Bromfed (brompheniramine/ phenylephrine)

+

insulin

1 interaction

Monitor/Modify Tx

phenylephrine + insulin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• irbesartan
Bromfed (brompheniramine/ phenylephrine)

+

irbesartan

1 interaction

Monitor/Modify Tx

phenylephrine + irbesartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• isoproterenol
Bromfed (brompheniramine/ phenylephrine)

+

isoproterenol

1 interaction

Monitor/Modify Tx

phenylephrine + isoproterenol

monitor HR: combo may incr. risk of tachycardia (additive effects)

• isradipine
Bromfed (brompheniramine/ phenylephrine)

+

isradipine

1 interaction

Monitor/Modify Tx

phenylephrine + isradipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ketamine
Bromfed (brompheniramine/ phenylephrine)

+

ketamine

2 interactions

Monitor/Modify Tx

brompheniramine + ketamine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment (additive effects)

phenylephrine + ketamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other sympathomimetic adverse effects (additive effects)

• ketoprofen
Bromfed (brompheniramine/ phenylephrine)

+

ketoprofen

1 interaction

Monitor/Modify Tx

phenylephrine + ketoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• ketorolac
Bromfed (brompheniramine/ phenylephrine)

+

ketorolac

1 interaction

Monitor/Modify Tx

phenylephrine + ketorolac

monitor BP: combo may incr. risk of HTN (additive effects)

• labetalol
Bromfed (brompheniramine/ phenylephrine)

+

labetalol

1 interaction

Monitor/Modify Tx

phenylephrine + labetalol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lanreotide
Bromfed (brompheniramine/ phenylephrine)

+

lanreotide

1 interaction

Monitor/Modify Tx

phenylephrine + lanreotide

monitor BP: combo may incr. risk of HTN (additive effects)

• leflunomide
Bromfed (brompheniramine/ phenylephrine)

+

leflunomide

1 interaction

Monitor/Modify Tx

phenylephrine + leflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• lemborexant
Bromfed (brompheniramine/ phenylephrine)

+

lemborexant

1 interaction

Monitor/Modify Tx

brompheniramine + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenvatinib
Bromfed (brompheniramine/ phenylephrine)

+

lenvatinib

1 interaction

Monitor/Modify Tx

phenylephrine + lenvatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• levalbuterol inhaled
Bromfed (brompheniramine/ phenylephrine)

+

levalbuterol inhaled

1 interaction

Monitor/Modify Tx

phenylephrine + levalbuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• levomilnacipran
Bromfed (brompheniramine/ phenylephrine)

+

levomilnacipran

2 interactions

Monitor/Modify Tx

phenylephrine + levomilnacipran

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + levomilnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levorphanol
Bromfed (brompheniramine/ phenylephrine)

+

levorphanol

1 interaction

Monitor/Modify Tx

brompheniramine + levorphanol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• levothyroxine
Bromfed (brompheniramine/ phenylephrine)

+

levothyroxine

1 interaction

Monitor/Modify Tx

phenylephrine + levothyroxine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• licorice
Bromfed (brompheniramine/ phenylephrine)

+

licorice

1 interaction

Monitor/Modify Tx

phenylephrine + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

• linagliptin
Bromfed (brompheniramine/ phenylephrine)

+

linagliptin

1 interaction

Monitor/Modify Tx

phenylephrine + linagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• liothyronine
Bromfed (brompheniramine/ phenylephrine)

+

liothyronine

1 interaction

Monitor/Modify Tx

phenylephrine + liothyronine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• liraglutide
Bromfed (brompheniramine/ phenylephrine)

+

liraglutide

1 interaction

Monitor/Modify Tx

phenylephrine + liraglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• lisdexamfetamine
Bromfed (brompheniramine/ phenylephrine)

+

lisdexamfetamine

1 interaction

Monitor/Modify Tx

phenylephrine + lisdexamfetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects)

• lisinopril
Bromfed (brompheniramine/ phenylephrine)

+

lisinopril

1 interaction

Monitor/Modify Tx

phenylephrine + lisinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lixisenatide
Bromfed (brompheniramine/ phenylephrine)

+

lixisenatide

1 interaction

Monitor/Modify Tx

phenylephrine + lixisenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• lorazepam
Bromfed (brompheniramine/ phenylephrine)

+

lorazepam

1 interaction

Monitor/Modify Tx

brompheniramine + lorazepam

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lorlatinib
Bromfed (brompheniramine/ phenylephrine)

+

lorlatinib

1 interaction

Monitor/Modify Tx

phenylephrine + lorlatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• losartan
Bromfed (brompheniramine/ phenylephrine)

+

losartan

1 interaction

Monitor/Modify Tx

phenylephrine + losartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lumacaftor/ivacaftor
Bromfed (brompheniramine/ phenylephrine)

+

lumacaftor/ ivacaftor

1 interaction

Monitor/Modify Tx

phenylephrine + lumacaftor/ ivacaftor

monitor BP: combo may incr. risk of HTN (additive effects)

• luspatercept
Bromfed (brompheniramine/ phenylephrine)

+

luspatercept

1 interaction

Monitor/Modify Tx

phenylephrine + luspatercept

monitor BP: combo may incr. risk of HTN (additive effects)

• magnesium salicylate
Bromfed (brompheniramine/ phenylephrine)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

phenylephrine + magnesium salicylate

monitor BP w/ high-dose magnesium salicylate: combo may incr. risk of HTN (additive effects)

• meclofenamate
Bromfed (brompheniramine/ phenylephrine)

+

meclofenamate

1 interaction

Monitor/Modify Tx

phenylephrine + meclofenamate

monitor BP: combo may incr. risk of HTN (additive effects)

• mefenamic acid
Bromfed (brompheniramine/ phenylephrine)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

phenylephrine + mefenamic acid

monitor BP: combo may incr. risk of HTN (additive effects)

• meloxicam
Bromfed (brompheniramine/ phenylephrine)

+

meloxicam

1 interaction

Monitor/Modify Tx

phenylephrine + meloxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• meperidine
Bromfed (brompheniramine/ phenylephrine)

+

meperidine

1 interaction

Monitor/Modify Tx

brompheniramine + meperidine

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• metformin
Bromfed (brompheniramine/ phenylephrine)

+

metformin

1 interaction

Monitor/Modify Tx

phenylephrine + metformin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• methadone
Bromfed (brompheniramine/ phenylephrine)

+

methadone

1 interaction

Monitor/Modify Tx

brompheniramine + methadone

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• methamphetamine
Bromfed (brompheniramine/ phenylephrine)

+

methamphetamine

1 interaction

Monitor/Modify Tx

phenylephrine + methamphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects)

• methoxy polyethylene glycol-epoetin beta
Bromfed (brompheniramine/ phenylephrine)

+

methoxy polyethylene glycol-epoetin beta

1 interaction

Monitor/Modify Tx

phenylephrine + methoxy polyethylene glycol-epoetin beta

monitor BP: combo may incr. risk of HTN (additive effects)

• methyldopa
Bromfed (brompheniramine/ phenylephrine)

+

methyldopa

2 interactions

Monitor/Modify Tx

phenylephrine + methyldopa

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

brompheniramine + methyldopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methylphenidate
Bromfed (brompheniramine/ phenylephrine)

+

methylphenidate

1 interaction

Monitor/Modify Tx

phenylephrine + methylphenidate

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects)

• methylprednisolone
Bromfed (brompheniramine/ phenylephrine)

+

methylprednisolone

1 interaction

Monitor/Modify Tx

phenylephrine + methylprednisolone

monitor BP: combo may incr. risk of HTN (additive effects)

• methyltestosterone
Bromfed (brompheniramine/ phenylephrine)

