Cialis

Overview

tadalafil

PDE5 inhibitor

• CYP3A4 substrate
• ototoxicity
• vasodilator agent

Contraindicated

• isosorbide dinitrate
Cialis (tadalafil)

+

isosorbide dinitrate

1 interaction

Contraindicated

tadalafil + isosorbide dinitrate

contraindicated; allow 48h to elapse after last dose of tadalafil before nitrate use: combo may incr. risk of severe hypotension, syncope, or MI (additive effects)

• isosorbide mononitrate
Cialis (tadalafil)

+

isosorbide mononitrate

1 interaction

Contraindicated

tadalafil + isosorbide mononitrate

contraindicated; allow 48h to elapse after last dose of tadalafil before nitrate use: combo may incr. risk of severe hypotension, syncope, or MI (additive effects)

• nitroglycerin
Cialis (tadalafil)

+

nitroglycerin

1 interaction

Contraindicated

tadalafil + nitroglycerin

contraindicated; allow 48h to elapse after last dose of tadalafil before nitrate use: combo may incr. risk of MI, severe hypotension, incl. orthostasis, syncope (additive effects)

• nitroprusside
Cialis (tadalafil)

+

nitroprusside

1 interaction

Contraindicated

tadalafil + nitroprusside

contraindicated: combo may incr. risk of severe or life-threatening hypotension (additive effects)

• riociguat
Cialis (tadalafil)

+

riociguat

1 interaction

Contraindicated

tadalafil + riociguat

contraindicated w/in 24h before or 48h after tadalafil use: combo may incr. risk of severe hypotension (additive effects)

• vericiguat
Cialis (tadalafil)

+

vericiguat

1 interaction

Contraindicated

tadalafil + vericiguat

contraindicated: combo may incr. risk of hypotension (additive effects)

Avoid/Use Alternative

• adagrasib
Cialis (tadalafil)

+

adagrasib

1 interaction

Avoid/Use Alternative

tadalafil + adagrasib

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• aldesleukin
Cialis (tadalafil)

+

aldesleukin

1 interaction

Avoid/Use Alternative

tadalafil + aldesleukin

avoid combo: combo may incr. risk of severe or life-threatening hypotension (additive effects)

• alfuzosin
Cialis (tadalafil)

+

alfuzosin

1 interaction

Avoid/Use Alternative

tadalafil + alfuzosin

BENIGN PROSTATIC HYPERPLASIA: avoid combo; D/C alfuzosin at least 1 day prior to tadalafil start; ERECTILE DYSFUNCTION: monitor BP; decr. tadalafil to lowest recommended start dose, consider decr. alfuzosin dose; PULMONARY ARTERIAL HTN: monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• amikacin
Cialis (tadalafil)

+

amikacin

1 interaction

Avoid/Use Alternative

tadalafil + amikacin

use alternative or monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• amikacin inhaled
Cialis (tadalafil)

+

amikacin inhaled

1 interaction

Avoid/Use Alternative

tadalafil + amikacin inhaled

use alternative or monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• apalutamide
Cialis (tadalafil)

+

apalutamide

1 interaction

Avoid/Use Alternative

tadalafil + apalutamide

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• atazanavir
Cialis (tadalafil)

+

atazanavir

1 interaction

Avoid/Use Alternative

tadalafil + atazanavir

BENIGN PROSTATIC HYPERPLASIA: avoid combo; PULMONARY HTN: monitor BP; start tadalafil 20 mg qd if on atazanavir >1wk; if on tadalafil, hold x24h before and x1wk after atazanavir start, then resume tadalafil 20 mg qd, max 40 mg qd; ERECTILE DYSFUNCTION: monitor BP; max tadalafil dose 10 mg q72h if prn use, 2.5 mg qd if daily use: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• avanafil
Cialis (tadalafil)

+

avanafil

1 interaction

Avoid/Use Alternative

tadalafil + avanafil

avoid combo: combo may incr. risk of hypotension (incl. orthostasis, syncope), auditory, vestibular, other adverse effects (additive effects, duplicate tx)

• bosentan
Cialis (tadalafil)

+

bosentan

1 interaction

Avoid/Use Alternative

tadalafil + bosentan

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• butalbital
Cialis (tadalafil)

+

butalbital

1 interaction

Avoid/Use Alternative

tadalafil + butalbital

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• carbamazepine
Cialis (tadalafil)

+

carbamazepine

1 interaction

Avoid/Use Alternative

tadalafil + carbamazepine

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• cenobamate
Cialis (tadalafil)

+

cenobamate

1 interaction

Avoid/Use Alternative

tadalafil + cenobamate

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• ceritinib
Cialis (tadalafil)

+

ceritinib

1 interaction

Avoid/Use Alternative

tadalafil + ceritinib

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• chloramphenicol
Cialis (tadalafil)

+

chloramphenicol

1 interaction

Avoid/Use Alternative

tadalafil + chloramphenicol

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• clarithromycin
Cialis (tadalafil)

+

clarithromycin

1 interaction

Avoid/Use Alternative

tadalafil + clarithromycin

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• cobicistat
Cialis (tadalafil)

+

cobicistat

1 interaction

Avoid/Use Alternative

tadalafil + cobicistat

BENIGN PROSTATIC HYPERPLASIA: avoid combo; PULMONARY HTN: monitor BP; start tadalafil 20 mg qd if on cobicistat >1wk; if on tadalafil, hold x24h before and x1wk after cobicistat start, then resume tadalafil 20 mg qd, max 40 mg qd; ERECTILE DYSFUNCTION: monitor BP; max tadalafil dose 10 mg q72h if prn use, 2.5 mg qd if daily use: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• dabrafenib
Cialis (tadalafil)

+

dabrafenib

1 interaction

Avoid/Use Alternative

tadalafil + dabrafenib

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• doxazosin
Cialis (tadalafil)

+

doxazosin

1 interaction

Avoid/Use Alternative

tadalafil + doxazosin

BENIGN PROSTATIC HYPERPLASIA: avoid combo; D/C doxazosin at least 1 day prior to tadalafil start; ERECTILE DYSFUNCTION: monitor BP; decr. tadalafil to lowest recommended start dose, consider decr. doxazosin dose; PULMONARY ARTERIAL HTN: consider alternative or monitor BP: combo may incr. risk of hypotension (incl. orthostasis, syncope), especially during doxazosin initiation/titration (additive effects)

• efavirenz
Cialis (tadalafil)

+

efavirenz

1 interaction

Avoid/Use Alternative

tadalafil + efavirenz

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• encorafenib
Cialis (tadalafil)

+

encorafenib

1 interaction

Avoid/Use Alternative

tadalafil + encorafenib

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• enzalutamide
Cialis (tadalafil)

+

enzalutamide

1 interaction

Avoid/Use Alternative

tadalafil + enzalutamide

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• ethacrynic acid
Cialis (tadalafil)

+

ethacrynic acid

1 interaction

Avoid/Use Alternative

tadalafil + ethacrynic acid

use alternative or monitor for ototoxicity, BP: combo may incr. risk of auditory, vestibular adverse effects, hypotension (additive effects)

• etravirine
Cialis (tadalafil)

+

etravirine

1 interaction

Avoid/Use Alternative

tadalafil + etravirine

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• fexinidazole
Cialis (tadalafil)

+

fexinidazole

1 interaction

Avoid/Use Alternative

tadalafil + fexinidazole

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• fosphenytoin
Cialis (tadalafil)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

tadalafil + fosphenytoin

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• gentamicin
Cialis (tadalafil)

+

gentamicin

1 interaction

Avoid/Use Alternative

tadalafil + gentamicin

use alternative or monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• idelalisib
Cialis (tadalafil)

+

idelalisib

1 interaction

Avoid/Use Alternative

tadalafil + idelalisib

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• itraconazole
Cialis (tadalafil)

+

itraconazole

1 interaction

Avoid/Use Alternative

tadalafil + itraconazole

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo during and x2wk after itraconazole tx; ERECTILE DYSFUNCTION: monitor BP; adjust max dose to tadalafil 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, auditory, vestibular and other adverse effects (hepatic metab. inhibited, additive effects)

• ivosidenib
Cialis (tadalafil)

+

ivosidenib

1 interaction

Avoid/Use Alternative

tadalafil + ivosidenib

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• ketoconazole
Cialis (tadalafil)

+

ketoconazole

1 interaction

Avoid/Use Alternative

tadalafil + ketoconazole

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo during and up to 1wk after ketoconazole tx; ERECTILE DYSFUNCTION: monitor BP; adjust max dose to tadalafil 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• lenacapavir
Cialis (tadalafil)

+

lenacapavir

1 interaction

Avoid/Use Alternative

tadalafil + lenacapavir

PAH: avoid combo during and x9mo after lenacapavir tx; ED: monitor BP during and x9mo after lenacapavir tx: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• levoketoconazole
Cialis (tadalafil)

+

levoketoconazole

1 interaction

Avoid/Use Alternative

tadalafil + levoketoconazole

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• lofexidine
Cialis (tadalafil)

+

lofexidine

1 interaction

Avoid/Use Alternative

tadalafil + lofexidine

use alternative or monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• lonafarnib
Cialis (tadalafil)

