fluphenazine decanoate

Overview

fluphenazine

phenothiazine

• CYP1A2 substrate
• CYP2D6 substrate
• anticholinergic effects
• CNS depression
• decreases central histamine effects
• dopamine antagonist
• extrapyramidal effects
• hyperprolactinemic effects
• hypotensive effects
• lowers seizure threshold
• myelosuppressive effects
• photosensitivity
• urine pH sensitive

Contraindicated

• potassium chloride
fluphenazine decanoate (generic)

+

potassium chloride

1 interaction

Contraindicated

fluphenazine + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium citrate
fluphenazine decanoate (generic)

+

potassium citrate

1 interaction

Contraindicated

fluphenazine + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

Avoid/Use Alternative

• aclidinium inhaled
fluphenazine decanoate (generic)

+

aclidinium inhaled

1 interaction

Avoid/Use Alternative

fluphenazine + aclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• aldesleukin
fluphenazine decanoate (generic)

+

aldesleukin

1 interaction

Avoid/Use Alternative

fluphenazine + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, severe or life-threatening hypotension (including orthostasis), myelosuppression, seizures (additive effects)

• amifampridine
fluphenazine decanoate (generic)

+

amifampridine

1 interaction

Avoid/Use Alternative

fluphenazine + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• aminolevulinic acid topical
fluphenazine decanoate (generic)

+

aminolevulinic acid topical

1 interaction

Avoid/Use Alternative

fluphenazine + aminolevulinic acid topical

avoid combo: combo may incr. risk of photosensitivity reaction (additive effects)

• amphetamine
fluphenazine decanoate (generic)

+

amphetamine

1 interaction

Avoid/Use Alternative

fluphenazine + amphetamine

avoid combo when phenothiazines used for psychosis: combo may decr. amphetamine efficacy, exacerbate psychotic symptoms (antagonistic effects)

• apomorphine
fluphenazine decanoate (generic)

+

apomorphine

1 interaction

Avoid/Use Alternative

fluphenazine + apomorphine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• benzphetamine
fluphenazine decanoate (generic)

+

benzphetamine

1 interaction

Avoid/Use Alternative

fluphenazine + benzphetamine

avoid combo when phenothiazines used for psychosis: combo may decr. amphetamine efficacy, exacerbate psychotic symptoms (antagonistic effects)

• benztropine
fluphenazine decanoate (generic)

+

benztropine

1 interaction

Avoid/Use Alternative

fluphenazine + benztropine

consider alternative: combo may incr. risk of life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

• bromocriptine
fluphenazine decanoate (generic)

+

bromocriptine

1 interaction

Avoid/Use Alternative

fluphenazine + bromocriptine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• butalbital
fluphenazine decanoate (generic)

+

butalbital

1 interaction

Avoid/Use Alternative

fluphenazine + butalbital

avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• cabergoline
fluphenazine decanoate (generic)

+

cabergoline

1 interaction

Avoid/Use Alternative

fluphenazine + cabergoline

use alternative: combo may incr. risk of hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• chloramphenicol
fluphenazine decanoate (generic)

+

chloramphenicol

1 interaction

Avoid/Use Alternative

fluphenazine + chloramphenicol

use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• cladribine oral
fluphenazine decanoate (generic)

+

cladribine oral

1 interaction

Avoid/Use Alternative

fluphenazine + cladribine oral

use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• clonidine
fluphenazine decanoate (generic)

+

clonidine

1 interaction

Avoid/Use Alternative

fluphenazine + clonidine

if ADHD use, avoid combo; otherwise, monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• clozapine
fluphenazine decanoate (generic)

+

clozapine

1 interaction

Avoid/Use Alternative

fluphenazine + clozapine

use alternative or monitor CBC, BP, HR; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, seizures, hypotension (including orthostasis, syncope), myelosuppression, life-threatening anticholinergic adverse effects, including constipation, paralytic ileus (additive effects)

• codeine
fluphenazine decanoate (generic)

+

codeine

1 interaction

Avoid/Use Alternative

fluphenazine + codeine

avoid combo if antitussive use; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• deferiprone
fluphenazine decanoate (generic)

+

deferiprone

1 interaction

Avoid/Use Alternative

fluphenazine + deferiprone

use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• doxylamine
fluphenazine decanoate (generic)

+

doxylamine

1 interaction

Avoid/Use Alternative

fluphenazine + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• eluxadoline
fluphenazine decanoate (generic)

+

eluxadoline

1 interaction

Avoid/Use Alternative

fluphenazine + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• epinephrine
fluphenazine decanoate (generic)

+

epinephrine

1 interaction

Avoid/Use Alternative

fluphenazine + epinephrine

use alternative or monitor BP: combo may decr. or reverse pressor effects of epinephrine (antagonistic effects)

• ethanol (alcoholic beverage)
fluphenazine decanoate (generic)

+

ethanol (alcoholic beverage)

1 interaction

Avoid/Use Alternative

fluphenazine + ethanol (alcoholic beverage)

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis (additive effects)

• ethanol injection
fluphenazine decanoate (generic)

+

ethanol injection

1 interaction

Avoid/Use Alternative

fluphenazine + ethanol injection

use alternative or monitor respiratory rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis (additive effects)

• fexinidazole
fluphenazine decanoate (generic)

+

fexinidazole

1 interaction

Avoid/Use Alternative

fluphenazine + fexinidazole

use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• fluphenazine
fluphenazine decanoate (generic)

+

fluphenazine

1 interaction

Avoid/Use Alternative

fluphenazine + fluphenazine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, myelosuppression, hypotension (including orthostasis), anticholinergic and other adverse effects (additive effects, duplicate therapy)

• ganciclovir
fluphenazine decanoate (generic)

+

ganciclovir

1 interaction

Avoid/Use Alternative

fluphenazine + ganciclovir

use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• glucagon
fluphenazine decanoate (generic)

+

glucagon

1 interaction

Avoid/Use Alternative

fluphenazine + glucagon

avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)

• glycopyrrolate inhaled
fluphenazine decanoate (generic)

+

glycopyrrolate inhaled

1 interaction

Avoid/Use Alternative

fluphenazine + glycopyrrolate inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• glycopyrronium topical
fluphenazine decanoate (generic)

+

glycopyrronium topical

1 interaction

Avoid/Use Alternative

fluphenazine + glycopyrronium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• haloperidol
fluphenazine decanoate (generic)

+

haloperidol

1 interaction

Avoid/Use Alternative

fluphenazine + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), extrapyramidal symptoms (additive effects)

• hydrocodone
fluphenazine decanoate (generic)

+

hydrocodone

1 interaction

Avoid/Use Alternative

fluphenazine + hydrocodone

avoid combo if antitussive use; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• ipratropium inhaled
fluphenazine decanoate (generic)

+

ipratropium inhaled

1 interaction

Avoid/Use Alternative

fluphenazine + ipratropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• isocarboxazid
fluphenazine decanoate (generic)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

fluphenazine + isocarboxazid

use alternative during and x10 days after isocarboxazid use: combo may incr. risk of CNS depression, psychomotor impairment, EPS, hypotension (including orthostasis), severe constipation, paralytic ileus, urinary retention (additive effects)

• kava
fluphenazine decanoate (generic)

+

kava

1 interaction

Avoid/Use Alternative

fluphenazine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• kratom
fluphenazine decanoate (generic)

+

kratom

1 interaction

Avoid/Use Alternative

fluphenazine + kratom

use alternative or monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lofexidine
fluphenazine decanoate (generic)

+

lofexidine

1 interaction

Avoid/Use Alternative

fluphenazine + lofexidine

use alternative or monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• meperidine
fluphenazine decanoate (generic)

+

meperidine

1 interaction

Avoid/Use Alternative

fluphenazine + meperidine

use alternative or monitor respiratory rate, BP; decr. meperidine dose 25-50%, consider decr. fluphenazine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• metaxalone
fluphenazine decanoate (generic)

+

metaxalone

1 interaction

Avoid/Use Alternative

fluphenazine + metaxalone

use alternative or monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methamphetamine
fluphenazine decanoate (generic)

+

methamphetamine

1 interaction

Avoid/Use Alternative

fluphenazine + methamphetamine

avoid combo when phenothiazines used for psychosis: combo may decr. amphetamine efficacy, exacerbate psychotic symptoms (antagonistic effects)

• metoclopramide
fluphenazine decanoate (generic)

+

metoclopramide

1 interaction

Avoid/Use Alternative

fluphenazine + metoclopramide

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• midazolam
fluphenazine decanoate (generic)

+

midazolam

1 interaction

Avoid/Use Alternative

fluphenazine + midazolam

use alternative or monitor respiratory rate, BP; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• olanzapine
fluphenazine decanoate (generic)

+

olanzapine

1 interaction

Avoid/Use Alternative

fluphenazine + olanzapine

consider alternative or monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

• oxybate
fluphenazine decanoate (generic)

+

oxybate

1 interaction

Avoid/Use Alternative

fluphenazine + oxybate

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

• phenelzine
fluphenazine decanoate (generic)

+

phenelzine

1 interaction

Avoid/Use Alternative

fluphenazine + phenelzine

use alternative or monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, EPS, hypotension (including orthostasis), severe constipation, paralytic ileus, urinary retention (additive effects)

• pitolisant
fluphenazine decanoate (generic)

+

pitolisant

1 interaction

Avoid/Use Alternative

fluphenazine + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

• porfimer
fluphenazine decanoate (generic)

+

porfimer

1 interaction

Avoid/Use Alternative

fluphenazine + porfimer

avoid combo: combo may incr. risk of photosensitivity reaction (additive effects)

• pramlintide
fluphenazine decanoate (generic)

+

pramlintide

1 interaction

Avoid/Use Alternative

fluphenazine + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• primaquine
fluphenazine decanoate (generic)

+

primaquine

1 interaction

Avoid/Use Alternative

fluphenazine + primaquine

use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• promethazine
fluphenazine decanoate (generic)

+

promethazine

1 interaction

Avoid/Use Alternative

fluphenazine + promethazine

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, seizures, extrapyramidal symptoms, hypotension (including orthostasis), anticholinergic adverse effects (additive effects, duplicate therapy)

• radium Ra 223 dichloride
fluphenazine decanoate (generic)

+

radium Ra 223 dichloride

1 interaction

Avoid/Use Alternative

fluphenazine + radium Ra 223 dichloride

use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• rasagiline
fluphenazine decanoate (generic)

+

rasagiline

1 interaction

Avoid/Use Alternative

fluphenazine + rasagiline

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• revefenacin inhaled
fluphenazine decanoate (generic)

+

revefenacin inhaled

1 interaction

Avoid/Use Alternative

fluphenazine + revefenacin inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• rivastigmine
fluphenazine decanoate (generic)

+

rivastigmine

1 interaction

Avoid/Use Alternative

fluphenazine + rivastigmine

use alternative: combo may incr. risk of extrapyramidal symptoms; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• ropeginterferon alfa-2b
fluphenazine decanoate (generic)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

fluphenazine + ropeginterferon alfa-2b

use alternative or monitor CBC; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression (additive effects)

• safinamide
fluphenazine decanoate (generic)

+

safinamide

1 interaction

Avoid/Use Alternative

fluphenazine + safinamide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• scopolamine
fluphenazine decanoate (generic)

+

scopolamine

1 interaction

Avoid/Use Alternative

fluphenazine + scopolamine

use alternative or consider decreasing dose of one or both drugs: combo may increase risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• selegiline
fluphenazine decanoate (generic)

+

selegiline

1 interaction

Avoid/Use Alternative

fluphenazine + selegiline

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• selegiline transdermal
fluphenazine decanoate (generic)

+

selegiline transdermal

1 interaction

Avoid/Use Alternative

fluphenazine + selegiline transdermal

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, EPS, hypotension, including orthostasis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• sofpironium topical
fluphenazine decanoate (generic)

+

sofpironium topical

1 interaction

Avoid/Use Alternative

fluphenazine + sofpironium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• thalidomide
fluphenazine decanoate (generic)

+

thalidomide

1 interaction

Avoid/Use Alternative

fluphenazine + thalidomide

use alternative or monitor CBC, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression, hypotension, including orthostasis (additive effects)

• tiotropium inhaled
fluphenazine decanoate (generic)

+

tiotropium inhaled

1 interaction

Avoid/Use Alternative

fluphenazine + tiotropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• tradipitant
fluphenazine decanoate (generic)

+

tradipitant

1 interaction

Avoid/Use Alternative

fluphenazine + tradipitant

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tranylcypromine
fluphenazine decanoate (generic)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

fluphenazine + tranylcypromine

use alternative or monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, EPS, hypotension (including orthostasis), severe constipation, paralytic ileus, urinary retention (additive effects)

• tretinoin topical
fluphenazine decanoate (generic)

+

tretinoin topical

1 interaction

Avoid/Use Alternative

fluphenazine + tretinoin topical

consider alternative, especially if tretinoin topical cosmetic use: combo may incr. risk of phototoxicity or augment phototoxic reaction (possible additive effects)

• trimethobenzamide
fluphenazine decanoate (generic)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

fluphenazine + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• triptorelin
fluphenazine decanoate (generic)

+

triptorelin

1 interaction

Avoid/Use Alternative

fluphenazine + triptorelin

avoid combo: combo may decr. triptorelin efficacy (fluphenazine may cause hyperprolactinemia, decr. GnRH receptors)

• umeclidinium inhaled
fluphenazine decanoate (generic)

