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Curosurf
poractant alfa intratracheal
Adult Dosing .
Adult dosing is currently unavailable or not applicable for this drug.
Peds Dosing .
- Dosage forms: SUSPENSION
respiratory distress syndrome
- [premature infants]
- Dose: 2.5 mL/kg/dose intratracheally x1 dose, then 1.25 mL/kg/dose intratracheally q12h prn up to 2 doses; Max: 5 mL/kg total dose; Info: may divide dose into 2 aliquots and administer in different positions
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
poractant alfa
surfactant
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- bradycardia
- hypoxia
- ETT reflux
- ETT obstruction
Common Reactions
- bradycardia
- hypotension
- ETT obstruction
- hypoxia
Safety/Monitoring .
Monitoring Parameters
oxygen saturation; vital signs
Pregnancy/Lactation .
Pregnancy
Clinical Summary
N/A; drug unlikely to be used during pregnancy based on indication
Lactation
Clinical Summary
N/A; drug unlikely to be used while breastfeeding based on indication
Pharmacology .
Metabolism: for poractant alfa: unknown; CYP450: unknown
Excretion: for poractant alfa: unknown; Half-life: unknown
Subclass: Surfactants
Mechanism of Action
for poractant alfa: lowers alveolar surface tension, preventing collapse
Formulary .
No Formulary Selected
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