+

lonafarnib

1 interaction

Avoid/Use Alternative

tadalafil + lonafarnib

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• lopinavir/ritonavir
Cialis (tadalafil)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

tadalafil + lopinavir/ ritonavir

BENIGN PROSTATIC HYPERPLASIA: avoid combo; PULMONARY HTN: monitor BP; start tadalafil 20 mg qd if on lopinavir/ritonavir >1wk; if on tadalafil, hold x24h before and x1wk after lopinavir/ritonavir start, then resume tadalafil 20 mg qd, max 40 mg qd; ERECTILE DYSFUNCTION: monitor BP; max tadalafil dose 10 mg q72h if prn use, 2.5 mg qd if daily use: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• lorlatinib
Cialis (tadalafil)

+

lorlatinib

1 interaction

Avoid/Use Alternative

tadalafil + lorlatinib

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• lumacaftor/ivacaftor
Cialis (tadalafil)

+

lumacaftor/ ivacaftor

1 interaction

Avoid/Use Alternative

tadalafil + lumacaftor/ ivacaftor

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• mavacamten
Cialis (tadalafil)

+

mavacamten

1 interaction

Avoid/Use Alternative

tadalafil + mavacamten

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• mifepristone
Cialis (tadalafil)

+

mifepristone

1 interaction

Avoid/Use Alternative

tadalafil + mifepristone

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo during and x14 days after daily mifepristone use; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen during and x14 days after daily mifepristone use: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• mitapivat
Cialis (tadalafil)

+

mitapivat

1 interaction

Avoid/Use Alternative

tadalafil + mitapivat

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• mitotane
Cialis (tadalafil)

+

mitotane

1 interaction

Avoid/Use Alternative

tadalafil + mitotane

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• modafinil
Cialis (tadalafil)

+

modafinil

1 interaction

Avoid/Use Alternative

tadalafil + modafinil

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• nafcillin
Cialis (tadalafil)

+

nafcillin

1 interaction

Avoid/Use Alternative

tadalafil + nafcillin

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• nefazodone
Cialis (tadalafil)

+

nefazodone

1 interaction

Avoid/Use Alternative

tadalafil + nefazodone

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• nelfinavir
Cialis (tadalafil)

+

nelfinavir

1 interaction

Avoid/Use Alternative

tadalafil + nelfinavir

BENIGN PROSTATIC HYPERPLASIA: avoid combo; PULMONARY HTN: monitor BP; start or adjust tadalafil dose to 20 mg qd, max 40 mg qd; ERECTILE DYSFUNCTION: monitor BP; adjust max dose to tadalafil 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• neomycin
Cialis (tadalafil)

+

neomycin

1 interaction

Avoid/Use Alternative

tadalafil + neomycin

use alternative or monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects if compromised gut wall allows oral aminoglycoside absorption (additive effects)

• netupitant
Cialis (tadalafil)

+

netupitant

1 interaction

Avoid/Use Alternative

tadalafil + netupitant

use alternative or monitor BP; consider decr. tadalafil dose during and x1wk after (fos)netupitant tx: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• pacritinib
Cialis (tadalafil)

+

pacritinib

1 interaction

Avoid/Use Alternative

tadalafil + pacritinib

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• pentobarbital
Cialis (tadalafil)

+

pentobarbital

1 interaction

Avoid/Use Alternative

tadalafil + pentobarbital

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative or monitor BP: combo may decr. tadalafil levels, efficacy; may incr. risk of hypotension (hepatic metab. induced; additive effects)

• pexidartinib
Cialis (tadalafil)

+

pexidartinib

1 interaction

Avoid/Use Alternative

tadalafil + pexidartinib

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• phenobarbital
Cialis (tadalafil)

+

phenobarbital

1 interaction

Avoid/Use Alternative

tadalafil + phenobarbital

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative or monitor BP: combo may decr. tadalafil levels, efficacy; may incr. risk of hypotension, incl. orthostasis (hepatic metab. induced; additive effects)

• phenytoin
Cialis (tadalafil)

+

phenytoin

1 interaction

Avoid/Use Alternative

tadalafil + phenytoin

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• plazomicin
Cialis (tadalafil)

+

plazomicin

1 interaction

Avoid/Use Alternative

tadalafil + plazomicin

use alternative or monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• posaconazole
Cialis (tadalafil)

+

posaconazole

1 interaction

Avoid/Use Alternative

tadalafil + posaconazole

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• prazosin
Cialis (tadalafil)

+

prazosin

1 interaction

Avoid/Use Alternative

tadalafil + prazosin

BENIGN PROSTATIC HYPERPLASIA: avoid combo; D/C prazosin at least 1 day prior to tadalafil start; ERECTILE DYSFUNCTION: monitor BP; decr. tadalafil to lowest recommended start dose, consider decr. prazosin dose; PULMONARY ARTERIAL HTN: monitor BP: combo may incr. risk of hypotension (incl. orthostasis, syncope), especially during prazosin initiation/titration (additive effects)

• primidone
Cialis (tadalafil)

+

primidone

1 interaction

Avoid/Use Alternative

tadalafil + primidone

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• repotrectinib
Cialis (tadalafil)

+

repotrectinib

1 interaction

Avoid/Use Alternative

tadalafil + repotrectinib

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• ribociclib
Cialis (tadalafil)

+

ribociclib

1 interaction

Avoid/Use Alternative

tadalafil + ribociclib

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• rifabutin
Cialis (tadalafil)

+

rifabutin

1 interaction

Avoid/Use Alternative

tadalafil + rifabutin

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• rifampin
Cialis (tadalafil)

+

rifampin

1 interaction

Avoid/Use Alternative

tadalafil + rifampin

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• rifapentine
Cialis (tadalafil)

+

rifapentine

1 interaction

Avoid/Use Alternative

tadalafil + rifapentine

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• ritonavir
Cialis (tadalafil)

+

ritonavir

1 interaction

Avoid/Use Alternative

tadalafil + ritonavir

BENIGN PROSTATIC HYPERPLASIA: avoid combo; PULMONARY HTN: avoid combo if ritonavir use w/ nirmatrelvir; otherwise monitor BP, start tadalafil 20 mg qd if on ritonavir >1wk; if on tadalafil, hold x24h before and x1wk after ritonavir start, then resume tadalafil 20 mg qd, max 40 mg qd; ERECTILE DYSFUNCTION: monitor BP; max tadalafil dose 10 mg q72h if prn use, 2.5 mg qd if daily use: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• sildenafil
Cialis (tadalafil)

+

sildenafil

1 interaction

Avoid/Use Alternative

tadalafil + sildenafil

avoid combo: combo may incr. risk of hypotension, auditory, vestibular, other adverse effects (additive effects, duplicate tx)

• silodosin
Cialis (tadalafil)

+

silodosin

1 interaction

Avoid/Use Alternative

tadalafil + silodosin

BENIGN PROSTATIC HYPERPLASIA: avoid combo; D/C silodosin at least 1 day prior to tadalafil start; ERECTILE DYSFUNCTION: monitor BP; decr. tadalafil to lowest recommended start dose, consider decr. silodosin dose; PULMONARY ARTERIAL HTN: monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• sotorasib
Cialis (tadalafil)

+

sotorasib

1 interaction

Avoid/Use Alternative

tadalafil + sotorasib

PULMONARY HTN: consider alternative; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: caution advised: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• St. John's wort
Cialis (tadalafil)

+

St. John's wort

1 interaction

Avoid/Use Alternative

tadalafil + St. John's wort

PULMONARY HTN: avoid combo; ERECTILE DYSFUNCTION and BENIGN PROSTATIC HYPERPLASIA: consider alternative: combo may decr. tadalafil levels, efficacy (hepatic metab. induced)

• streptomycin
Cialis (tadalafil)

+

streptomycin

1 interaction

Avoid/Use Alternative

tadalafil + streptomycin

use alternative or monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• tadalafil
Cialis (tadalafil)

+

tadalafil

1 interaction

Avoid/Use Alternative

tadalafil + tadalafil

avoid combo: combo may incr. risk of hypotension, auditory, vestibular, other adverse effects (additive effects, duplicate tx)

• tamsulosin
Cialis (tadalafil)

+

tamsulosin

1 interaction

Avoid/Use Alternative

tadalafil + tamsulosin

BENIGN PROSTATIC HYPERPLASIA: avoid combo; D/C tamsulosin at least 1 day prior to tadalafil start; ERECTILE DYSFUNCTION: monitor BP; decr. tadalafil to lowest recommended start dose, consider decr. tamsulosin dose; PULMONARY ARTERIAL HTN: monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• terazosin
Cialis (tadalafil)

+

terazosin

1 interaction

Avoid/Use Alternative

tadalafil + terazosin

BENIGN PROSTATIC HYPERPLASIA: avoid combo; D/C terazosin at least 1 day prior to tadalafil start; ERECTILE DYSFUNCTION: monitor BP; decr. tadalafil to lowest recommended start dose, consider decr. terazosin dose; PULMONARY ARTERIAL HTN: monitor BP: combo may incr. risk of hypotension (incl. orthostasis, syncope), especially during terazosin initiation/titration (additive effects)

• tipranavir
Cialis (tadalafil)