+

umeclidinium inhaled

1 interaction

Avoid/Use Alternative

fluphenazine + umeclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• valganciclovir
fluphenazine decanoate (generic)

+

valganciclovir

1 interaction

Avoid/Use Alternative

fluphenazine + valganciclovir

use alternative or monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• zuranolone
fluphenazine decanoate (generic)

+

zuranolone

1 interaction

Avoid/Use Alternative

fluphenazine + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• 5-HTP
fluphenazine decanoate (generic)

+

5-HTP

1 interaction

Monitor/Modify Tx

fluphenazine + 5-HTP

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• abemaciclib
fluphenazine decanoate (generic)

+

abemaciclib

1 interaction

Monitor/Modify Tx

fluphenazine + abemaciclib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• acalabrutinib
fluphenazine decanoate (generic)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

fluphenazine + acalabrutinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• acebutolol
fluphenazine decanoate (generic)

+

acebutolol

1 interaction

Monitor/Modify Tx

fluphenazine + acebutolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ado-trastuzumab emtansine
fluphenazine decanoate (generic)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

fluphenazine + ado-trastuzumab emtansine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• afamitresgene autoleucel
fluphenazine decanoate (generic)

+

afamitresgene autoleucel

1 interaction

Monitor/Modify Tx

fluphenazine + afamitresgene autoleucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• albendazole
fluphenazine decanoate (generic)

+

albendazole

1 interaction

Monitor/Modify Tx

fluphenazine + albendazole

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• alemtuzumab
fluphenazine decanoate (generic)

+

alemtuzumab

1 interaction

Monitor/Modify Tx

fluphenazine + alemtuzumab

monitor CBC; myelosuppression risk may be lower w/ alemtuzumab doses used for MS: combo may incr. risk of myelosuppression (additive effects)

• alfentanil
fluphenazine decanoate (generic)

+

alfentanil

1 interaction

Monitor/Modify Tx

fluphenazine + alfentanil

monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• alfuzosin
fluphenazine decanoate (generic)

+

alfuzosin

1 interaction

Monitor/Modify Tx

fluphenazine + alfuzosin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• aliskiren
fluphenazine decanoate (generic)

+

aliskiren

1 interaction

Monitor/Modify Tx

fluphenazine + aliskiren

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• allopurinol
fluphenazine decanoate (generic)

+

allopurinol

1 interaction

Monitor/Modify Tx

fluphenazine + allopurinol

consider decr. dose of one or both drugs; monitor CBC: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression (additive effects)

• almotriptan
fluphenazine decanoate (generic)

+

almotriptan

1 interaction

Monitor/Modify Tx

fluphenazine + almotriptan

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alprazolam
fluphenazine decanoate (generic)

+

alprazolam

1 interaction

Monitor/Modify Tx

fluphenazine + alprazolam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• alprostadil intracavernous
fluphenazine decanoate (generic)

+

alprostadil intracavernous

1 interaction

Monitor/Modify Tx

fluphenazine + alprostadil intracavernous

monitor BP: combo may increase risk of hypotension, including orthostasis (additive effects)

• amantadine
fluphenazine decanoate (generic)

+

amantadine

1 interaction

Monitor/Modify Tx

fluphenazine + amantadine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, including orthostasis, syncope; may decr. phenothiazine efficacy (additive effects; antagonistic effects)

• amifostine
fluphenazine decanoate (generic)

+

amifostine

1 interaction

Monitor/Modify Tx

fluphenazine + amifostine

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• amiloride
fluphenazine decanoate (generic)

+

amiloride

1 interaction

Monitor/Modify Tx

fluphenazine + amiloride

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• amitriptyline
fluphenazine decanoate (generic)

+

amitriptyline

1 interaction

Monitor/Modify Tx

fluphenazine + amitriptyline

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), hyperthermia, anticholinergic adverse effects (additive effects)

• amlodipine
fluphenazine decanoate (generic)

+

amlodipine

1 interaction

Monitor/Modify Tx

fluphenazine + amlodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• amoxapine
fluphenazine decanoate (generic)

+

amoxapine

1 interaction

Monitor/Modify Tx

fluphenazine + amoxapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), anticholinergic adverse effects (additive effects)

• anti-thymocyte globulin
fluphenazine decanoate (generic)

+

anti-thymocyte globulin

1 interaction

Monitor/Modify Tx

fluphenazine + anti-thymocyte globulin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• apraclonidine ophthalmic
fluphenazine decanoate (generic)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

fluphenazine + apraclonidine ophthalmic

monitor BP, consider decr. dose of one or both drugs if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• aprocitentan
fluphenazine decanoate (generic)

+

aprocitentan

1 interaction

Monitor/Modify Tx

fluphenazine + aprocitentan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• aripiprazole bimonthly injection
fluphenazine decanoate (generic)

+

aripiprazole bimonthly injection

1 interaction

Monitor/Modify Tx

fluphenazine + aripiprazole bimonthly injection

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, extrapyramidal symptoms, hypotension, including orthostasis, syncope (additive effects)

• aripiprazole lauroxil
fluphenazine decanoate (generic)

+

aripiprazole lauroxil

1 interaction

Monitor/Modify Tx

fluphenazine + aripiprazole lauroxil

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis (additive effects)

• aripiprazole monthly injection
fluphenazine decanoate (generic)

+

aripiprazole monthly injection

1 interaction

Monitor/Modify Tx

fluphenazine + aripiprazole monthly injection

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis (additive effects)

• aripiprazole oral
fluphenazine decanoate (generic)

+

aripiprazole oral

1 interaction

Monitor/Modify Tx

fluphenazine + aripiprazole oral

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, extrapyramidal symptoms, hypotension, including orthostasis (additive effects)

• arsenic trioxide
fluphenazine decanoate (generic)

+

arsenic trioxide

1 interaction

Monitor/Modify Tx

fluphenazine + arsenic trioxide

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• articaine
fluphenazine decanoate (generic)

+

articaine

1 interaction

Monitor/Modify Tx

fluphenazine + articaine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• asciminib
fluphenazine decanoate (generic)

+

asciminib

1 interaction

Monitor/Modify Tx

fluphenazine + asciminib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• asenapine
fluphenazine decanoate (generic)

+

asenapine

1 interaction

Monitor/Modify Tx

fluphenazine + asenapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• atenolol
fluphenazine decanoate (generic)

+

atenolol

1 interaction

Monitor/Modify Tx

fluphenazine + atenolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• atidarsagene autotemcel
fluphenazine decanoate (generic)

+

atidarsagene autotemcel

1 interaction

Monitor/Modify Tx

fluphenazine + atidarsagene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• auranofin
fluphenazine decanoate (generic)

+

auranofin

1 interaction

Monitor/Modify Tx

fluphenazine + auranofin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• avanafil
fluphenazine decanoate (generic)

+

avanafil

1 interaction

Monitor/Modify Tx

fluphenazine + avanafil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• axicabtagene ciloleucel
fluphenazine decanoate (generic)

+

axicabtagene ciloleucel

1 interaction

Monitor/Modify Tx

fluphenazine + axicabtagene ciloleucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• azacitidine
fluphenazine decanoate (generic)

+

azacitidine

1 interaction

Monitor/Modify Tx

fluphenazine + azacitidine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• azathioprine
fluphenazine decanoate (generic)

+

azathioprine

1 interaction

Monitor/Modify Tx

fluphenazine + azathioprine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• azilsartan medoxomil
fluphenazine decanoate (generic)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

fluphenazine + azilsartan medoxomil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• baclofen
fluphenazine decanoate (generic)

+

baclofen

1 interaction

Monitor/Modify Tx

fluphenazine + baclofen

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen intrathecal
fluphenazine decanoate (generic)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

fluphenazine + baclofen intrathecal

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• balsalazide
fluphenazine decanoate (generic)

+

balsalazide

1 interaction

Monitor/Modify Tx

fluphenazine + balsalazide

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• baricitinib
fluphenazine decanoate (generic)

+

baricitinib

1 interaction

Monitor/Modify Tx

fluphenazine + baricitinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• belantamab mafodotin
fluphenazine decanoate (generic)

+

belantamab mafodotin

1 interaction

Monitor/Modify Tx

fluphenazine + belantamab mafodotin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• belinostat
fluphenazine decanoate (generic)

+

belinostat

1 interaction

Monitor/Modify Tx

fluphenazine + belinostat

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• benazepril
fluphenazine decanoate (generic)

+

benazepril

1 interaction

Monitor/Modify Tx

fluphenazine + benazepril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• bendamustine
fluphenazine decanoate (generic)

+

bendamustine

1 interaction

Monitor/Modify Tx

fluphenazine + bendamustine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• benznidazole
fluphenazine decanoate (generic)

+

benznidazole

1 interaction

Monitor/Modify Tx

fluphenazine + benznidazole

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• berberine
fluphenazine decanoate (generic)

+

berberine

1 interaction

Monitor/Modify Tx

fluphenazine + berberine

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• betaxolol
fluphenazine decanoate (generic)

+

betaxolol

1 interaction

Monitor/Modify Tx

fluphenazine + betaxolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• betaxolol ophthalmic
fluphenazine decanoate (generic)

+

betaxolol ophthalmic

1 interaction

Monitor/Modify Tx

fluphenazine + betaxolol ophthalmic

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• bethanechol
fluphenazine decanoate (generic)

+

bethanechol

1 interaction

Monitor/Modify Tx

fluphenazine + bethanechol

monitor BP: combo may incr. risk of hypotension, including orthostasis; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• betibeglogene autotemcel
fluphenazine decanoate (generic)

+

betibeglogene autotemcel

1 interaction

Monitor/Modify Tx

fluphenazine + betibeglogene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• bevacizumab
fluphenazine decanoate (generic)

+

bevacizumab

1 interaction

Monitor/Modify Tx

fluphenazine + bevacizumab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• bexagliflozin
fluphenazine decanoate (generic)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

fluphenazine + bexagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• bexarotene
fluphenazine decanoate (generic)

+

bexarotene

1 interaction

Monitor/Modify Tx

fluphenazine + bexarotene

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• bisoprolol
fluphenazine decanoate (generic)

+

bisoprolol

1 interaction

Monitor/Modify Tx

fluphenazine + bisoprolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• blinatumomab
fluphenazine decanoate (generic)

+

blinatumomab

1 interaction

Monitor/Modify Tx

fluphenazine + blinatumomab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• bortezomib
fluphenazine decanoate (generic)

+

bortezomib

1 interaction

Monitor/Modify Tx

fluphenazine + bortezomib

monitor CBC, BP: combo may incr. risk of myelosuppression, severe hypotension, including orthostasis, syncope (additive effects)

• bosutinib
fluphenazine decanoate (generic)

+

bosutinib

1 interaction

Monitor/Modify Tx

fluphenazine + bosutinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• brentuximab vedotin
fluphenazine decanoate (generic)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

fluphenazine + brentuximab vedotin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• brexpiprazole
fluphenazine decanoate (generic)

+

brexpiprazole

1 interaction

Monitor/Modify Tx

fluphenazine + brexpiprazole

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of hypotension (including orthostasis, syncope), CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia (additive effects)

• brexucabtagene autoleucel
fluphenazine decanoate (generic)

+

brexucabtagene autoleucel

1 interaction

Monitor/Modify Tx

fluphenazine + brexucabtagene autoleucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• brimonidine ophthalmic
fluphenazine decanoate (generic)

+

brimonidine ophthalmic

1 interaction

Monitor/Modify Tx

fluphenazine + brimonidine ophthalmic

monitor BP if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• brimonidine topical
fluphenazine decanoate (generic)

+

brimonidine topical

1 interaction

Monitor/Modify Tx

fluphenazine + brimonidine topical

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• brivaracetam
fluphenazine decanoate (generic)

+

brivaracetam

1 interaction

Monitor/Modify Tx

fluphenazine + brivaracetam

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• brompheniramine
fluphenazine decanoate (generic)

+

brompheniramine

1 interaction

Monitor/Modify Tx

fluphenazine + brompheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• bumetanide
fluphenazine decanoate (generic)

+

bumetanide

1 interaction

Monitor/Modify Tx

fluphenazine + bumetanide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• bupivacaine
fluphenazine decanoate (generic)

+

bupivacaine

1 interaction

Monitor/Modify Tx

fluphenazine + bupivacaine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• bupivacaine liposomal
fluphenazine decanoate (generic)

+

bupivacaine liposomal

1 interaction

Monitor/Modify Tx

fluphenazine + bupivacaine liposomal

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• buprenorphine
fluphenazine decanoate (generic)

+

buprenorphine

1 interaction

Monitor/Modify Tx

fluphenazine + buprenorphine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• bupropion
fluphenazine decanoate (generic)

+

bupropion

1 interaction

Monitor/Modify Tx

fluphenazine + bupropion

consider lower bupropion doses: combo may incr. fluphenazine levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• buspirone
fluphenazine decanoate (generic)

+

buspirone

1 interaction

Monitor/Modify Tx

fluphenazine + buspirone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• busulfan
fluphenazine decanoate (generic)

+

busulfan

1 interaction

Monitor/Modify Tx

fluphenazine + busulfan

monitor CBC: combo may incr. risk of myelosuppression, seizures (additive effects)

• butorphanol
fluphenazine decanoate (generic)

+

butorphanol

1 interaction

Monitor/Modify Tx

fluphenazine + butorphanol

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• cabazitaxel
fluphenazine decanoate (generic)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

fluphenazine + cabazitaxel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• canagliflozin
fluphenazine decanoate (generic)