+

methyltestosterone

1 interaction

Monitor/Modify Tx

phenylephrine + methyltestosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• metolazone
Bromfed (brompheniramine/ phenylephrine)

+

metolazone

1 interaction

Monitor/Modify Tx

phenylephrine + metolazone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• metoprolol
Bromfed (brompheniramine/ phenylephrine)

+

metoprolol

1 interaction

Monitor/Modify Tx

phenylephrine + metoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• miglitol
Bromfed (brompheniramine/ phenylephrine)

+

miglitol

1 interaction

Monitor/Modify Tx

phenylephrine + miglitol

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• milnacipran
Bromfed (brompheniramine/ phenylephrine)

+

milnacipran

2 interactions

Monitor/Modify Tx

phenylephrine + milnacipran

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + milnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• minoxidil
Bromfed (brompheniramine/ phenylephrine)

+

minoxidil

1 interaction

Monitor/Modify Tx

phenylephrine + minoxidil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• mirabegron
Bromfed (brompheniramine/ phenylephrine)

+

mirabegron

2 interactions

Monitor/Modify Tx

phenylephrine + mirabegron

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + mirabegron

caution advised: combo may incr. risk of urinary retention (additive effects)

• mirtazapine
Bromfed (brompheniramine/ phenylephrine)

+

mirtazapine

1 interaction

Monitor/Modify Tx

brompheniramine + mirtazapine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• modafinil
Bromfed (brompheniramine/ phenylephrine)

+

modafinil

1 interaction

Monitor/Modify Tx

phenylephrine + modafinil

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• moexipril
Bromfed (brompheniramine/ phenylephrine)

+

moexipril

1 interaction

Monitor/Modify Tx

phenylephrine + moexipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• morphine
Bromfed (brompheniramine/ phenylephrine)

+

morphine

1 interaction

Monitor/Modify Tx

brompheniramine + morphine

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• nabumetone
Bromfed (brompheniramine/ phenylephrine)

+

nabumetone

1 interaction

Monitor/Modify Tx

phenylephrine + nabumetone

monitor BP: combo may incr. risk of HTN (additive effects)

• nadolol
Bromfed (brompheniramine/ phenylephrine)

+

nadolol

1 interaction

Monitor/Modify Tx

phenylephrine + nadolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nalbuphine
Bromfed (brompheniramine/ phenylephrine)

+

nalbuphine

1 interaction

Monitor/Modify Tx

brompheniramine + nalbuphine

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• naproxen
Bromfed (brompheniramine/ phenylephrine)

+

naproxen

1 interaction

Monitor/Modify Tx

phenylephrine + naproxen

monitor BP: combo may incr. risk of HTN (additive effects)

• naratriptan
Bromfed (brompheniramine/ phenylephrine)

+

naratriptan

2 interactions

Monitor/Modify Tx

phenylephrine + naratriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + naratriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nateglinide
Bromfed (brompheniramine/ phenylephrine)

+

nateglinide

1 interaction

Monitor/Modify Tx

phenylephrine + nateglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• naxitamab
Bromfed (brompheniramine/ phenylephrine)

+

naxitamab

1 interaction

Monitor/Modify Tx

phenylephrine + naxitamab

monitor BP: combo may incr. risk of HTN (additive effects)

• nebivolol
Bromfed (brompheniramine/ phenylephrine)

+

nebivolol

1 interaction

Monitor/Modify Tx

phenylephrine + nebivolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nelarabine
Bromfed (brompheniramine/ phenylephrine)

+

nelarabine

1 interaction

Monitor/Modify Tx

brompheniramine + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nicardipine
Bromfed (brompheniramine/ phenylephrine)

+

nicardipine

1 interaction

Monitor/Modify Tx

phenylephrine + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nifedipine
Bromfed (brompheniramine/ phenylephrine)

+

nifedipine

1 interaction

Monitor/Modify Tx

phenylephrine + nifedipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nimodipine
Bromfed (brompheniramine/ phenylephrine)

+

nimodipine

1 interaction

Monitor/Modify Tx

phenylephrine + nimodipine

monitor BP: combo may decr. nimodipine efficacy (antagonistic effects)

• niraparib
Bromfed (brompheniramine/ phenylephrine)

+

niraparib

1 interaction

Monitor/Modify Tx

phenylephrine + niraparib

monitor BP: combo may incr. risk of HTN (additive effects)

• nisoldipine
Bromfed (brompheniramine/ phenylephrine)

+

nisoldipine

1 interaction

Monitor/Modify Tx

phenylephrine + nisoldipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• norepinephrine
Bromfed (brompheniramine/ phenylephrine)

+

norepinephrine

1 interaction

Monitor/Modify Tx

phenylephrine + norepinephrine

monitor BP: combo may incr. risk of severe HTN (additive effects)

• nortriptyline
Bromfed (brompheniramine/ phenylephrine)

+

nortriptyline

2 interactions

Monitor/Modify Tx

phenylephrine + nortriptyline

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + nortriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• obinutuzumab
Bromfed (brompheniramine/ phenylephrine)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

phenylephrine + obinutuzumab

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• oliceridine
Bromfed (brompheniramine/ phenylephrine)

+

oliceridine

1 interaction

Monitor/Modify Tx

brompheniramine + oliceridine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, other anticholinergic adverse effects (additive effects)

• olmesartan medoxomil
Bromfed (brompheniramine/ phenylephrine)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

phenylephrine + olmesartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• olodaterol inhaled
Bromfed (brompheniramine/ phenylephrine)

+

olodaterol inhaled

1 interaction

Monitor/Modify Tx

phenylephrine + olodaterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• opicapone
Bromfed (brompheniramine/ phenylephrine)

+

opicapone

1 interaction

Monitor/Modify Tx

brompheniramine + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• opium
Bromfed (brompheniramine/ phenylephrine)

+

opium

1 interaction

Monitor/Modify Tx

brompheniramine + opium

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• osilodrostat
Bromfed (brompheniramine/ phenylephrine)

+

osilodrostat

1 interaction

Monitor/Modify Tx

phenylephrine + osilodrostat

monitor BP: combo may incr. risk of HTN (additive effects)

• oxaprozin
Bromfed (brompheniramine/ phenylephrine)

+

oxaprozin

1 interaction

Monitor/Modify Tx

phenylephrine + oxaprozin

monitor BP: combo may incr. risk of HTN (additive effects)

• oxazepam
Bromfed (brompheniramine/ phenylephrine)

+

oxazepam

1 interaction

Monitor/Modify Tx

brompheniramine + oxazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• oxybutynin
Bromfed (brompheniramine/ phenylephrine)

+

oxybutynin

1 interaction

Monitor/Modify Tx

brompheniramine + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely with oxybutynin transdermal patch (additive effects)

• oxycodone
Bromfed (brompheniramine/ phenylephrine)

+

oxycodone

1 interaction

Monitor/Modify Tx

brompheniramine + oxycodone

monitor respiratory rate; decr. oxycodone start dose by at least 50%, consider decr. brompheniramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• oxymetazoline nasal
Bromfed (brompheniramine/ phenylephrine)

+

oxymetazoline nasal

1 interaction

Monitor/Modify Tx

phenylephrine + oxymetazoline nasal

monitor BP: combo may incr. risk of HTN (additive effects)

• oxymetazoline ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

oxymetazoline ophthalmic

1 interaction

Monitor/Modify Tx

phenylephrine + oxymetazoline ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• oxymorphone
Bromfed (brompheniramine/ phenylephrine)

+

oxymorphone

1 interaction

Monitor/Modify Tx

brompheniramine + oxymorphone

monitor respiratory rate; decr. oxymorphone start dose by at least 50%, consider decr. brompheniramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• oxytocin
Bromfed (brompheniramine/ phenylephrine)