+

tipranavir

1 interaction

Avoid/Use Alternative

tadalafil + tipranavir

BENIGN PROSTATIC HYPERPLASIA: avoid combo; PULMONARY HTN: monitor BP; start tadalafil 20 mg qd if on tipranavir >1wk; if on tadalafil, hold x24h before and x1wk after tipranavir start, then resume tadalafil 20 mg qd, max 40 mg qd; ERECTILE DYSFUNCTION: monitor BP; max tadalafil dose 10 mg q72h if prn use, 2.5 mg qd if daily use: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• tobramycin
Cialis (tadalafil)

+

tobramycin

1 interaction

Avoid/Use Alternative

tadalafil + tobramycin

use alternative or monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• tobramycin inhaled
Cialis (tadalafil)

+

tobramycin inhaled

1 interaction

Avoid/Use Alternative

tadalafil + tobramycin inhaled

use alternative or monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• tucatinib
Cialis (tadalafil)

+

tucatinib

1 interaction

Avoid/Use Alternative

tadalafil + tucatinib

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• vardenafil
Cialis (tadalafil)

+

vardenafil

1 interaction

Avoid/Use Alternative

tadalafil + vardenafil

avoid combo: combo may incr. risk of hypotension, auditory, vestibular, other adverse effects (additive effects, duplicate tx)

• voriconazole
Cialis (tadalafil)

+

voriconazole

1 interaction

Avoid/Use Alternative

tadalafil + voriconazole

PULMONARY HTN and BENIGN PROSTATIC HYPERPLASIA: avoid combo; ERECTILE DYSFUNCTION: monitor BP; adjust tadalafil max dose to 10 mg/dose q72h if prn dosing regimen, 2.5 mg/day if daily dosing regimen: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

Monitor/Modify Tx

• acebutolol
Cialis (tadalafil)

+

acebutolol

1 interaction

Monitor/Modify Tx

tadalafil + acebutolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• alfentanil
Cialis (tadalafil)

+

alfentanil

1 interaction

Monitor/Modify Tx

tadalafil + alfentanil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• aliskiren
Cialis (tadalafil)

+

aliskiren

1 interaction

Monitor/Modify Tx

tadalafil + aliskiren

monitor BP: combo may incr. risk of hypotension (additive effects)

• alprazolam
Cialis (tadalafil)

+

alprazolam

1 interaction

Monitor/Modify Tx

tadalafil + alprazolam

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• amantadine
Cialis (tadalafil)

+

amantadine

1 interaction

Monitor/Modify Tx

tadalafil + amantadine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• amifostine
Cialis (tadalafil)

+

amifostine

1 interaction

Monitor/Modify Tx

tadalafil + amifostine

monitor BP: combo may incr. risk of severe hypotension, incl. syncope (additive effects)

• amiloride
Cialis (tadalafil)

+

amiloride

1 interaction

Monitor/Modify Tx

tadalafil + amiloride

monitor BP: combo may incr. risk of hypotension (additive effects)

• amiodarone
Cialis (tadalafil)

+

amiodarone

1 interaction

Monitor/Modify Tx

tadalafil + amiodarone

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• amitriptyline
Cialis (tadalafil)

+

amitriptyline

1 interaction

Monitor/Modify Tx

tadalafil + amitriptyline

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• amlodipine
Cialis (tadalafil)

+

amlodipine

1 interaction

Monitor/Modify Tx

tadalafil + amlodipine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• amoxapine
Cialis (tadalafil)

+

amoxapine

1 interaction

Monitor/Modify Tx

tadalafil + amoxapine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• apomorphine
Cialis (tadalafil)

+

apomorphine

1 interaction

Monitor/Modify Tx

tadalafil + apomorphine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• apraclonidine ophthalmic
Cialis (tadalafil)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

tadalafil + apraclonidine ophthalmic

monitor BP if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of hypotension (additive effects)

• aprepitant
Cialis (tadalafil)

+

aprepitant

1 interaction

Monitor/Modify Tx

tadalafil + aprepitant

if aprepitant 3-day regimen, monitor BP; aprepitant single dose-regimen OK: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• aprocitentan
Cialis (tadalafil)

+

aprocitentan

1 interaction

Monitor/Modify Tx

tadalafil + aprocitentan

monitor BP: combo may incr. risk of hypotension (additive effects)

• aripiprazole bimonthly injection
Cialis (tadalafil)

+

aripiprazole bimonthly injection

1 interaction

Monitor/Modify Tx

tadalafil + aripiprazole bimonthly injection

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole lauroxil
Cialis (tadalafil)

+

aripiprazole lauroxil

1 interaction

Monitor/Modify Tx

tadalafil + aripiprazole lauroxil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• aripiprazole monthly injection
Cialis (tadalafil)

+

aripiprazole monthly injection

1 interaction

Monitor/Modify Tx

tadalafil + aripiprazole monthly injection

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• aripiprazole oral
Cialis (tadalafil)

+

aripiprazole oral

1 interaction

Monitor/Modify Tx

tadalafil + aripiprazole oral

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• articaine
Cialis (tadalafil)

+

articaine

1 interaction

Monitor/Modify Tx

tadalafil + articaine

monitor BP: combo may incr. risk of hypotension (additive effects)

• asciminib
Cialis (tadalafil)

+

asciminib

1 interaction

Monitor/Modify Tx

tadalafil + asciminib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• asenapine
Cialis (tadalafil)

+

asenapine

1 interaction

Monitor/Modify Tx

tadalafil + asenapine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• atenolol
Cialis (tadalafil)

+

atenolol

1 interaction

Monitor/Modify Tx

tadalafil + atenolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• atorvastatin
Cialis (tadalafil)

+

atorvastatin

1 interaction

Monitor/Modify Tx

tadalafil + atorvastatin

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• avacopan
Cialis (tadalafil)

+

avacopan

1 interaction

Monitor/Modify Tx

tadalafil + avacopan

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• azilsartan medoxomil
Cialis (tadalafil)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

tadalafil + azilsartan medoxomil

monitor BP: combo may incr. risk of hypotension (additive effects)

• belumosudil
Cialis (tadalafil)

+

belumosudil

1 interaction

Monitor/Modify Tx

tadalafil + belumosudil

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• benazepril
Cialis (tadalafil)

+

benazepril

1 interaction

Monitor/Modify Tx

tadalafil + benazepril

monitor BP: combo may incr. risk of hypotension (additive effects)

• berberine
Cialis (tadalafil)

+

berberine

1 interaction

Monitor/Modify Tx

tadalafil + berberine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• berotralstat
Cialis (tadalafil)

+

berotralstat

1 interaction

Monitor/Modify Tx

tadalafil + berotralstat

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• betaxolol
Cialis (tadalafil)

+

betaxolol

1 interaction

Monitor/Modify Tx

tadalafil + betaxolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• betaxolol ophthalmic
Cialis (tadalafil)

+

betaxolol ophthalmic

1 interaction

Monitor/Modify Tx

tadalafil + betaxolol ophthalmic

monitor BP: combo may incr. risk of hypotension (additive effects)

• bethanechol
Cialis (tadalafil)

+

bethanechol

1 interaction

Monitor/Modify Tx

tadalafil + bethanechol

monitor BP: combo may incr. risk of hypotension (additive effects)

• bexagliflozin
Cialis (tadalafil)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

tadalafil + bexagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• bicalutamide
Cialis (tadalafil)

+

bicalutamide

1 interaction

Monitor/Modify Tx

tadalafil + bicalutamide

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• bisoprolol
Cialis (tadalafil)

+

bisoprolol

1 interaction

Monitor/Modify Tx

tadalafil + bisoprolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• bortezomib
Cialis (tadalafil)

+

bortezomib

1 interaction

Monitor/Modify Tx

tadalafil + bortezomib

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• brexpiprazole
Cialis (tadalafil)

+

brexpiprazole

1 interaction

Monitor/Modify Tx

tadalafil + brexpiprazole

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• brimonidine ophthalmic
Cialis (tadalafil)

+

brimonidine ophthalmic

1 interaction

Monitor/Modify Tx

tadalafil + brimonidine ophthalmic

monitor BP if elevated IOP use; OTC ocular redness use OK: combo may incr. risk of hypotension (additive effects)

• brimonidine topical
Cialis (tadalafil)

+

brimonidine topical

1 interaction

Monitor/Modify Tx

tadalafil + brimonidine topical

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• bromocriptine
Cialis (tadalafil)

+

bromocriptine

1 interaction

Monitor/Modify Tx

tadalafil + bromocriptine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• bumetanide
Cialis (tadalafil)

+

bumetanide

1 interaction

Monitor/Modify Tx

tadalafil + bumetanide

monitor for ototoxicity, BP: combo may incr. risk of auditory, vestibular adverse effects, hypotension (additive effects)

• bupivacaine
Cialis (tadalafil)

+

bupivacaine

1 interaction

Monitor/Modify Tx

tadalafil + bupivacaine

monitor BP: combo may incr. risk of hypotension (additive effects)

• bupivacaine liposomal
Cialis (tadalafil)

+

bupivacaine liposomal

1 interaction

Monitor/Modify Tx

tadalafil + bupivacaine liposomal

monitor BP: combo may incr. risk of hypotension (additive effects)

• buprenorphine
Cialis (tadalafil)

+

buprenorphine

1 interaction

Monitor/Modify Tx

tadalafil + buprenorphine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• butorphanol
Cialis (tadalafil)

+

butorphanol

1 interaction

Monitor/Modify Tx

tadalafil + butorphanol

monitor BP: combo may incr. risk of hypotension, incl. syncope (additive effects)