+

canagliflozin

1 interaction

Monitor/Modify Tx

fluphenazine + canagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• candesartan cilexetil
fluphenazine decanoate (generic)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

fluphenazine + candesartan cilexetil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• cannabidiol
fluphenazine decanoate (generic)

+

cannabidiol

1 interaction

Monitor/Modify Tx

fluphenazine + cannabidiol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• cannabis
fluphenazine decanoate (generic)

+

cannabis

1 interaction

Monitor/Modify Tx

fluphenazine + cannabis

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• capecitabine
fluphenazine decanoate (generic)

+

capecitabine

1 interaction

Monitor/Modify Tx

fluphenazine + capecitabine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• captopril
fluphenazine decanoate (generic)

+

captopril

1 interaction

Monitor/Modify Tx

fluphenazine + captopril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• carbamazepine
fluphenazine decanoate (generic)

+

carbamazepine

1 interaction

Monitor/Modify Tx

fluphenazine + carbamazepine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including syncope; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• carbinoxamine
fluphenazine decanoate (generic)

+

carbinoxamine

1 interaction

Monitor/Modify Tx

fluphenazine + carbinoxamine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• carboplatin
fluphenazine decanoate (generic)

+

carboplatin

1 interaction

Monitor/Modify Tx

fluphenazine + carboplatin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• carfilzomib
fluphenazine decanoate (generic)

+

carfilzomib

1 interaction

Monitor/Modify Tx

fluphenazine + carfilzomib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• cariprazine
fluphenazine decanoate (generic)

+

cariprazine

1 interaction

Monitor/Modify Tx

fluphenazine + cariprazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, hyperthermia (additive effects)

• carisoprodol
fluphenazine decanoate (generic)

+

carisoprodol

1 interaction

Monitor/Modify Tx

fluphenazine + carisoprodol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carmustine
fluphenazine decanoate (generic)

+

carmustine

1 interaction

Monitor/Modify Tx

fluphenazine + carmustine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• carteolol ophthalmic
fluphenazine decanoate (generic)

+

carteolol ophthalmic

1 interaction

Monitor/Modify Tx

fluphenazine + carteolol ophthalmic

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• carvedilol
fluphenazine decanoate (generic)

+

carvedilol

1 interaction

Monitor/Modify Tx

fluphenazine + carvedilol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• cenobamate
fluphenazine decanoate (generic)

+

cenobamate

1 interaction

Monitor/Modify Tx

fluphenazine + cenobamate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• cetirizine
fluphenazine decanoate (generic)

+

cetirizine

1 interaction

Monitor/Modify Tx

fluphenazine + cetirizine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chamomile, German
fluphenazine decanoate (generic)

+

chamomile, German

1 interaction

Monitor/Modify Tx

fluphenazine + chamomile, German

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
fluphenazine decanoate (generic)

+

chlophedianol

1 interaction

Monitor/Modify Tx

fluphenazine + chlophedianol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorambucil
fluphenazine decanoate (generic)

+

chlorambucil

1 interaction

Monitor/Modify Tx

fluphenazine + chlorambucil

monitor CBC, consider chlorambucil dose adjustment: combo may incr. risk of myelosuppression, seizures (additive effects)

• chlorcyclizine
fluphenazine decanoate (generic)

+

chlorcyclizine

1 interaction

Monitor/Modify Tx

fluphenazine + chlorcyclizine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlordiazepoxide
fluphenazine decanoate (generic)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

fluphenazine + chlordiazepoxide

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• chloroprocaine
fluphenazine decanoate (generic)

+

chloroprocaine

1 interaction

Monitor/Modify Tx

fluphenazine + chloroprocaine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• chlorothiazide
fluphenazine decanoate (generic)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

fluphenazine + chlorothiazide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• chlorpheniramine
fluphenazine decanoate (generic)

+

chlorpheniramine

1 interaction

Monitor/Modify Tx

fluphenazine + chlorpheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorpromazine
fluphenazine decanoate (generic)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

fluphenazine + chlorpromazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, anticholinergic adverse effects (additive effects, duplicate therapy)

• chlorthalidone
fluphenazine decanoate (generic)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

fluphenazine + chlorthalidone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• chlorzoxazone
fluphenazine decanoate (generic)

+

chlorzoxazone

1 interaction

Monitor/Modify Tx

fluphenazine + chlorzoxazone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cidofovir
fluphenazine decanoate (generic)

+

cidofovir

1 interaction

Monitor/Modify Tx

fluphenazine + cidofovir

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• cilostazol
fluphenazine decanoate (generic)

+

cilostazol

1 interaction

Monitor/Modify Tx

fluphenazine + cilostazol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ciltacabtagene autoleucel
fluphenazine decanoate (generic)

+

ciltacabtagene autoleucel

1 interaction

Monitor/Modify Tx

fluphenazine + ciltacabtagene autoleucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• cisplatin
fluphenazine decanoate (generic)

+

cisplatin

1 interaction

Monitor/Modify Tx

fluphenazine + cisplatin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• citalopram
fluphenazine decanoate (generic)

+

citalopram

1 interaction

Monitor/Modify Tx

fluphenazine + citalopram

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cladribine injection
fluphenazine decanoate (generic)

+

cladribine injection

1 interaction

Monitor/Modify Tx

fluphenazine + cladribine injection

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• clemastine
fluphenazine decanoate (generic)

+

clemastine

1 interaction

Monitor/Modify Tx

fluphenazine + clemastine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clevidipine
fluphenazine decanoate (generic)

+

clevidipine

1 interaction

Monitor/Modify Tx

fluphenazine + clevidipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• clobazam
fluphenazine decanoate (generic)

+

clobazam

1 interaction

Monitor/Modify Tx

fluphenazine + clobazam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• clofarabine
fluphenazine decanoate (generic)

+

clofarabine

1 interaction

Monitor/Modify Tx

fluphenazine + clofarabine

monitor CBC, BP: combo may incr. risk of myelosuppression, severe hypotension, including orthostasis (additive effects)

• clomipramine
fluphenazine decanoate (generic)

+

clomipramine

1 interaction

Monitor/Modify Tx

fluphenazine + clomipramine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, seizures, hypotension (including orthostasis), anticholinergic adverse effects (additive effects)

• clonazepam
fluphenazine decanoate (generic)

+

clonazepam

1 interaction

Monitor/Modify Tx

fluphenazine + clonazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• clorazepate
fluphenazine decanoate (generic)

+

clorazepate

1 interaction

Monitor/Modify Tx

fluphenazine + clorazepate

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• coenzyme Q-10
fluphenazine decanoate (generic)

+

coenzyme Q-10

1 interaction

Monitor/Modify Tx

fluphenazine + coenzyme Q-10

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• colchicine
fluphenazine decanoate (generic)

+

colchicine

1 interaction

Monitor/Modify Tx

fluphenazine + colchicine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• copanlisib
fluphenazine decanoate (generic)

+

copanlisib

1 interaction

Monitor/Modify Tx

fluphenazine + copanlisib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• copper histidinate
fluphenazine decanoate (generic)

+

copper histidinate

1 interaction

Monitor/Modify Tx

fluphenazine + copper histidinate

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• crizotinib
fluphenazine decanoate (generic)

+

crizotinib

1 interaction

Monitor/Modify Tx

fluphenazine + crizotinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• cyclobenzaprine
fluphenazine decanoate (generic)

+

cyclobenzaprine

1 interaction

Monitor/Modify Tx

fluphenazine + cyclobenzaprine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• cyclophosphamide
fluphenazine decanoate (generic)

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

fluphenazine + cyclophosphamide

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• cyproheptadine
fluphenazine decanoate (generic)

+

cyproheptadine

1 interaction

Monitor/Modify Tx

fluphenazine + cyproheptadine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• cytarabine
fluphenazine decanoate (generic)

+

cytarabine

1 interaction

Monitor/Modify Tx

fluphenazine + cytarabine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• dacarbazine
fluphenazine decanoate (generic)

+

dacarbazine

1 interaction

Monitor/Modify Tx

fluphenazine + dacarbazine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• dactinomycin
fluphenazine decanoate (generic)

+

dactinomycin

1 interaction

Monitor/Modify Tx

fluphenazine + dactinomycin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• dantrolene
fluphenazine decanoate (generic)

+

dantrolene

1 interaction

Monitor/Modify Tx

fluphenazine + dantrolene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dapagliflozin
fluphenazine decanoate (generic)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

fluphenazine + dapagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• dapsone
fluphenazine decanoate (generic)

+

dapsone

1 interaction

Monitor/Modify Tx

fluphenazine + dapsone

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• daratumumab
fluphenazine decanoate (generic)

+

daratumumab

1 interaction

Monitor/Modify Tx

fluphenazine + daratumumab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• daridorexant
fluphenazine decanoate (generic)

+

daridorexant

1 interaction

Monitor/Modify Tx

fluphenazine + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
fluphenazine decanoate (generic)

+

darifenacin

1 interaction

Monitor/Modify Tx

fluphenazine + darifenacin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dasatinib
fluphenazine decanoate (generic)

+

dasatinib

1 interaction

Monitor/Modify Tx

fluphenazine + dasatinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• daunorubicin
fluphenazine decanoate (generic)

+

daunorubicin

1 interaction

Monitor/Modify Tx

fluphenazine + daunorubicin

monitor CBC, bleeding signs/symptoms: combo may incr. risk of myelosuppression, bleeding, including life-threatening (additive effects)

• decitabine
fluphenazine decanoate (generic)

+

decitabine

1 interaction

Monitor/Modify Tx

fluphenazine + decitabine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• deferasirox
fluphenazine decanoate (generic)

+

deferasirox

1 interaction

Monitor/Modify Tx

fluphenazine + deferasirox

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• denileukin diftitox
fluphenazine decanoate (generic)

+

denileukin diftitox

1 interaction

Monitor/Modify Tx

fluphenazine + denileukin diftitox

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• desflurane
fluphenazine decanoate (generic)

+

desflurane

1 interaction

Monitor/Modify Tx

fluphenazine + desflurane

monitor respiratory rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• desipramine
fluphenazine decanoate (generic)

+

desipramine

1 interaction

Monitor/Modify Tx

fluphenazine + desipramine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), anticholinergic adverse effects (additive effects)

• desvenlafaxine
fluphenazine decanoate (generic)

+

desvenlafaxine

1 interaction

Monitor/Modify Tx

fluphenazine + desvenlafaxine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• deuruxolitinib
fluphenazine decanoate (generic)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

fluphenazine + deuruxolitinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• deutetrabenazine
fluphenazine decanoate (generic)

+

deutetrabenazine

1 interaction

Monitor/Modify Tx

fluphenazine + deutetrabenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms, (additive effects)

• dexbrompheniramine
fluphenazine decanoate (generic)

+

dexbrompheniramine

1 interaction

Monitor/Modify Tx

fluphenazine + dexbrompheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexchlorpheniramine
fluphenazine decanoate (generic)

+

dexchlorpheniramine

1 interaction

Monitor/Modify Tx

fluphenazine + dexchlorpheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexmedetomidine
fluphenazine decanoate (generic)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

fluphenazine + dexmedetomidine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• dexmedetomidine injection
fluphenazine decanoate (generic)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

fluphenazine + dexmedetomidine injection

monitor BP, respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, severe or life-threatening hypotension, including orthostasis (additive effects)

• dexrazoxane
fluphenazine decanoate (generic)

+

dexrazoxane

1 interaction

Monitor/Modify Tx

fluphenazine + dexrazoxane

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• diazepam
fluphenazine decanoate (generic)

+

diazepam

1 interaction

Monitor/Modify Tx

fluphenazine + diazepam

monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• dichlorphenamide
fluphenazine decanoate (generic)

+

dichlorphenamide

1 interaction

Monitor/Modify Tx

fluphenazine + dichlorphenamide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difelikefalin
fluphenazine decanoate (generic)

+

difelikefalin

1 interaction

Monitor/Modify Tx

fluphenazine + difelikefalin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
fluphenazine decanoate (generic)

+

difenoxin

1 interaction

Monitor/Modify Tx

fluphenazine + difenoxin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

• dihydrocodeine
fluphenazine decanoate (generic)

+

dihydrocodeine

1 interaction

Monitor/Modify Tx

fluphenazine + dihydrocodeine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• diltiazem
fluphenazine decanoate (generic)

+

diltiazem

1 interaction

Monitor/Modify Tx

fluphenazine + diltiazem

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• dimenhydrinate
fluphenazine decanoate (generic)

+

dimenhydrinate

1 interaction

Monitor/Modify Tx

fluphenazine + dimenhydrinate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dinutuximab
fluphenazine decanoate (generic)

+

dinutuximab

1 interaction

Monitor/Modify Tx

fluphenazine + dinutuximab

monitor CBC, BP: combo may incr. risk of myelosuppression, severe hypotension, including orthostasis (additive effects)

• diphenhydramine
fluphenazine decanoate (generic)

+

diphenhydramine

1 interaction

Monitor/Modify Tx

fluphenazine + diphenhydramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• diphenoxylate
fluphenazine decanoate (generic)

+

diphenoxylate

1 interaction

Monitor/Modify Tx

fluphenazine + diphenoxylate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

• dipyridamole
fluphenazine decanoate (generic)

+

dipyridamole

1 interaction

Monitor/Modify Tx

fluphenazine + dipyridamole

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• docetaxel
fluphenazine decanoate (generic)

+

docetaxel

1 interaction

Monitor/Modify Tx

fluphenazine + docetaxel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• domperidone
fluphenazine decanoate (generic)