+

oxytocin

1 interaction

Monitor/Modify Tx

phenylephrine + oxytocin

monitor BP: combo may incr. risk of HTN, including life-threatening (additive effects)

• pazopanib
Bromfed (brompheniramine/ phenylephrine)

+

pazopanib

1 interaction

Monitor/Modify Tx

phenylephrine + pazopanib

monitor BP: combo may incr. risk of HTN (additive effects)

• pentazocine
Bromfed (brompheniramine/ phenylephrine)

+

pentazocine

1 interaction

Monitor/Modify Tx

brompheniramine + pentazocine

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• pentobarbital
Bromfed (brompheniramine/ phenylephrine)

+

pentobarbital

1 interaction

Monitor/Modify Tx

brompheniramine + pentobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• perindopril
Bromfed (brompheniramine/ phenylephrine)

+

perindopril

1 interaction

Monitor/Modify Tx

phenylephrine + perindopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• perphenazine
Bromfed (brompheniramine/ phenylephrine)

+

perphenazine

1 interaction

Monitor/Modify Tx

brompheniramine + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pexidartinib
Bromfed (brompheniramine/ phenylephrine)

+

pexidartinib

1 interaction

Monitor/Modify Tx

phenylephrine + pexidartinib

monitor BP: combo may incr. risk of HTN (additive effects)

• phendimetrazine
Bromfed (brompheniramine/ phenylephrine)

+

phendimetrazine

1 interaction

Monitor/Modify Tx

phenylephrine + phendimetrazine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• phenobarbital
Bromfed (brompheniramine/ phenylephrine)

+

phenobarbital

1 interaction

Monitor/Modify Tx

brompheniramine + phenobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• phenoxybenzamine
Bromfed (brompheniramine/ phenylephrine)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

phenylephrine + phenoxybenzamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phentermine
Bromfed (brompheniramine/ phenylephrine)

+

phentermine

1 interaction

Monitor/Modify Tx

phenylephrine + phentermine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• phentolamine
Bromfed (brompheniramine/ phenylephrine)

+

phentolamine

1 interaction

Monitor/Modify Tx

phenylephrine + phentolamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phenylephrine injection
Bromfed (brompheniramine/ phenylephrine)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

phenylephrine + phenylephrine injection

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• phenylephrine nasal
Bromfed (brompheniramine/ phenylephrine)

+

phenylephrine nasal

1 interaction

Monitor/Modify Tx

phenylephrine + phenylephrine nasal

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• phenylephrine ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

phenylephrine ophthalmic

1 interaction

Monitor/Modify Tx

phenylephrine + phenylephrine ophthalmic

monitor BP, HR; risk may be lower w/ phenylephrine ophthalmic 2.5%: combo may incr. risk of HTN, tachycardia (additive effects, duplicate therapy)

• phenylephrine rectal
Bromfed (brompheniramine/ phenylephrine)

+

phenylephrine rectal

1 interaction

Monitor/Modify Tx

phenylephrine + phenylephrine rectal

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• pindolol
Bromfed (brompheniramine/ phenylephrine)

+

pindolol

1 interaction

Monitor/Modify Tx

phenylephrine + pindolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• pioglitazone
Bromfed (brompheniramine/ phenylephrine)

+

pioglitazone

1 interaction

Monitor/Modify Tx

phenylephrine + pioglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• piroxicam
Bromfed (brompheniramine/ phenylephrine)

+

piroxicam

1 interaction

Monitor/Modify Tx

phenylephrine + piroxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• ponatinib
Bromfed (brompheniramine/ phenylephrine)

+

ponatinib

1 interaction

Monitor/Modify Tx

phenylephrine + ponatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ponesimod
Bromfed (brompheniramine/ phenylephrine)

+

ponesimod

1 interaction

Monitor/Modify Tx

phenylephrine + ponesimod

monitor BP: combo may incr. risk of HTN (additive effects)

• pralsetinib
Bromfed (brompheniramine/ phenylephrine)

+

pralsetinib

1 interaction

Monitor/Modify Tx

phenylephrine + pralsetinib

monitor BP: combo may incr. risk of HTN (additive effects)

• prazosin
Bromfed (brompheniramine/ phenylephrine)

+

prazosin

1 interaction

Monitor/Modify Tx

phenylephrine + prazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• prednisolone
Bromfed (brompheniramine/ phenylephrine)

+

prednisolone

1 interaction

Monitor/Modify Tx

phenylephrine + prednisolone

monitor BP: combo may incr. risk of HTN (additive effects)

• prednisone
Bromfed (brompheniramine/ phenylephrine)

+

prednisone

1 interaction

Monitor/Modify Tx

phenylephrine + prednisone

monitor BP: combo may incr. risk of HTN (additive effects)

• pregabalin
Bromfed (brompheniramine/ phenylephrine)

+

pregabalin

1 interaction

Monitor/Modify Tx

brompheniramine + pregabalin

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• primidone
Bromfed (brompheniramine/ phenylephrine)

+

primidone

1 interaction

Monitor/Modify Tx

brompheniramine + primidone

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• propofol
Bromfed (brompheniramine/ phenylephrine)

+

propofol

1 interaction

Monitor/Modify Tx

brompheniramine + propofol

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• propranolol
Bromfed (brompheniramine/ phenylephrine)

+

propranolol

1 interaction

Monitor/Modify Tx

phenylephrine + propranolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• protriptyline
Bromfed (brompheniramine/ phenylephrine)

+

protriptyline

2 interactions

Monitor/Modify Tx

phenylephrine + protriptyline

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + protriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• quazepam
Bromfed (brompheniramine/ phenylephrine)

+

quazepam

1 interaction

Monitor/Modify Tx

brompheniramine + quazepam

consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• quetiapine
Bromfed (brompheniramine/ phenylephrine)

+

quetiapine

2 interactions

Monitor/Modify Tx

phenylephrine + quetiapine

monitor BP, especially in pts <18 yo: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + quetiapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• quinapril
Bromfed (brompheniramine/ phenylephrine)

+

quinapril

1 interaction

Monitor/Modify Tx

phenylephrine + quinapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ramipril
Bromfed (brompheniramine/ phenylephrine)

+

ramipril

1 interaction

Monitor/Modify Tx

phenylephrine + ramipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ramucirumab
Bromfed (brompheniramine/ phenylephrine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

phenylephrine + ramucirumab

monitor BP: combo may incr. risk of HTN (additive effects)

• regorafenib
Bromfed (brompheniramine/ phenylephrine)

+

regorafenib

1 interaction

Monitor/Modify Tx

phenylephrine + regorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• remifentanil
Bromfed (brompheniramine/ phenylephrine)

+

remifentanil

1 interaction

Monitor/Modify Tx

brompheniramine + remifentanil

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• remimazolam
Bromfed (brompheniramine/ phenylephrine)

+

remimazolam

1 interaction

Monitor/Modify Tx

brompheniramine + remimazolam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• repaglinide
Bromfed (brompheniramine/ phenylephrine)

+

repaglinide

1 interaction

Monitor/Modify Tx

phenylephrine + repaglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rimegepant
Bromfed (brompheniramine/ phenylephrine)

+

rimegepant

1 interaction

Monitor/Modify Tx

phenylephrine + rimegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ripretinib
Bromfed (brompheniramine/ phenylephrine)

+

ripretinib

1 interaction

Monitor/Modify Tx

phenylephrine + ripretinib

monitor BP: combo may incr. risk of HTN (additive effects)

• rizatriptan
Bromfed (brompheniramine/ phenylephrine)

+

rizatriptan

2 interactions

Monitor/Modify Tx

phenylephrine + rizatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + rizatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ropinirole
Bromfed (brompheniramine/ phenylephrine)