• cabergoline
Cialis (tadalafil)

+

cabergoline

1 interaction

Monitor/Modify Tx

tadalafil + cabergoline

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• canagliflozin
Cialis (tadalafil)

+

canagliflozin

1 interaction

Monitor/Modify Tx

tadalafil + canagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• candesartan cilexetil
Cialis (tadalafil)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

tadalafil + candesartan cilexetil

monitor BP: combo may incr. risk of hypotension (additive effects)

• cannabis
Cialis (tadalafil)

+

cannabis

1 interaction

Monitor/Modify Tx

tadalafil + cannabis

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• capivasertib
Cialis (tadalafil)

+

capivasertib

1 interaction

Monitor/Modify Tx

tadalafil + capivasertib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• captopril
Cialis (tadalafil)

+

captopril

1 interaction

Monitor/Modify Tx

tadalafil + captopril

monitor BP: combo may incr. risk of hypotension (additive effects)

• cariprazine
Cialis (tadalafil)

+

cariprazine

1 interaction

Monitor/Modify Tx

tadalafil + cariprazine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• carteolol ophthalmic
Cialis (tadalafil)

+

carteolol ophthalmic

1 interaction

Monitor/Modify Tx

tadalafil + carteolol ophthalmic

monitor BP: combo may incr. risk of hypotension (additive effects)

• carvedilol
Cialis (tadalafil)

+

carvedilol

1 interaction

Monitor/Modify Tx

tadalafil + carvedilol

monitor BP: combo may incr. risk of hypotension (additive effects)

• chloroprocaine
Cialis (tadalafil)

+

chloroprocaine

1 interaction

Monitor/Modify Tx

tadalafil + chloroprocaine

monitor BP: combo may incr. risk of hypotension (additive effects)

• chlorothiazide
Cialis (tadalafil)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

tadalafil + chlorothiazide

monitor BP: combo may incr. risk of hypotension (additive effects)

• chlorpromazine
Cialis (tadalafil)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

tadalafil + chlorpromazine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• chlorthalidone
Cialis (tadalafil)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

tadalafil + chlorthalidone

monitor BP: combo may incr. risk of hypotension (additive effects)

• chlorzoxazone
Cialis (tadalafil)

+

chlorzoxazone

1 interaction

Monitor/Modify Tx

tadalafil + chlorzoxazone

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• cilostazol
Cialis (tadalafil)

+

cilostazol

1 interaction

Monitor/Modify Tx

tadalafil + cilostazol

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• cimetidine
Cialis (tadalafil)

+

cimetidine

1 interaction

Monitor/Modify Tx

tadalafil + cimetidine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• ciprofloxacin
Cialis (tadalafil)

+

ciprofloxacin

1 interaction

Monitor/Modify Tx

tadalafil + ciprofloxacin

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• cisplatin
Cialis (tadalafil)

+

cisplatin

1 interaction

Monitor/Modify Tx

tadalafil + cisplatin

monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• clevidipine
Cialis (tadalafil)

+

clevidipine

1 interaction

Monitor/Modify Tx

tadalafil + clevidipine

monitor BP: combo may incr. risk of hypotension (additive effects)

• clofarabine
Cialis (tadalafil)

+

clofarabine

1 interaction

Monitor/Modify Tx

tadalafil + clofarabine

monitor BP: combo may incr. risk of severe hypotension (additive effects)

• clofazimine
Cialis (tadalafil)

+

clofazimine

1 interaction

Monitor/Modify Tx

tadalafil + clofazimine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• clomipramine
Cialis (tadalafil)

+

clomipramine

1 interaction

Monitor/Modify Tx

tadalafil + clomipramine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• clonidine
Cialis (tadalafil)

+

clonidine

1 interaction

Monitor/Modify Tx

tadalafil + clonidine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• clotrimazole oropharyngeal
Cialis (tadalafil)

+

clotrimazole oropharyngeal

1 interaction

Monitor/Modify Tx

tadalafil + clotrimazole oropharyngeal

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• clozapine
Cialis (tadalafil)

+

clozapine

1 interaction

Monitor/Modify Tx

tadalafil + clozapine

monitor BP, HR: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• codeine
Cialis (tadalafil)

+

codeine

1 interaction

Monitor/Modify Tx

tadalafil + codeine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• coenzyme Q-10
Cialis (tadalafil)

+

coenzyme Q-10

1 interaction

Monitor/Modify Tx

tadalafil + coenzyme Q-10

monitor BP: combo may incr. risk of hypotension (additive effects)

• conivaptan
Cialis (tadalafil)

+

conivaptan

1 interaction

Monitor/Modify Tx

tadalafil + conivaptan

monitor BP during and x7 days after conivaptan tx: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• cranberry
Cialis (tadalafil)

+

cranberry

1 interaction

Monitor/Modify Tx

tadalafil + cranberry

monitor BP, especially w/ large amounts of cranberry: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (GI metab. inhibited)

• crizotinib
Cialis (tadalafil)

+

crizotinib

1 interaction

Monitor/Modify Tx

tadalafil + crizotinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• cyclosporine
Cialis (tadalafil)

+

cyclosporine

1 interaction

Monitor/Modify Tx

tadalafil + cyclosporine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• danazol
Cialis (tadalafil)

+

danazol

1 interaction

Monitor/Modify Tx

tadalafil + danazol

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• dapagliflozin
Cialis (tadalafil)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

tadalafil + dapagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• daridorexant
Cialis (tadalafil)

+

daridorexant

1 interaction

Monitor/Modify Tx

tadalafil + daridorexant

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• darunavir
Cialis (tadalafil)

+

darunavir

1 interaction

Monitor/Modify Tx

tadalafil + darunavir

monitor BP; PULMONARY HTN: start tadalafil 20 mg qd if on darunavir >1wk; if on tadalafil, hold x24h before and x1wk after darunavir start, then resume tadalafil 20 mg qd, max 40 mg qd; ERECTILE DYSFUNCTION: max tadalafil dose 10 mg q72h if prn use, 2.5 mg qd if daily use: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• deferasirox
Cialis (tadalafil)

+

deferasirox

1 interaction

Monitor/Modify Tx

tadalafil + deferasirox

monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• deferoxamine
Cialis (tadalafil)

+

deferoxamine

1 interaction

Monitor/Modify Tx

tadalafil + deferoxamine

monitor ototoxicity s/sx: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• denileukin diftitox
Cialis (tadalafil)

+

denileukin diftitox

1 interaction

Monitor/Modify Tx

tadalafil + denileukin diftitox

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• desflurane
Cialis (tadalafil)

+

desflurane

1 interaction

Monitor/Modify Tx

tadalafil + desflurane

monitor BP: combo may incr. risk of hypotension (additive effects)

• desipramine
Cialis (tadalafil)

+

desipramine

1 interaction

Monitor/Modify Tx

tadalafil + desipramine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• dexmedetomidine
Cialis (tadalafil)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

tadalafil + dexmedetomidine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• dexmedetomidine injection
Cialis (tadalafil)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

tadalafil + dexmedetomidine injection

monitor BP: combo may incr. risk of severe or life-threatening hypotension (additive effects)

• dihydrocodeine
Cialis (tadalafil)

+

dihydrocodeine

1 interaction

Monitor/Modify Tx

tadalafil + dihydrocodeine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• diltiazem
Cialis (tadalafil)

+

diltiazem

1 interaction

Monitor/Modify Tx

tadalafil + diltiazem

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• dinutuximab
Cialis (tadalafil)

+

dinutuximab

1 interaction

Monitor/Modify Tx

tadalafil + dinutuximab

monitor BP: combo may incr. risk of severe hypotension (additive effects)

• diosmin
Cialis (tadalafil)

+

diosmin

1 interaction

Monitor/Modify Tx

tadalafil + diosmin

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• dipyridamole
Cialis (tadalafil)

+

dipyridamole

1 interaction

Monitor/Modify Tx

tadalafil + dipyridamole

monitor BP: combo may incr. risk of severe hypotension (additive effects)

• doxepin
Cialis (tadalafil)

+

doxepin

1 interaction

Monitor/Modify Tx

tadalafil + doxepin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• dronabinol
Cialis (tadalafil)

+

dronabinol

1 interaction

Monitor/Modify Tx

tadalafil + dronabinol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• dronedarone
Cialis (tadalafil)

+

dronedarone

1 interaction

Monitor/Modify Tx

tadalafil + dronedarone

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• duloxetine
Cialis (tadalafil)

+

duloxetine

1 interaction

Monitor/Modify Tx

tadalafil + duloxetine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• duvelisib
Cialis (tadalafil)

+

duvelisib

1 interaction

Monitor/Modify Tx

tadalafil + duvelisib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• eflornithine
Cialis (tadalafil)

+

eflornithine

1 interaction

Monitor/Modify Tx

tadalafil + eflornithine

monitor ototoxicity s/sx: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• empagliflozin
Cialis (tadalafil)

+

empagliflozin

1 interaction

Monitor/Modify Tx

tadalafil + empagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• enalapril
Cialis (tadalafil)

+

enalapril

1 interaction

Monitor/Modify Tx

tadalafil + enalapril

monitor BP: combo may incr. risk of hypotension (additive effects)

• enalaprilat
Cialis (tadalafil)

