Select a medication above to begin.
Nicorette Gum
nicotine transmucosal
Dosing .
adults
- [ 1st cigarette >30min after waking ]
- Dose: 2 mg PO q1-2h x6wk, then q2-4h x3wk, then q4-8h x3wk; Start: on cigarette quit day; Max: 24 pieces/24h; Info: use >9 pieces/day during initial 6wk; avoid food/drink 15min before and after use
- [ 1st cigarette <30min after waking ]
- Dose: 4 mg PO q1-2h x6wk, then q2-4h x3wk, then q4-8h x3wk; Start: on cigarette quit day; Max: 24 pieces/24h; Info: use >9 pieces/day during initial 6wk; avoid food/drink 15min before and after use
renal dosing
- [ see below ]
- mild impairment: not defined; moderate-severe impairment: consider decr. usual dose
- HD/PD: not defined
hepatic dosing
- [ see below ]
- mild impairment: not defined; moderate-severe impairment: consider decr. usual dose
Formulations .
gum
- [active ingredients per piece]
- nicotine 2 mg or 4 mg (2 strengths available)
- [flavors/selected other ingredients]
- various flavors; see packaging for ingredients
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to soy or soybean (gum or mint flavor form)
- arrhythmia, severe
- acute MI within 2wk
- angina, worsening
- angina, severe
- caution: asthma
- caution: reactive airway disease
- caution: cardiovascular disease
- caution: PVD
- caution: hepatic impairment, moderate-severe
- caution: renal impairment, moderate-severe
- caution: hyperthyroidism
- caution: pheochromocytoma
- caution: diabetes mellitus, insulin-dependent
- caution: PUD, active
- caution: HTN
- caution: seizure history
Drug Interactions .
Overview
nicotine
nicotinic agonist
Interaction Characteristics:
- CYP2A6 substrate
- caution advised with concomitant drugs; dose adjustments may be necessary; smoking cessation may alter pharmacokinetics or pharmacodynamics of certain drugs
Monitor/Modify Tx
- bupropion
- ceritinib
- corticotropin
- everolimus
- lutetium Lu 177 dotatate
Caution Advised
- dihydroergotamine
- ergotamine
- methoxsalen
- methylergonovine
- varenicline
Adverse Reactions .
Serious Reactions
- nicotine dependence transference
Common Reactions
- headache
- diarrhea
- flatulence
- dyspepsia
- hiccups
- nausea
- cough
- sore throat
- URI symptoms
- withdrawal symptoms
- paresthesia
- arthralgia
- HTN
- palpitations