+

ropinirole

2 interactions

Monitor/Modify Tx

phenylephrine + ropinirole

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + ropinirole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rosiglitazone
Bromfed (brompheniramine/ phenylephrine)

+

rosiglitazone

1 interaction

Monitor/Modify Tx

phenylephrine + rosiglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rotigotine transdermal
Bromfed (brompheniramine/ phenylephrine)

+

rotigotine transdermal

2 interactions

Monitor/Modify Tx

phenylephrine + rotigotine transdermal

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + rotigotine transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• salmeterol inhaled
Bromfed (brompheniramine/ phenylephrine)

+

salmeterol inhaled

1 interaction

Monitor/Modify Tx

phenylephrine + salmeterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• salsalate
Bromfed (brompheniramine/ phenylephrine)

+

salsalate

1 interaction

Monitor/Modify Tx

phenylephrine + salsalate

monitor BP w/ high-dose salsalate: combo may incr. risk of HTN (additive effects)

• saxagliptin
Bromfed (brompheniramine/ phenylephrine)

+

saxagliptin

1 interaction

Monitor/Modify Tx

phenylephrine + saxagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• selpercatinib
Bromfed (brompheniramine/ phenylephrine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

phenylephrine + selpercatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• semaglutide
Bromfed (brompheniramine/ phenylephrine)

+

semaglutide

1 interaction

Monitor/Modify Tx

phenylephrine + semaglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sevoflurane
Bromfed (brompheniramine/ phenylephrine)

+

sevoflurane

1 interaction

Monitor/Modify Tx

brompheniramine + sevoflurane

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• siponimod
Bromfed (brompheniramine/ phenylephrine)

+

siponimod

1 interaction

Monitor/Modify Tx

phenylephrine + siponimod

monitor BP: combo may incr. risk of HTN (additive effects)

• sitagliptin
Bromfed (brompheniramine/ phenylephrine)

+

sitagliptin

1 interaction

Monitor/Modify Tx

phenylephrine + sitagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• solriamfetol
Bromfed (brompheniramine/ phenylephrine)

+

solriamfetol

1 interaction

Monitor/Modify Tx

phenylephrine + solriamfetol

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• sorafenib
Bromfed (brompheniramine/ phenylephrine)

+

sorafenib

1 interaction

Monitor/Modify Tx

phenylephrine + sorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• spironolactone
Bromfed (brompheniramine/ phenylephrine)

+

spironolactone

1 interaction

Monitor/Modify Tx

phenylephrine + spironolactone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• sufentanil
Bromfed (brompheniramine/ phenylephrine)

+

sufentanil

1 interaction

Monitor/Modify Tx

brompheniramine + sufentanil

monitor respiratory rate, decr. sufentanil start dose, consider decr. brompheniramine dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• sulindac
Bromfed (brompheniramine/ phenylephrine)

+

sulindac

1 interaction

Monitor/Modify Tx

phenylephrine + sulindac

monitor BP: combo may incr. risk of HTN (additive effects)

• sumatriptan
Bromfed (brompheniramine/ phenylephrine)

+

sumatriptan

2 interactions

Monitor/Modify Tx

phenylephrine + sumatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + sumatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sunitinib
Bromfed (brompheniramine/ phenylephrine)

+

sunitinib

1 interaction

Monitor/Modify Tx

phenylephrine + sunitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• suvorexant
Bromfed (brompheniramine/ phenylephrine)

+

suvorexant

1 interaction

Monitor/Modify Tx

brompheniramine + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tacrolimus
Bromfed (brompheniramine/ phenylephrine)

+

tacrolimus

1 interaction

Monitor/Modify Tx

phenylephrine + tacrolimus

monitor BP: combo may incr. risk of HTN (additive effects)

• tagraxofusp
Bromfed (brompheniramine/ phenylephrine)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

phenylephrine + tagraxofusp

monitor BP: combo may incr. risk of HTN (additive effects)

• tapentadol
Bromfed (brompheniramine/ phenylephrine)

+

tapentadol

1 interaction

Monitor/Modify Tx

brompheniramine + tapentadol

monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• telmisartan
Bromfed (brompheniramine/ phenylephrine)

+

telmisartan

1 interaction

Monitor/Modify Tx

phenylephrine + telmisartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• terazosin
Bromfed (brompheniramine/ phenylephrine)

+

terazosin

1 interaction

Monitor/Modify Tx

phenylephrine + terazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• terbutaline
Bromfed (brompheniramine/ phenylephrine)

+

terbutaline

1 interaction

Monitor/Modify Tx

phenylephrine + terbutaline

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• teriflunomide
Bromfed (brompheniramine/ phenylephrine)

+

teriflunomide

1 interaction

Monitor/Modify Tx

phenylephrine + teriflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• testosterone
Bromfed (brompheniramine/ phenylephrine)

+

testosterone

1 interaction

Monitor/Modify Tx

phenylephrine + testosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• thioridazine
Bromfed (brompheniramine/ phenylephrine)

+

thioridazine

1 interaction

Monitor/Modify Tx

brompheniramine + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• thiothixene
Bromfed (brompheniramine/ phenylephrine)

+

thiothixene

1 interaction

Monitor/Modify Tx

brompheniramine + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• thyroid
Bromfed (brompheniramine/ phenylephrine)

+

thyroid

1 interaction

Monitor/Modify Tx

phenylephrine + thyroid

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• timolol
Bromfed (brompheniramine/ phenylephrine)

+

timolol

1 interaction

Monitor/Modify Tx

phenylephrine + timolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tirzepatide
Bromfed (brompheniramine/ phenylephrine)

+

tirzepatide

1 interaction

Monitor/Modify Tx

phenylephrine + tirzepatide

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• tivozanib
Bromfed (brompheniramine/ phenylephrine)

+

tivozanib

1 interaction

Monitor/Modify Tx

phenylephrine + tivozanib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• tolmetin
Bromfed (brompheniramine/ phenylephrine)

+

tolmetin

1 interaction

Monitor/Modify Tx

phenylephrine + tolmetin

monitor BP: combo may incr. risk of HTN (additive effects)

• torsemide
Bromfed (brompheniramine/ phenylephrine)

+

torsemide

1 interaction

Monitor/Modify Tx

phenylephrine + torsemide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tramadol
Bromfed (brompheniramine/ phenylephrine)

+

tramadol

1 interaction

Monitor/Modify Tx

brompheniramine + tramadol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• trametinib
Bromfed (brompheniramine/ phenylephrine)

+

trametinib

1 interaction

Monitor/Modify Tx

phenylephrine + trametinib

monitor BP: combo may incr. risk of HTN (additive effects)

• trandolapril
Bromfed (brompheniramine/ phenylephrine)

+

trandolapril

1 interaction

Monitor/Modify Tx

phenylephrine + trandolapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triamcinolone
Bromfed (brompheniramine/ phenylephrine)

+

triamcinolone

1 interaction

Monitor/Modify Tx

phenylephrine + triamcinolone

monitor BP: combo may incr. risk of HTN (additive effects)

• triamterene
Bromfed (brompheniramine/ phenylephrine)

+

triamterene

1 interaction

Monitor/Modify Tx

phenylephrine + triamterene

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triazolam
Bromfed (brompheniramine/ phenylephrine)

+

triazolam

1 interaction

Monitor/Modify Tx

brompheniramine + triazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• trimipramine
Bromfed (brompheniramine/ phenylephrine)

+

trimipramine

2 interactions

Monitor/Modify Tx

phenylephrine + trimipramine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + trimipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ubrogepant
Bromfed (brompheniramine/ phenylephrine)