+

enalaprilat

1 interaction

Monitor/Modify Tx

tadalafil + enalaprilat

monitor BP: combo may incr. risk of hypotension (additive effects)

• entacapone
Cialis (tadalafil)

+

entacapone

1 interaction

Monitor/Modify Tx

tadalafil + entacapone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• entrectinib
Cialis (tadalafil)

+

entrectinib

1 interaction

Monitor/Modify Tx

tadalafil + entrectinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• eplerenone
Cialis (tadalafil)

+

eplerenone

1 interaction

Monitor/Modify Tx

tadalafil + eplerenone

monitor BP: combo may incr. risk of hypotension (additive effects)

• epoprostenol
Cialis (tadalafil)

+

epoprostenol

1 interaction

Monitor/Modify Tx

tadalafil + epoprostenol

monitor BP: combo may incr. risk of severe hypotension (additive effects)

• ertugliflozin
Cialis (tadalafil)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

tadalafil + ertugliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• erythromycin
Cialis (tadalafil)

+

erythromycin

1 interaction

Monitor/Modify Tx

tadalafil + erythromycin

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• esmolol
Cialis (tadalafil)

+

esmolol

1 interaction

Monitor/Modify Tx

tadalafil + esmolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• ethanol
Cialis (tadalafil)

+

ethanol

1 interaction

Monitor/Modify Tx

tadalafil + ethanol

monitor BP: combo may incr. risk of severe hypotension (additive effects)

• ethinyl estradiol (contraceptive)
Cialis (tadalafil)

+

ethinyl estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

tadalafil + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• everolimus
Cialis (tadalafil)

+

everolimus

1 interaction

Monitor/Modify Tx

tadalafil + everolimus

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• fedratinib
Cialis (tadalafil)

+

fedratinib

1 interaction

Monitor/Modify Tx

tadalafil + fedratinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• felodipine
Cialis (tadalafil)

+

felodipine

1 interaction

Monitor/Modify Tx

tadalafil + felodipine

monitor BP: combo may incr. risk of hypotension (additive effects)

• fenoldopam
Cialis (tadalafil)

+

fenoldopam

1 interaction

Monitor/Modify Tx

tadalafil + fenoldopam

monitor BP: combo may incr. risk of hypotension (additive effects)

• fentanyl
Cialis (tadalafil)

+

fentanyl

1 interaction

Monitor/Modify Tx

tadalafil + fentanyl

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• ferumoxytol
Cialis (tadalafil)

+

ferumoxytol

1 interaction

Monitor/Modify Tx

tadalafil + ferumoxytol

monitor BP: combo may incr. risk of hypotension (additive effects)

• finerenone
Cialis (tadalafil)

+

finerenone

1 interaction

Monitor/Modify Tx

tadalafil + finerenone

monitor BP if on finerenone 40 mg/day: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• flaxseed
Cialis (tadalafil)

+

flaxseed

1 interaction

Monitor/Modify Tx

tadalafil + flaxseed

monitor BP: combo may incr. risk of hypotension (additive effects)

• flibanserin
Cialis (tadalafil)

+

flibanserin

1 interaction

Monitor/Modify Tx

tadalafil + flibanserin

monitor BP: combo may incr. tadalafil levels, risk of severe hypotension (incl. syncope), priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• fluconazole
Cialis (tadalafil)

+

fluconazole

1 interaction

Monitor/Modify Tx

tadalafil + fluconazole

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• fluphenazine
Cialis (tadalafil)

+

fluphenazine

1 interaction

Monitor/Modify Tx

tadalafil + fluphenazine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• fluvoxamine
Cialis (tadalafil)

+

fluvoxamine

1 interaction

Monitor/Modify Tx

tadalafil + fluvoxamine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• fosamprenavir
Cialis (tadalafil)

+

fosamprenavir

1 interaction

Monitor/Modify Tx

tadalafil + fosamprenavir

monitor BP; PULMONARY HTN: start tadalafil 20 mg qd if on fosamprenavir >1wk; if on tadalafil, hold x24h before and x1wk after fosamprenavir start, then resume tadalafil 20 mg qd, max 40 mg qd; ERECTILE DYSFUNCTION: max tadalafil dose 10 mg q72h if prn use, 2.5 mg qd if daily use: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• fosaprepitant
Cialis (tadalafil)

+

fosaprepitant

1 interaction

Monitor/Modify Tx

tadalafil + fosaprepitant

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• fosinopril
Cialis (tadalafil)

+

fosinopril

1 interaction

Monitor/Modify Tx

tadalafil + fosinopril

monitor BP: combo may incr. risk of hypotension (additive effects)

• foslevodopa
Cialis (tadalafil)

+

foslevodopa

1 interaction

Monitor/Modify Tx

tadalafil + foslevodopa

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• fostamatinib
Cialis (tadalafil)

+

fostamatinib

1 interaction

Monitor/Modify Tx

tadalafil + fostamatinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• furosemide
Cialis (tadalafil)

+

furosemide

1 interaction

Monitor/Modify Tx

tadalafil + furosemide

monitor for ototoxicity, BP: combo may incr. risk of auditory, vestibular adverse effects, hypotension (additive effects)

• garlic
Cialis (tadalafil)

+

garlic

1 interaction

Monitor/Modify Tx

tadalafil + garlic

monitor BP w/ supplemental garlic; dietary intake OK: combo may decr. tadalafil levels, efficacy; may incr. risk of hypotension (hepatic metab. induced; additive effects)

• gepotidacin
Cialis (tadalafil)

+

gepotidacin

1 interaction

Monitor/Modify Tx

tadalafil + gepotidacin

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• gilteritinib
Cialis (tadalafil)

+

gilteritinib

1 interaction

Monitor/Modify Tx

tadalafil + gilteritinib

monitor BP: combo may incr. risk of hypotension (additive effects)

• ginkgo
Cialis (tadalafil)

+

ginkgo

1 interaction

Monitor/Modify Tx

tadalafil + ginkgo

monitor BP: combo may incr. or decr. tadalafil levels, incr. risk of hypotension, priapism, other adverse effects or decr. efficacy (hepatic metab. altered)

• givinostat
Cialis (tadalafil)

+

givinostat

1 interaction

Monitor/Modify Tx

tadalafil + givinostat

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (GI metab. inhibited)

• givosiran
Cialis (tadalafil)

+

givosiran

1 interaction

Monitor/Modify Tx

tadalafil + givosiran

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited; givosiran effects on hepatic heme biosynthesis may reduce CYP450 enzyme activity)

• glecaprevir
Cialis (tadalafil)

+

glecaprevir

1 interaction

Monitor/Modify Tx

tadalafil + glecaprevir

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• goldenseal
Cialis (tadalafil)

+

goldenseal

1 interaction

Monitor/Modify Tx

tadalafil + goldenseal

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• grapefruit
Cialis (tadalafil)

+

grapefruit

1 interaction

Monitor/Modify Tx

tadalafil + grapefruit

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (GI metab. inhibited)

• grazoprevir
Cialis (tadalafil)

+

grazoprevir

1 interaction

Monitor/Modify Tx

tadalafil + grazoprevir

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• guanfacine
Cialis (tadalafil)

+

guanfacine

1 interaction

Monitor/Modify Tx

tadalafil + guanfacine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• haloperidol
Cialis (tadalafil)

+

haloperidol

1 interaction

Monitor/Modify Tx

tadalafil + haloperidol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• hydralazine
Cialis (tadalafil)

+

hydralazine

1 interaction

Monitor/Modify Tx

tadalafil + hydralazine

monitor BP: combo may incr. risk of severe hypotension (additive effects)

• hydrochlorothiazide
Cialis (tadalafil)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

tadalafil + hydrochlorothiazide

monitor BP: combo may incr. risk of hypotension (additive effects)

• hydrocodone
Cialis (tadalafil)

+

hydrocodone

1 interaction

Monitor/Modify Tx

tadalafil + hydrocodone

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• hydromorphone
Cialis (tadalafil)

+

hydromorphone

1 interaction

Monitor/Modify Tx

tadalafil + hydromorphone

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• iloperidone
Cialis (tadalafil)

+

iloperidone

1 interaction

Monitor/Modify Tx

tadalafil + iloperidone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• iloprost
Cialis (tadalafil)

+

iloprost

1 interaction

Monitor/Modify Tx

tadalafil + iloprost

monitor BP; consider holding tadalafil during iloprost admin.: combo may incr. risk of severe hypotension, incl. orthostasis (additive effects)

• iloprost inhaled
Cialis (tadalafil)

+

iloprost inhaled

1 interaction

Monitor/Modify Tx

tadalafil + iloprost inhaled

monitor BP: combo may incr. risk of hypotension (additive effects)

• imatinib
Cialis (tadalafil)

+

imatinib

1 interaction

Monitor/Modify Tx

tadalafil + imatinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• imipramine
Cialis (tadalafil)

+

imipramine

1 interaction

Monitor/Modify Tx

tadalafil + imipramine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• indapamide
Cialis (tadalafil)

+

indapamide

1 interaction

Monitor/Modify Tx

tadalafil + indapamide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• irbesartan
Cialis (tadalafil)

+

irbesartan

1 interaction

Monitor/Modify Tx

tadalafil + irbesartan

monitor BP: combo may incr. risk of hypotension (additive effects)

• iron sucrose
Cialis (tadalafil)