+

domperidone

1 interaction

Monitor/Modify Tx

fluphenazine + domperidone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)

• dostarlimab
fluphenazine decanoate (generic)

+

dostarlimab

1 interaction

Monitor/Modify Tx

fluphenazine + dostarlimab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• doxazosin
fluphenazine decanoate (generic)

+

doxazosin

1 interaction

Monitor/Modify Tx

fluphenazine + doxazosin

monitor BP, especially during doxazosin initiation/titration: combo may incr. risk of hypotension, including orthostasis, syncope; combo with doxazosin ER dosage form may incr. doxazosin levels, risk of adverse effects (additive effects; absorption increased)

• doxepin
fluphenazine decanoate (generic)

+

doxepin

1 interaction

Monitor/Modify Tx

fluphenazine + doxepin

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), hyperthermia, anticholinergic adverse effects (additive effects)

• doxepin topical
fluphenazine decanoate (generic)

+

doxepin topical

1 interaction

Monitor/Modify Tx

fluphenazine + doxepin topical

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• doxorubicin
fluphenazine decanoate (generic)

+

doxorubicin

1 interaction

Monitor/Modify Tx

fluphenazine + doxorubicin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• dronabinol
fluphenazine decanoate (generic)

+

dronabinol

1 interaction

Monitor/Modify Tx

fluphenazine + dronabinol

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• droperidol
fluphenazine decanoate (generic)

+

droperidol

1 interaction

Monitor/Modify Tx

fluphenazine + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• duloxetine
fluphenazine decanoate (generic)

+

duloxetine

1 interaction

Monitor/Modify Tx

fluphenazine + duloxetine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis) (additive effects)

• duvelisib
fluphenazine decanoate (generic)

+

duvelisib

1 interaction

Monitor/Modify Tx

fluphenazine + duvelisib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• efavirenz
fluphenazine decanoate (generic)

+

efavirenz

1 interaction

Monitor/Modify Tx

fluphenazine + efavirenz

consider decr. fluphenazine dose: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eflornithine
fluphenazine decanoate (generic)

+

eflornithine

1 interaction

Monitor/Modify Tx

fluphenazine + eflornithine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• eletriptan
fluphenazine decanoate (generic)

+

eletriptan

1 interaction

Monitor/Modify Tx

fluphenazine + eletriptan

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• elinzanetant
fluphenazine decanoate (generic)

+

elinzanetant

1 interaction

Monitor/Modify Tx

fluphenazine + elinzanetant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• elivaldogene autotemcel
fluphenazine decanoate (generic)

+

elivaldogene autotemcel

1 interaction

Monitor/Modify Tx

fluphenazine + elivaldogene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• elranatamab
fluphenazine decanoate (generic)

+

elranatamab

1 interaction

Monitor/Modify Tx

fluphenazine + elranatamab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• empagliflozin
fluphenazine decanoate (generic)

+

empagliflozin

1 interaction

Monitor/Modify Tx

fluphenazine + empagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• enalapril
fluphenazine decanoate (generic)

+

enalapril

1 interaction

Monitor/Modify Tx

fluphenazine + enalapril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• enalaprilat
fluphenazine decanoate (generic)

+

enalaprilat

1 interaction

Monitor/Modify Tx

fluphenazine + enalaprilat

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• enfortumab vedotin
fluphenazine decanoate (generic)

+

enfortumab vedotin

1 interaction

Monitor/Modify Tx

fluphenazine + enfortumab vedotin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• entacapone
fluphenazine decanoate (generic)

+

entacapone

1 interaction

Monitor/Modify Tx

fluphenazine + entacapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• entrectinib
fluphenazine decanoate (generic)

+

entrectinib

1 interaction

Monitor/Modify Tx

fluphenazine + entrectinib

monitor CBC, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression, hypotension, including orthostasis (additive effects)

• epcoritamab
fluphenazine decanoate (generic)

+

epcoritamab

1 interaction

Monitor/Modify Tx

fluphenazine + epcoritamab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• epirubicin
fluphenazine decanoate (generic)

+

epirubicin

1 interaction

Monitor/Modify Tx

fluphenazine + epirubicin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• eplerenone
fluphenazine decanoate (generic)

+

eplerenone

1 interaction

Monitor/Modify Tx

fluphenazine + eplerenone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• epoprostenol
fluphenazine decanoate (generic)

+

epoprostenol

1 interaction

Monitor/Modify Tx

fluphenazine + epoprostenol

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• eribulin
fluphenazine decanoate (generic)

+

eribulin

1 interaction

Monitor/Modify Tx

fluphenazine + eribulin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ertugliflozin
fluphenazine decanoate (generic)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

fluphenazine + ertugliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• escitalopram
fluphenazine decanoate (generic)

+

escitalopram

1 interaction

Monitor/Modify Tx

fluphenazine + escitalopram

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• esketamine
fluphenazine decanoate (generic)

+

esketamine

1 interaction

Monitor/Modify Tx

fluphenazine + esketamine

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
fluphenazine decanoate (generic)

+

eslicarbazepine acetate

1 interaction

Monitor/Modify Tx

fluphenazine + eslicarbazepine acetate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• esmolol
fluphenazine decanoate (generic)

+

esmolol

1 interaction

Monitor/Modify Tx

fluphenazine + esmolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• estazolam
fluphenazine decanoate (generic)

+

estazolam

1 interaction

Monitor/Modify Tx

fluphenazine + estazolam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• eszopiclone
fluphenazine decanoate (generic)

+

eszopiclone

1 interaction

Monitor/Modify Tx

fluphenazine + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
fluphenazine decanoate (generic)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

fluphenazine + ethacrynic acid

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ethanol (in some formulations)
fluphenazine decanoate (generic)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

fluphenazine + ethanol (in some formulations)

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ethosuximide
fluphenazine decanoate (generic)

+

ethosuximide

1 interaction

Monitor/Modify Tx

fluphenazine + ethosuximide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• etomidate
fluphenazine decanoate (generic)

+

etomidate

1 interaction

Monitor/Modify Tx

fluphenazine + etomidate

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• etoposide
fluphenazine decanoate (generic)

+

etoposide

1 interaction

Monitor/Modify Tx

fluphenazine + etoposide

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• etripamil nasal
fluphenazine decanoate (generic)

+

etripamil nasal

1 interaction

Monitor/Modify Tx

fluphenazine + etripamil nasal

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• etuvetidigene autotemcel
fluphenazine decanoate (generic)

+

etuvetidigene autotemcel

1 interaction

Monitor/Modify Tx

fluphenazine + etuvetidigene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, bleeding (additive effects)

• everolimus
fluphenazine decanoate (generic)

+

everolimus

1 interaction

Monitor/Modify Tx

fluphenazine + everolimus

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• exagamglogene autotemcel
fluphenazine decanoate (generic)

+

exagamglogene autotemcel

1 interaction

Monitor/Modify Tx

fluphenazine + exagamglogene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, bleeding (additive effects)

• fam-trastuzumab deruxtecan
fluphenazine decanoate (generic)

+

fam-trastuzumab deruxtecan

1 interaction

Monitor/Modify Tx

fluphenazine + fam-trastuzumab deruxtecan

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• fedratinib
fluphenazine decanoate (generic)

+

fedratinib

1 interaction

Monitor/Modify Tx

fluphenazine + fedratinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• felbamate
fluphenazine decanoate (generic)

+

felbamate

1 interaction

Monitor/Modify Tx

fluphenazine + felbamate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• felodipine
fluphenazine decanoate (generic)

+

felodipine

1 interaction

Monitor/Modify Tx

fluphenazine + felodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• fenfluramine
fluphenazine decanoate (generic)

+

fenfluramine

1 interaction

Monitor/Modify Tx

fluphenazine + fenfluramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• fenoldopam
fluphenazine decanoate (generic)

+

fenoldopam

1 interaction

Monitor/Modify Tx

fluphenazine + fenoldopam

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• fentanyl
fluphenazine decanoate (generic)

+

fentanyl

1 interaction

Monitor/Modify Tx

fluphenazine + fentanyl

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• ferumoxytol
fluphenazine decanoate (generic)

+

ferumoxytol

1 interaction

Monitor/Modify Tx

fluphenazine + ferumoxytol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• fesoterodine
fluphenazine decanoate (generic)

+

fesoterodine

1 interaction

Monitor/Modify Tx

fluphenazine + fesoterodine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; may decr. phenothiazine efficacy (additive effects; antagonistic effects)

• flaxseed
fluphenazine decanoate (generic)

+

flaxseed

1 interaction

Monitor/Modify Tx

fluphenazine + flaxseed

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• flibanserin
fluphenazine decanoate (generic)

+

flibanserin

1 interaction

Monitor/Modify Tx

fluphenazine + flibanserin

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• floxuridine
fluphenazine decanoate (generic)

+

floxuridine

1 interaction

Monitor/Modify Tx

fluphenazine + floxuridine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• flucytosine
fluphenazine decanoate (generic)

+

flucytosine

1 interaction

Monitor/Modify Tx

fluphenazine + flucytosine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• fludarabine
fluphenazine decanoate (generic)

+

fludarabine

1 interaction

Monitor/Modify Tx

fluphenazine + fludarabine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• fluorouracil
fluphenazine decanoate (generic)

+

fluorouracil

1 interaction

Monitor/Modify Tx

fluphenazine + fluorouracil

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• fluoxetine
fluphenazine decanoate (generic)

+

fluoxetine

1 interaction

Monitor/Modify Tx

fluphenazine + fluoxetine

consider decr. dose of one or both drugs: combo may incr. fluphenazine levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• flurazepam
fluphenazine decanoate (generic)

+

flurazepam

1 interaction

Monitor/Modify Tx

fluphenazine + flurazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• fluvoxamine
fluphenazine decanoate (generic)

+

fluvoxamine

1 interaction

Monitor/Modify Tx

fluphenazine + fluvoxamine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• foscarnet
fluphenazine decanoate (generic)

+

foscarnet

1 interaction

Monitor/Modify Tx

fluphenazine + foscarnet

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• fosfomycin injection
fluphenazine decanoate (generic)

+

fosfomycin injection

1 interaction

Monitor/Modify Tx

fluphenazine + fosfomycin injection

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• fosinopril
fluphenazine decanoate (generic)

+

fosinopril

1 interaction

Monitor/Modify Tx

fluphenazine + fosinopril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• foslevodopa
fluphenazine decanoate (generic)

+

foslevodopa

1 interaction

Monitor/Modify Tx

fluphenazine + foslevodopa

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• fosphenytoin
fluphenazine decanoate (generic)

+

fosphenytoin

1 interaction

Monitor/Modify Tx

fluphenazine + fosphenytoin

consider fluphenazine dose adjustment: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control; may decr. fluphenazine levels, efficacy (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold; hepatic metabolism induced)

• fostamatinib
fluphenazine decanoate (generic)

+

fostamatinib

1 interaction

Monitor/Modify Tx

fluphenazine + fostamatinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• frovatriptan
fluphenazine decanoate (generic)

+

frovatriptan

1 interaction

Monitor/Modify Tx

fluphenazine + frovatriptan

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• furosemide
fluphenazine decanoate (generic)

+

furosemide

1 interaction

Monitor/Modify Tx

fluphenazine + furosemide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• gabapentin
fluphenazine decanoate (generic)

+

gabapentin

1 interaction

Monitor/Modify Tx

fluphenazine + gabapentin

monitor respiratory rate; consider decreasing dose of one or both drugs: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decrease seizure threshold)

• gabapentin enacarbil
fluphenazine decanoate (generic)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

fluphenazine + gabapentin enacarbil

monitor respiratory rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ganaxolone
fluphenazine decanoate (generic)

+

ganaxolone

1 interaction

Monitor/Modify Tx

fluphenazine + ganaxolone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• garlic
fluphenazine decanoate (generic)

+

garlic

1 interaction

Monitor/Modify Tx

fluphenazine + garlic

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, including orthostasis (additive effects)

• gemcitabine
fluphenazine decanoate (generic)

+

gemcitabine

1 interaction

Monitor/Modify Tx

fluphenazine + gemcitabine

monitor CBC; risk may be lower w/ intravesical gemcitabine administration: combo may incr. risk of myelosuppression (additive effects)

• gemtuzumab ozogamicin
fluphenazine decanoate (generic)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

fluphenazine + gemtuzumab ozogamicin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• gilteritinib
fluphenazine decanoate (generic)

+

gilteritinib

1 interaction

Monitor/Modify Tx

fluphenazine + gilteritinib

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• givinostat
fluphenazine decanoate (generic)

+

givinostat

1 interaction

Monitor/Modify Tx

fluphenazine + givinostat

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• glasdegib
fluphenazine decanoate (generic)

+

glasdegib

1 interaction

Monitor/Modify Tx

fluphenazine + glasdegib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• glofitamab
fluphenazine decanoate (generic)

+

glofitamab

1 interaction

Monitor/Modify Tx

fluphenazine + glofitamab

monitor CBC; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression (additive effects)

• glycopyrrolate
fluphenazine decanoate (generic)

+

glycopyrrolate

1 interaction

Monitor/Modify Tx

fluphenazine + glycopyrrolate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• guanfacine
fluphenazine decanoate (generic)

+

guanfacine

1 interaction

Monitor/Modify Tx

fluphenazine + guanfacine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• hydralazine
fluphenazine decanoate (generic)