+

ubrogepant

1 interaction

Monitor/Modify Tx

phenylephrine + ubrogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• vadadustat
Bromfed (brompheniramine/ phenylephrine)

+

vadadustat

1 interaction

Monitor/Modify Tx

phenylephrine + vadadustat

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• valsartan
Bromfed (brompheniramine/ phenylephrine)

+

valsartan

1 interaction

Monitor/Modify Tx

phenylephrine + valsartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vamorolone
Bromfed (brompheniramine/ phenylephrine)

+

vamorolone

1 interaction

Monitor/Modify Tx

phenylephrine + vamorolone

monitor BP: combo may incr. risk of HTN (additive effects)

• vandetanib
Bromfed (brompheniramine/ phenylephrine)

+

vandetanib

1 interaction

Monitor/Modify Tx

phenylephrine + vandetanib

monitor BP: combo may incr. risk of HTN (additive effects)

• vasopressin
Bromfed (brompheniramine/ phenylephrine)

+

vasopressin

1 interaction

Monitor/Modify Tx

phenylephrine + vasopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• venlafaxine
Bromfed (brompheniramine/ phenylephrine)

+

venlafaxine

2 interactions

Monitor/Modify Tx

phenylephrine + venlafaxine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + venlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• verapamil
Bromfed (brompheniramine/ phenylephrine)

+

verapamil

1 interaction

Monitor/Modify Tx

phenylephrine + verapamil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vilanterol inhaled
Bromfed (brompheniramine/ phenylephrine)

+

vilanterol inhaled

1 interaction

Monitor/Modify Tx

phenylephrine + vilanterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• viloxazine
Bromfed (brompheniramine/ phenylephrine)

+

viloxazine

2 interactions

Monitor/Modify Tx

phenylephrine + viloxazine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + viloxazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• voclosporin
Bromfed (brompheniramine/ phenylephrine)

+

voclosporin

1 interaction

Monitor/Modify Tx

phenylephrine + voclosporin

monitor BP: combo may incr. risk of HTN (additive effects)

• zaleplon
Bromfed (brompheniramine/ phenylephrine)

+

zaleplon

1 interaction

Monitor/Modify Tx

brompheniramine + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zavegepant
Bromfed (brompheniramine/ phenylephrine)

+

zavegepant

1 interaction

Monitor/Modify Tx

phenylephrine + zavegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ziconotide
Bromfed (brompheniramine/ phenylephrine)

+

ziconotide

1 interaction

Monitor/Modify Tx

brompheniramine + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziv-aflibercept
Bromfed (brompheniramine/ phenylephrine)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

phenylephrine + ziv-aflibercept

monitor BP: combo may incr. risk of HTN (additive effects)

• zolmitriptan
Bromfed (brompheniramine/ phenylephrine)

+

zolmitriptan

2 interactions

Monitor/Modify Tx

phenylephrine + zolmitriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + zolmitriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
Bromfed (brompheniramine/ phenylephrine)

+

zolpidem

1 interaction

Monitor/Modify Tx

brompheniramine + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Caution Advised

• 5-HTP
Bromfed (brompheniramine/ phenylephrine)

+

5-HTP

1 interaction

Caution Advised

brompheniramine + 5-HTP

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aceclidine ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

aceclidine ophthalmic

1 interaction

Caution Advised

brompheniramine + aceclidine ophthalmic

caution advised: combo may decr. aceclidine efficacy (antagonistic effects)

• allopurinol
Bromfed (brompheniramine/ phenylephrine)

+

allopurinol

1 interaction

Caution Advised

brompheniramine + allopurinol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alosetron
Bromfed (brompheniramine/ phenylephrine)

+

alosetron

1 interaction

Caution Advised

brompheniramine + alosetron

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• amantadine
Bromfed (brompheniramine/ phenylephrine)

+

amantadine

1 interaction

Caution Advised

brompheniramine + amantadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• apomorphine
Bromfed (brompheniramine/ phenylephrine)

+

apomorphine

1 interaction

Caution Advised

brompheniramine + apomorphine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

apraclonidine ophthalmic

1 interaction

Caution Advised

brompheniramine + apraclonidine ophthalmic

caution advised if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole bimonthly injection
Bromfed (brompheniramine/ phenylephrine)

+

aripiprazole bimonthly injection

1 interaction

Caution Advised

brompheniramine + aripiprazole bimonthly injection

caution advised: combo may incr. risk of hyperthermia, CNS depression, psychomotor impairment (additive effects)

• aripiprazole lauroxil
Bromfed (brompheniramine/ phenylephrine)

+

aripiprazole lauroxil

1 interaction

Caution Advised

brompheniramine + aripiprazole lauroxil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• aripiprazole monthly injection
Bromfed (brompheniramine/ phenylephrine)

+

aripiprazole monthly injection

1 interaction

Caution Advised

brompheniramine + aripiprazole monthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• aripiprazole oral
Bromfed (brompheniramine/ phenylephrine)

+

aripiprazole oral

1 interaction

Caution Advised

brompheniramine + aripiprazole oral

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• asenapine
Bromfed (brompheniramine/ phenylephrine)

+

asenapine

1 interaction

Caution Advised

brompheniramine + asenapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• atropine
Bromfed (brompheniramine/ phenylephrine)

+

atropine

1 interaction

Caution Advised

brompheniramine + atropine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• baclofen
Bromfed (brompheniramine/ phenylephrine)

+

baclofen

1 interaction

Caution Advised

brompheniramine + baclofen

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen intrathecal
Bromfed (brompheniramine/ phenylephrine)

+

baclofen intrathecal

1 interaction

Caution Advised

brompheniramine + baclofen intrathecal

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• barium
Bromfed (brompheniramine/ phenylephrine)

+

barium

1 interaction

Caution Advised

brompheniramine + barium

caution advised: combo may incr. risk of intestinal obstruction (additive effects)

• belladonna alkaloids
Bromfed (brompheniramine/ phenylephrine)

+

belladonna alkaloids

1 interaction

Caution Advised

brompheniramine + belladonna alkaloids

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• benztropine
Bromfed (brompheniramine/ phenylephrine)

+

benztropine

1 interaction

Caution Advised

brompheniramine + benztropine

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• bethanechol
Bromfed (brompheniramine/ phenylephrine)

+

bethanechol

1 interaction

Caution Advised

brompheniramine + bethanechol

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• botulinum toxin
Bromfed (brompheniramine/ phenylephrine)

+

botulinum toxin

1 interaction

Caution Advised

brompheniramine + botulinum toxin

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• brexpiprazole
Bromfed (brompheniramine/ phenylephrine)

+

brexpiprazole

1 interaction

Caution Advised

brompheniramine + brexpiprazole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• brimonidine ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

brimonidine ophthalmic

1 interaction

Caution Advised

brompheniramine + brimonidine ophthalmic

caution advised if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment (additive effects)

• brimonidine topical
Bromfed (brompheniramine/ phenylephrine)

+

brimonidine topical

1 interaction

Caution Advised

brompheniramine + brimonidine topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brivaracetam
Bromfed (brompheniramine/ phenylephrine)

+

brivaracetam

1 interaction

Caution Advised

brompheniramine + brivaracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brompheniramine
Bromfed (brompheniramine/ phenylephrine)

+

brompheniramine

1 interaction

Caution Advised

brompheniramine + brompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

• buspirone
Bromfed (brompheniramine/ phenylephrine)

+

buspirone

1 interaction

Caution Advised

brompheniramine + buspirone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cannabidiol
Bromfed (brompheniramine/ phenylephrine)

+

cannabidiol

1 interaction

Caution Advised

brompheniramine + cannabidiol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carbinoxamine
Bromfed (brompheniramine/ phenylephrine)