+

iron sucrose

1 interaction

Monitor/Modify Tx

tadalafil + iron sucrose

monitor BP: combo may incr. risk of hypotension (additive effects)

• isavuconazonium
Cialis (tadalafil)

+

isavuconazonium

1 interaction

Monitor/Modify Tx

tadalafil + isavuconazonium

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• isocarboxazid
Cialis (tadalafil)

+

isocarboxazid

1 interaction

Monitor/Modify Tx

tadalafil + isocarboxazid

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• isoflurane
Cialis (tadalafil)

+

isoflurane

1 interaction

Monitor/Modify Tx

tadalafil + isoflurane

monitor BP: combo may incr. risk of hypotension (additive effects)

• isoniazid
Cialis (tadalafil)

+

isoniazid

1 interaction

Monitor/Modify Tx

tadalafil + isoniazid

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• isradipine
Cialis (tadalafil)

+

isradipine

1 interaction

Monitor/Modify Tx

tadalafil + isradipine

monitor BP: combo may incr. risk of hypotension (additive effects)

• istradefylline
Cialis (tadalafil)

+

istradefylline

1 interaction

Monitor/Modify Tx

tadalafil + istradefylline

monitor BP, especially w/ istradefylline 40 mg dose: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• ivacaftor
Cialis (tadalafil)

+

ivacaftor

1 interaction

Monitor/Modify Tx

tadalafil + ivacaftor

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• kratom
Cialis (tadalafil)

+

kratom

1 interaction

Monitor/Modify Tx

tadalafil + kratom

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• labetalol
Cialis (tadalafil)

+

labetalol

1 interaction

Monitor/Modify Tx

tadalafil + labetalol

monitor BP: combo may incr. risk of hypotension (additive effects)

• landiolol
Cialis (tadalafil)

+

landiolol

1 interaction

Monitor/Modify Tx

tadalafil + landiolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• lapatinib
Cialis (tadalafil)

+

lapatinib

1 interaction

Monitor/Modify Tx

tadalafil + lapatinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• larotrectinib
Cialis (tadalafil)

+

larotrectinib

1 interaction

Monitor/Modify Tx

tadalafil + larotrectinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• lazertinib
Cialis (tadalafil)

+

lazertinib

1 interaction

Monitor/Modify Tx

tadalafil + lazertinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• lefamulin
Cialis (tadalafil)

+

lefamulin

1 interaction

Monitor/Modify Tx

tadalafil + lefamulin

ORAL LEFAMULIN: monitor BP; IV lefamulin use OK: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• letermovir
Cialis (tadalafil)

+

letermovir

1 interaction

Monitor/Modify Tx

tadalafil + letermovir

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• levobunolol ophthalmic
Cialis (tadalafil)

+

levobunolol ophthalmic

1 interaction

Monitor/Modify Tx

tadalafil + levobunolol ophthalmic

monitor BP: combo may incr. risk of hypotension (additive effects)

• levodopa
Cialis (tadalafil)

+

levodopa

1 interaction

Monitor/Modify Tx

tadalafil + levodopa

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• levorphanol
Cialis (tadalafil)

+

levorphanol

1 interaction

Monitor/Modify Tx

tadalafil + levorphanol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• lidocaine
Cialis (tadalafil)

+

lidocaine

1 interaction

Monitor/Modify Tx

tadalafil + lidocaine

monitor BP: combo may incr. risk of hypotension (additive effects)

• lisinopril
Cialis (tadalafil)

+

lisinopril

1 interaction

Monitor/Modify Tx

tadalafil + lisinopril

monitor BP: combo may incr. risk of hypotension (additive effects)

• lomitapide
Cialis (tadalafil)

+

lomitapide

1 interaction

Monitor/Modify Tx

tadalafil + lomitapide

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• losartan
Cialis (tadalafil)

+

losartan

1 interaction

Monitor/Modify Tx

tadalafil + losartan

monitor BP: combo may incr. risk of hypotension (additive effects)

• lovastatin
Cialis (tadalafil)

+

lovastatin

1 interaction

Monitor/Modify Tx

tadalafil + lovastatin

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• loxapine
Cialis (tadalafil)

+

loxapine

1 interaction

Monitor/Modify Tx

tadalafil + loxapine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• lubiprostone
Cialis (tadalafil)

+

lubiprostone

1 interaction

Monitor/Modify Tx

tadalafil + lubiprostone

monitor BP: combo may incr. risk of hypotension, incl. syncope (additive effects)

• lumateperone
Cialis (tadalafil)

+

lumateperone

1 interaction

Monitor/Modify Tx

tadalafil + lumateperone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• lurasidone
Cialis (tadalafil)

+

lurasidone

1 interaction

Monitor/Modify Tx

tadalafil + lurasidone

monitor BP; consider lowest lurasidone start dose, titrate slowly: combo may incr. tadalafil levels, risk of hypotension (incl. orthostasis, syncope), priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• magnesium sulfate
Cialis (tadalafil)

+

magnesium sulfate

1 interaction

Monitor/Modify Tx

tadalafil + magnesium sulfate

monitor BP: combo may incr. risk of hypotension (additive effects)

• maraviroc
Cialis (tadalafil)

+

maraviroc

1 interaction

Monitor/Modify Tx

tadalafil + maraviroc

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• maribavir
Cialis (tadalafil)

+

maribavir

1 interaction

Monitor/Modify Tx

tadalafil + maribavir

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• mavorixafor
Cialis (tadalafil)

+

mavorixafor

1 interaction

Monitor/Modify Tx

tadalafil + mavorixafor

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• meperidine
Cialis (tadalafil)

+

meperidine

1 interaction

Monitor/Modify Tx

tadalafil + meperidine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• mepivacaine
Cialis (tadalafil)

+

mepivacaine

1 interaction

Monitor/Modify Tx

tadalafil + mepivacaine

monitor BP: combo may incr. risk of hypotension (additive effects)

• methadone
Cialis (tadalafil)

+

methadone

1 interaction

Monitor/Modify Tx

tadalafil + methadone

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• methohexital
Cialis (tadalafil)

+

methohexital

1 interaction

Monitor/Modify Tx

tadalafil + methohexital

monitor BP: combo may incr. risk of hypotension (additive effects)

• methyldopa
Cialis (tadalafil)

+

methyldopa

1 interaction

Monitor/Modify Tx

tadalafil + methyldopa

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• methylene blue injection
Cialis (tadalafil)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

tadalafil + methylene blue injection

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• metolazone
Cialis (tadalafil)

+

metolazone

1 interaction

Monitor/Modify Tx

tadalafil + metolazone

monitor BP: combo may incr. risk of hypotension (additive effects)

• metoprolol
Cialis (tadalafil)

+

metoprolol

1 interaction

Monitor/Modify Tx

tadalafil + metoprolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• midazolam
Cialis (tadalafil)

+

midazolam

1 interaction

Monitor/Modify Tx

tadalafil + midazolam

monitor BP: combo may incr. risk of hypotension (additive effects)

• milrinone
Cialis (tadalafil)

+

milrinone

1 interaction

Monitor/Modify Tx

tadalafil + milrinone

monitor BP: combo may incr. risk of hypotension (additive effects)

• minoxidil
Cialis (tadalafil)

+

minoxidil

1 interaction

Monitor/Modify Tx

tadalafil + minoxidil

monitor BP: combo may incr. risk of hypotension (additive effects)

• mirtazapine
Cialis (tadalafil)

+

mirtazapine

1 interaction

Monitor/Modify Tx

tadalafil + mirtazapine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• moexipril
Cialis (tadalafil)

+

moexipril

1 interaction

Monitor/Modify Tx

tadalafil + moexipril

monitor BP: combo may incr. risk of hypotension (additive effects)

• molindone
Cialis (tadalafil)

+

molindone

1 interaction

Monitor/Modify Tx

tadalafil + molindone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• morphine
Cialis (tadalafil)

+

morphine

1 interaction

Monitor/Modify Tx

tadalafil + morphine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nadolol
Cialis (tadalafil)

+

nadolol

1 interaction

Monitor/Modify Tx

tadalafil + nadolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• nalbuphine
Cialis (tadalafil)

+

nalbuphine

1 interaction

Monitor/Modify Tx

tadalafil + nalbuphine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nattokinase
Cialis (tadalafil)

+

nattokinase

1 interaction

Monitor/Modify Tx

tadalafil + nattokinase

monitor BP: combo may incr. risk of hypotension (additive effects)

• naxitamab
Cialis (tadalafil)

+

naxitamab

1 interaction

Monitor/Modify Tx

tadalafil + naxitamab

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nebivolol
Cialis (tadalafil)

+

nebivolol

1 interaction

Monitor/Modify Tx

tadalafil + nebivolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• niacin (vitamin B3)
Cialis (tadalafil)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

tadalafil + niacin (vitamin B3)

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• nicardipine
Cialis (tadalafil)

+

nicardipine

1 interaction

Monitor/Modify Tx

tadalafil + nicardipine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• nifedipine
Cialis (tadalafil)

+

nifedipine

1 interaction

Monitor/Modify Tx

tadalafil + nifedipine

monitor BP: combo may incr. risk of hypotension (additive effects)

• nilotinib
Cialis (tadalafil)

+

nilotinib

1 interaction

Monitor/Modify Tx

tadalafil + nilotinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• nimodipine
Cialis (tadalafil)