+

hydralazine

1 interaction

Monitor/Modify Tx

fluphenazine + hydralazine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• hydrochlorothiazide
fluphenazine decanoate (generic)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

fluphenazine + hydrochlorothiazide

monitor BP: combo may incr. hydrochlorothiazide levels, risk of hypotension (including orthostasis), other adverse effects (absorption increased, additive effects)

• hydromorphone
fluphenazine decanoate (generic)

+

hydromorphone

1 interaction

Monitor/Modify Tx

fluphenazine + hydromorphone

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• hydroxychloroquine
fluphenazine decanoate (generic)

+

hydroxychloroquine

1 interaction

Monitor/Modify Tx

fluphenazine + hydroxychloroquine

monitor CBC: combo may incr. risk of myelosuppression, seizures (additive effects)

• hydroxyurea
fluphenazine decanoate (generic)

+

hydroxyurea

1 interaction

Monitor/Modify Tx

fluphenazine + hydroxyurea

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• hydroxyzine
fluphenazine decanoate (generic)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

fluphenazine + hydroxyzine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• hyoscyamine
fluphenazine decanoate (generic)

+

hyoscyamine

1 interaction

Monitor/Modify Tx

fluphenazine + hyoscyamine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ibritumomab tiuxetan
fluphenazine decanoate (generic)

+

ibritumomab tiuxetan

1 interaction

Monitor/Modify Tx

fluphenazine + ibritumomab tiuxetan

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ibrutinib
fluphenazine decanoate (generic)

+

ibrutinib

1 interaction

Monitor/Modify Tx

fluphenazine + ibrutinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• idarubicin
fluphenazine decanoate (generic)

+

idarubicin

1 interaction

Monitor/Modify Tx

fluphenazine + idarubicin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• idecabtagene vicleucel
fluphenazine decanoate (generic)

+

idecabtagene vicleucel

1 interaction

Monitor/Modify Tx

fluphenazine + idecabtagene vicleucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• idelalisib
fluphenazine decanoate (generic)

+

idelalisib

1 interaction

Monitor/Modify Tx

fluphenazine + idelalisib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ifosfamide
fluphenazine decanoate (generic)

+

ifosfamide

1 interaction

Monitor/Modify Tx

fluphenazine + ifosfamide

consider decr. fluphenazine dose; monitor CBC; D/C one or both drugs if encephalopathy occurs: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression (additive effects)

• iloperidone
fluphenazine decanoate (generic)

+

iloperidone

1 interaction

Monitor/Modify Tx

fluphenazine + iloperidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• iloprost
fluphenazine decanoate (generic)

+

iloprost

1 interaction

Monitor/Modify Tx

fluphenazine + iloprost

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• imatinib
fluphenazine decanoate (generic)

+

imatinib

1 interaction

Monitor/Modify Tx

fluphenazine + imatinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• imetelstat
fluphenazine decanoate (generic)

+

imetelstat

1 interaction

Monitor/Modify Tx

fluphenazine + imetelstat

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• imipramine
fluphenazine decanoate (generic)

+

imipramine

1 interaction

Monitor/Modify Tx

fluphenazine + imipramine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), anticholinergic adverse effects (additive effects)

• indapamide
fluphenazine decanoate (generic)

+

indapamide

1 interaction

Monitor/Modify Tx

fluphenazine + indapamide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• inotuzumab ozogamicin
fluphenazine decanoate (generic)

+

inotuzumab ozogamicin

1 interaction

Monitor/Modify Tx

fluphenazine + inotuzumab ozogamicin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• interferon beta 1a
fluphenazine decanoate (generic)

+

interferon beta 1a

1 interaction

Monitor/Modify Tx

fluphenazine + interferon beta 1a

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• interferon beta 1b
fluphenazine decanoate (generic)

+

interferon beta 1b

1 interaction

Monitor/Modify Tx

fluphenazine + interferon beta 1b

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• interferon gamma 1b
fluphenazine decanoate (generic)

+

interferon gamma 1b

1 interaction

Monitor/Modify Tx

fluphenazine + interferon gamma 1b

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• iohexol
fluphenazine decanoate (generic)

+

iohexol

1 interaction

Monitor/Modify Tx

fluphenazine + iohexol

if intrathecal iohexol use, D/C fluphenazine at least 48h before myelography, may resume at least 24h after procedure: combo may incr. risk of seizures (additive effects)

• iopamidol
fluphenazine decanoate (generic)

+

iopamidol

1 interaction

Monitor/Modify Tx

fluphenazine + iopamidol

caution advised if intrathecal iopamidol use; consider holding fluphenazine at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• irbesartan
fluphenazine decanoate (generic)

+

irbesartan

1 interaction

Monitor/Modify Tx

fluphenazine + irbesartan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• irinotecan
fluphenazine decanoate (generic)

+

irinotecan

1 interaction

Monitor/Modify Tx

fluphenazine + irinotecan

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• iron sucrose
fluphenazine decanoate (generic)

+

iron sucrose

1 interaction

Monitor/Modify Tx

fluphenazine + iron sucrose

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• isatuximab
fluphenazine decanoate (generic)

+

isatuximab

1 interaction

Monitor/Modify Tx

fluphenazine + isatuximab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• isoflurane
fluphenazine decanoate (generic)

+

isoflurane

1 interaction

Monitor/Modify Tx

fluphenazine + isoflurane

monitor respiratory rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• isosorbide dinitrate
fluphenazine decanoate (generic)

+

isosorbide dinitrate

1 interaction

Monitor/Modify Tx

fluphenazine + isosorbide dinitrate

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• isosorbide mononitrate
fluphenazine decanoate (generic)

+

isosorbide mononitrate

1 interaction

Monitor/Modify Tx

fluphenazine + isosorbide mononitrate

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• isradipine
fluphenazine decanoate (generic)

+

isradipine

1 interaction

Monitor/Modify Tx

fluphenazine + isradipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• ivosidenib
fluphenazine decanoate (generic)

+

ivosidenib

1 interaction

Monitor/Modify Tx

fluphenazine + ivosidenib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ixabepilone
fluphenazine decanoate (generic)

+

ixabepilone

1 interaction

Monitor/Modify Tx

fluphenazine + ixabepilone

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ketamine
fluphenazine decanoate (generic)

+

ketamine

1 interaction

Monitor/Modify Tx

fluphenazine + ketamine

monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment (additive effects)

• labetalol
fluphenazine decanoate (generic)

+

labetalol

1 interaction

Monitor/Modify Tx

fluphenazine + labetalol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• lacosamide
fluphenazine decanoate (generic)

+

lacosamide

1 interaction

Monitor/Modify Tx

fluphenazine + lacosamide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• lamotrigine
fluphenazine decanoate (generic)

+

lamotrigine

1 interaction

Monitor/Modify Tx

fluphenazine + lamotrigine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• landiolol
fluphenazine decanoate (generic)

+

landiolol

1 interaction

Monitor/Modify Tx

fluphenazine + landiolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• leflunomide
fluphenazine decanoate (generic)

+

leflunomide

1 interaction

Monitor/Modify Tx

fluphenazine + leflunomide

monitor CBC: combo may decr. fluphenazine levels, efficacy; may incr. risk of myelosuppression (hepatic metabolism induced; additive effects)

• lemborexant
fluphenazine decanoate (generic)

+

lemborexant

1 interaction

Monitor/Modify Tx

fluphenazine + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenalidomide
fluphenazine decanoate (generic)

+

lenalidomide

1 interaction

Monitor/Modify Tx

fluphenazine + lenalidomide

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• levetiracetam
fluphenazine decanoate (generic)

+

levetiracetam

1 interaction

Monitor/Modify Tx

fluphenazine + levetiracetam

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• levobunolol ophthalmic
fluphenazine decanoate (generic)

+

levobunolol ophthalmic

1 interaction

Monitor/Modify Tx

fluphenazine + levobunolol ophthalmic

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• levocetirizine
fluphenazine decanoate (generic)

+

levocetirizine

1 interaction

Monitor/Modify Tx

fluphenazine + levocetirizine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
fluphenazine decanoate (generic)

+

levodopa

1 interaction

Monitor/Modify Tx

fluphenazine + levodopa

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• levomilnacipran
fluphenazine decanoate (generic)

+

levomilnacipran

1 interaction

Monitor/Modify Tx

fluphenazine + levomilnacipran

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levorphanol
fluphenazine decanoate (generic)

+

levorphanol

1 interaction

Monitor/Modify Tx

fluphenazine + levorphanol

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• lidocaine
fluphenazine decanoate (generic)

+

lidocaine

1 interaction

Monitor/Modify Tx

fluphenazine + lidocaine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• lifileucel
fluphenazine decanoate (generic)

+

lifileucel

1 interaction

Monitor/Modify Tx

fluphenazine + lifileucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• linezolid
fluphenazine decanoate (generic)

+

linezolid

1 interaction

Monitor/Modify Tx

fluphenazine + linezolid

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• linvoseltamab
fluphenazine decanoate (generic)

+

linvoseltamab

1 interaction

Monitor/Modify Tx

fluphenazine + linvoseltamab

monitor CBC; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression (additive effects)

• lisinopril
fluphenazine decanoate (generic)

+

lisinopril

1 interaction

Monitor/Modify Tx

fluphenazine + lisinopril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• lisocabtagene maraleucel
fluphenazine decanoate (generic)

+

lisocabtagene maraleucel

1 interaction

Monitor/Modify Tx

fluphenazine + lisocabtagene maraleucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• lithium
fluphenazine decanoate (generic)

+

lithium

1 interaction

Monitor/Modify Tx

fluphenazine + lithium

D/C one or both drugs if encephalopathy occurs: combo may incr. risk of encephalopathic syndrome, extrapyramidal symptoms (additive effects)

• lomustine
fluphenazine decanoate (generic)

+

lomustine

1 interaction

Monitor/Modify Tx

fluphenazine + lomustine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• lonafarnib
fluphenazine decanoate (generic)

+

lonafarnib

1 interaction

Monitor/Modify Tx

fluphenazine + lonafarnib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• loncastuximab tesirine
fluphenazine decanoate (generic)

+

loncastuximab tesirine

1 interaction

Monitor/Modify Tx

fluphenazine + loncastuximab tesirine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• lorazepam
fluphenazine decanoate (generic)

+

lorazepam

1 interaction

Monitor/Modify Tx

fluphenazine + lorazepam

monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• losartan
fluphenazine decanoate (generic)

+

losartan

1 interaction

Monitor/Modify Tx

fluphenazine + losartan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• lovotibeglogene autotemcel
fluphenazine decanoate (generic)

+

lovotibeglogene autotemcel

1 interaction

Monitor/Modify Tx

fluphenazine + lovotibeglogene autotemcel

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression, bleeding (additive effects)

• loxapine
fluphenazine decanoate (generic)

+

loxapine

1 interaction

Monitor/Modify Tx

fluphenazine + loxapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, anticholinergic adverse effects (additive effects)

• lubiprostone
fluphenazine decanoate (generic)

+

lubiprostone

1 interaction

Monitor/Modify Tx

fluphenazine + lubiprostone

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• lumateperone
fluphenazine decanoate (generic)

+

lumateperone

1 interaction

Monitor/Modify Tx

fluphenazine + lumateperone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• lurasidone
fluphenazine decanoate (generic)

+

lurasidone

1 interaction

Monitor/Modify Tx

fluphenazine + lurasidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, hyperthermia (additive effects)

• lurbinectedin
fluphenazine decanoate (generic)

+

lurbinectedin

1 interaction

Monitor/Modify Tx

fluphenazine + lurbinectedin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• lutetium Lu 177 dotatate
fluphenazine decanoate (generic)

+

lutetium Lu 177 dotatate

1 interaction

Monitor/Modify Tx

fluphenazine + lutetium Lu 177 dotatate

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• lutetium Lu 177 vipivotide tetraxetan
fluphenazine decanoate (generic)

+

lutetium Lu 177 vipivotide tetraxetan

1 interaction

Monitor/Modify Tx

fluphenazine + lutetium Lu 177 vipivotide tetraxetan

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• lymphocyte immune globulin, anti-thymocyte globulin
fluphenazine decanoate (generic)

+

lymphocyte immune globulin, anti-thymocyte globulin

1 interaction

Monitor/Modify Tx

fluphenazine + lymphocyte immune globulin, anti-thymocyte globulin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• magnesium sulfate
fluphenazine decanoate (generic)

+

magnesium sulfate

1 interaction

Monitor/Modify Tx

fluphenazine + magnesium sulfate

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• maraviroc
fluphenazine decanoate (generic)

+

maraviroc

1 interaction

Monitor/Modify Tx

fluphenazine + maraviroc

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• meclizine
fluphenazine decanoate (generic)

+

meclizine

1 interaction

Monitor/Modify Tx

fluphenazine + meclizine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• melatonin
fluphenazine decanoate (generic)

+

melatonin

1 interaction

Monitor/Modify Tx

fluphenazine + melatonin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• melphalan
fluphenazine decanoate (generic)

+

melphalan

1 interaction

Monitor/Modify Tx

fluphenazine + melphalan

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• mepivacaine
fluphenazine decanoate (generic)

+

mepivacaine

1 interaction

Monitor/Modify Tx

fluphenazine + mepivacaine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• meprobamate
fluphenazine decanoate (generic)

+

meprobamate

1 interaction

Monitor/Modify Tx

fluphenazine + meprobamate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mercaptopurine
fluphenazine decanoate (generic)

+

mercaptopurine

1 interaction

Monitor/Modify Tx

fluphenazine + mercaptopurine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• mesalamine
fluphenazine decanoate (generic)