+

carbinoxamine

1 interaction

Caution Advised

brompheniramine + carbinoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• cariprazine
Bromfed (brompheniramine/ phenylephrine)

+

cariprazine

1 interaction

Caution Advised

brompheniramine + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• carisoprodol
Bromfed (brompheniramine/ phenylephrine)

+

carisoprodol

1 interaction

Caution Advised

brompheniramine + carisoprodol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cenobamate
Bromfed (brompheniramine/ phenylephrine)

+

cenobamate

1 interaction

Caution Advised

brompheniramine + cenobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cetirizine
Bromfed (brompheniramine/ phenylephrine)

+

cetirizine

1 interaction

Caution Advised

brompheniramine + cetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cevimeline
Bromfed (brompheniramine/ phenylephrine)

+

cevimeline

1 interaction

Caution Advised

brompheniramine + cevimeline

caution advised: combo may decrease efficacy of both drugs (antagonistic effects)

• chamomile, German
Bromfed (brompheniramine/ phenylephrine)

+

chamomile, German

1 interaction

Caution Advised

brompheniramine + chamomile, German

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Bromfed (brompheniramine/ phenylephrine)

+

chlophedianol

1 interaction

Caution Advised

brompheniramine + chlophedianol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlordiazepoxide
Bromfed (brompheniramine/ phenylephrine)

+

chlordiazepoxide

1 interaction

Caution Advised

brompheniramine + chlordiazepoxide

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• chlorpheniramine
Bromfed (brompheniramine/ phenylephrine)

+

chlorpheniramine

1 interaction

Caution Advised

brompheniramine + chlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorzoxazone
Bromfed (brompheniramine/ phenylephrine)

+

chlorzoxazone

1 interaction

Caution Advised

brompheniramine + chlorzoxazone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cisapride
Bromfed (brompheniramine/ phenylephrine)

+

cisapride

1 interaction

Caution Advised

brompheniramine + cisapride

caution advised: combo may decr. cisapride efficacy (antagonistic effects)

• citalopram
Bromfed (brompheniramine/ phenylephrine)

+

citalopram

1 interaction

Caution Advised

brompheniramine + citalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clemastine
Bromfed (brompheniramine/ phenylephrine)

+

clemastine

1 interaction

Caution Advised

brompheniramine + clemastine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clidinium
Bromfed (brompheniramine/ phenylephrine)

+

clidinium

1 interaction

Caution Advised

brompheniramine + clidinium

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• cyclobenzaprine
Bromfed (brompheniramine/ phenylephrine)

+

cyclobenzaprine

1 interaction

Caution Advised

brompheniramine + cyclobenzaprine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• cyclopentolate ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

cyclopentolate ophthalmic

1 interaction

Caution Advised

brompheniramine + cyclopentolate ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• cyproheptadine
Bromfed (brompheniramine/ phenylephrine)

+

cyproheptadine

1 interaction

Caution Advised

brompheniramine + cyproheptadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dantrolene
Bromfed (brompheniramine/ phenylephrine)

+

dantrolene

1 interaction

Caution Advised

brompheniramine + dantrolene

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Bromfed (brompheniramine/ phenylephrine)

+

darifenacin

1 interaction

Caution Advised

brompheniramine + darifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• deutetrabenazine
Bromfed (brompheniramine/ phenylephrine)

+

deutetrabenazine

1 interaction

Caution Advised

brompheniramine + deutetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Bromfed (brompheniramine/ phenylephrine)

+

dexchlorpheniramine

1 interaction

Caution Advised

brompheniramine + dexchlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dichlorphenamide
Bromfed (brompheniramine/ phenylephrine)

+

dichlorphenamide

1 interaction

Caution Advised

brompheniramine + dichlorphenamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dicyclomine
Bromfed (brompheniramine/ phenylephrine)

+

dicyclomine

1 interaction

Caution Advised

brompheniramine + dicyclomine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• difelikefalin
Bromfed (brompheniramine/ phenylephrine)

+

difelikefalin

1 interaction

Caution Advised

brompheniramine + difelikefalin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Bromfed (brompheniramine/ phenylephrine)

+

difenoxin

1 interaction

Caution Advised

brompheniramine + difenoxin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

• digoxin
Bromfed (brompheniramine/ phenylephrine)

+

digoxin

1 interaction

Caution Advised

phenylephrine + digoxin

caution advised: combo with decongestants may incr. risk of cardiac arrhythmias (additive effects)

• dimenhydrinate
Bromfed (brompheniramine/ phenylephrine)

+

dimenhydrinate

1 interaction

Caution Advised

brompheniramine + dimenhydrinate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• diphenhydramine
Bromfed (brompheniramine/ phenylephrine)

+

diphenhydramine

1 interaction

Caution Advised

brompheniramine + diphenhydramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• diphenoxylate
Bromfed (brompheniramine/ phenylephrine)

+

diphenoxylate

1 interaction

Caution Advised

brompheniramine + diphenoxylate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• disopyramide
Bromfed (brompheniramine/ phenylephrine)

+

disopyramide

1 interaction

Caution Advised

brompheniramine + disopyramide

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• domperidone
Bromfed (brompheniramine/ phenylephrine)

+

domperidone

1 interaction

Caution Advised

brompheniramine + domperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)

• donepezil
Bromfed (brompheniramine/ phenylephrine)

+

donepezil

1 interaction

Caution Advised

brompheniramine + donepezil

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• doxepin topical
Bromfed (brompheniramine/ phenylephrine)

+

doxepin topical

1 interaction

Caution Advised

brompheniramine + doxepin topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• duloxetine
Bromfed (brompheniramine/ phenylephrine)

+

duloxetine

1 interaction

Caution Advised

brompheniramine + duloxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• efavirenz
Bromfed (brompheniramine/ phenylephrine)

+

efavirenz

1 interaction

Caution Advised

brompheniramine + efavirenz

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• elinzanetant
Bromfed (brompheniramine/ phenylephrine)

+

elinzanetant

1 interaction

Caution Advised

brompheniramine + elinzanetant

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entacapone
Bromfed (brompheniramine/ phenylephrine)

+

entacapone

1 interaction

Caution Advised

brompheniramine + entacapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entrectinib
Bromfed (brompheniramine/ phenylephrine)

+

entrectinib

1 interaction

Caution Advised

brompheniramine + entrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• erythromycin
Bromfed (brompheniramine/ phenylephrine)

+

erythromycin

1 interaction

Caution Advised

brompheniramine + erythromycin

caution advised: combo may decr. erythromycin efficacy when used for GI promotility (antagonistic effects)

• escitalopram
Bromfed (brompheniramine/ phenylephrine)

+

escitalopram

1 interaction

Caution Advised

brompheniramine + escitalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Bromfed (brompheniramine/ phenylephrine)

+

eslicarbazepine acetate

1 interaction

Caution Advised

brompheniramine + eslicarbazepine acetate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• estazolam
Bromfed (brompheniramine/ phenylephrine)

+

estazolam

1 interaction

Caution Advised

brompheniramine + estazolam

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ethanol (in some formulations)
Bromfed (brompheniramine/ phenylephrine)

+

ethanol (in some formulations)

1 interaction

Caution Advised

brompheniramine + ethanol (in some formulations)

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ethosuximide
Bromfed (brompheniramine/ phenylephrine)

+

ethosuximide

1 interaction

Caution Advised

brompheniramine + ethosuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• felbamate
Bromfed (brompheniramine/ phenylephrine)

+

felbamate

1 interaction

Caution Advised

brompheniramine + felbamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fesoterodine
Bromfed (brompheniramine/ phenylephrine)

+

fesoterodine

1 interaction

Caution Advised

brompheniramine + fesoterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• flavoxate
Bromfed (brompheniramine/ phenylephrine)