+

nimodipine

1 interaction

Monitor/Modify Tx

tadalafil + nimodipine

monitor BP: combo may incr. risk of hypotension (additive effects)

• nirogacestat
Cialis (tadalafil)

+

nirogacestat

1 interaction

Monitor/Modify Tx

tadalafil + nirogacestat

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• nisoldipine
Cialis (tadalafil)

+

nisoldipine

1 interaction

Monitor/Modify Tx

tadalafil + nisoldipine

monitor BP: combo may incr. risk of hypotension (additive effects)

• nitric oxide
Cialis (tadalafil)

+

nitric oxide

1 interaction

Monitor/Modify Tx

tadalafil + nitric oxide

monitor BP: combo may incr. risk of hypotension (additive effects)

• nitrite
Cialis (tadalafil)

+

nitrite

1 interaction

Monitor/Modify Tx

tadalafil + nitrite

monitor BP: combo may incr. risk of severe or life-threatening hypotension, incl. syncope (additive effects)

• nortriptyline
Cialis (tadalafil)

+

nortriptyline

1 interaction

Monitor/Modify Tx

tadalafil + nortriptyline

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• obinutuzumab
Cialis (tadalafil)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

tadalafil + obinutuzumab

consider holding tadalafil x12h before and during obinutuzumab infusion: combo may incr. risk of hypotension (additive effects)

• olanzapine
Cialis (tadalafil)

+

olanzapine

1 interaction

Monitor/Modify Tx

tadalafil + olanzapine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• oliceridine
Cialis (tadalafil)

+

oliceridine

1 interaction

Monitor/Modify Tx

tadalafil + oliceridine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• olmesartan medoxomil
Cialis (tadalafil)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

tadalafil + olmesartan medoxomil

monitor BP: combo may incr. risk of hypotension (additive effects)

• opicapone
Cialis (tadalafil)

+

opicapone

1 interaction

Monitor/Modify Tx

tadalafil + opicapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• opium
Cialis (tadalafil)

+

opium

1 interaction

Monitor/Modify Tx

tadalafil + opium

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• osilodrostat
Cialis (tadalafil)

+

osilodrostat

1 interaction

Monitor/Modify Tx

tadalafil + osilodrostat

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• oxaliplatin
Cialis (tadalafil)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

tadalafil + oxaliplatin

monitor for ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• oxazepam
Cialis (tadalafil)

+

oxazepam

1 interaction

Monitor/Modify Tx

tadalafil + oxazepam

monitor BP: combo may incr. risk of hypotension (additive effects)

• oxycodone
Cialis (tadalafil)

+

oxycodone

1 interaction

Monitor/Modify Tx

tadalafil + oxycodone

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• oxymorphone
Cialis (tadalafil)

+

oxymorphone

1 interaction

Monitor/Modify Tx

tadalafil + oxymorphone

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• palbociclib
Cialis (tadalafil)

+

palbociclib

1 interaction

Monitor/Modify Tx

tadalafil + palbociclib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• paliperidone
Cialis (tadalafil)

+

paliperidone

1 interaction

Monitor/Modify Tx

tadalafil + paliperidone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• palopegteriparatide
Cialis (tadalafil)

+

palopegteriparatide

1 interaction

Monitor/Modify Tx

tadalafil + palopegteriparatide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• paromomycin
Cialis (tadalafil)

+

paromomycin

1 interaction

Monitor/Modify Tx

tadalafil + paromomycin

monitor for ototoxicity if compromised gut wall: combo may incr. risk of auditory, vestibular adverse effects (additive effects; minimal paromomycin systemic absorption w/ intact gut wall)

• pazopanib
Cialis (tadalafil)

+

pazopanib

1 interaction

Monitor/Modify Tx

tadalafil + pazopanib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• pentamidine
Cialis (tadalafil)

+

pentamidine

1 interaction

Monitor/Modify Tx

tadalafil + pentamidine

monitor BP: combo may incr. risk of severe or life-threatening hypotension (additive effects)

• pentazocine
Cialis (tadalafil)

+

pentazocine

1 interaction

Monitor/Modify Tx

tadalafil + pentazocine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• peppermint
Cialis (tadalafil)

+

peppermint

1 interaction

Monitor/Modify Tx

tadalafil + peppermint

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• perindopril
Cialis (tadalafil)

+

perindopril

1 interaction

Monitor/Modify Tx

tadalafil + perindopril

monitor BP: combo may incr. risk of hypotension (additive effects)

• perphenazine
Cialis (tadalafil)

+

perphenazine

1 interaction

Monitor/Modify Tx

tadalafil + perphenazine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• phenelzine
Cialis (tadalafil)

+

phenelzine

1 interaction

Monitor/Modify Tx

tadalafil + phenelzine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• phenoxybenzamine
Cialis (tadalafil)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

tadalafil + phenoxybenzamine

monitor BP: combo may incr. risk of hypotension (additive effects)

• phentolamine
Cialis (tadalafil)

+

phentolamine

1 interaction

Monitor/Modify Tx

tadalafil + phentolamine

monitor BP: combo may incr. risk of hypotension (additive effects)

• phenylephrine injection
Cialis (tadalafil)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

tadalafil + phenylephrine injection

monitor BP: combo may decr. phenylephrine efficacy (antagonistic effects)

• pibrentasvir
Cialis (tadalafil)

+

pibrentasvir

1 interaction

Monitor/Modify Tx

tadalafil + pibrentasvir

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• pindolol
Cialis (tadalafil)

+

pindolol

1 interaction

Monitor/Modify Tx

tadalafil + pindolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• pirtobrutinib
Cialis (tadalafil)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

tadalafil + pirtobrutinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• pramipexole
Cialis (tadalafil)

+

pramipexole

1 interaction

Monitor/Modify Tx

tadalafil + pramipexole

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• procarbazine
Cialis (tadalafil)

+

procarbazine

1 interaction

Monitor/Modify Tx

tadalafil + procarbazine

monitor BP: combo may incr. risk of hypotension (additive effects)

• prochlorperazine
Cialis (tadalafil)

+

prochlorperazine

1 interaction

Monitor/Modify Tx

tadalafil + prochlorperazine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• promethazine
Cialis (tadalafil)

+

promethazine

1 interaction

Monitor/Modify Tx

tadalafil + promethazine

monitor BP: combo may incr. risk of hypotension (additive effects)

• propafenone
Cialis (tadalafil)

+

propafenone

1 interaction

Monitor/Modify Tx

tadalafil + propafenone

monitor BP: combo may incr. risk of hypotension (additive effects)

• propofol
Cialis (tadalafil)

+

propofol

1 interaction

Monitor/Modify Tx

tadalafil + propofol

monitor BP: combo may incr. risk of severe hypotension (additive effects)

• propranolol
Cialis (tadalafil)

+

propranolol

1 interaction

Monitor/Modify Tx

tadalafil + propranolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• protriptyline
Cialis (tadalafil)

+

protriptyline

1 interaction

Monitor/Modify Tx

tadalafil + protriptyline

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• quercetin
Cialis (tadalafil)

+

quercetin

1 interaction

Monitor/Modify Tx

tadalafil + quercetin

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• quetiapine
Cialis (tadalafil)

+

quetiapine

1 interaction

Monitor/Modify Tx

tadalafil + quetiapine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• quinapril
Cialis (tadalafil)

+

quinapril

1 interaction

Monitor/Modify Tx

tadalafil + quinapril

monitor BP: combo may incr. risk of hypotension (additive effects)

• ramipril
Cialis (tadalafil)

+

ramipril

1 interaction

Monitor/Modify Tx

tadalafil + ramipril

monitor BP: combo may incr. risk of hypotension (additive effects)

• ranolazine
Cialis (tadalafil)

+

ranolazine

1 interaction

Monitor/Modify Tx

tadalafil + ranolazine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• rasagiline
Cialis (tadalafil)

+

rasagiline

1 interaction

Monitor/Modify Tx

tadalafil + rasagiline

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• remdesivir
Cialis (tadalafil)

+

remdesivir

1 interaction

Monitor/Modify Tx

tadalafil + remdesivir

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• remifentanil
Cialis (tadalafil)

+

remifentanil

1 interaction

Monitor/Modify Tx

tadalafil + remifentanil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• remimazolam
Cialis (tadalafil)

+

remimazolam

1 interaction

Monitor/Modify Tx

tadalafil + remimazolam

monitor BP: combo may incr. risk of hypotension (additive effects)

• resveratrol
Cialis (tadalafil)

+

resveratrol

1 interaction

Monitor/Modify Tx

tadalafil + resveratrol

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• risperidone
Cialis (tadalafil)

+

risperidone

1 interaction

Monitor/Modify Tx

tadalafil + risperidone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• ritlecitinib
Cialis (tadalafil)

+

ritlecitinib

1 interaction

Monitor/Modify Tx

tadalafil + ritlecitinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• ropinirole
Cialis (tadalafil)

+

ropinirole

1 interaction

Monitor/Modify Tx

tadalafil + ropinirole

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• ropivacaine
Cialis (tadalafil)

+

ropivacaine

1 interaction

Monitor/Modify Tx

tadalafil + ropivacaine

monitor BP: combo may incr. risk of hypotension (additive effects)

• rotigotine transdermal
Cialis (tadalafil)