+

mesalamine

1 interaction

Monitor/Modify Tx

fluphenazine + mesalamine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• mesalamine rectal
fluphenazine decanoate (generic)

+

mesalamine rectal

1 interaction

Monitor/Modify Tx

fluphenazine + mesalamine rectal

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• methadone
fluphenazine decanoate (generic)

+

methadone

1 interaction

Monitor/Modify Tx

fluphenazine + methadone

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• methocarbamol
fluphenazine decanoate (generic)

+

methocarbamol

1 interaction

Monitor/Modify Tx

fluphenazine + methocarbamol

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methohexital
fluphenazine decanoate (generic)

+

methohexital

1 interaction

Monitor/Modify Tx

fluphenazine + methohexital

monitor respiratory rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• methotrexate
fluphenazine decanoate (generic)

+

methotrexate

1 interaction

Monitor/Modify Tx

fluphenazine + methotrexate

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• methsuximide
fluphenazine decanoate (generic)

+

methsuximide

1 interaction

Monitor/Modify Tx

fluphenazine + methsuximide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• methyldopa
fluphenazine decanoate (generic)

+

methyldopa

1 interaction

Monitor/Modify Tx

fluphenazine + methyldopa

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• methylene blue injection
fluphenazine decanoate (generic)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

fluphenazine + methylene blue injection

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• metolazone
fluphenazine decanoate (generic)

+

metolazone

1 interaction

Monitor/Modify Tx

fluphenazine + metolazone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• metoprolol
fluphenazine decanoate (generic)

+

metoprolol

1 interaction

Monitor/Modify Tx

fluphenazine + metoprolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• metyrapone
fluphenazine decanoate (generic)

+

metyrapone

1 interaction

Monitor/Modify Tx

fluphenazine + metyrapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
fluphenazine decanoate (generic)

+

metyrosine

1 interaction

Monitor/Modify Tx

fluphenazine + metyrosine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• midostaurin
fluphenazine decanoate (generic)

+

midostaurin

1 interaction

Monitor/Modify Tx

fluphenazine + midostaurin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• milnacipran
fluphenazine decanoate (generic)

+

milnacipran

1 interaction

Monitor/Modify Tx

fluphenazine + milnacipran

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• milrinone
fluphenazine decanoate (generic)

+

milrinone

1 interaction

Monitor/Modify Tx

fluphenazine + milrinone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• milsaperidone
fluphenazine decanoate (generic)

+

milsaperidone

1 interaction

Monitor/Modify Tx

fluphenazine + milsaperidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• minoxidil
fluphenazine decanoate (generic)

+

minoxidil

1 interaction

Monitor/Modify Tx

fluphenazine + minoxidil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• mirtazapine
fluphenazine decanoate (generic)

+

mirtazapine

1 interaction

Monitor/Modify Tx

fluphenazine + mirtazapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, hypotension, including orthostasis (additive effects)

• mitomycin
fluphenazine decanoate (generic)

+

mitomycin

1 interaction

Monitor/Modify Tx

fluphenazine + mitomycin

monitor CBC; risk may be lower w/ intravesical mitomycin administration: combo may incr. risk of myelosuppression (additive effects)

• mitotane
fluphenazine decanoate (generic)

+

mitotane

1 interaction

Monitor/Modify Tx

fluphenazine + mitotane

consider decr. dose of one or both drugs; monitor CBC: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression (additive effects)

• mitoxantrone
fluphenazine decanoate (generic)

+

mitoxantrone

1 interaction

Monitor/Modify Tx

fluphenazine + mitoxantrone

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• moexipril
fluphenazine decanoate (generic)

+

moexipril

1 interaction

Monitor/Modify Tx

fluphenazine + moexipril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• mogamulizumab
fluphenazine decanoate (generic)

+

mogamulizumab

1 interaction

Monitor/Modify Tx

fluphenazine + mogamulizumab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• molindone
fluphenazine decanoate (generic)

+

molindone

1 interaction

Monitor/Modify Tx

fluphenazine + molindone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, extrapyramidal symptoms, hypotension, including orthostasis (additive effects)

• momelotinib
fluphenazine decanoate (generic)

+

momelotinib

1 interaction

Monitor/Modify Tx

fluphenazine + momelotinib

monitor CBC, bleeding s/sx: combo may incr. risk of myelosuppression (additive effects)

• morphine
fluphenazine decanoate (generic)

+

morphine

1 interaction

Monitor/Modify Tx

fluphenazine + morphine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• mosunetuzumab
fluphenazine decanoate (generic)

+

mosunetuzumab

1 interaction

Monitor/Modify Tx

fluphenazine + mosunetuzumab

monitor CBC; consider decr. dose of one or both drugs: combo may incr. risk of myelosuppression, CNS depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
fluphenazine decanoate (generic)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

fluphenazine + mycophenolate mofetil

monitor CBC; consider decr. fluphenazine dose: combo may incr. risk of myelosuppression, CNS depression, psychomotor impairment (additive effects)

• mycophenolic acid
fluphenazine decanoate (generic)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

fluphenazine + mycophenolic acid

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• nadolol
fluphenazine decanoate (generic)

+

nadolol

1 interaction

Monitor/Modify Tx

fluphenazine + nadolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nalbuphine
fluphenazine decanoate (generic)

+

nalbuphine

1 interaction

Monitor/Modify Tx

fluphenazine + nalbuphine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• naltrexone
fluphenazine decanoate (generic)

+

naltrexone

1 interaction

Monitor/Modify Tx

fluphenazine + naltrexone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naratriptan
fluphenazine decanoate (generic)

+

naratriptan

1 interaction

Monitor/Modify Tx

fluphenazine + naratriptan

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nattokinase
fluphenazine decanoate (generic)

+

nattokinase

1 interaction

Monitor/Modify Tx

fluphenazine + nattokinase

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• naxitamab
fluphenazine decanoate (generic)

+

naxitamab

1 interaction

Monitor/Modify Tx

fluphenazine + naxitamab

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nebivolol
fluphenazine decanoate (generic)

+

nebivolol

1 interaction

Monitor/Modify Tx

fluphenazine + nebivolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nefazodone
fluphenazine decanoate (generic)

+

nefazodone

1 interaction

Monitor/Modify Tx

fluphenazine + nefazodone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nelarabine
fluphenazine decanoate (generic)

+

nelarabine

1 interaction

Monitor/Modify Tx

fluphenazine + nelarabine

monitor CBC; consider decr. fluphenazine dose; withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of myelosuppression, CNS depression, psychomotor impairment (additive effects)

• niacin (vitamin B3)
fluphenazine decanoate (generic)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

fluphenazine + niacin (vitamin B3)

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nicardipine
fluphenazine decanoate (generic)

+

nicardipine

1 interaction

Monitor/Modify Tx

fluphenazine + nicardipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nifedipine
fluphenazine decanoate (generic)

+

nifedipine

1 interaction

Monitor/Modify Tx

fluphenazine + nifedipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nilotinib
fluphenazine decanoate (generic)

+

nilotinib

1 interaction

Monitor/Modify Tx

fluphenazine + nilotinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• nimodipine
fluphenazine decanoate (generic)

+

nimodipine

1 interaction

Monitor/Modify Tx

fluphenazine + nimodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• niraparib
fluphenazine decanoate (generic)

+

niraparib

1 interaction

Monitor/Modify Tx

fluphenazine + niraparib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• nisoldipine
fluphenazine decanoate (generic)

+

nisoldipine

1 interaction

Monitor/Modify Tx

fluphenazine + nisoldipine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nitric oxide
fluphenazine decanoate (generic)

+

nitric oxide

1 interaction

Monitor/Modify Tx

fluphenazine + nitric oxide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• nitrite
fluphenazine decanoate (generic)

+

nitrite

1 interaction

Monitor/Modify Tx

fluphenazine + nitrite

monitor BP: combo may incr. risk of severe or life-threatening hypotension, including orthostasis, syncope (additive effects)

• nitroglycerin
fluphenazine decanoate (generic)

+

nitroglycerin

1 interaction

Monitor/Modify Tx

fluphenazine + nitroglycerin

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• nitroprusside
fluphenazine decanoate (generic)

+

nitroprusside

1 interaction

Monitor/Modify Tx

fluphenazine + nitroprusside

monitor BP: combo may incr. risk of severe or life-threatening hypotension, including orthostasis (additive effects)

• nortriptyline
fluphenazine decanoate (generic)

+

nortriptyline

1 interaction

Monitor/Modify Tx

fluphenazine + nortriptyline

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), anticholinergic adverse effects (additive effects)

• obecabtagene autoleucel
fluphenazine decanoate (generic)

+

obecabtagene autoleucel

1 interaction

Monitor/Modify Tx

fluphenazine + obecabtagene autoleucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• obinutuzumab
fluphenazine decanoate (generic)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

fluphenazine + obinutuzumab

monitor CBC, BP: combo may incr. risk of myelosuppression, hypotension, including orthostasis (additive effects)

• ofatumumab
fluphenazine decanoate (generic)

+

ofatumumab

1 interaction

Monitor/Modify Tx

fluphenazine + ofatumumab

monitor CBC; myelosuppression risk may be lower w/ ofatumumab doses used for MS: combo may incr. risk of myelosuppression (additive effects)

• olaparib
fluphenazine decanoate (generic)

+

olaparib

1 interaction

Monitor/Modify Tx

fluphenazine + olaparib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• oliceridine
fluphenazine decanoate (generic)

+

oliceridine

1 interaction

Monitor/Modify Tx

fluphenazine + oliceridine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• olmesartan medoxomil
fluphenazine decanoate (generic)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

fluphenazine + olmesartan medoxomil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• olsalazine
fluphenazine decanoate (generic)

+

olsalazine

1 interaction

Monitor/Modify Tx

fluphenazine + olsalazine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• opicapone
fluphenazine decanoate (generic)

+

opicapone

1 interaction

Monitor/Modify Tx

fluphenazine + opicapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• opium
fluphenazine decanoate (generic)

+

opium

1 interaction

Monitor/Modify Tx

fluphenazine + opium

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• orphenadrine
fluphenazine decanoate (generic)

+

orphenadrine

1 interaction

Monitor/Modify Tx

fluphenazine + orphenadrine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• oxaliplatin
fluphenazine decanoate (generic)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

fluphenazine + oxaliplatin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• oxazepam
fluphenazine decanoate (generic)

+

oxazepam

1 interaction

Monitor/Modify Tx

fluphenazine + oxazepam

monitor respiratory rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• oxcarbazepine
fluphenazine decanoate (generic)

+

oxcarbazepine

1 interaction

Monitor/Modify Tx

fluphenazine + oxcarbazepine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• oxybutynin
fluphenazine decanoate (generic)

+

oxybutynin

1 interaction

Monitor/Modify Tx

fluphenazine + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely with oxybutynin transdermal patch; may decr. fluphenazine efficacy (additive effects; antagonistic effects)

• oxycodone
fluphenazine decanoate (generic)

+

oxycodone

1 interaction

Monitor/Modify Tx

fluphenazine + oxycodone

monitor respiratory rate, BP; decr. oxycodone start dose by at least 50%, consider decr. fluphenazine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• oxymorphone
fluphenazine decanoate (generic)

+

oxymorphone

1 interaction

Monitor/Modify Tx

fluphenazine + oxymorphone

monitor respiratory rate, BP; decr. oxymorphone start dose by at least 50%, consider decr. fluphenazine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• paclitaxel
fluphenazine decanoate (generic)

+

paclitaxel

1 interaction

Monitor/Modify Tx

fluphenazine + paclitaxel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• pacritinib
fluphenazine decanoate (generic)

+

pacritinib

1 interaction

Monitor/Modify Tx

fluphenazine + pacritinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• palbociclib
fluphenazine decanoate (generic)

+

palbociclib

1 interaction

Monitor/Modify Tx

fluphenazine + palbociclib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• paliperidone
fluphenazine decanoate (generic)

+

paliperidone

1 interaction

Monitor/Modify Tx

fluphenazine + paliperidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• palopegteriparatide
fluphenazine decanoate (generic)

+

palopegteriparatide

1 interaction

Monitor/Modify Tx

fluphenazine + palopegteriparatide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• paroxetine
fluphenazine decanoate (generic)

+

paroxetine

1 interaction

Monitor/Modify Tx

fluphenazine + paroxetine

consider decr. dose of one or both drugs: combo may incr. fluphenazine levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• passion flower
fluphenazine decanoate (generic)

+

passion flower

1 interaction

Monitor/Modify Tx

fluphenazine + passion flower

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• peginterferon alfa 2a
fluphenazine decanoate (generic)

+

peginterferon alfa 2a

1 interaction

Monitor/Modify Tx

fluphenazine + peginterferon alfa 2a

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• peginterferon beta 1a
fluphenazine decanoate (generic)

+

peginterferon beta 1a

1 interaction

Monitor/Modify Tx

fluphenazine + peginterferon beta 1a

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• pemetrexed
fluphenazine decanoate (generic)

+

pemetrexed

1 interaction

Monitor/Modify Tx

fluphenazine + pemetrexed

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• penicillamine
fluphenazine decanoate (generic)

+

penicillamine

1 interaction

Monitor/Modify Tx

fluphenazine + penicillamine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• pentamidine
fluphenazine decanoate (generic)

+

pentamidine

1 interaction

Monitor/Modify Tx

fluphenazine + pentamidine

monitor CBC, BP: combo may incr. risk of myelosuppression, severe or life-threatening hypotension (additive effects)

• pentazocine
fluphenazine decanoate (generic)