+

flavoxate

1 interaction

Caution Advised

brompheniramine + flavoxate

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• flibanserin
Bromfed (brompheniramine/ phenylephrine)

+

flibanserin

1 interaction

Caution Advised

brompheniramine + flibanserin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluoxetine
Bromfed (brompheniramine/ phenylephrine)

+

fluoxetine

1 interaction

Caution Advised

brompheniramine + fluoxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluvoxamine
Bromfed (brompheniramine/ phenylephrine)

+

fluvoxamine

1 interaction

Caution Advised

brompheniramine + fluvoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• foslevodopa
Bromfed (brompheniramine/ phenylephrine)

+

foslevodopa

1 interaction

Caution Advised

brompheniramine + foslevodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fosphenytoin
Bromfed (brompheniramine/ phenylephrine)

+

fosphenytoin

1 interaction

Caution Advised

brompheniramine + fosphenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• galantamine
Bromfed (brompheniramine/ phenylephrine)

+

galantamine

1 interaction

Caution Advised

brompheniramine + galantamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• ganaxolone
Bromfed (brompheniramine/ phenylephrine)

+

ganaxolone

1 interaction

Caution Advised

brompheniramine + ganaxolone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glofitamab
Bromfed (brompheniramine/ phenylephrine)

+

glofitamab

1 interaction

Caution Advised

brompheniramine + glofitamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate inhaled
Bromfed (brompheniramine/ phenylephrine)

+

glycopyrrolate inhaled

1 interaction

Caution Advised

brompheniramine + glycopyrrolate inhaled

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• homatropine
Bromfed (brompheniramine/ phenylephrine)

+

homatropine

1 interaction

Caution Advised

brompheniramine + homatropine

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• hyoscyamine
Bromfed (brompheniramine/ phenylephrine)

+

hyoscyamine

1 interaction

Caution Advised

brompheniramine + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• iloperidone
Bromfed (brompheniramine/ phenylephrine)

+

iloperidone

1 interaction

Caution Advised

brompheniramine + iloperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• ipratropium inhaled
Bromfed (brompheniramine/ phenylephrine)

+

ipratropium inhaled

1 interaction

Caution Advised

brompheniramine + ipratropium inhaled

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• ipratropium nasal
Bromfed (brompheniramine/ phenylephrine)

+

ipratropium nasal

1 interaction

Caution Advised

brompheniramine + ipratropium nasal

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• isoflurane
Bromfed (brompheniramine/ phenylephrine)

+

isoflurane

1 interaction

Caution Advised

brompheniramine + isoflurane

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• lacosamide
Bromfed (brompheniramine/ phenylephrine)

+

lacosamide

1 interaction

Caution Advised

brompheniramine + lacosamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lamotrigine
Bromfed (brompheniramine/ phenylephrine)

+

lamotrigine

1 interaction

Caution Advised

brompheniramine + lamotrigine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levetiracetam
Bromfed (brompheniramine/ phenylephrine)

+

levetiracetam

1 interaction

Caution Advised

brompheniramine + levetiracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levocetirizine
Bromfed (brompheniramine/ phenylephrine)

+

levocetirizine

1 interaction

Caution Advised

brompheniramine + levocetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Bromfed (brompheniramine/ phenylephrine)

+

levodopa

1 interaction

Caution Advised

brompheniramine + levodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• linvoseltamab
Bromfed (brompheniramine/ phenylephrine)

+

linvoseltamab

1 interaction

Caution Advised

brompheniramine + linvoseltamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lofexidine
Bromfed (brompheniramine/ phenylephrine)

+

lofexidine

1 interaction

Caution Advised

brompheniramine + lofexidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• loperamide
Bromfed (brompheniramine/ phenylephrine)

+

loperamide

1 interaction

Caution Advised

brompheniramine + loperamide

caution advised: combo may incr. risk of severe constipation/paralytic ileus (additive effects)

• loxapine
Bromfed (brompheniramine/ phenylephrine)

+

loxapine

1 interaction

Caution Advised

brompheniramine + loxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• lumateperone
Bromfed (brompheniramine/ phenylephrine)

+

lumateperone

1 interaction

Caution Advised

brompheniramine + lumateperone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• lurasidone
Bromfed (brompheniramine/ phenylephrine)

+

lurasidone

1 interaction

Caution Advised

brompheniramine + lurasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• meclizine
Bromfed (brompheniramine/ phenylephrine)

+

meclizine

1 interaction

Caution Advised

brompheniramine + meclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• melatonin
Bromfed (brompheniramine/ phenylephrine)

+

melatonin

1 interaction

Caution Advised

brompheniramine + melatonin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meprobamate
Bromfed (brompheniramine/ phenylephrine)

+

meprobamate

1 interaction

Caution Advised

brompheniramine + meprobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methocarbamol
Bromfed (brompheniramine/ phenylephrine)

+

methocarbamol

1 interaction

Caution Advised

brompheniramine + methocarbamol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methohexital
Bromfed (brompheniramine/ phenylephrine)

+

methohexital

1 interaction

Caution Advised

brompheniramine + methohexital

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methscopolamine
Bromfed (brompheniramine/ phenylephrine)

+

methscopolamine

1 interaction

Caution Advised

brompheniramine + methscopolamine

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• methsuximide
Bromfed (brompheniramine/ phenylephrine)

+

methsuximide

1 interaction

Caution Advised

brompheniramine + methsuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrapone
Bromfed (brompheniramine/ phenylephrine)

+

metyrapone

1 interaction

Caution Advised

brompheniramine + metyrapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Bromfed (brompheniramine/ phenylephrine)

+

metyrosine

1 interaction

Caution Advised

brompheniramine + metyrosine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mexiletine
Bromfed (brompheniramine/ phenylephrine)

+

mexiletine

1 interaction

Caution Advised

brompheniramine + mexiletine

caution advised: combo may decr. peak mexiletine levels, delay antiarrhythmic onset (absorption delayed)

• milsaperidone
Bromfed (brompheniramine/ phenylephrine)

+

milsaperidone

1 interaction

Caution Advised

brompheniramine + milsaperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• mitotane
Bromfed (brompheniramine/ phenylephrine)

+

mitotane

1 interaction

Caution Advised

brompheniramine + mitotane

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• molindone
Bromfed (brompheniramine/ phenylephrine)

+

molindone

1 interaction

Caution Advised

brompheniramine + molindone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• mosunetuzumab
Bromfed (brompheniramine/ phenylephrine)

+

mosunetuzumab

1 interaction

Caution Advised

brompheniramine + mosunetuzumab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Bromfed (brompheniramine/ phenylephrine)

+

mycophenolate mofetil

1 interaction

Caution Advised

brompheniramine + mycophenolate mofetil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naltrexone
Bromfed (brompheniramine/ phenylephrine)

+

naltrexone

1 interaction

Caution Advised

brompheniramine + naltrexone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nefazodone
Bromfed (brompheniramine/ phenylephrine)

+

nefazodone

1 interaction

Caution Advised

brompheniramine + nefazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• neostigmine
Bromfed (brompheniramine/ phenylephrine)

+

neostigmine

1 interaction

Caution Advised

brompheniramine + neostigmine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• orphenadrine
Bromfed (brompheniramine/ phenylephrine)

+

orphenadrine

1 interaction

Caution Advised

brompheniramine + orphenadrine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• oxcarbazepine
Bromfed (brompheniramine/ phenylephrine)

+

oxcarbazepine

1 interaction

Caution Advised

brompheniramine + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• paliperidone
Bromfed (brompheniramine/ phenylephrine)

+

paliperidone

1 interaction

Caution Advised

brompheniramine + paliperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• paroxetine
Bromfed (brompheniramine/ phenylephrine)