+

rotigotine transdermal

1 interaction

Monitor/Modify Tx

tadalafil + rotigotine transdermal

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• rucaparib
Cialis (tadalafil)

+

rucaparib

1 interaction

Monitor/Modify Tx

tadalafil + rucaparib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• sacubitril
Cialis (tadalafil)

+

sacubitril

1 interaction

Monitor/Modify Tx

tadalafil + sacubitril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• safinamide
Cialis (tadalafil)

+

safinamide

1 interaction

Monitor/Modify Tx

tadalafil + safinamide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• sapropterin
Cialis (tadalafil)

+

sapropterin

1 interaction

Monitor/Modify Tx

tadalafil + sapropterin

monitor BP: combo may incr. risk of hypotension (additive effects)

• selegiline
Cialis (tadalafil)

+

selegiline

1 interaction

Monitor/Modify Tx

tadalafil + selegiline

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• selegiline transdermal
Cialis (tadalafil)

+

selegiline transdermal

1 interaction

Monitor/Modify Tx

tadalafil + selegiline transdermal

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• selpercatinib
Cialis (tadalafil)

+

selpercatinib

1 interaction

Monitor/Modify Tx

tadalafil + selpercatinib

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• sepiapterin
Cialis (tadalafil)

+

sepiapterin

1 interaction

Monitor/Modify Tx

tadalafil + sepiapterin

monitor BP: combo may incr. risk of hypotension (additive effects)

• sevoflurane
Cialis (tadalafil)

+

sevoflurane

1 interaction

Monitor/Modify Tx

tadalafil + sevoflurane

monitor BP: combo may incr. risk of hypotension (additive effects)

• sodium ferric gluconate complex
Cialis (tadalafil)

+

sodium ferric gluconate complex

1 interaction

Monitor/Modify Tx

tadalafil + sodium ferric gluconate complex

monitor BP: combo may incr. risk of hypotension (additive effects)

• sotagliflozin
Cialis (tadalafil)

+

sotagliflozin

1 interaction

Monitor/Modify Tx

tadalafil + sotagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• sotalol
Cialis (tadalafil)

+

sotalol

1 interaction

Monitor/Modify Tx

tadalafil + sotalol

monitor BP: combo may incr. risk of hypotension (additive effects)

• sparsentan
Cialis (tadalafil)

+

sparsentan

1 interaction

Monitor/Modify Tx

tadalafil + sparsentan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• spironolactone
Cialis (tadalafil)

+

spironolactone

1 interaction

Monitor/Modify Tx

tadalafil + spironolactone

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. possibly inhibited, additive effects)

• stiripentol
Cialis (tadalafil)

+

stiripentol

1 interaction

Monitor/Modify Tx

tadalafil + stiripentol

monitor BP: combo may incr. or decr. tadalafil levels, incr. risk of hypotension, priapism, other adverse effects or decr. efficacy (hepatic metab. possibly altered)

• sufentanil
Cialis (tadalafil)

+

sufentanil

1 interaction

Monitor/Modify Tx

tadalafil + sufentanil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• tagraxofusp
Cialis (tadalafil)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

tadalafil + tagraxofusp

monitor BP: combo may incr. risk of hypotension (additive effects)

• tapentadol
Cialis (tadalafil)

+

tapentadol

1 interaction

Monitor/Modify Tx

tadalafil + tapentadol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• taurine
Cialis (tadalafil)

+

taurine

1 interaction

Monitor/Modify Tx

tadalafil + taurine

monitor BP: combo may incr. risk of hypotension (additive effects)

• telmisartan
Cialis (tadalafil)

+

telmisartan

1 interaction

Monitor/Modify Tx

tadalafil + telmisartan

monitor BP: combo may incr. risk of hypotension (additive effects)

• teprotumumab
Cialis (tadalafil)

+

teprotumumab

1 interaction

Monitor/Modify Tx

tadalafil + teprotumumab

monitor ototoxicity s/sx: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• thalidomide
Cialis (tadalafil)

+

thalidomide

1 interaction

Monitor/Modify Tx

tadalafil + thalidomide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• thioridazine
Cialis (tadalafil)

+

thioridazine

1 interaction

Monitor/Modify Tx

tadalafil + thioridazine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• thiothixene
Cialis (tadalafil)

+

thiothixene

1 interaction

Monitor/Modify Tx

tadalafil + thiothixene

monitor BP: combo may incr. risk of hypotension, syncope (additive effects)

• ticagrelor
Cialis (tadalafil)

+

ticagrelor

1 interaction

Monitor/Modify Tx

tadalafil + ticagrelor

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• timolol
Cialis (tadalafil)

+

timolol

1 interaction

Monitor/Modify Tx

tadalafil + timolol

monitor BP: combo may incr. risk of hypotension (additive effects)

• timolol ophthalmic
Cialis (tadalafil)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

tadalafil + timolol ophthalmic

monitor BP: combo may incr. risk of hypotension (additive effects)

• tizanidine
Cialis (tadalafil)

+

tizanidine

1 interaction

Monitor/Modify Tx

tadalafil + tizanidine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• tolcapone
Cialis (tadalafil)

+

tolcapone

1 interaction

Monitor/Modify Tx

tadalafil + tolcapone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• tolvaptan
Cialis (tadalafil)

+

tolvaptan

1 interaction

Monitor/Modify Tx

tadalafil + tolvaptan

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• torsemide
Cialis (tadalafil)

+

torsemide

1 interaction

Monitor/Modify Tx

tadalafil + torsemide

monitor BP: combo may incr. risk of hypotension, auditory, vestibular adverse effects (additive effects)

• tramadol
Cialis (tadalafil)

+

tramadol

1 interaction

Monitor/Modify Tx

tadalafil + tramadol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• trandolapril
Cialis (tadalafil)

+

trandolapril

1 interaction

Monitor/Modify Tx

tadalafil + trandolapril

monitor BP: combo may incr. risk of hypotension (additive effects)

• tranylcypromine
Cialis (tadalafil)

+

tranylcypromine

1 interaction

Monitor/Modify Tx

tadalafil + tranylcypromine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• trazodone
Cialis (tadalafil)

+

trazodone

1 interaction

Monitor/Modify Tx

tadalafil + trazodone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• treosulfan
Cialis (tadalafil)

+

treosulfan

1 interaction

Monitor/Modify Tx

tadalafil + treosulfan

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. possibly inhibited)

• treprostinil
Cialis (tadalafil)

+

treprostinil

1 interaction

Monitor/Modify Tx

tadalafil + treprostinil

monitor BP: combo may incr. risk of severe hypotension, incl. syncope (additive effects)

• triamterene
Cialis (tadalafil)

+

triamterene

1 interaction

Monitor/Modify Tx

tadalafil + triamterene

monitor BP: combo may incr. risk of hypotension (additive effects)

• trifluoperazine
Cialis (tadalafil)

+

trifluoperazine

1 interaction

Monitor/Modify Tx

tadalafil + trifluoperazine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis (additive effects)

• trimipramine
Cialis (tadalafil)

+

trimipramine

1 interaction

Monitor/Modify Tx

tadalafil + trimipramine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis (additive effects)

• trofinetide
Cialis (tadalafil)

+

trofinetide

1 interaction

Monitor/Modify Tx

tadalafil + trofinetide

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• valsartan
Cialis (tadalafil)

+

valsartan

1 interaction

Monitor/Modify Tx

tadalafil + valsartan

monitor BP: combo may incr. risk of hypotension (additive effects)

• vancomycin
Cialis (tadalafil)

+

vancomycin

1 interaction

Monitor/Modify Tx

tadalafil + vancomycin

monitor renal fxn, ototoxicity: combo may incr. risk of auditory, vestibular adverse effects (additive effects)

• verapamil
Cialis (tadalafil)

+

verapamil

1 interaction

Monitor/Modify Tx

tadalafil + verapamil

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited, additive effects)

• viloxazine
Cialis (tadalafil)

+

viloxazine

1 interaction

Monitor/Modify Tx

tadalafil + viloxazine

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• vonoprazan
Cialis (tadalafil)

+

vonoprazan

1 interaction

Monitor/Modify Tx

tadalafil + vonoprazan

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• vosoritide
Cialis (tadalafil)

+

vosoritide

1 interaction

Monitor/Modify Tx

tadalafil + vosoritide

monitor BP: combo may incr. risk of hypotension (additive effects)

• voxelotor
Cialis (tadalafil)

+

voxelotor

1 interaction

Monitor/Modify Tx

tadalafil + voxelotor

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• xanomeline
Cialis (tadalafil)

+

xanomeline

1 interaction

Monitor/Modify Tx

tadalafil + xanomeline

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (GI metab. possibly inhibited)

• yohimbe
Cialis (tadalafil)

+

yohimbe

1 interaction

Monitor/Modify Tx

tadalafil + yohimbe

monitor BP, especially w/ high yohimbe doses: combo may incr. risk of hypotension (additive effects)

• zileuton
Cialis (tadalafil)

+

zileuton

1 interaction

Monitor/Modify Tx

tadalafil + zileuton

monitor BP: combo may incr. tadalafil levels, risk of hypotension, priapism, other adverse effects (hepatic metab. inhibited)

• ziprasidone
Cialis (tadalafil)

+

ziprasidone

1 interaction

Monitor/Modify Tx

tadalafil + ziprasidone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)