+

pentazocine

1 interaction

Monitor/Modify Tx

fluphenazine + pentazocine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• pentobarbital
fluphenazine decanoate (generic)

+

pentobarbital

1 interaction

Monitor/Modify Tx

fluphenazine + pentobarbital

monitor respiratory rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• pentostatin
fluphenazine decanoate (generic)

+

pentostatin

1 interaction

Monitor/Modify Tx

fluphenazine + pentostatin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• perampanel
fluphenazine decanoate (generic)

+

perampanel

1 interaction

Monitor/Modify Tx

fluphenazine + perampanel

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• perindopril
fluphenazine decanoate (generic)

+

perindopril

1 interaction

Monitor/Modify Tx

fluphenazine + perindopril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• perphenazine
fluphenazine decanoate (generic)

+

perphenazine

1 interaction

Monitor/Modify Tx

fluphenazine + perphenazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), extrapyramidal symptoms, anticholinergic adverse effects (additive effects, duplicate therapy)

• pheniramine
fluphenazine decanoate (generic)

+

pheniramine

1 interaction

Monitor/Modify Tx

fluphenazine + pheniramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• phenobarbital
fluphenazine decanoate (generic)

+

phenobarbital

1 interaction

Monitor/Modify Tx

fluphenazine + phenobarbital

monitor BP, respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• phenoxybenzamine
fluphenazine decanoate (generic)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

fluphenazine + phenoxybenzamine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• phentolamine
fluphenazine decanoate (generic)

+

phentolamine

1 interaction

Monitor/Modify Tx

fluphenazine + phentolamine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• phenytoin
fluphenazine decanoate (generic)

+

phenytoin

1 interaction

Monitor/Modify Tx

fluphenazine + phenytoin

monitor phenytoin levels; consider fluphenazine dose adjustment: combo may incr. phenytoin levels, risk of toxicity; may decr. fluphenazine levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (mechanism unknown; hepatic metabolism induced; additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• pimozide
fluphenazine decanoate (generic)

+

pimozide

1 interaction

Monitor/Modify Tx

fluphenazine + pimozide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects, extrapyramidal symptoms (additive effects)

• pindolol
fluphenazine decanoate (generic)

+

pindolol

1 interaction

Monitor/Modify Tx

fluphenazine + pindolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• pirtobrutinib
fluphenazine decanoate (generic)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

fluphenazine + pirtobrutinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• polatuzumab vedotin
fluphenazine decanoate (generic)

+

polatuzumab vedotin

1 interaction

Monitor/Modify Tx

fluphenazine + polatuzumab vedotin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• pomalidomide
fluphenazine decanoate (generic)

+

pomalidomide

1 interaction

Monitor/Modify Tx

fluphenazine + pomalidomide

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ponatinib
fluphenazine decanoate (generic)

+

ponatinib

1 interaction

Monitor/Modify Tx

fluphenazine + ponatinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• pralatrexate
fluphenazine decanoate (generic)

+

pralatrexate

1 interaction

Monitor/Modify Tx

fluphenazine + pralatrexate

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• pramipexole
fluphenazine decanoate (generic)

+

pramipexole

1 interaction

Monitor/Modify Tx

fluphenazine + pramipexole

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• prazosin
fluphenazine decanoate (generic)

+

prazosin

1 interaction

Monitor/Modify Tx

fluphenazine + prazosin

monitor BP, especially during prazosin initiation/titration: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• pregabalin
fluphenazine decanoate (generic)

+

pregabalin

1 interaction

Monitor/Modify Tx

fluphenazine + pregabalin

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• primidone
fluphenazine decanoate (generic)

+

primidone

1 interaction

Monitor/Modify Tx

fluphenazine + primidone

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• procarbazine
fluphenazine decanoate (generic)

+

procarbazine

1 interaction

Monitor/Modify Tx

fluphenazine + procarbazine

monitor BP, CBC; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression, hypotension including orthostasis (additive effects)

• prochlorperazine
fluphenazine decanoate (generic)

+

prochlorperazine

1 interaction

Monitor/Modify Tx

fluphenazine + prochlorperazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, anticholinergic adverse effects (additive effects; duplicate therapy)

• proguanil
fluphenazine decanoate (generic)

+

proguanil

1 interaction

Monitor/Modify Tx

fluphenazine + proguanil

monitor CBC, especially if concomitant renal impairment: combo may incr. risk of myelosuppression (additive effects)

• propafenone
fluphenazine decanoate (generic)

+

propafenone

1 interaction

Monitor/Modify Tx

fluphenazine + propafenone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• propofol
fluphenazine decanoate (generic)

+

propofol

1 interaction

Monitor/Modify Tx

fluphenazine + propofol

monitor respiratory rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis (additive effects)

• propranolol
fluphenazine decanoate (generic)

+

propranolol

1 interaction

Monitor/Modify Tx

fluphenazine + propranolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• protriptyline
fluphenazine decanoate (generic)

+

protriptyline

1 interaction

Monitor/Modify Tx

fluphenazine + protriptyline

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), hyperthermia, anticholinergic adverse effects (additive effects)

• pyrilamine
fluphenazine decanoate (generic)

+

pyrilamine

1 interaction

Monitor/Modify Tx

fluphenazine + pyrilamine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pyrimethamine
fluphenazine decanoate (generic)

+

pyrimethamine

1 interaction

Monitor/Modify Tx

fluphenazine + pyrimethamine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• quazepam
fluphenazine decanoate (generic)

+

quazepam

1 interaction

Monitor/Modify Tx

fluphenazine + quazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• quetiapine
fluphenazine decanoate (generic)

+

quetiapine

1 interaction

Monitor/Modify Tx

fluphenazine + quetiapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hypotension (including orthostasis, syncope), hyperthermia, anticholinergic adverse effects (additive effects)

• quinapril
fluphenazine decanoate (generic)

+

quinapril

1 interaction

Monitor/Modify Tx

fluphenazine + quinapril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• quizartinib
fluphenazine decanoate (generic)

+

quizartinib

1 interaction

Monitor/Modify Tx

fluphenazine + quizartinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ramelteon
fluphenazine decanoate (generic)

+

ramelteon

1 interaction

Monitor/Modify Tx

fluphenazine + ramelteon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ramipril
fluphenazine decanoate (generic)

+

ramipril

1 interaction

Monitor/Modify Tx

fluphenazine + ramipril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• relacorilant
fluphenazine decanoate (generic)

+

relacorilant

1 interaction

Monitor/Modify Tx

fluphenazine + relacorilant

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• remifentanil
fluphenazine decanoate (generic)

+

remifentanil

1 interaction

Monitor/Modify Tx

fluphenazine + remifentanil

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• remimazolam
fluphenazine decanoate (generic)

+

remimazolam

1 interaction

Monitor/Modify Tx

fluphenazine + remimazolam

monitor BP, respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of hypotension (including orthostasis), profound CNS and respiratory depression, psychomotor impairment (additive effects)

• repotrectinib
fluphenazine decanoate (generic)

+

repotrectinib

1 interaction

Monitor/Modify Tx

fluphenazine + repotrectinib

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ribavirin
fluphenazine decanoate (generic)

+

ribavirin

1 interaction

Monitor/Modify Tx

fluphenazine + ribavirin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ribociclib
fluphenazine decanoate (generic)

+

ribociclib

1 interaction

Monitor/Modify Tx

fluphenazine + ribociclib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• rifabutin
fluphenazine decanoate (generic)

+

rifabutin

1 interaction

Monitor/Modify Tx

fluphenazine + rifabutin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• riociguat
fluphenazine decanoate (generic)

+

riociguat

1 interaction

Monitor/Modify Tx

fluphenazine + riociguat

monitor BP: combo may incr. risk of severe hypotension, including orthostasis (additive effects)

• risperidone
fluphenazine decanoate (generic)

+

risperidone

1 interaction

Monitor/Modify Tx

fluphenazine + risperidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• rituximab
fluphenazine decanoate (generic)

+

rituximab

1 interaction

Monitor/Modify Tx

fluphenazine + rituximab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• rizatriptan
fluphenazine decanoate (generic)

+

rizatriptan

1 interaction

Monitor/Modify Tx

fluphenazine + rizatriptan

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• romidepsin
fluphenazine decanoate (generic)

+

romidepsin

1 interaction

Monitor/Modify Tx

fluphenazine + romidepsin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ropinirole
fluphenazine decanoate (generic)

+

ropinirole

1 interaction

Monitor/Modify Tx

fluphenazine + ropinirole

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• ropivacaine
fluphenazine decanoate (generic)

+

ropivacaine

1 interaction

Monitor/Modify Tx

fluphenazine + ropivacaine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• rotigotine transdermal
fluphenazine decanoate (generic)

+

rotigotine transdermal

1 interaction

Monitor/Modify Tx

fluphenazine + rotigotine transdermal

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• rucaparib
fluphenazine decanoate (generic)

+

rucaparib

1 interaction

Monitor/Modify Tx

fluphenazine + rucaparib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• rufinamide
fluphenazine decanoate (generic)

+

rufinamide

1 interaction

Monitor/Modify Tx

fluphenazine + rufinamide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• ruxolitinib
fluphenazine decanoate (generic)

+

ruxolitinib

1 interaction

Monitor/Modify Tx

fluphenazine + ruxolitinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ruxolitinib topical
fluphenazine decanoate (generic)

+

ruxolitinib topical

1 interaction

Monitor/Modify Tx

fluphenazine + ruxolitinib topical

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• sacituzumab govitecan
fluphenazine decanoate (generic)

+

sacituzumab govitecan

1 interaction

Monitor/Modify Tx

fluphenazine + sacituzumab govitecan

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• sacubitril
fluphenazine decanoate (generic)

+

sacubitril

1 interaction

Monitor/Modify Tx

fluphenazine + sacubitril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• sarilumab
fluphenazine decanoate (generic)

+

sarilumab

1 interaction

Monitor/Modify Tx

fluphenazine + sarilumab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• satralizumab
fluphenazine decanoate (generic)

+

satralizumab

1 interaction

Monitor/Modify Tx

fluphenazine + satralizumab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• selinexor
fluphenazine decanoate (generic)

+

selinexor

1 interaction

Monitor/Modify Tx

fluphenazine + selinexor

monitor CBC; consider decr. dose of one or both drugs: combo may incr. risk of myelosuppression, CNS depression, psychomotor impairment (additive effects)

• sertraline
fluphenazine decanoate (generic)

+

sertraline

1 interaction

Monitor/Modify Tx

fluphenazine + sertraline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sevoflurane
fluphenazine decanoate (generic)

+

sevoflurane

1 interaction

Monitor/Modify Tx

fluphenazine + sevoflurane

monitor respiratory rate, BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• sildenafil
fluphenazine decanoate (generic)

+

sildenafil

1 interaction

Monitor/Modify Tx

fluphenazine + sildenafil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• silodosin
fluphenazine decanoate (generic)

+

silodosin

1 interaction

Monitor/Modify Tx

fluphenazine + silodosin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• sirolimus
fluphenazine decanoate (generic)

+

sirolimus

1 interaction

Monitor/Modify Tx

fluphenazine + sirolimus

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• sirolimus albumin-bound
fluphenazine decanoate (generic)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

fluphenazine + sirolimus albumin-bound

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• sodium ferric gluconate complex
fluphenazine decanoate (generic)

+

sodium ferric gluconate complex

1 interaction

Monitor/Modify Tx

fluphenazine + sodium ferric gluconate complex

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• solifenacin
fluphenazine decanoate (generic)

+

solifenacin

1 interaction

Monitor/Modify Tx

fluphenazine + solifenacin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• sotagliflozin
fluphenazine decanoate (generic)

+

sotagliflozin

1 interaction

Monitor/Modify Tx

fluphenazine + sotagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• sotalol
fluphenazine decanoate (generic)

+

sotalol

1 interaction

Monitor/Modify Tx

fluphenazine + sotalol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• sparsentan
fluphenazine decanoate (generic)

+

sparsentan

1 interaction

Monitor/Modify Tx

fluphenazine + sparsentan

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• spironolactone
fluphenazine decanoate (generic)

+

spironolactone

1 interaction

Monitor/Modify Tx

fluphenazine + spironolactone

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• stiripentol
fluphenazine decanoate (generic)

+

stiripentol

1 interaction

Monitor/Modify Tx

fluphenazine + stiripentol

monitor CBC; consider decr. dose of one or both drugs: combo may incr. risk of myelosuppression, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• streptozocin
fluphenazine decanoate (generic)

+

streptozocin

1 interaction

Monitor/Modify Tx

fluphenazine + streptozocin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• succimer
fluphenazine decanoate (generic)

+

succimer

1 interaction

Monitor/Modify Tx

fluphenazine + succimer

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• sufentanil
fluphenazine decanoate (generic)

+

sufentanil

1 interaction

Monitor/Modify Tx

fluphenazine + sufentanil

monitor respiratory rate, BP; decr. sufentanil start dose, consider decr. fluphenazine dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• sulfasalazine
fluphenazine decanoate (generic)

+

sulfasalazine

1 interaction

Monitor/Modify Tx

fluphenazine + sulfasalazine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• sumatriptan
fluphenazine decanoate (generic)

+

sumatriptan

1 interaction

Monitor/Modify Tx

fluphenazine + sumatriptan

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• suvorexant
fluphenazine decanoate (generic)

+

suvorexant

1 interaction

Monitor/Modify Tx

fluphenazine + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tadalafil
fluphenazine decanoate (generic)