+

paroxetine

1 interaction

Caution Advised

brompheniramine + paroxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• passion flower
Bromfed (brompheniramine/ phenylephrine)

+

passion flower

1 interaction

Caution Advised

brompheniramine + passion flower

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• perampanel
Bromfed (brompheniramine/ phenylephrine)

+

perampanel

1 interaction

Caution Advised

brompheniramine + perampanel

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pheniramine
Bromfed (brompheniramine/ phenylephrine)

+

pheniramine

1 interaction

Caution Advised

brompheniramine + pheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• phenytoin
Bromfed (brompheniramine/ phenylephrine)

+

phenytoin

1 interaction

Caution Advised

brompheniramine + phenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pilocarpine
Bromfed (brompheniramine/ phenylephrine)

+

pilocarpine

1 interaction

Caution Advised

brompheniramine + pilocarpine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• pilocarpine ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

pilocarpine ophthalmic

1 interaction

Caution Advised

brompheniramine + pilocarpine ophthalmic

caution advised: combo may decr. pilocarpine efficacy (antagonistic effects)

• pimozide
Bromfed (brompheniramine/ phenylephrine)

+

pimozide

1 interaction

Caution Advised

brompheniramine + pimozide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• potassium acid phosphate
Bromfed (brompheniramine/ phenylephrine)

+

potassium acid phosphate

1 interaction

Caution Advised

brompheniramine + potassium acid phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium gluconate
Bromfed (brompheniramine/ phenylephrine)

+

potassium gluconate

1 interaction

Caution Advised

brompheniramine + potassium gluconate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium phosphate
Bromfed (brompheniramine/ phenylephrine)

+

potassium phosphate

1 interaction

Caution Advised

brompheniramine + potassium phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• pramipexole
Bromfed (brompheniramine/ phenylephrine)

+

pramipexole

1 interaction

Caution Advised

brompheniramine + pramipexole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• prochlorperazine
Bromfed (brompheniramine/ phenylephrine)

+

prochlorperazine

1 interaction

Caution Advised

brompheniramine + prochlorperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pyridostigmine
Bromfed (brompheniramine/ phenylephrine)

+

pyridostigmine

1 interaction

Caution Advised

brompheniramine + pyridostigmine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• quinidine (antiarrhythmic)
Bromfed (brompheniramine/ phenylephrine)

+

quinidine (antiarrhythmic)

1 interaction

Caution Advised

brompheniramine + quinidine (antiarrhythmic)

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• quinidine (CYP2D6 inhibitor)
Bromfed (brompheniramine/ phenylephrine)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Caution Advised

brompheniramine + quinidine (CYP2D6 inhibitor)

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• ramelteon
Bromfed (brompheniramine/ phenylephrine)

+

ramelteon

1 interaction

Caution Advised

brompheniramine + ramelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• repotrectinib
Bromfed (brompheniramine/ phenylephrine)

+

repotrectinib

1 interaction

Caution Advised

brompheniramine + repotrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• risperidone
Bromfed (brompheniramine/ phenylephrine)

+

risperidone

1 interaction

Caution Advised

brompheniramine + risperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• rufinamide
Bromfed (brompheniramine/ phenylephrine)

+

rufinamide

1 interaction

Caution Advised

brompheniramine + rufinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selinexor
Bromfed (brompheniramine/ phenylephrine)

+

selinexor

1 interaction

Caution Advised

brompheniramine + selinexor

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sertraline
Bromfed (brompheniramine/ phenylephrine)

+

sertraline

1 interaction

Caution Advised

brompheniramine + sertraline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• solifenacin
Bromfed (brompheniramine/ phenylephrine)

+

solifenacin

1 interaction

Caution Advised

brompheniramine + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• stiripentol
Bromfed (brompheniramine/ phenylephrine)

+

stiripentol

1 interaction

Caution Advised

brompheniramine + stiripentol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tasimelteon
Bromfed (brompheniramine/ phenylephrine)

+

tasimelteon

1 interaction

Caution Advised

brompheniramine + tasimelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• temazepam
Bromfed (brompheniramine/ phenylephrine)

+

temazepam

1 interaction

Caution Advised

brompheniramine + temazepam

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• tetrabenazine
Bromfed (brompheniramine/ phenylephrine)

+

tetrabenazine

1 interaction

Caution Advised

brompheniramine + tetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiotepa
Bromfed (brompheniramine/ phenylephrine)

+

thiotepa

1 interaction

Caution Advised

brompheniramine + thiotepa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tiagabine
Bromfed (brompheniramine/ phenylephrine)

+

tiagabine

1 interaction

Caution Advised

brompheniramine + tiagabine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tizanidine
Bromfed (brompheniramine/ phenylephrine)

+

tizanidine

1 interaction

Caution Advised

brompheniramine + tizanidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolcapone
Bromfed (brompheniramine/ phenylephrine)

+

tolcapone

1 interaction

Caution Advised

brompheniramine + tolcapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolterodine
Bromfed (brompheniramine/ phenylephrine)

+

tolterodine

1 interaction

Caution Advised

brompheniramine + tolterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• topiramate
Bromfed (brompheniramine/ phenylephrine)

+

topiramate

1 interaction

Caution Advised

brompheniramine + topiramate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• trazodone
Bromfed (brompheniramine/ phenylephrine)

+

trazodone

1 interaction

Caution Advised

brompheniramine + trazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trifluoperazine
Bromfed (brompheniramine/ phenylephrine)

+

trifluoperazine

1 interaction

Caution Advised

brompheniramine + trifluoperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• trihexyphenidyl
Bromfed (brompheniramine/ phenylephrine)

+

trihexyphenidyl

1 interaction

Caution Advised

brompheniramine + trihexyphenidyl

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• triprolidine
Bromfed (brompheniramine/ phenylephrine)

+

triprolidine

1 interaction

Caution Advised

brompheniramine + triprolidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• tropicamide ophthalmic
Bromfed (brompheniramine/ phenylephrine)

+

tropicamide ophthalmic

1 interaction

Caution Advised

brompheniramine + tropicamide ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• trospium
Bromfed (brompheniramine/ phenylephrine)

+

trospium

1 interaction

Caution Advised

brompheniramine + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• umeclidinium inhaled
Bromfed (brompheniramine/ phenylephrine)

+

umeclidinium inhaled

1 interaction

Caution Advised

brompheniramine + umeclidinium inhaled

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• valbenazine
Bromfed (brompheniramine/ phenylephrine)

+

valbenazine

1 interaction

Caution Advised

brompheniramine + valbenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Bromfed (brompheniramine/ phenylephrine)

+

valerian

1 interaction

Caution Advised

brompheniramine + valerian

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
Bromfed (brompheniramine/ phenylephrine)

+

valproic acid

1 interaction

Caution Advised

brompheniramine + valproic acid

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vibegron
Bromfed (brompheniramine/ phenylephrine)

+

vibegron

1 interaction

Caution Advised

brompheniramine + vibegron

caution advised: combo may incr. risk of urinary retention (additive effects)

• vigabatrin
Bromfed (brompheniramine/ phenylephrine)

+

vigabatrin

1 interaction

Caution Advised

brompheniramine + vigabatrin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vilazodone
Bromfed (brompheniramine/ phenylephrine)

+

vilazodone

1 interaction

Caution Advised

brompheniramine + vilazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziprasidone
Bromfed (brompheniramine/ phenylephrine)

+

ziprasidone

1 interaction

Caution Advised

brompheniramine + ziprasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• zonisamide
Bromfed (brompheniramine/ phenylephrine)

+

zonisamide

1 interaction

Caution Advised

brompheniramine + zonisamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)