+

tadalafil

1 interaction

Monitor/Modify Tx

fluphenazine + tadalafil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• tafasitamab
fluphenazine decanoate (generic)

+

tafasitamab

1 interaction

Monitor/Modify Tx

fluphenazine + tafasitamab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• tagraxofusp
fluphenazine decanoate (generic)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

fluphenazine + tagraxofusp

monitor CBC, BP: combo may incr. risk of myelosuppression, hypotension, including orthostasis (additive effects)

• talazoparib
fluphenazine decanoate (generic)

+

talazoparib

1 interaction

Monitor/Modify Tx

fluphenazine + talazoparib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• talquetamab
fluphenazine decanoate (generic)

+

talquetamab

1 interaction

Monitor/Modify Tx

fluphenazine + talquetamab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• tamsulosin
fluphenazine decanoate (generic)

+

tamsulosin

1 interaction

Monitor/Modify Tx

fluphenazine + tamsulosin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• tapentadol
fluphenazine decanoate (generic)

+

tapentadol

1 interaction

Monitor/Modify Tx

fluphenazine + tapentadol

monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• tarlatamab
fluphenazine decanoate (generic)

+

tarlatamab

1 interaction

Monitor/Modify Tx

fluphenazine + tarlatamab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• tasimelteon
fluphenazine decanoate (generic)

+

tasimelteon

1 interaction

Monitor/Modify Tx

fluphenazine + tasimelteon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• taurine
fluphenazine decanoate (generic)

+

taurine

1 interaction

Monitor/Modify Tx

fluphenazine + taurine

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• tazemetostat
fluphenazine decanoate (generic)

+

tazemetostat

1 interaction

Monitor/Modify Tx

fluphenazine + tazemetostat

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• teclistamab
fluphenazine decanoate (generic)

+

teclistamab

1 interaction

Monitor/Modify Tx

fluphenazine + teclistamab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• telmisartan
fluphenazine decanoate (generic)

+

telmisartan

1 interaction

Monitor/Modify Tx

fluphenazine + telmisartan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• temazepam
fluphenazine decanoate (generic)

+

temazepam

1 interaction

Monitor/Modify Tx

fluphenazine + temazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• temozolomide
fluphenazine decanoate (generic)

+

temozolomide

1 interaction

Monitor/Modify Tx

fluphenazine + temozolomide

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• temsirolimus
fluphenazine decanoate (generic)

+

temsirolimus

1 interaction

Monitor/Modify Tx

fluphenazine + temsirolimus

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• teplizumab
fluphenazine decanoate (generic)

+

teplizumab

1 interaction

Monitor/Modify Tx

fluphenazine + teplizumab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• terazosin
fluphenazine decanoate (generic)

+

terazosin

1 interaction

Monitor/Modify Tx

fluphenazine + terazosin

monitor BP, especially during terazosin initiation/titration: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• teriflunomide
fluphenazine decanoate (generic)

+

teriflunomide

1 interaction

Monitor/Modify Tx

fluphenazine + teriflunomide

monitor CBC: combo may decr. fluphenazine levels, efficacy; may incr. risk of myelosuppression (hepatic metabolism induced; additive effects)

• tetrabenazine
fluphenazine decanoate (generic)

+

tetrabenazine

1 interaction

Monitor/Modify Tx

fluphenazine + tetrabenazine

consider decr. dose of one or both drugs: combo may incr. risk of neuroleptic malignant syndrome, extrapyramidal symptoms, CNS depression, psychomotor impairment (additive effects)

• thioguanine
fluphenazine decanoate (generic)

+

thioguanine

1 interaction

Monitor/Modify Tx

fluphenazine + thioguanine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• thioridazine
fluphenazine decanoate (generic)

+

thioridazine

1 interaction

Monitor/Modify Tx

fluphenazine + thioridazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), anticholinergic and other adverse effects (additive effects, duplicate therapy)

• thiotepa
fluphenazine decanoate (generic)

+

thiotepa

1 interaction

Monitor/Modify Tx

fluphenazine + thiotepa

monitor CBC, bleeding s/sx; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, myelosuppression (additive effects)

• thiothixene
fluphenazine decanoate (generic)

+

thiothixene

1 interaction

Monitor/Modify Tx

fluphenazine + thiothixene

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, anticholinergic adverse effects (additive effects)

• tiagabine
fluphenazine decanoate (generic)

+

tiagabine

1 interaction

Monitor/Modify Tx

fluphenazine + tiagabine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• timolol
fluphenazine decanoate (generic)

+

timolol

1 interaction

Monitor/Modify Tx

fluphenazine + timolol

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• timolol ophthalmic
fluphenazine decanoate (generic)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

fluphenazine + timolol ophthalmic

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• tisagenlecleucel
fluphenazine decanoate (generic)

+

tisagenlecleucel

1 interaction

Monitor/Modify Tx

fluphenazine + tisagenlecleucel

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• tizanidine
fluphenazine decanoate (generic)

+

tizanidine

1 interaction

Monitor/Modify Tx

fluphenazine + tizanidine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• tocilizumab
fluphenazine decanoate (generic)

+

tocilizumab

1 interaction

Monitor/Modify Tx

fluphenazine + tocilizumab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• tofacitinib
fluphenazine decanoate (generic)

+

tofacitinib

1 interaction

Monitor/Modify Tx

fluphenazine + tofacitinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• tolcapone
fluphenazine decanoate (generic)

+

tolcapone

1 interaction

Monitor/Modify Tx

fluphenazine + tolcapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• tolterodine
fluphenazine decanoate (generic)

+

tolterodine

1 interaction

Monitor/Modify Tx

fluphenazine + tolterodine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; may decr. phenothiazine efficacy (additive effects; antagonistic effects)

• topiramate
fluphenazine decanoate (generic)

+

topiramate

1 interaction

Monitor/Modify Tx

fluphenazine + topiramate

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• topotecan
fluphenazine decanoate (generic)

+

topotecan

1 interaction

Monitor/Modify Tx

fluphenazine + topotecan

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• torsemide
fluphenazine decanoate (generic)

+

torsemide

1 interaction

Monitor/Modify Tx

fluphenazine + torsemide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• trabectedin
fluphenazine decanoate (generic)

+

trabectedin

1 interaction

Monitor/Modify Tx

fluphenazine + trabectedin

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• tramadol
fluphenazine decanoate (generic)

+

tramadol

1 interaction

Monitor/Modify Tx

fluphenazine + tramadol

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, seizures, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• trandolapril
fluphenazine decanoate (generic)

+

trandolapril

1 interaction

Monitor/Modify Tx

fluphenazine + trandolapril

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• trastuzumab
fluphenazine decanoate (generic)

+

trastuzumab

1 interaction

Monitor/Modify Tx

fluphenazine + trastuzumab

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• trazodone
fluphenazine decanoate (generic)

+

trazodone

1 interaction

Monitor/Modify Tx

fluphenazine + trazodone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• treosulfan
fluphenazine decanoate (generic)

+

treosulfan

1 interaction

Monitor/Modify Tx

fluphenazine + treosulfan

monitor CBC: combo may incr. risk of myelosuppression, seizures (additive effects)

• treprostinil
fluphenazine decanoate (generic)

+

treprostinil

1 interaction

Monitor/Modify Tx

fluphenazine + treprostinil

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• triamterene
fluphenazine decanoate (generic)

+

triamterene

1 interaction

Monitor/Modify Tx

fluphenazine + triamterene

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• triazolam
fluphenazine decanoate (generic)

+

triazolam

1 interaction

Monitor/Modify Tx

fluphenazine + triazolam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• trifluoperazine
fluphenazine decanoate (generic)

+

trifluoperazine

1 interaction

Monitor/Modify Tx

fluphenazine + trifluoperazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), extrapyramidal symptoms, anticholinergic adverse effects (additive effects, duplicate therapy)

• trifluridine
fluphenazine decanoate (generic)

+

trifluridine

1 interaction

Monitor/Modify Tx

fluphenazine + trifluridine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• trihexyphenidyl
fluphenazine decanoate (generic)

+

trihexyphenidyl

1 interaction

Monitor/Modify Tx

fluphenazine + trihexyphenidyl

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects; may decr. phenothiazine efficacy (additive effects; antagonistic effects)

• trimethoprim
fluphenazine decanoate (generic)

+

trimethoprim

1 interaction

Monitor/Modify Tx

fluphenazine + trimethoprim

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• trimipramine
fluphenazine decanoate (generic)

+

trimipramine

1 interaction

Monitor/Modify Tx

fluphenazine + trimipramine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), anticholinergic adverse effects (additive effects)

• triprolidine
fluphenazine decanoate (generic)

+

triprolidine

1 interaction

Monitor/Modify Tx

fluphenazine + triprolidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• trospium
fluphenazine decanoate (generic)

+

trospium

1 interaction

Monitor/Modify Tx

fluphenazine + trospium

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; may decr. phenothiazine efficacy (additive effects; antagonistic effects)

• upadacitinib
fluphenazine decanoate (generic)

+

upadacitinib

1 interaction

Monitor/Modify Tx

fluphenazine + upadacitinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• valbenazine
fluphenazine decanoate (generic)

+

valbenazine

1 interaction

Monitor/Modify Tx

fluphenazine + valbenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
fluphenazine decanoate (generic)

+

valerian

1 interaction

Monitor/Modify Tx

fluphenazine + valerian

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
fluphenazine decanoate (generic)

+

valproic acid

1 interaction

Monitor/Modify Tx

fluphenazine + valproic acid

monitor CBC; consider decr. dose of one or both drugs: combo may incr. risk of myelosuppression, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• valsartan
fluphenazine decanoate (generic)

+

valsartan

1 interaction

Monitor/Modify Tx

fluphenazine + valsartan

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• vancomycin
fluphenazine decanoate (generic)

+

vancomycin

1 interaction

Monitor/Modify Tx

fluphenazine + vancomycin

VANCOMYCIN IV: monitor CBC, especially w/ long-term vancomycin; VANCOMYCIN PO use OK: combo may incr. risk of myelosuppression (additive effects)

• vardenafil
fluphenazine decanoate (generic)

+

vardenafil

1 interaction

Monitor/Modify Tx

fluphenazine + vardenafil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• venetoclax
fluphenazine decanoate (generic)

+

venetoclax

1 interaction

Monitor/Modify Tx

fluphenazine + venetoclax

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• venlafaxine
fluphenazine decanoate (generic)

+

venlafaxine

1 interaction

Monitor/Modify Tx

fluphenazine + venlafaxine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• verapamil
fluphenazine decanoate (generic)

+

verapamil

1 interaction

Monitor/Modify Tx

fluphenazine + verapamil

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• vigabatrin
fluphenazine decanoate (generic)

+

vigabatrin

1 interaction

Monitor/Modify Tx

fluphenazine + vigabatrin

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• vilazodone
fluphenazine decanoate (generic)

+

vilazodone

1 interaction

Monitor/Modify Tx

fluphenazine + vilazodone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• viloxazine
fluphenazine decanoate (generic)

+

viloxazine

1 interaction

Monitor/Modify Tx

fluphenazine + viloxazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vinblastine
fluphenazine decanoate (generic)

+

vinblastine

1 interaction

Monitor/Modify Tx

fluphenazine + vinblastine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• vincristine
fluphenazine decanoate (generic)

+

vincristine

1 interaction

Monitor/Modify Tx

fluphenazine + vincristine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• vinorelbine
fluphenazine decanoate (generic)

+

vinorelbine

1 interaction

Monitor/Modify Tx

fluphenazine + vinorelbine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• vosoritide
fluphenazine decanoate (generic)

+

vosoritide

1 interaction

Monitor/Modify Tx

fluphenazine + vosoritide

monitor BP: combo may incr. risk of hypotension, including orthostasis (additive effects)

• warfarin
fluphenazine decanoate (generic)

+

warfarin

1 interaction

Monitor/Modify Tx

fluphenazine + warfarin

monitor INR: combo may decr. warfarin efficacy (mechanism unknown)

• yohimbe
fluphenazine decanoate (generic)

+

yohimbe

1 interaction

Monitor/Modify Tx

fluphenazine + yohimbe

monitor BP, especially w/ high yohimbe doses: combo may incr. risk of hypotension, including orthostasis (additive effects)

• zaleplon
fluphenazine decanoate (generic)

+

zaleplon

1 interaction

Monitor/Modify Tx

fluphenazine + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zanubrutinib
fluphenazine decanoate (generic)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

fluphenazine + zanubrutinib

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ziconotide
fluphenazine decanoate (generic)

+

ziconotide

1 interaction

Monitor/Modify Tx

fluphenazine + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zidovudine
fluphenazine decanoate (generic)

+

zidovudine

1 interaction

Monitor/Modify Tx

fluphenazine + zidovudine

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• ziprasidone
fluphenazine decanoate (generic)

+

ziprasidone

1 interaction

Monitor/Modify Tx

fluphenazine + ziprasidone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• ziv-aflibercept
fluphenazine decanoate (generic)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

fluphenazine + ziv-aflibercept

monitor CBC: combo may incr. risk of myelosuppression (additive effects)

• zolmitriptan
fluphenazine decanoate (generic)

+

zolmitriptan

1 interaction

Monitor/Modify Tx

fluphenazine + zolmitriptan

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
fluphenazine decanoate (generic)

+

zolpidem

1 interaction

Monitor/Modify Tx

fluphenazine + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
fluphenazine decanoate (generic)

+

zonisamide

1 interaction

Monitor/Modify Tx

fluphenazine + zonisamide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)